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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
2007 1
2008 3
2009 3
2010 6
2011 5
2012 13
2013 20
2014 37
2015 49
2016 56
2017 60
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2019 62
2020 78
2021 100
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814 results

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Page 1
SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways.
Yuan H, Han Y, Wang X, Li N, Liu Q, Yin Y, Wang H, Pan L, Li L, Song K, Qiu T, Pan Q, Chen Q, Zhang G, Zang Y, Tan M, Zhang J, Li Q, Wang X, Jiang J, Qin J. Yuan H, et al. Cancer Cell. 2020 Sep 14;38(3):350-365.e7. doi: 10.1016/j.ccell.2020.05.022. Epub 2020 Jul 2. Cancer Cell. 2020. PMID: 32619406 Free article.
The level of SETD2-mediated H3K36me3 is inversely correlated with that of EZH2-catalyzed H3K27me3. ...Conversely, mice harboring nonmethylated EZH2 mutant or SETD2 mutant defective in binding to EZH2 develop metastatic PCa. Furthermore, we identify that metformin-st …
The level of SETD2-mediated H3K36me3 is inversely correlated with that of EZH2-catalyzed H3K27me3. ...Conversely, mice harboring nonm …
SETD2 Neurodevelopmental Disorders.
Pappas J, Rabin R. Pappas J, et al. 2021 Dec 30 [updated 2022 Sep 22]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. 2021 Dec 30 [updated 2022 Sep 22]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. PMID: 34978780 Free Books & Documents. Review.
DIAGNOSIS/TESTING: The diagnosis of a SETD2-NDD is established in a proband with suggestive findings and a heterozygous pathogenic variant in SETD2 identified by molecular genetic testing. ...Each child of an individual with a SETD2-NDD has a 50% chance of in …
DIAGNOSIS/TESTING: The diagnosis of a SETD2-NDD is established in a proband with suggestive findings and a heterozygous pathogenic va …
SETD2-H3K36ME3: an important bridge between the environment and tumors.
He J, Xu T, Zhao F, Guo J, Hu Q. He J, et al. Front Genet. 2023 Jun 9;14:1204463. doi: 10.3389/fgene.2023.1204463. eCollection 2023. Front Genet. 2023. PMID: 37359376 Free PMC article. Review.
As an important bridge between the environment and tumors, SETD2-H3K36me3 plays an important role in the occurrence and development of tumors. Many tumors, including renal cancer, gastric cancer, lung cancer, are closely related to SETD2 gene mutations. As a key com …
As an important bridge between the environment and tumors, SETD2-H3K36me3 plays an important role in the occurrence and development o …
Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC.
Xue W, Jian W, Meng Y, Wang T, Cai L, Yu Y, Yu Y, Xia Z, Zhang C. Xue W, et al. Cell Death Dis. 2023 Aug 21;14(8):539. doi: 10.1038/s41419-023-06057-8. Cell Death Dis. 2023. PMID: 37604811 Free PMC article.
Ferroptosis, a form of death distinct from apoptosis and necrosis, has been reported in recent years in renal cancer. However, the relationship between SETD2 and ferroptosis in renal cancer is not clear. Here, we demonstrated that SETD2 was expressed at low levels i …
Ferroptosis, a form of death distinct from apoptosis and necrosis, has been reported in recent years in renal cancer. However, the relations …
Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia-mesenchymal transition during pancreatic carcinogenesis.
Niu N, Lu P, Yang Y, He R, Zhang L, Shi J, Wu J, Yang M, Zhang ZG, Wang LW, Gao WQ, Habtezion A, Xiao GG, Sun Y, Li L, Xue J. Niu N, et al. Gut. 2020 Apr;69(4):715-726. doi: 10.1136/gutjnl-2019-318362. Epub 2019 Jul 11. Gut. 2020. PMID: 31300513
However, whether SETD2/H3K36me3 alteration results in PDAC remains largely unknown. DESIGN: TCGA(PAAD) public database and PDAC tissue array with SETD2/H3K36me3 staining were used to investigate the clinical relevance of SETD2 in PDAC. Furthermore, to define …
However, whether SETD2/H3K36me3 alteration results in PDAC remains largely unknown. DESIGN: TCGA(PAAD) public database and PDAC tissu …
SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes.
