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Docetaxel-carboxymethylcellulose nanoparticles ameliorate CCl4-induced hepatic fibrosis in mice.
Chang CC, Yang Y, Gao DY, Cheng HT, Hoang B, Chao PH, Chen LH, Bteich J, Chiang T, Liu JY, Li SD, Chen Y. Chang CC, et al. Among authors: li sd. J Drug Target. 2018 Jun-Jul;26(5-6):516-524. doi: 10.1080/1061186X.2017.1419358. Epub 2017 Dec 27. J Drug Target. 2018. PMID: 29251522
Furthermore, Cellax NPs alleviated CCl(4)-induced hepatic fibrosis and suppressed HCC progression in a clinically relevant HCC model associated with underlying liver fibrosis in vivo. Taken together, Cellax NPs demonstrate great therapeutic promise as a treatment fo …
Furthermore, Cellax NPs alleviated CCl(4)-induced hepatic fibrosis and suppressed HCC progression in a clinically relevant HCC model …
Cabazitaxel-conjugated nanoparticles for docetaxel-resistant and bone metastatic prostate cancer.
Hoang B, Ernsting MJ, Tang WS, Bteich J, Undzys E, Kiyota T, Li SD. Hoang B, et al. Among authors: li sd. Cancer Lett. 2017 Dec 1;410:169-179. doi: 10.1016/j.canlet.2017.09.029. Epub 2017 Sep 28. Cancer Lett. 2017. PMID: 28965854
Cellax-CBZ induced mild and reversible neutropenia in mice but no other tissue damage. Cellax-CBZ showed significant potential for improving therapy of mCRPC over clinically approved CBZ....
Cellax-CBZ induced mild and reversible neutropenia in mice but no other tissue damage. Cellax-CBZ showed significant potential …
Current Update of a Carboxymethylcellulose-PEG Conjugate Platform for Delivery of Insoluble Cytotoxic Agents to Tumors.
Yang Y, Bteich J, Li SD. Yang Y, et al. Among authors: li sd. AAPS J. 2017 Mar;19(2):386-396. doi: 10.1208/s12248-016-0014-z. Epub 2016 Nov 21. AAPS J. 2017. PMID: 27873118 Review.
The Cellax platform was employed to deliver podophyllotoxin (Cellax-PPT) and cabazitaxel (Cellax-CBZ), and increased their safety and efficacy against multidrug-resistant tumors. This review discusses the rational design of the Cellax platform and summ …
The Cellax platform was employed to deliver podophyllotoxin (Cellax-PPT) and cabazitaxel (Cellax-CBZ), and increased th …
Docetaxel-carboxymethylcellulose nanoparticles target cells via a SPARC and albumin dependent mechanism.
Hoang B, Ernsting MJ, Roy A, Murakami M, Undzys E, Li SD. Hoang B, et al. