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48 results

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Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.
Morishita D, Tomita T, Mori S, Kimura T, Oshima T, Fukui H, Miwa H. Morishita D, et al. Am J Gastroenterol. 2021 Jan 1;116(1):152-161. doi: 10.14309/ajg.0000000000000942. Am J Gastroenterol. 2021. PMID: 32969946 Clinical Trial.

The response rate for overall improvement was 11.7% in the placebo group, 69.2% in the senna group, and 68.3% in the MgO group (P < 0.0001). Change in SBM was significantly greater in the senna and MgO groups than that in the placebo group (P < 0.001). Similar

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The response rate for overall improvement was 11.7% in the placebo group, 69.2% in the senna group, and 68.3% in the MgO group (P &lt …
Pharmacological prevention and treatment of opioid-induced constipation in cancer patients: A systematic review and meta-analysis.
Kistemaker KRJ, Sijani F, Brinkman DJ, de Graeff A, Burchell GL, Steegers MAH, van Zuylen L. Kistemaker KRJ, et al. Cancer Treat Rev. 2024 Apr;125:102704. doi: 10.1016/j.ctrv.2024.102704. Epub 2024 Mar 1. Cancer Treat Rev. 2024. PMID: 38452708 Free article.
Regarding the treatment of OIC, two RCTs compared laxatives, of which one RCT found that polyethylene glycol was significantly more effective than sennosides. Seven studies compared an opioid antagonist (naloxone, methylnaltrexone or naldemedine) with placebo and three stu …
Regarding the treatment of OIC, two RCTs compared laxatives, of which one RCT found that polyethylene glycol was significantly more effectiv …
Osmotic and stimulant laxatives for the management of childhood constipation.
Gordon M, MacDonald JK, Parker CE, Akobeng AK, Thomas AG. Gordon M, et al. Cochrane Database Syst Rev. 2016 Aug 17;2016(8):CD009118. doi: 10.1002/14651858.CD009118.pub3. Cochrane Database Syst Rev. 2016. PMID: 27531591 Free PMC article.
No statistically significant differences in the number of stools per week were found between PEG and enemas (1 study, 90 patients, MD 1.00, 95% CI -1.58 to 3.58), dietary fibre mix and lactulose (1 study, 125 patients, P = 0.481), senna and lactulose (1 study, 21 patients, …
No statistically significant differences in the number of stools per week were found between PEG and enemas (1 study, 90 patients, MD 1.00, …
The Efficacy of Senna Bowel Preparation for Colonoscopy: A Systematic Review and Meta-analysis.
Tian H, Fan Y, Yang L, Hou S, Huang W, Dong R, Li S, Zhu X, Liu W, Shi G, Li X, Zhou S, Wang X. Tian H, et al. Gastroenterol Nurs. 2022 Nov-Dec 01;45(6):428-439. doi: 10.1097/SGA.0000000000000664. Epub 2022 Jun 25. Gastroenterol Nurs. 2022. PMID: 35758925
The quality of bowel preparation is an extremely important determinant of colonoscopy results. However, the efficacy of senna regimens in improving bowel cleanliness is uncertain. We conducted a systematic review and meta-analysis to synthesize data on whether using a s …
The quality of bowel preparation is an extremely important determinant of colonoscopy results. However, the efficacy of senna regimen …
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
van der Schoot A, Creedon A, Whelan K, Dimidi E. van der Schoot A, et al. Neurogastroenterol Motil. 2023 Nov;35(11):e14613. doi: 10.1111/nmo.14613. Epub 2023 May 27. Neurogastroenterol Motil. 2023. PMID: 37243443
KEY RESULTS: Eight RCTs (787 participants) were included, investigating kiwifruit (n = 3 RCTs), senna (n = 2), magnesium oxide (n = 2), Ziziphus jujuba (n = 1), and Malva Sylvestris (n = 1) supplements. ...CONCLUSIONS AND INFERENCES: Magnesium oxide supplements are effecti …
KEY RESULTS: Eight RCTs (787 participants) were included, investigating kiwifruit (n = 3 RCTs), senna (n = 2), magnesium oxide (n = 2 …
Effect of senna glycoside on serum potassium levels among patients on maintenance hemodialysis: A randomized controlled trial.
