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2,172 results

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Page 1
Nintedanib Ameliorates Bleomycin-Induced Pulmonary Fibrosis, Inflammation, Apoptosis, and Oxidative Stress by Modulating PI3K/Akt/mTOR Pathway in Mice.
Pan L, Cheng Y, Yang W, Wu X, Zhu H, Hu M, Zhang Y, Zhang M. Pan L, et al. Inflammation. 2023 Aug;46(4):1531-1542. doi: 10.1007/s10753-023-01825-2. Epub 2023 May 9. Inflammation. 2023. PMID: 37160579 Free PMC article.
In addition, nintedanib showed lung-protective effects by up-regulating antioxidant levels, down-regulating inflammatory protein expression, and reducing collagen accumulation. ...According to our findings, nintedanib restores the antioxidant system, suppresses pro- …
In addition, nintedanib showed lung-protective effects by up-regulating antioxidant levels, down-regulating inflammatory protein expr …
DNA damage response pathway regulates Nrf2 in response to oxidative stress.
Jiang XY, Guo QQ, Wang SS, Guo R, Zou Y, Liu JW, Feng YL, Guo Y, Li YH, Liu XY, Zhang XY, Hao S, Wu XX, Li MH, Liu A, Li CL, Guo WD, Xu HD, Song XY, Finkel T, Cao L. Jiang XY, et al. Sci Adv. 2025 Jul 25;11(30):eadu9555. doi: 10.1126/sciadv.adu9555. Epub 2025 Jul 25. Sci Adv. 2025. PMID: 40712037 Free PMC article.
Nrf2 acts as a transcriptional master regulator to orchestrate antioxidant responses and maintain redox balance. However, the cellular pathway for translating oxidative stress signals into Nrf2-dependent antioxidant responses remain incompletely unders …
Nrf2 acts as a transcriptional master regulator to orchestrate antioxidant responses and maintain redox balance. However, the cellula …
Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity.
Datta S, Cano M, Satyanarayana G, Liu T, Wang L, Wang J, Cheng J, Itoh K, Sharma A, Bhutto I, Kannan R, Qian J, Sinha D, Handa JT. Datta S, et al. Autophagy. 2023 Mar;19(3):966-983. doi: 10.1080/15548627.2022.2109286. Epub 2022 Aug 13. Autophagy. 2023. PMID: 35921555 Free PMC article.
Due to the daily phagocytosis of photoreceptor outer segments, unique photo-oxidative stress, and high metabolism for maintaining vision, the RPE has robust macroautophagy/autophagy, and mitochondrial and antioxidant networks. ...This reprogramming is mediate …
Due to the daily phagocytosis of photoreceptor outer segments, unique photo-oxidative stress, and high metabolism for maintain …
Effect of L-serine on oxidative stress markers in the kidney of streptozotocin-induced diabetic mice.
Langroudi FE, Narani MS, Kheirollahi A, Vatannejad A, Shokrpoor S, Alizadeh S. Langroudi FE, et al. Amino Acids. 2023 Jun;55(6):799-806. doi: 10.1007/s00726-023-03270-9. Epub 2023 May 8. Amino Acids. 2023. PMID: 37156853
L-serine has recently been shown to reduce oxidative stress, the incidence of autoimmune diabetes and improve glucose homeostasis. ...This study revealed that L-serine effectively ameliorates oxidative stress in kidney tissue and reduces …
L-serine has recently been shown to reduce oxidative stress, the incidence of autoimmune diabetes and improve glucose h …
Serine Deficiency Exacerbates Inflammation and Oxidative Stress via Microbiota-Gut-Brain Axis in D-Galactose-Induced Aging Mice.
Wang F, Zhou H, Deng L, Wang L, Chen J, Zhou X. Wang F, et al. Mediators Inflamm. 2020 Mar 2;2020:5821428. doi: 10.1155/2020/5821428. eCollection 2020. Mediators Inflamm. 2020. PMID: 32189994 Free PMC article.
Inflammation and oxidative stress play key roles in the process of aging and age-related diseases. Since serine availability plays important roles in the support of antioxidant and anti-inflammatory defense system, we explored whether serine def …
Inflammation and oxidative stress play key roles in the process of aging and age-related diseases. Since serine availab …
Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense.
