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Identification of bioactive compounds and potential mechanisms of scutellariae radix-coptidis rhizoma in the treatment of atherosclerosis by integrating network pharmacology and experimental validation.
Ji L, Song T, Ge C, Wu Q, Ma L, Chen X, Chen T, Chen Q, Chen Z, Chen W. Ji L, et al. Biomed Pharmacother. 2023 Sep;165:115210. doi: 10.1016/j.biopha.2023.115210. Epub 2023 Jul 25. Biomed Pharmacother. 2023. PMID: 37499457 Free article.
OBJECTIVE: This study aims at investigating the potential targets and functional mechanisms of Scutellariae Radix-Coptidis Rhizoma (QLYD) against atherosclerosis (AS) through network pharmacology, molecular docking, bioinformatic analysis and experimental validation …
OBJECTIVE: This study aims at investigating the potential targets and functional mechanisms of Scutellariae Radix-Coptidis Rhizoma (Q …
Immuno-modulatory role of baicalin in atherosclerosis prevention and treatment: current scenario and future directions.
Wang L, Huang S, Liang X, Zhou J, Han Y, He J, Xu D. Wang L, et al. Front Immunol. 2024 Apr 18;15:1377470. doi: 10.3389/fimmu.2024.1377470. eCollection 2024. Front Immunol. 2024. PMID: 38698839 Free PMC article. Review.
Atherosclerosis (AS) is recognized as a chronic inflammatory condition characterized by the accumulation of lipids and inflammatory cells within the damaged walls of arterial vessels. ...Thus, there is a pressing need for the development of new supplementary and alternativ …
Atherosclerosis (AS) is recognized as a chronic inflammatory condition characterized by the accumulation of lipids and inflammatory c …
Jiawei Dachaihu decoction protects against mitochondrial dysfunction in atherosclerosis (AS) mice with chronic unpredictable mild stress (CUMS) via SIRT1/PGC-1alpha/TFAM/LON signaling pathway.
Shi H, Sun M, Wang S, He F, Yang R, Li Z, Chen W, Wang F. Shi H, et al. J Ethnopharmacol. 2024 Aug 10;330:118150. doi: 10.1016/j.jep.2024.118150. Epub 2024 Apr 15. J Ethnopharmacol. 2024. PMID: 38631487
ETHNOPHARMACOLOGICAL RELEVANCE: JiaWei DaChaiHu is composed of Bupleurum chinense, Scutellaria baicalensis, Pinellia ternata, Paeonia lactiflora, Zingiber officinaleRoscoe, Poncirus tuifoliata, Rheum palmatum L., Curcumae Radix, Herba Lysimachiae, Ziziphus. ...AIM OF THE S …
ETHNOPHARMACOLOGICAL RELEVANCE: JiaWei DaChaiHu is composed of Bupleurum chinense, Scutellaria baicalensis, Pinellia ternata, Paeonia …
Wogonin Attenuates Atherosclerosis via KLF11-Mediated Suppression of PPARalpha-YAP1-Driven Glycolysis and Enhancement of ABCA1/G1-Mediated Cholesterol Efflux.
Ma C, Hua Y, Yang S, Zhao Y, Zhang W, Miao Y, Zhang J, Feng B, Zheng G, Li L, Liu Z, Zhang H, Zhu M, Gao X, Fan G. Ma C, et al. Adv Sci (Weinh). 2025 May 21:e2500610. doi: 10.1002/advs.202500610. Online ahead of print. Adv Sci (Weinh). 2025. PMID: 40397286
Emerging evidence suggests that metabolic reprogramming of macrophages represents a promising therapeutic approach for atherosclerosis management. In this study, the therapeutic potential of wogonin, a bioactive flavonoid isolated from Scutellaria baicalensis, in mo …
Emerging evidence suggests that metabolic reprogramming of macrophages represents a promising therapeutic approach for atherosclerosis …
Pharmacological mechanisms by which baicalin ameliorates cardiovascular disease.
Si L, Lai Y. Si L, et al. Front Pharmacol. 2024 Aug 9;15:1415971. doi: 10.3389/fphar.2024.1415971. eCollection 2024. Front Pharmacol. 2024. PMID: 39185317 Free PMC article. Review.
