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2009 3
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Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis.
Dai J, Liang K, Zhao S, Jia W, Liu Y, Wu H, Lv J, Cao C, Chen T, Zhuang S, Hou X, Zhou S, Zhang X, Chen XW, Huang Y, Xiao RP, Wang YL, Luo T, Xiao J, Wang C. Dai J, et al. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5896-E5905. doi: 10.1073/pnas.1801745115. Epub 2018 Jun 11. Proc Natl Acad Sci U S A. 2018. PMID: 29891721 Free PMC article.
Obesity and related metabolic diseases are becoming worldwide epidemics that lead to increased death rates and heavy health care costs. ...The flavonoid directly activated hepatic CPT1 with isoform selectivity to accelerate the lipid influx into mitochondria for oxidation.
Obesity and related metabolic diseases are becoming worldwide epidemics that lead to increased death rates and heavy health care cost
The mechanisms of baicalin ameliorate obesity and hyperlipidemia through a network pharmacology approach.
Wang ZY, Jiang ZM, Xiao PT, Jiang YQ, Liu WJ, Liu EH. Wang ZY, et al. Eur J Pharmacol. 2020 Jul 5;878:173103. doi: 10.1016/j.ejphar.2020.173103. Epub 2020 Apr 9. Eur J Pharmacol. 2020. PMID: 32278854
Obesity is one of the main causes of human cardiovascular and cerebrovascular diseases. Baicalin, a bioactive flavonoid isolated from the herbal medicine Scutellaria baicalensis Georgi, is reported to ameliorate obesity and hyperlipidemia. ...
Obesity is one of the main causes of human cardiovascular and cerebrovascular diseases. Baicalin, a bioactive flavonoid isolated from
Scutellaria baicalensis Alleviates Insulin Resistance in Diet-Induced Obese Mice by Modulating Inflammation.
Na HY, Lee BC. Na HY, et al. Int J Mol Sci. 2019 Feb 8;20(3):727. doi: 10.3390/ijms20030727. Int J Mol Sci. 2019. PMID: 30744038 Free PMC article.
Insulin resistance is strongly associated with the metabolic syndrome, and chronic inflammation is known to be a major mechanism of insulin resistance and is a therapeutic target. This study was designed to evaluate the effect of Scutellaria baicalensis (SB) in high-fat di …
Insulin resistance is strongly associated with the metabolic syndrome, and chronic inflammation is known to be a major mechanism of insulin …
Therapeutic properties of Scutellaria baicalensis in db/db mice evaluated using Connectivity Map and network pharmacology.
Kim BY, Song KH, Lim CY, Cho SI. Kim BY, et al. Sci Rep. 2017 Jan 31;7:41711. doi: 10.1038/srep41711. Sci Rep. 2017. PMID: 28139721 Free PMC article.
We have reported that an extract of Scutellaria baicalensis (ESB) has effects against obesity and hypertriglyceridemia in type 2 diabetic animal model (db/db mouse). ...
We have reported that an extract of Scutellaria baicalensis (ESB) has effects against obesity and hypertriglyceridemia in type …
Herbal Combination of Phyllostachys pubescens and Scutellaria baicalensis Inhibits Adipogenesis and Promotes Browning via AMPK Activation in 3T3-L1 Adipocytes.
Sung YY, Son E, Im G, Kim DS. Sung YY, et al. Plants (Basel). 2020 Oct 23;9(11):1422. doi: 10.3390/plants9111422. Plants (Basel). 2020. PMID: 33114092 Free PMC article.
To investigate the anti-obesity effects and underlying mechanism of BS21, a combination of Phyllostachys pubescens leaves and Scutellaria baicalensis roots was used to investigate the effects of BS21 on adipogenesis, lipogenesis, and browning in 3T3-L1 adipocytes. . …
To investigate the anti-obesity effects and underlying mechanism of BS21, a combination of Phyllostachys pubescens leaves and Scut
Extracts of Scutellaria baicalensis reduced body weight and blood triglyceride in db/db Mice.
