Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1983 1
1989 1
1990 2
1991 1
1994 1
1998 2
1999 4
2000 4
2003 1
2006 3
2008 1
2010 1
2011 2
2012 1
2013 3
2015 1
2016 3
2017 1
2019 3
2020 3
2021 5
2022 3
2023 3
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

45 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.
Morishita D, Tomita T, Mori S, Kimura T, Oshima T, Fukui H, Miwa H. Morishita D, et al. Am J Gastroenterol. 2021 Jan 1;116(1):152-161. doi: 10.14309/ajg.0000000000000942. Am J Gastroenterol. 2021. PMID: 32969946 Clinical Trial.

The response rate for overall improvement was 11.7% in the placebo group, 69.2% in the senna group, and 68.3% in the MgO group (P < 0.0001). Change in SBM was significantly greater in the senna and MgO groups than that in the placebo group (P < 0.001). Similar

The response rate for overall improvement was 11.7% in the placebo group, 69.2% in the senna group, and 68.3% in the MgO group (P &lt …
Osmotic and stimulant laxatives for the management of childhood constipation.
Gordon M, MacDonald JK, Parker CE, Akobeng AK, Thomas AG. Gordon M, et al. Cochrane Database Syst Rev. 2016 Aug 17;2016(8):CD009118. doi: 10.1002/14651858.CD009118.pub3. Cochrane Database Syst Rev. 2016. PMID: 27531591 Free PMC article. Review.
No statistically significant differences in the number of stools per week were found between PEG and enemas (1 study, 90 patients, MD 1.00, 95% CI -1.58 to 3.58), dietary fibre mix and lactulose (1 study, 125 patients, P = 0.481), senna and lactulose (1 study, 21 patients, …
No statistically significant differences in the number of stools per week were found between PEG and enemas (1 study, 90 patients, MD 1.00, …
Effect of senna glycoside on serum potassium levels among patients on maintenance hemodialysis: A randomized controlled trial.
Nata N, Bunpeth W, Tasanavipas P, Varothai N, Supasyndh O, Satirapoj B. Nata N, et al. Ther Apher Dial. 2022 Oct;26(5):908-914. doi: 10.1111/1744-9987.13774. Epub 2021 Dec 19. Ther Apher Dial. 2022. PMID: 38318690 Clinical Trial.
The prevalence of hyperkalemia during the study occurred at 13.8% in the control and 5.4% in the senna glycoside (p = 0.309). No serious adverse events were observed. CONCLUSION: Among patients with ESRD on hemodialysis, senna glycoside significantly decreases serum …
The prevalence of hyperkalemia during the study occurred at 13.8% in the control and 5.4% in the senna glycoside (p = 0.309). No seri …
The Efficacy of Senna Bowel Preparation for Colonoscopy: A Systematic Review and Meta-analysis.
Tian H, Fan Y, Yang L, Hou S, Huang W, Dong R, Li S, Zhu X, Liu W, Shi G, Li X, Zhou S, Wang X. Tian H, et al. Gastroenterol Nurs. 2022 Nov-Dec 01;45(6):428-439. doi: 10.1097/SGA.0000000000000664. Epub 2022 Jun 25. Gastroenterol Nurs. 2022. PMID: 35758925
The quality of bowel preparation is an extremely important determinant of colonoscopy results. However, the efficacy of senna regimens in improving bowel cleanliness is uncertain. We conducted a systematic review and meta-analysis to synthesize data on whether using a s
The quality of bowel preparation is an extremely important determinant of colonoscopy results. However, the efficacy of senna regimen …
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
van der Schoot A, Creedon A, Whelan K, Dimidi E. van der Schoot A, et al. Neurogastroenterol Motil. 2023 Nov;35(11):e14613. doi: 10.1111/nmo.14613. Epub 2023 May 27. Neurogastroenterol Motil. 2023. PMID: 37243443
KEY RESULTS: Eight RCTs (787 participants) were included, investigating kiwifruit (n = 3 RCTs), senna (n = 2), magnesium oxide (n = 2), Ziziphus jujuba (n = 1), and Malva Sylvestris (n = 1) supplements. ...CONCLUSIONS AND INFERENCES: Magnesium oxide supplements are effecti …
