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39 results

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Page 1
Wogonin Attenuates Atherosclerosis via KLF11-Mediated Suppression of PPARalpha-YAP1-Driven Glycolysis and Enhancement of ABCA1/G1-Mediated Cholesterol Efflux.
Ma C, Hua Y, Yang S, Zhao Y, Zhang W, Miao Y, Zhang J, Feng B, Zheng G, Li L, Liu Z, Zhang H, Zhu M, Gao X, Fan G. Ma C, et al. Adv Sci (Weinh). 2025 Jun;12(23):e2500610. doi: 10.1002/advs.202500610. Epub 2025 May 21. Adv Sci (Weinh). 2025. PMID: 40397286 Free PMC article.
Emerging evidence suggests that metabolic reprogramming of macrophages represents a promising therapeutic approach for atherosclerosis management. In this study, the therapeutic potential of wogonin, a bioactive flavonoid isolated from Scutellaria baicalensis, in mo …
Emerging evidence suggests that metabolic reprogramming of macrophages represents a promising therapeutic approach for atherosclerosis …
Identification of bioactive compounds and potential mechanisms of scutellariae radix-coptidis rhizoma in the treatment of atherosclerosis by integrating network pharmacology and experimental validation.
Ji L, Song T, Ge C, Wu Q, Ma L, Chen X, Chen T, Chen Q, Chen Z, Chen W. Ji L, et al. Biomed Pharmacother. 2023 Sep;165:115210. doi: 10.1016/j.biopha.2023.115210. Epub 2023 Jul 25. Biomed Pharmacother. 2023. PMID: 37499457 Free article.
OBJECTIVE: This study aims at investigating the potential targets and functional mechanisms of Scutellariae Radix-Coptidis Rhizoma (QLYD) against atherosclerosis (AS) through network pharmacology, molecular docking, bioinformatic analysis and experimental validation …
OBJECTIVE: This study aims at investigating the potential targets and functional mechanisms of Scutellariae Radix-Coptidis Rhizoma (Q …
Immuno-modulatory role of baicalin in atherosclerosis prevention and treatment: current scenario and future directions.
Wang L, Huang S, Liang X, Zhou J, Han Y, He J, Xu D. Wang L, et al. Front Immunol. 2024 Apr 18;15:1377470. doi: 10.3389/fimmu.2024.1377470. eCollection 2024. Front Immunol. 2024. PMID: 38698839 Free PMC article. Review.
Atherosclerosis (AS) is recognized as a chronic inflammatory condition characterized by the accumulation of lipids and inflammatory cells within the damaged walls of arterial vessels. ...Thus, there is a pressing need for the development of new supplementary and alternativ …
Atherosclerosis (AS) is recognized as a chronic inflammatory condition characterized by the accumulation of lipids and inflammatory c …
Pharmacological mechanisms by which baicalin ameliorates cardiovascular disease.
Si L, Lai Y. Si L, et al. Front Pharmacol. 2024 Aug 9;15:1415971. doi: 10.3389/fphar.2024.1415971. eCollection 2024. Front Pharmacol. 2024. PMID: 39185317 Free PMC article. Review.
Baicalin is a flavonoid glycoside obtained from the dried root of Scutellaria baicalensis Georgi, which belongs to the Labiatae family. Accumulating evidence indicates that baicalin has favorable therapeutic effects on cardiovascular diseases. Previous studies have reveale …
Baicalin is a flavonoid glycoside obtained from the dried root of Scutellaria baicalensis Georgi, which belongs to the Labiatae famil …
Unlocking Toll-Like Receptors: Targeting Therapeutics for Respiratory Tract Infections and Inflammatory Disorders.
Pandey V, Sen D, Rathee S, Soni S, Mishra S, Jain SK, Patil UK. Pandey V, et al. Recent Adv Inflamm Allergy Drug Discov. 2025;19(3):303-315. doi: 10.2174/0127722708329138240926073013. Recent Adv Inflamm Allergy Drug Discov. 2025. PMID: 41392909 Review.