Nata N, Bunpeth W, Tasanavipas P, Varothai N, Supasyndh O, Satirapoj B. Nata N, et al. Ther Apher Dial. 2022 Oct;26(5):908-914. doi: 10.1111/1744-9987.13774. Epub 2021 Dec 19. Ther Apher Dial. 2022. PMID: 38318690 Clinical Trial.
The prevalence of hyperkalemia during the study occurred at 13.8% in the control and 5.4% in the senna glycoside (p = 0.309). No serious adverse events were observed. CONCLUSION: Among patients with ESRD on hemodialysis, senna glycoside significantly decreases serum …
The prevalence of hyperkalemia during the study occurred at 13.8% in the control and 5.4% in the senna glycoside (p = 0.309). No seri …
Polyethylene glycol versus split high-dose senna for bowel preparation: A comparative prospective randomized study.
Coskun Y, Yuksel I. Coskun Y, et al. J Gastroenterol Hepatol. 2020 Nov;35(11):1923-1929. doi: 10.1111/jgh.15101. Epub 2020 Jun 8. J Gastroenterol Hepatol. 2020. PMID: 32424868 Clinical Trial.
RESULTS: The quality of colon cleansing and the ease of bowel preparation were significantly better in the senna group; the mean of total BBPS scores was 7.35 in the senna group and 6.57 in the PEG group, cleansing was adequate (BBPS score 6) in 89.9% of patients ta …
RESULTS: The quality of colon cleansing and the ease of bowel preparation were significantly better in the senna group; the mean of t …
Effectiveness of senna vs polyethylene glycol as laxative therapy in children with constipation related to anorectal malformation.
Santos-Jasso KA, Arredondo-García JL, Maza-Vallejos J, Lezama-Del Valle P. Santos-Jasso KA, et al. J Pediatr Surg. 2017 Jan;52(1):84-88. doi: 10.1016/j.jpedsurg.2016.10.021. Epub 2016 Oct 27. J Pediatr Surg. 2017. PMID: 27836356 Clinical Trial.
We designed this trial to study the effectiveness of Senna versus polyethylene glycol for the treatment of constipation in children with anorectal malformation. ...The maximum daily dose of Senna (sennosides A and B) was 38.7mg and 17g for polyethylene glycol …
We designed this trial to study the effectiveness of Senna versus polyethylene glycol for the treatment of constipation in children w …
Efficacy of 1 L Polyethylene Glycol Plus Ascorbic Acid With Linaclotide Versus Senna for Bowel Preparation: A Multicenter, Endoscopist-Blinded, Randomized Controlled Trial (Apple Trial).
Maeda N, Higashimori A, Kabata D, Yamamoto I, Yanagida T, Kin D, Matsumoto Y, Nakata R, Hashimoto A, Sawada A, Maruyama H, Okamoto J, Katsuno T, Nadatani Y, Ominami M, Fukunaga S, Morimoto K, Hosomi S, Tanaka F, Nakatani M, Taira K, Sasaki E, Fukuda T, Ota K, Yoshida H, Watanabe T, Fujiwara Y. Maeda N, et al. Am J Gastroenterol. 2025 Nov 1;120(11):2679-2686. doi: 10.14309/ajg.0000000000003370. Epub 2025 Feb 25. Am J Gastroenterol. 2025. PMID: 39996602 Free PMC article. Clinical Trial.
The aim of this study was to evaluate whether adding 0.5 mg linaclotide to 1 L PEG-Asc (1 L-PEG/AL) improves superior cleansing compared with adding 24 mg senna (1 L-PEG/AS), which we previously reported to be noninferior to the standard regimen of 2 L PEG-Asc. ...DISCUSSI …
The aim of this study was to evaluate whether adding 0.5 mg linaclotide to 1 L PEG-Asc (1 L-PEG/AL) improves superior cleansing compared wit …
Influence of a highly purified senna extract on colonic epithelium.
van Gorkom BA, Karrenbeld A, van Der Sluis T, Koudstaal J, de Vries EG, Kleibeuker JH. van Gorkom BA, et al. Digestion. 2000;61(2):113-20. doi: 10.1159/000007743. Digestion. 2000. PMID: 10705175 Clinical Trial.
AIMS: To evaluate in a controlled study the effects of highly purified senna extract on cell proliferation and crypt length in the entire colon and on p53 and bcl-2 expression. METHODS: Addition of a senna extract to colonic lavage was studied in 184 consecutive out …
AIMS: To evaluate in a controlled study the effects of highly purified senna extract on cell proliferation and crypt length in the en …
48 results