Choi EJ, Oh HT, Lee SH, Zhang CS, Li M, Kim SY, Park S, Chang TS, Lee BH, Lin SC, Jeon SM. Choi EJ, et al. Autophagy. 2024 Nov;20(11):2490-2510. doi: 10.1080/15548627.2024.2374692. Epub 2024 Jul 10. Autophagy. 2024. PMID: 38953310 Free PMC article.
Characterizing the regulatory crosstalk between the STK11-AMPK and KEAP1-NFE2L2 pathways during metabolic stress is crucial for understanding the implications of co-occurring mutations. Here, we found that metabolic stress increased the expression and phosphorylatio …
Characterizing the regulatory crosstalk between the STK11-AMPK and KEAP1-NFE2L2 pathways during metabolic stress is crucial for under …
Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer.
Lee HM, Muhammad N, Lieu EL, Cai F, Mu J, Ha YS, Cao G, Suchors C, Joves K, Chronis C, Li K, Ducker GS, Olszewski K, Cai L, Allison DB, Bachert SE, Ewing WR, Wong H, Seo H, Kim IY, Faubert B, Kim J, Kim J. Lee HM, et al. Nat Metab. 2024 Jul;6(7):1310-1328. doi: 10.1038/s42255-024-01066-z. Epub 2024 Jun 14. Nat Metab. 2024. PMID: 38877143 Free PMC article.
LKB1 loss, in collaboration with KEAP1 loss, activated SHMT through inactivation of the salt-induced kinase (SIK)-NRF2 axis and satisfied the increased demand for one-carbon units necessary for antioxidant defence. Chemical and genetic SHMT suppression increased cellular s …
LKB1 loss, in collaboration with KEAP1 loss, activated SHMT through inactivation of the salt-induced kinase (SIK)-NRF2 axis and satisfied th …
Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets.
Rahman I. Rahman I. Curr Drug Targets Inflamm Allergy. 2002 Sep;1(3):291-315. doi: 10.2174/1568010023344607. Curr Drug Targets Inflamm Allergy. 2002. PMID: 14561194 Review.
Furthermore, oxidative stress may alter the balance between gene expression of pro-inflammatory mediators and antioxidant enzymes in favor of inflammatory mediators in the lung. Thus, the presence of oxidative stress may have important consequen …
Furthermore, oxidative stress may alter the balance between gene expression of pro-inflammatory mediators and antioxidant …
Serine alleviates oxidative stress via supporting glutathione synthesis and methionine cycle in mice.
Zhou X, He L, Wu C, Zhang Y, Wu X, Yin Y. Zhou X, et al. Mol Nutr Food Res. 2017 Nov;61(11). doi: 10.1002/mnfr.201700262. Epub 2017 Sep 1. Mol Nutr Food Res. 2017. PMID: 28759161
The present study was conducted to determine the effects of serine supplementation on oxidative stress and its relative mechanisms. METHODS AND RESULTS: Diquat treatment was performed to induce oxidative stress in mice and primary hepatocytes. . …
The present study was conducted to determine the effects of serine supplementation on oxidative stress and its relative …
PHGDH-dependent serine metabolism in astrocytes: A key regulator of oxidative stress and pyroptosis in cerebral ischemia-reperfusion injury.
Zhang J, Luo Y, Xie C, Zhang M, Qin H, Zhou Y, Wu X, Hu C, Hu F, Fei X, Zhang H, Li J, Fu Y, Yuan Y, Yang S, Gao D. Zhang J, et al. Redox Biol. 2026 Feb;89:103954. doi: 10.1016/j.redox.2025.103954. Epub 2025 Nov 29. Redox Biol. 2026. PMID: 41344159 Free PMC article.
Ischemia-reperfusion injury is predominantly triggered by oxidative stress and inflammatory responses; however, the underlying molecular mechanisms remain incompletely understood. ...Specifically, downregulation of PHGDH in astrocytes induces oxidative str …
Ischemia-reperfusion injury is predominantly triggered by oxidative stress and inflammatory responses; however, the underlying …
2,172 results