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Methylome-wide association studies and epigenetic biomarker development for 133 mass spectrometry-assessed circulating proteins in 14,671 Generation Scotland participants.
Robertson JA, Bajzik J, Vernardis S, Chybowska AD, McCartney DL, Grauslys A, Mur J, Smith HM, Campbell A, Drake C, Grant H, Pearce J, Russ TC, Adkin P, White M, Brigden C, Messner CB, Porteous DJ, Hayward C, Cox SR, Zelezniak A, Ralser M, Robinson MR, Marioni RE. Robertson JA, et al. Among authors: smith hm. Genome Biol. 2025 Dec 8;26(1):417. doi: 10.1186/s13059-025-03892-0. Genome Biol. 2025. PMID: 41361833 Free PMC article.
Bayesian epigenome-wide association studies of the same 133 proteins reveal 697 CpG-Protein associations (posterior inclusion probability > 0.95). 112 protein EpiScores correlate significantly with their respective protein in a holdout test-set. Of these, sixteen associ …
Bayesian epigenome-wide association studies of the same 133 proteins reveal 697 CpG-Protein associations (posterior inclusion probability &g …
The protist symbionts of Reticulitermes tibialis: Unexpected diversity enables a new taxonomic framework.
Coots NL, Jasso-Selles DE, Swichtenberg KL, Aguilar SG, Nguyen L, Sidles PG, Woo C, Smith HM, Bresee BJ, Abboud AA, Abd Al Rahman T, Anand R, Avalle SR, Batra A, Brown MA, Camacho Ruelas H, Fajardo Chavez A, Gallegos CN, Grambs A, Hernández DA, Singh Johal A, Jones SA, McAnally KB, McNamara M, Munigala L, Nguyen HL, Salas Perez K, Shah R, Sharma NK, Thomas MK, Vega Beltran E, Verne NM, De Martini F, Gile GH. Coots NL, et al. Among authors: smith hm. Protist. 2025 Mar;176:126087. doi: 10.1016/j.protis.2025.126087. Epub 2025 Feb 3. Protist. 2025. PMID: 39929034
Symbiont species varied in their prevalence across colonies, with a core set of about 12 highly prevalent symbiont species, 11 species with intermediate prevalence, and 18 rare species. ...
Symbiont species varied in their prevalence across colonies, with a core set of about 12 highly prevalent symbiont species, 11 specie …
DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain.
Gadd DA, Smith HM, Mullin D, Chybowska O, Hillary RF, Kimenai DM, Bernabeu E, Cheng Y, Fawns-Ritchie C, Campbell A, Page D, Taylor A, Corley J, Del C Valdés-Hernández M, Maniega SM, Bastin ME, Wardlaw JM, Walker RM, Evans KL, McIntosh AM, Hayward C, Russ TC, Harris SE, Welsh P, Sattar N, Cox SR, McCartney DL, Marioni RE. Gadd DA, et al. Among authors: smith hm. Clin Epigenetics. 2024 Sep 10;16(1):124. doi: 10.1186/s13148-024-01734-7. Clin Epigenetics. 2024. PMID: 39256775 Free PMC article.

The GDF15 EpiScore replicated protein associations with incident dementia, type 2 diabetes and ischaemic stroke in the Generation Scotland test set (hazard ratios (HR) range 1.36-1.41, P(FDR) < 0.05). The EpiScore for NT-proBNP replicated the protein association with ty

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The GDF15 EpiScore replicated protein associations with incident dementia, type 2 diabetes and ischaemic stroke in the Generation Scotland t …
Web apps for profile fitting and power balance analysis at Wendelstein 7-X.
Wappl M, Bozhenkov SA, Beurskens MNA, Bannmann S, Kuczyński MD, Smith HM, Brunner KJ, Ford OP, Fuchert G, Knauer JP, Langenberg A, Pablant NA, Pasch E, Poloskei PZ, Wolf RC; W7-X Team. Wappl M, et al. Among authors: smith hm. Rev Sci Instrum. 2024 Sep 1;95(9):093529. doi: 10.1063/5.0225315. Rev Sci Instrum. 2024. PMID: 39292159
A global, neoclassical simulation with the code EUTERPE is performed for a set of experimental profiles to gain an understanding of the neoclassical root transition....
A global, neoclassical simulation with the code EUTERPE is performed for a set of experimental profiles to gain an understanding of t …
The Role of Scientific Research in Human Papillomavirus Vaccine Discussions on Twitter: Social Network Analysis.
Jessiman-Perreault G, Boucher JC, Kim SY, Frenette N, Badami A, Smith HM, Allen Scott LK. Jessiman-Perreault G, et al. Among authors: smith hm. JMIR Infodemiology. 2024 May 9;4:e50551. doi: 10.2196/50551. JMIR Infodemiology. 2024. PMID: 38722678 Free PMC article.
METHODS: To analyze the use of scientific research on social media, we collected tweets and retweets using a list of keywords associated with HPV and HPV vaccines using the Academic Research Product Track application programming interface from January 2019 to May 2021. From this …
METHODS: To analyze the use of scientific research on social media, we collected tweets and retweets using a list of keywords associated wit …
Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals.
Hillary RF, McCartney DL, Smith HM, Bernabeu E, Gadd DA, Chybowska AD, Cheng Y, Murphy L, Wrobel N, Campbell A, Walker RM, Hayward C, Evans KL, McIntosh AM, Marioni RE. Hillary RF, et al. Among authors: smith hm. PLoS Med. 2023 Jul 6;20(7):e1004247. doi: 10.1371/journal.pmed.1004247. eCollection 2023 Jul. PLoS Med. 2023. PMID: 37410739 Free PMC article. Review.
Incident cases were identified using linkage to Scottish primary (Read 2) and secondary (ICD-10) care records, and the censoring date was set to October 2020. The mean time-to-diagnosis ranged from 5.0 years (for chronic pain) to 11.7 years (for Coronavirus Disease 2019 (C …
Incident cases were identified using linkage to Scottish primary (Read 2) and secondary (ICD-10) care records, and the censoring date was …