It has been observed that inflammatory diseases such as atherosclerosis, viral myocarditis, and other comorbidities associated with the spread of COVID-19 have increased, although the exact mechanisms remain not fully understood. ...This review explains the role of TLRs in …
It has been observed that inflammatory diseases such as atherosclerosis, viral myocarditis, and other comorbidities associated with t …
Promising influences of Scutellaria baicalensis and its two active constituents, baicalin, and baicalein, against metabolic syndrome: A review.
Baradaran Rahimi V, Askari VR, Hosseinzadeh H. Baradaran Rahimi V, et al. Phytother Res. 2021 Jul;35(7):3558-3574. doi: 10.1002/ptr.7046. Epub 2021 Feb 16. Phytother Res. 2021. PMID: 33590943 Review.
Previous studies showed the ameliorating effects of Scutellaria baicalensis on metabolic syndrome parameters, including antidiabetic, anti-hyperlipidemic, anti-obesity, and antihypertensive. In this review, we deeply and mechanistically evaluated different studies on the e …
Previous studies showed the ameliorating effects of Scutellaria baicalensis on metabolic syndrome parameters, including antidiabetic, …
Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review.
Xin L, Gao J, Lin H, Qu Y, Shang C, Wang Y, Lu Y, Cui X. Xin L, et al. Front Pharmacol. 2020 Nov 2;11:583200. doi: 10.3389/fphar.2020.583200. eCollection 2020. Front Pharmacol. 2020. PMID: 33224035 Free PMC article. Review.
In eastern countries, traditional Chinese medicine Scutellaria baicalensis Georgi has been used clinically for thousands of years. Baicalin is one of the main active ingredients extracted from Chinese herbal medicine S. baicalensis. ...Thereby it offers beneficial roles ag …
In eastern countries, traditional Chinese medicine Scutellaria baicalensis Georgi has been used clinically for thousands of years. Ba …
Baicalin and its aglycone: a novel approach for treatment of metabolic disorders.
Fang P, Yu M, Shi M, Bo P, Gu X, Zhang Z. Fang P, et al. Pharmacol Rep. 2020 Feb;72(1):13-23. doi: 10.1007/s43440-019-00024-x. Epub 2020 Jan 8. Pharmacol Rep. 2020. PMID: 32016847
Therefore, novel ways to prevent insulin resistance and type 2 diabetes are urgently needed. The roots of Scutellaria radix are commonly used in traditional Chinese medicines for prevention and treatment of type 2 diabetes, atherosclerosis, hypertension, hyperlipide …
Therefore, novel ways to prevent insulin resistance and type 2 diabetes are urgently needed. The roots of Scutellaria radix are commo …
Unraveling the Role of Scutellaria baicalensis for the Treatment of Breast Cancer Using Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation.
Jiao Y, Shi C, Sun Y. Jiao Y, et al. Int J Mol Sci. 2023 Feb 10;24(4):3594. doi: 10.3390/ijms24043594. Int J Mol Sci. 2023. PMID: 36835006 Free PMC article.
Scutellaria baicalensis is often used to treat breast cancer, but the molecular mechanism behind the action is unclear. ...On the one hand, our study demonstrates that Scutellaria baicalensis has the characteristics of multicomponent and multitarget synergistic effe …
Scutellaria baicalensis is often used to treat breast cancer, but the molecular mechanism behind the action is unclear. ...On the one …
Neuraminidase 1 and its Inhibitors from Chinese Herbal Medicines: An Emerging Role for Cardiovascular Diseases.
Zhang JY, Chen QQ, Li J, Zhang L, Qi LW. Zhang JY, et al. Am J Chin Med. 2021;49(4):843-862. doi: 10.1142/S0192415X21500403. Epub 2021 Apr 6. Am J Chin Med. 2021. PMID: 33827385 Review.
In this review, we center the attention to the role of Neu1 in cardiovascular diseases, including atherosclerosis, ischemic myocardial injury, cerebrovascular disease, congenital heart disease, and pulmonary embolism. ...Many Chinese herbs and Chinese herb preparations, su …
In this review, we center the attention to the role of Neu1 in cardiovascular diseases, including atherosclerosis, ischemic myocardia …
39 results