Xie Y, Sahin M, Sinha S, Wang Y, Nargund AM, Lyu Y, Han S, Dong Y, Hsieh JJ, Leslie CS, Cheng EH. Xie Y, et al. Nat Cancer. 2022 Feb;3(2):188-202. doi: 10.1038/s43018-021-00316-3. Epub 2022 Feb 3. Nat Cancer. 2022. PMID: 35115713 Free PMC article.
Genomic profiling of primary ccRCC tumors reveals a positive correlation between SETD2 mutations and metastasis. However, whether and how SETD2 loss promotes metastasis remains unclear. In this study, we used a SETD2-mutant (SETD2(MT)) metastatic ccRCC …
Genomic profiling of primary ccRCC tumors reveals a positive correlation between SETD2 mutations and metastasis. However, whether and …
Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.
Chen K, Liu J, Liu S, Xia M, Zhang X, Han D, Jiang Y, Wang C, Cao X. Chen K, et al. Cell. 2017 Jul 27;170(3):492-506.e14. doi: 10.1016/j.cell.2017.06.042. Cell. 2017. PMID: 28753426 Free article.
In addition, SETD2 selectively catalyzes the tri-methylation of H3K36 on promoters of some ISGs such as ISG15, leading to gene activation. Our study identifies STAT1 methylation on K525 catalyzed by the methyltransferase SETD2 as an essential signaling event for IFN …
In addition, SETD2 selectively catalyzes the tri-methylation of H3K36 on promoters of some ISGs such as ISG15, leading to gene activa …
SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer.
Rao H, Liu C, Wang A, Ma C, Xu Y, Ye T, Su W, Zhou P, Gao WQ, Li L, Ding X. Rao H, et al. Nat Commun. 2023 Nov 21;14(1):7572. doi: 10.1038/s41467-023-43378-w. Nat Commun. 2023. PMID: 37989747 Free PMC article.
However, the role of SETD2 in ccRCC generation in PKD remains largely unexplored. Herein, we perform metabolomics, lipidomics, transcriptomics and proteomics within SETD2 loss induced PKD-ccRCC transition mouse model. ...This study introduces high-quality multi-omic …
However, the role of SETD2 in ccRCC generation in PKD remains largely unexplored. Herein, we perform metabolomics, lipidomics, transc …
SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development.
Xu Q, Xiang Y, Wang Q, Wang L, Brind'Amour J, Bogutz AB, Zhang Y, Zhang B, Yu G, Xia W, Du Z, Huang C, Ma J, Zheng H, Li Y, Liu C, Walker CL, Jonasch E, Lefebvre L, Wu M, Lorincz MC, Li W, Li L, Xie W. Xu Q, et al. Nat Genet. 2019 May;51(5):844-856. doi: 10.1038/s41588-019-0398-7. Epub 2019 Apr 29. Nat Genet. 2019. PMID: 31040401
Here, we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse oocyte epigenome. ...Importantly, maternal depletion of SETD2 results in oocyte maturation defects and subsequent one-cell arrest after …
Here, we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse ooc …
Tumor Cell-Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis.
Niu N, Shen X, Zhang L, Chen Y, Lu P, Yang W, Liu M, Shi J, Xu D, Tang Y, Yang X, Weng Y, Zhao X, Wu LM, Sun Y, Xue J. Niu N, et al. Adv Sci (Weinh). 2023 Jan;10(2):e2202937. doi: 10.1002/advs.202202937. Epub 2022 Dec 1. Adv Sci (Weinh). 2023. PMID: 36453584 Free PMC article.
By comprehensive profiling of the intratumoral immune cells, neutrophils are identified as the subset with the most significant changes upon Setd2 loss. Setd2-deficient pancreatic tumor cells directly enhance neutrophil recruitment and reprogramming, thereby inhibit …
By comprehensive profiling of the intratumoral immune cells, neutrophils are identified as the subset with the most significant changes upon …
814 results