Baicalin is a flavonoid glycoside obtained from the dried root of Scutellaria baicalensis Georgi, which belongs to the Labiatae family. Accumulating evidence indicates that baicalin has favorable therapeutic effects on cardiovascular diseases. Previous studies have reveale …
Baicalin is a flavonoid glycoside obtained from the dried root of Scutellaria baicalensis Georgi, which belongs to the Labiatae famil …
Promising influences of Scutellaria baicalensis and its two active constituents, baicalin, and baicalein, against metabolic syndrome: A review.
Baradaran Rahimi V, Askari VR, Hosseinzadeh H. Baradaran Rahimi V, et al. Phytother Res. 2021 Jul;35(7):3558-3574. doi: 10.1002/ptr.7046. Epub 2021 Feb 16. Phytother Res. 2021. PMID: 33590943 Review.
Previous studies showed the ameliorating effects of Scutellaria baicalensis on metabolic syndrome parameters, including antidiabetic, anti-hyperlipidemic, anti-obesity, and antihypertensive. In this review, we deeply and mechanistically evaluated different studies on the e …
Previous studies showed the ameliorating effects of Scutellaria baicalensis on metabolic syndrome parameters, including antidiabetic, …
Banxia Xiexin decoction alleviates AS co-depression disease by regulating the gut microbiome-lipid metabolic axis.
Liao XX, Hu K, Xie XH, Wen YL, Wang R, Hu ZW, Zhou YL, Li JJ, Wu MK, Yu JX, Chen JW, Ren P, Wu XY, Zhou JJ. Liao XX, et al. J Ethnopharmacol. 2023 Sep 15;313:116468. doi: 10.1016/j.jep.2023.116468. Epub 2023 Apr 10. J Ethnopharmacol. 2023. PMID: 37044233 Free article.
ETHNOPHARMACOLOGICAL RELEVANCE: Banxia Xiexin decoction (BXD) is a classic Chinese herbal formulation consisting of 7 herbs including Pinelliae Rhizoma, Scutellariae Radix, Zingiberis Rhizoma, Ginseng Radix, Glycyrrhizae Radix, Coptidis Rhizoma, and Jujubae Fructus, which …
ETHNOPHARMACOLOGICAL RELEVANCE: Banxia Xiexin decoction (BXD) is a classic Chinese herbal formulation consisting of 7 herbs including Pinell …
Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review.
Xin L, Gao J, Lin H, Qu Y, Shang C, Wang Y, Lu Y, Cui X. Xin L, et al. Front Pharmacol. 2020 Nov 2;11:583200. doi: 10.3389/fphar.2020.583200. eCollection 2020. Front Pharmacol. 2020. PMID: 33224035 Free PMC article. Review.
In eastern countries, traditional Chinese medicine Scutellaria baicalensis Georgi has been used clinically for thousands of years. Baicalin is one of the main active ingredients extracted from Chinese herbal medicine S. baicalensis. ...Thereby it offers beneficial roles ag …
In eastern countries, traditional Chinese medicine Scutellaria baicalensis Georgi has been used clinically for thousands of years. Ba …
Unraveling the Role of Scutellaria baicalensis for the Treatment of Breast Cancer Using Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation.
Jiao Y, Shi C, Sun Y. Jiao Y, et al. Int J Mol Sci. 2023 Feb 10;24(4):3594. doi: 10.3390/ijms24043594. Int J Mol Sci. 2023. PMID: 36835006 Free PMC article.
Scutellaria baicalensis is often used to treat breast cancer, but the molecular mechanism behind the action is unclear. ...On the one hand, our study demonstrates that Scutellaria baicalensis has the characteristics of multicomponent and multitarget synergistic effe …
Scutellaria baicalensis is often used to treat breast cancer, but the molecular mechanism behind the action is unclear. ...On the one …
Anti-proliferative and anti-migratory effects of Scutellaria strigillosa Hemsley extracts against vascular smooth muscle cells.
Li J, Wang H, Shi X, Zhao L, Lv T, Yuan Q, Hao W, Zhu J. Li J, et al. J Ethnopharmacol. 2019 May 10;235:155-163. doi: 10.1016/j.jep.2019.02.016. Epub 2019 Feb 11. J Ethnopharmacol. 2019. PMID: 30763696
ETHNOPHARMACOLOGICAL RELEVANCE: The abnormal increase in vascular smooth muscle cell (VSMC) proliferation and migration are critical events in the pathogenesis of cardiovascular diseases (CVDs) including restenosis and atherosclerosis. The dried roots of Scutellaria …
ETHNOPHARMACOLOGICAL RELEVANCE: The abnormal increase in vascular smooth muscle cell (VSMC) proliferation and migration are critical events …
36 results