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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 1
2008 2
2009 1
2012 4
2013 5
2014 8
2015 7
2016 4
2017 4
2018 5
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2021 10
2022 5
2023 7
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83 results

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Page 1
Non-genotoxic transplantation and in vivo selection through epitope editing.
Casirati G, Cosentino A, Freschi M, Zeng J, Mucci A, Levesque S, Neri N, Drago E, Carzaniga V, Romano F, Katta V, Matsubara A, Li Y, Mahmoud MS, Chávez-Navarro M, Brendel C, Manis JP, Tsai S, Pellin D, Bauer D, Genovese P. Casirati G, et al. Among authors: tsai s. Nature. 2026 Jul 8. doi: 10.1038/s41586-026-10737-8. Online ahead of print. Nature. 2026. PMID: 42420446
Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation.
Omura SN, Nakagawa R, Kajimoto S, Okazaki S, Ishiguro S, Mori H, Onishi K, Kashiwakura Y, Hiramoto T, Horinaka K, Tanaka M, Hirano H, Jividen K, Yamashita K, Tsai SQ, Yachie N, Ohmori T, Nishimasu H, Nureki O. Omura SN, et al. Among authors: tsai sq. Nat Commun. 2026 Apr 16;17(1):3584. doi: 10.1038/s41467-026-71626-2. Nat Commun. 2026. PMID: 41991526 Free PMC article.
Monitoring biological effects of somatic cell genome editing.
Freedman BS, Bulte JWM, Conklin BR, Judge LM, Dwinell MR, Geurts AM, Sitton MJ, Mahajan V, Kiani S, Gersbach CA, Ebrahimkhani MR, Kelly JJ, Ronald JA, Morizane R, Gupta N, Shakeri-Zadeh A, Vo N, Saha K, Saxena S, Gamm DM, Sinha D, Tarantal AF, Vandsburger M, Matsubara A, Fu H, Tsai SQ; SCGE Dissemination and Coordinating Center Toolkit Team; SCGE Biological Effects Initiative. Freedman BS, et al. Among authors: tsai sq. Nat Rev Genet. 2026 Apr;27(4):323-342. doi: 10.1038/s41576-025-00916-0. Epub 2026 Jan 13. Nat Rev Genet. 2026. PMID: 41530266 Free PMC article. Review.
Brain-wide Genome Editing via STEP-RNPs for Treatment of Angelman Syndrome.
Lu X, Xie Y, Bao Y, Yu J, Wang Z, Fan J, Sheu WC, Long G, Tu Z, Tong J, Manquen G, Li Y, Katta V, Chow R, Chen B, Meng Z, Ma YH, Qiu C, Chen S, Tsai SQ, De Kumar B, Hendry CE, Jiang YH, Zhou J. Lu X, et al. Among authors: tsai sq. bioRxiv [Preprint]. 2025 Nov 14:2025.11.13.684643. doi: 10.1101/2025.11.13.684643. bioRxiv. 2025. PMID: 41292800 Free PMC article. Preprint.
Measurement and clinical interpretation of CRISPR off-targets.
Angelini Stewart A, Ahrens-Nicklas RC, Tsai SQ, Musunuru K, Giannikopoulos P, Clelland CD. Angelini Stewart A, et al. Among authors: tsai sq. Nat Genet. 2026 Jan;58(1):20-27. doi: 10.1038/s41588-025-02428-3. Epub 2025 Nov 24. Nat Genet. 2026. PMID: 41286106 Free PMC article. Review.
Treatment of a severe vascular disease using a bespoke CRISPR-Cas9 base editor in mice.
Alves CRR, Das S, Krishnan V, Ha LL, Fox LR, Stutzman HE, Shamber CE, Kalailingam P, McCarthy S, Lino Cardenas CL, Fong CE, Imai T, Mitra S, Yun S, Wood RK, Benning FMC, Roh K, Lawton J, Kim N, Silverstein RA, Ferreira da Silva J, de la Cruz D, Richa R, Xie J, Gray-Edwards HL, Malhotra R, Chung DY, Chao LH, Tsai SQ, Maguire CA, Lindsay ME, Kleinstiver BP, Musolino PL. Alves CRR, et al. Among authors: tsai sq. Nat Biomed Eng. 2026 May;10(5):952-967. doi: 10.1038/s41551-025-01499-1. Epub 2025 Sep 11. Nat Biomed Eng. 2026. PMID: 40935887 Free PMC article.
Custom CRISPR-Cas9 PAM variants via scalable engineering and machine learning.
Silverstein RA, Kim N, Kroell AS, Walton RT, Delano J, Butcher RM, Pacesa M, Smith BK, Christie KA, Ha LL, Meis RJ, Clark AB, Spinner AD, Lazzarotto CR, Li Y, Matsubara A, Urbina EO, Dahl GA, Correia BE, Marks DS, Tsai SQ, Pinello L, De Ravin SS, Liu Q, Kleinstiver BP. Silverstein RA, et al. Among authors: tsai sq. Nature. 2025 Jul;643(8071):539-550. doi: 10.1038/s41586-025-09021-y. Epub 2025 Apr 22. Nature. 2025. PMID: 40262634 Free PMC article.
83 results