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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1973 1
1975 1
1976 1
1978 2
1979 8
1980 7
1981 8
1982 3
1983 5
1984 4
1985 2
1986 3
1987 6
1988 11
1989 9
1990 11
1991 8
1992 11
1993 15
1994 16
1995 17
1996 21
1997 19
1998 19
1999 20
2000 33
2001 58
2002 234
2003 785
2004 1915
2005 3002
2006 3926
2007 4900
2008 5575
2009 6295
2010 6714
2011 7152
2012 7725
2013 7892
2014 7467
2015 7349
2016 6433
2017 6014
2018 6292
2019 5677
2020 4769
2021 4110
2022 3618
2023 2783
2024 2771
2025 2900
2026 2090
2027 4

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104,389 results

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Page 1
Short hairpin RNA (shRNA): design, delivery, and assessment of gene knockdown.
Moore CB, Guthrie EH, Huang MT, Taxman DJ. Moore CB, et al. Methods Mol Biol. 2010;629:141-58. doi: 10.1007/978-1-60761-657-3_10. Methods Mol Biol. 2010. PMID: 20387148 Free PMC article.
Shortly after the cellular mechanism of RNA interference (RNAi) was first described, scientists began using this powerful technique to study gene function. This included designing better methods for the successful delivery of small interfering RNAs (siRNAs) a …
Shortly after the cellular mechanism of RNA interference (RNAi) was first described, scientists began using this powerful technique t …
Short hairpin RNA-mediated gene silencing.
Lambeth LS, Smith CA. Lambeth LS, et al. Methods Mol Biol. 2013;942:205-32. doi: 10.1007/978-1-62703-119-6_12. Methods Mol Biol. 2013. PMID: 23027054 Review.
Since the first application of RNA interference (RNAi) in mammalian cells, the expression of short hairpin RNAs (shRNAs) for targeted gene silencing has become a benchmark technology. ...
Since the first application of RNA interference (RNAi) in mammalian cells, the expression of short hairpin RNAs (shRNAs …
siRNA vs. shRNA: similarities and differences.
Rao DD, Vorhies JS, Senzer N, Nemunaitis J. Rao DD, et al. Adv Drug Deliv Rev. 2009 Jul 25;61(9):746-59. doi: 10.1016/j.addr.2009.04.004. Epub 2009 Apr 20. Adv Drug Deliv Rev. 2009. PMID: 19389436 Review.
RNA interference (RNAi) is a natural process through which expression of a targeted gene can be knocked down with high specificity and selectivity. ...Methods of mediating the RNAi effect involve small interfering RNA (siRNA), short hairpin …
RNA interference (RNAi) is a natural process through which expression of a targeted gene can be knocked down with high specificity an …
Silence of FIZZ1 by Short Hairpin RNA Inhibits Atherosclerosis.
Tang F, Yang F, Li T, Yang Y, Deng J. Tang F, et al. Ann Clin Lab Sci. 2022 Mar;52(2):170-178. Ann Clin Lab Sci. 2022. PMID: 35414495
METHODS: The murine aortic endothelial cells were treated with an adenoviral vector encoding FIZZ1 short hairpin RNA (Ad-shFIZZ1). Murine atherosclerosis model was established with ApoE(-/-) mice. ...
METHODS: The murine aortic endothelial cells were treated with an adenoviral vector encoding FIZZ1 short hairpin RNA (A …
Expression strategies for short hairpin RNA interference triggers.
Rossi JJ. Rossi JJ. Hum Gene Ther. 2008 Apr;19(4):313-7. doi: 10.1089/hum.2008.026. Hum Gene Ther. 2008. PMID: 18363506 Free PMC article. Review.
Since the discovery that the triggers for RNA interference (RNAi), small interfering RNAs, could mediate silencing in mammalian cells without triggering a toxic response, RNAi has become the standard tool for sequence-specific knockdown of gene expression in …
Since the discovery that the triggers for RNA interference (RNAi), small interfering RNAs, could mediate silencing in m …
Selective gene silencing by viral delivery of short hairpin RNA.
Sliva K, Schnierle BS. Sliva K, et al. Virol J. 2010 Sep 21;7:248. doi: 10.1186/1743-422X-7-248. Virol J. 2010. PMID: 20858246 Free PMC article. Review.
RNA interference (RNAi) technology has not only become a powerful tool for functional genomics, but also allows rapid drug target discovery and in vitro validation of these targets in cell culture. ...Selective gene silencing by RNAi can be achieved essentially by two nucl …
RNA interference (RNAi) technology has not only become a powerful tool for functional genomics, but also allows rapid drug target dis …
Therapeutic short hairpin RNA expression in the liver: viral targets and vectors.
Grimm D, Kay MA. Grimm D, et al. Gene Ther. 2006 Mar;13(6):563-75. doi: 10.1038/sj.gt.3302727. Gene Ther. 2006. PMID: 16453009 Review.
A promising new avenue currently being explored is to harness the power of RNA interference for development of an antiviral therapy. The timing to pursue this particular approach is excellent, with the first in vivo animal models for HCV infection becoming available, and t …
A promising new avenue currently being explored is to harness the power of RNA interference for development of an antiviral therapy. …
Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A.
Li X, Han YR, Xuefeng X, Ma YX, Xing GS, Yang ZW, Zhang Z, Shi L, Wu XL. Li X, et al. World J Gastroenterol. 2022 Oct 7;28(37):5420-5443. doi: 10.3748/wjg.v28.i37.5420. World J Gastroenterol. 2022. PMID: 36312839 Free PMC article.
We investigated the expression of CENPK in RKO and HCT116 cells using quantitative polymerase chain reaction (qPCR), western blot, and flow cytometry. The effect of short hairpin RNA (shRNA) virus-infected RKO cells on tumor growth was evaluated in vivo using …
We investigated the expression of CENPK in RKO and HCT116 cells using quantitative polymerase chain reaction (qPCR), western blot, and flow …
Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia.
Ruan Z, Takamatsu-Yukawa K, Wang Y, Ushman ML, Labadorf AT, Ericsson M, Ikezu S, Ikezu T. Ruan Z, et al. Cell Rep. 2022 May 10;39(6):110791. doi: 10.1016/j.celrep.2022.110791. Cell Rep. 2022. PMID: 35545052 Free PMC article.
We generate a GFP(+) tdTomato(+) cell library expressing TurboGFP and barcoded short hairpin RNAs for genome-wide screening using next-generation sequencing. We identify Mcfd2, Sepp1, and Sdc1 as critical regulators of ATP-induced EV secretion from murine microglia. …
We generate a GFP(+) tdTomato(+) cell library expressing TurboGFP and barcoded short hairpin RNAs for genome-wide screening us …
Delivery of short hairpin RNA in the neotropical brown stink bug, Euschistus heros, using a composite nanomaterial.
Laisney J, Loczenski Rose V, Watters K, Donohue KV, Unrine JM. Laisney J, et al. Pestic Biochem Physiol. 2021 Aug;177:104906. doi: 10.1016/j.pestbp.2021.104906. Epub 2021 Jun 24. Pestic Biochem Physiol. 2021. PMID: 34301367
Improving the delivery of dsRNA to stink bugs will improve the likelihood of using RNA-based biocontrols for the management of these economically important pests. Short hairpin RNA (shRNA) is a useful molecule with which to test improvements in the del …
Improving the delivery of dsRNA to stink bugs will improve the likelihood of using RNA-based biocontrols for the management of these …
104,389 results
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