KEY RESULTS: Eight RCTs (787 participants) were included, investigating kiwifruit (n = 3 RCTs), senna (n = 2), magnesium oxide (n = 2 …
Pharmacological prevention and treatment of opioid-induced constipation in cancer patients: A systematic review and meta-analysis.
Kistemaker KRJ, Sijani F, Brinkman DJ, de Graeff A, Burchell GL, Steegers MAH, van Zuylen L. Kistemaker KRJ, et al. Cancer Treat Rev. 2024 Apr;125:102704. doi: 10.1016/j.ctrv.2024.102704. Epub 2024 Mar 1. Cancer Treat Rev. 2024. PMID: 38452708 Free article. Review.
Regarding the treatment of OIC, two RCTs compared laxatives, of which one RCT found that polyethylene glycol was significantly more effective than sennosides. Seven studies compared an opioid antagonist (naloxone, methylnaltrexone or naldemedine) with placebo and three stu …
Regarding the treatment of OIC, two RCTs compared laxatives, of which one RCT found that polyethylene glycol was significantly more effectiv …
Polyethylene glycol versus split high-dose senna for bowel preparation: A comparative prospective randomized study.
Coskun Y, Yuksel I. Coskun Y, et al. J Gastroenterol Hepatol. 2020 Nov;35(11):1923-1929. doi: 10.1111/jgh.15101. Epub 2020 Jun 8. J Gastroenterol Hepatol. 2020. PMID: 32424868 Clinical Trial.
RESULTS: The quality of colon cleansing and the ease of bowel preparation were significantly better in the senna group; the mean of total BBPS scores was 7.35 in the senna group and 6.57 in the PEG group, cleansing was adequate (BBPS score 6) in 89.9% of patients ta …
RESULTS: The quality of colon cleansing and the ease of bowel preparation were significantly better in the senna group; the mean of t …
Cleaning effect and tolerance of 16 bowel preparation regimens on adult patients before colonoscopy: a network meta-analysis.
Sun M, Yang G, Wang Y. Sun M, et al. Int J Colorectal Dis. 2023 Mar 11;38(1):69. doi: 10.1007/s00384-023-04355-3. Int J Colorectal Dis. 2023. PMID: 36905434 Review.
PEG + Sim (OR,1.5, 95%CrI, 1.0-2.2) regimen is ranked first in adenoma detection rate(ADR). Senna (OR, 3.23, 95%CrI, 1.04-9.97) and SP/MC (OR, 249.91, 95%CrI, 78.49-958.19) regimens are ranked first in abdominal pain and willingness to repeat, respectively. ...In addition, …
PEG + Sim (OR,1.5, 95%CrI, 1.0-2.2) regimen is ranked first in adenoma detection rate(ADR). Senna (OR, 3.23, 95%CrI, 1.04-9.97) and S …
Effectiveness of senna vs polyethylene glycol as laxative therapy in children with constipation related to anorectal malformation.
Santos-Jasso KA, Arredondo-García JL, Maza-Vallejos J, Lezama-Del Valle P. Santos-Jasso KA, et al. J Pediatr Surg. 2017 Jan;52(1):84-88. doi: 10.1016/j.jpedsurg.2016.10.021. Epub 2016 Oct 27. J Pediatr Surg. 2017. PMID: 27836356 Clinical Trial.
We designed this trial to study the effectiveness of Senna versus polyethylene glycol for the treatment of constipation in children with anorectal malformation. ...The maximum daily dose of Senna (sennosides A and B) was 38.7mg and 17g for polyethylene glycol …
We designed this trial to study the effectiveness of Senna versus polyethylene glycol for the treatment of constipation in children w …
What Is the Optimal Bowel Preparation for Capsule Colonoscopy and Pan-intestinal Capsule Endoscopy? A Systematic Review and Meta-Analysis.
Rosa B, Donato H, Cúrdia Gonçalves T, Sousa-Pinto B, Cotter J. Rosa B, et al. Dig Dis Sci. 2023 Dec;68(12):4418-4431. doi: 10.1007/s10620-023-08133-7. Epub 2023 Oct 13. Dig Dis Sci. 2023. PMID: 37833441 Free PMC article.
Despite considerable heterogeneity, our results support low-fibre diet, use of adjunctive sennosides, split dose < 4L PEG, and routine prokinetics, while NaP remains the most consistent option as booster....

Despite considerable heterogeneity, our results support low-fibre diet, use of adjunctive sennosides, split dose < 4L PEG, and rou

45 results