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129 results

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Page 1
Selenoproteins.
Lu J, Holmgren A. Lu J, et al. J Biol Chem. 2009 Jan 9;284(2):723-7. doi: 10.1074/jbc.R800045200. Epub 2008 Aug 29. J Biol Chem. 2009. PMID: 18757362 Free article. Review.
A unique mechanism is used to decode the UGA codon in mRNA to co-translationally incorporate Sec into the growing polypeptide because there is no free pool of Sec. In the human genome, 25 genes for selenoproteins have been identified. Selenoproteins such as gluta …
A unique mechanism is used to decode the UGA codon in mRNA to co-translationally incorporate Sec into the growing polypeptide because there …
Selenium, Iodine and Iron-Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism.
Köhrle J. Köhrle J. Int J Mol Sci. 2023 Feb 8;24(4):3393. doi: 10.3390/ijms24043393. Int J Mol Sci. 2023. PMID: 36834802 Free PMC article. Review.
Selenocysteine-containing proteins convey both cellular protection along with H(2)O(2)-dependent biosynthesis and the deiodinase-mediated (in-)activation of thyroid hormones, which is critical for their receptor-mediated mechanism of cellular action. Disbalances bet …
Selenocysteine-containing proteins convey both cellular protection along with H(2)O(2)-dependent biosynthesis and the deiodinase-medi …
Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease.
Rayman MP. Rayman MP. Proc Nutr Soc. 2019 Feb;78(1):34-44. doi: 10.1017/S0029665118001192. Epub 2018 Sep 13. Proc Nutr Soc. 2019. PMID: 30208979 Review.
Hashimoto's thyroiditis (HT) and Graves' disease (GD) are examples of autoimmune thyroid disease (AITD), the commonest autoimmune condition. Antibodies to thyroid peroxidase (TPO), the enzyme that catalyses thyroid-hormone production and antibod …
Hashimoto's thyroiditis (HT) and Graves' disease (GD) are examples of autoimmune thyroid disease (AITD), the commonest autoimm …
Selenium and thyroid.
Köhrle J, Gärtner R. Köhrle J, et al. Best Pract Res Clin Endocrinol Metab. 2009 Dec;23(6):815-27. doi: 10.1016/j.beem.2009.08.002. Best Pract Res Clin Endocrinol Metab. 2009. PMID: 19942156 Review.
Selenoproteins involved in cellular antioxidative defence systems and redox control, such as the glutathione peroxidase (GPx) and the thioredoxin reductase (TxnRd) family, are involved in protection of the thyroid gland from excess hydrogen pero …
Selenoproteins involved in cellular antioxidative defence systems and redox control, such as the glutathione peroxidase …
Selenium Deficiency.
Shreenath AP, Hashmi MF, Dooley J. Shreenath AP, et al. 2023 Oct 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. 2023 Oct 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 29489289 Free Books & Documents.
In particular, glutathione peroxidase (G-Px), a selenoprotein, contributes to antioxidant defense, safeguarding the body against the damaging effects of reactive oxygen and nitrogen species. Another significant selenium-dependent function involves iodothyroni …
In particular, glutathione peroxidase (G-Px), a selenoprotein, contributes to antioxidant defense, safeguarding the bod …
Selenium supply regulates thyroid function, thyroid hormone synthesis and metabolism by altering the expression of the selenoenzymes Type I 5'-deiodinase and glutathione peroxidase.
Köhrle J, Oertel M, Gross M. Köhrle J, et al. Thyroidology. 1992 Apr;4(1):17-21. Thyroidology. 1992. PMID: 1284327 Review.
Human and rat Type I 5'deiodinase have been identified as selenoprotein containing selenocysteine in its active site. ...The role of other newly discovered selenoproteins for thyroid hormone synthesis, activation, and action has to be investigated....
Human and rat Type I 5'deiodinase have been identified as selenoprotein containing selenocysteine in its active site. ...The r …
Selenium and endocrine systems.
Beckett GJ, Arthur JR. Beckett GJ, et al. J Endocrinol. 2005 Mar;184(3):455-65. doi: 10.1677/joe.1.05971. J Endocrinol. 2005. PMID: 15749805 Review.
The trace element selenium (Se) is capable of exerting multiple actions on endocrine systems by modifying the expression of at least 30 selenoproteins, many of which have clearly defined functions. Well-characterized selenoenzymes are the families of glutathione per …
The trace element selenium (Se) is capable of exerting multiple actions on endocrine systems by modifying the expression of at least 30 s …
Selenium nutritional status and thyroid dysfunction.
Souza LSL, Campos RO, Braga JS Filho, Jesus JDS, Anunciação SM, Cassemiro JF, Rende PRF, Hecht F, Ramos HE. Souza LSL, et al. Arch Endocrinol Metab. 2025 Feb 24;69(1):e230348. doi: 10.20945/2359-4292-2023-0348. Arch Endocrinol Metab. 2025. PMID: 39992731 Free PMC article. Review.
Selenium(Se) is an essential micronutrient for several immune and regulatory functions in the body. In thyroid tissue, Se contributes to the antioxidant system and is a crucial component of deiodinases, which are selenoproteins that participate in thyroid …
Selenium(Se) is an essential micronutrient for several immune and regulatory functions in the body. In thyroid tissue, Se contributes …
Selenium and the brain: a review.
Whanger PD. Whanger PD. Nutr Neurosci. 2001;4(2):81-97. doi: 10.1080/1028415x.2001.11747353. Nutr Neurosci. 2001. PMID: 11842884 Review.
Selenium does not have as great effect on glutathione peroxidase (GPX) activity in the brain as in most other organs. Prolonged selenium and iodine deficiencies will compromise thyroid hormone homeostatus in the brain and this is due to changes in deiodina …
Selenium does not have as great effect on glutathione peroxidase (GPX) activity in the brain as in most other organs. Prolonge …
The diverse role of selenium within selenoproteins: a review.
Holben DH, Smith AM. Holben DH, et al. J Am Diet Assoc. 1999 Jul;99(7):836-43. doi: 10.1016/S0002-8223(99)00198-4. J Am Diet Assoc. 1999. PMID: 10405682 Review.
Eleven selenoproteins have been identified: cellular or classical glutathione peroxidase; plasma (or extracellular) glutathione peroxidase; phospholipid hydroperoxide glutathione peroxidase; gastrointestinal glutathione p …
Eleven selenoproteins have been identified: cellular or classical glutathione peroxidase; plasma (or extracellular) …
129 results