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Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria.
Cárdenas C, Müller M, McNeal A, Lovy A, Jaňa F, Bustos G, Urra F, Smith N, Molgó J, Diehl JA, Ridky TW, Foskett JK. Cárdenas C, et al. Cell Rep. 2016 Mar 15;14(10):2313-24. doi: 10.1016/j.celrep.2016.02.030. Epub 2016 Mar 3. Cell Rep. 2016. PMID: 26947070 Free PMC article.
Here, we demonstrate that tumorigenic cancer cell lines, transformed primary human fibroblasts, and tumors in vivo respond similarly but that autophagy is insufficient for survival, and cancer cells die while their normal counterparts are spared. ...Our findi …
Here, we demonstrate that tumorigenic cancer cell lines, transformed primary human fibroblasts, and tumors in vivo respond similarly …
Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells.
Cruz P, Ahumada-Castro U, Bustos G, Molgó J, Sauma D, Lovy A, Cárdenas C. Cruz P, et al. Int J Mol Sci. 2021 Jan 11;22(2):651. doi: 10.3390/ijms22020651. Int J Mol Sci. 2021. PMID: 33440859 Free PMC article.
Mitochondrial function is sustained by a constitutive transfer of calcium from the endoplasmic reticulum to mitochondria through the inositol 1,4,5-trisphosphate receptor (InsP3R), making T-ALL cells vulnerable to its inhibition. ...Moreover, th …
Mitochondrial function is sustained by a constitutive transfer of calcium from the endoplasmic reticulum to mitochondria throu …