SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development.
Xu Q, Xiang Y, Wang Q, Wang L, Brind'Amour J, Bogutz AB, Zhang Y, Zhang B, Yu G, Xia W, Du Z, Huang C, Ma J, Zheng H, Li Y, Liu C, Walker CL, Jonasch E, Lefebvre L, Wu M, Lorincz MC, Li W, Li L, Xie W.
Xu Q, et al.
Nat Genet. 2019 May;51(5):844-856. doi: 10.1038/s41588-019-0398-7. Epub 2019 Apr 29.
Nat Genet. 2019.
PMID: 31040401
Here, we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse oocyte epigenome. ...Importantly, maternal depletion of SETD2 results in oocyte maturation defects and subsequent one-cell arrest after …
Here, we report that histone-lysine N-methyltransferase SETD2, an H3K36me3 methyltransferase, is a crucial regulator of the mouse ooc …