Song KH, Lee SH, Kim BY, Park AY, Kim JY. Song KH, et al. Phytother Res. 2013 Feb;27(2):244-50. doi: 10.1002/ptr.4691. Epub 2012 Apr 25. Phytother Res. 2013. PMID: 22532505
Scutellaria baicalensis has been extensively employed for the clinical treatment of hyperlipidemia, atherosclerosis, hypertension, dysentery, inflammatory diseases, and the common cold. The present study was performed to investigate the anti-obesity and anti-dyslipi
Scutellaria baicalensis has been extensively employed for the clinical treatment of hyperlipidemia, atherosclerosis, hypertension, dy
Yin Zhi Huang, a traditional Chinese herbal formula, ameliorates diet-induced obesity and hepatic steatosis by activating the AMPK/SREBP-1 and the AMPK/ACC/CPT1A pathways.
Yao Q, Li S, Cheng X, Zou Y, Shen Y, Zhang S. Yao Q, et al. Ann Transl Med. 2020 Mar;8(5):231. doi: 10.21037/atm.2020.01.31. Ann Transl Med. 2020. PMID: 32309378 Free PMC article.
BACKGROUND: Yin Zhi Huang (YZH) is a formula composed of Artemisia scoparia, Gardeniae fructus, Scutellaria baicalensis Georgi, and Lonicerae Japonicae Flos. Most of the components are eaten as food in Asia. ...Body weight gain, adipose mass, and plasma lipids levels were …
BACKGROUND: Yin Zhi Huang (YZH) is a formula composed of Artemisia scoparia, Gardeniae fructus, Scutellaria baicalensis Georgi, and L …
Baicalin and its aglycone: a novel approach for treatment of metabolic disorders.
Fang P, Yu M, Shi M, Bo P, Gu X, Zhang Z. Fang P, et al. Pharmacol Rep. 2020 Feb;72(1):13-23. doi: 10.1007/s43440-019-00024-x. Epub 2020 Jan 8. Pharmacol Rep. 2020. PMID: 32016847
RESULTS: Emerging evidence indicated that baicalin and baicalein possessed hepatoprotective, anti-oxidative, anti-dyslipidemic, anti-lipogenic, anti-obese, anti-inflammatory, and anti-diabetic effects, being effective for treating obesity, insulin resistance, non-al …
RESULTS: Emerging evidence indicated that baicalin and baicalein possessed hepatoprotective, anti-oxidative, anti-dyslipidemic, anti-lipogen …
SH21B, an anti-obesity herbal composition, inhibits fat accumulation in 3T3-L1 adipocytes and high fat diet-induced obese mice through the modulation of the adipogenesis pathway.
Lee H, Kang R, Yoon Y. Lee H, et al. J Ethnopharmacol. 2010 Feb 17;127(3):709-17. doi: 10.1016/j.jep.2009.12.002. Epub 2009 Dec 4. J Ethnopharmacol. 2010. PMID: 19963057
ETHNOPHARMACOLOGICAL RELEVANCE: SH21B is an anti-obesity composition composed of seven herbs: Scutellaria baicalensis Georgi, Prunus armeniaca Maxim, Ephedra sinica Stapf, Acorus gramineus Soland, Typha orientalis Presl, Polygala tenuifolia Willd and Nelumbo nucifer …
ETHNOPHARMACOLOGICAL RELEVANCE: SH21B is an anti-obesity composition composed of seven herbs: Scutellaria baicalensis Georgi, …
In vivo therapeutic effect of combination treatment with metformin and Scutellaria baicalensis on maintaining bile acid homeostasis.
Han K, Bose S, Wang JH, Lim SK, Chin YW, Kim YM, Choi HS, Kim H. Han K, et al. PLoS One. 2017 Sep 6;12(9):e0182467. doi: 10.1371/journal.pone.0182467. eCollection 2017. PLoS One. 2017. PMID: 28877164 Free PMC article.
The radix of Scutellaria baicalensis (SB) is a herb widely used in traditional Chinese medicine to treat metabolic diseases. Several main components, including baicalin and wogonoside, possess anti-dyslipidemia, anti-obesity and anti-diabetic effects. We hypothesize …
The radix of Scutellaria baicalensis (SB) is a herb widely used in traditional Chinese medicine to treat metabolic diseases. Several …
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