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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 7
1964 5
1966 1
1967 3
1968 7
1969 18
1970 17
1971 17
1972 18
1973 9
1974 13
1975 10
1976 12
1977 14
1978 11
1979 21
1980 20
1981 24
1982 21
1983 24
1984 28
1985 39
1986 29
1987 40
1988 52
1989 68
1990 75
1991 104
1992 107
1993 145
1994 176
1995 197
1996 234
1997 248
1998 264
1999 342
2000 329
2001 402
2002 504
2003 578
2004 599
2005 618
2006 652
2007 584
2008 626
2009 617
2010 726
2011 871
2012 873
2013 896
2014 837
2015 829
2016 784
2017 772
2018 722
2019 719
2020 876
2021 880
2022 636
2023 542
2024 755
2025 915
2026 523

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19,227 results

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Page 1
Serine and glycine metabolism in cancer.
Amelio I, Cutruzzolá F, Antonov A, Agostini M, Melino G. Amelio I, et al. Trends Biochem Sci. 2014 Apr;39(4):191-8. doi: 10.1016/j.tibs.2014.02.004. Epub 2014 Mar 20. Trends Biochem Sci. 2014. PMID: 24657017 Free PMC article. Review.
A crucial contribution of serine/glycine to cellular metabolism is through the glycine cleavage system, which refuels one-carbon metabolism; a complex cyclic metabolic network based on chemical reactions of folate compounds. The importance of serine …
A crucial contribution of serine/glycine to cellular metabolism is through the glycine cleavage system, which refuels one-carb …
Serine, glycine and one-carbon metabolism in cancer (Review).
Pan S, Fan M, Liu Z, Li X, Wang H. Pan S, et al. Int J Oncol. 2021 Feb;58(2):158-170. doi: 10.3892/ijo.2020.5158. Epub 2020 Dec 11. Int J Oncol. 2021. PMID: 33491748 Free PMC article. Review.
Serine/glycine biosynthesis and one-carbon metabolism are crucial in sustaining cancer cell survival and rapid proliferation, and of high clinical relevance. Excessive activation of serine/glycine biosynthesis drives tumorigenesis and provides a single carbon …
Serine/glycine biosynthesis and one-carbon metabolism are crucial in sustaining cancer cell survival and rapid proliferation, …
A comprehensive review on signaling attributes of serine and serine metabolism in health and disease.
Wu D, Zhang K, Khan FA, Pandupuspitasari NS, Guan K, Sun F, Huang C. Wu D, et al. Int J Biol Macromol. 2024 Mar;260(Pt 2):129607. doi: 10.1016/j.ijbiomac.2024.129607. Epub 2024 Jan 20. Int J Biol Macromol. 2024. PMID: 38253153 Review.
Serine is a metabolite with ever-expanding metabolic and non-metabolic signaling attributes. ...Metabolic control and epigenetic- and posttranslational regulation of serine metabolism are also discussed. ...
Serine is a metabolite with ever-expanding metabolic and non-metabolic signaling attributes. ...Metabolic contro …
Serine, glycine and one-carbon units: cancer metabolism in full circle.
Locasale JW. Locasale JW. Nat Rev Cancer. 2013 Aug;13(8):572-83. doi: 10.1038/nrc3557. Epub 2013 Jul 4. Nat Rev Cancer. 2013. PMID: 23822983 Free PMC article. Review.
One-carbon metabolism involving the folate and methionine cycles integrates nutritional status from amino acids, glucose and vitamins, and generates diverse outputs, such as the biosynthesis of lipids, nucleotides and proteins, the maintenance of redox status and the subst …
One-carbon metabolism involving the folate and methionine cycles integrates nutritional status from amino acids, glucose and vitamins …
More than just protein building blocks: how amino acids and related metabolic pathways fuel macrophage polarization.
Kieler M, Hofmann M, Schabbauer G. Kieler M, et al. FEBS J. 2021 Jun;288(12):3694-3714. doi: 10.1111/febs.15715. Epub 2021 Feb 22. FEBS J. 2021. PMID: 33460504 Free PMC article. Review.
This 'arginine dichotomy' has recently become a matter of debate; however, in parallel with the emerging field of immunometabolism there is accumulating evidence that these two enzymes and their related metabolites are fundamentally involved in the intrinsic regulation of macroph …
This 'arginine dichotomy' has recently become a matter of debate; however, in parallel with the emerging field of immunometabolism there is …
l-Serine links metabolism with neurotransmission.
Maugard M, Vigneron PA, Bolaños JP, Bonvento G. Maugard M, et al. Prog Neurobiol. 2021 Feb;197:101896. doi: 10.1016/j.pneurobio.2020.101896. Epub 2020 Aug 14. Prog Neurobiol. 2021. PMID: 32798642 Review.
This metabolic pathway is called the phosphorylated pathway and transforms 3PG into l-serine via three enzymatic reactions. We first compiled the available data on the mechanisms that regulate the flux through this metabolic pathway. We then reviewed the curr …
This metabolic pathway is called the phosphorylated pathway and transforms 3PG into l-serine via three enzymatic reactions. We …
Serine-deficiency syndromes.
de Koning TJ, Klomp LW. de Koning TJ, et al. Curr Opin Neurol. 2004 Apr;17(2):197-204. doi: 10.1097/00019052-200404000-00019. Curr Opin Neurol. 2004. PMID: 15021249 Review.
PURPOSE OF REVIEW: Serine-deficiency disorders comprise a new group of neurometabolic diseases and are caused by defects in the biosynthesis of the amino acid L-serine. ...Disturbances of serine-glycine metabolism in relation to N-methyl-D-aspar …
PURPOSE OF REVIEW: Serine-deficiency disorders comprise a new group of neurometabolic diseases and are caused by defects in th …
The Intersection of Serine Metabolism and Cellular Dysfunction in Retinal Degeneration.
Sinha T, Ikelle L, Naash MI, Al-Ubaidi MR. Sinha T, et al. Cells. 2020 Mar 10;9(3):674. doi: 10.3390/cells9030674. Cells. 2020. PMID: 32164325 Free PMC article. Review.
Serine-derived sphingolipids and phosphatidylserine for phagocytosis by the retinal pigment epithelium (RPE) and neuronal crosstalk of the inner retina via D-serine require proper serine metabolism. ...Finally and perhaps the most vital part of seri …
Serine-derived sphingolipids and phosphatidylserine for phagocytosis by the retinal pigment epithelium (RPE) and neuronal crosstalk o …
The importance of serine metabolism in cancer.
Mattaini KR, Sullivan MR, Vander Heiden MG. Mattaini KR, et al. J Cell Biol. 2016 Aug 1;214(3):249-57. doi: 10.1083/jcb.201604085. Epub 2016 Jul 25. J Cell Biol. 2016. PMID: 27458133 Free PMC article. Review.
Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. ...Recent studies cast new light on the role of serine metabolism in cancer, suggesting that active serine synthesis …
Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversia …
Serine metabolism in aging and age-related diseases.
Shan S, Hoffman JM. Shan S, et al. Geroscience. 2025 Feb;47(1):611-630. doi: 10.1007/s11357-024-01444-1. Epub 2024 Nov 25. Geroscience. 2025. PMID: 39585647 Free PMC article. Review.
Interestingly, increasing evidence suggests that serine metabolism may impact the aging process, and supplementation with serine may confer benefits in safeguarding against aging and age-related disorders. This review synthesizes recent insights into t …
Interestingly, increasing evidence suggests that serine metabolism may impact the aging process, and supplementation with s …
19,227 results
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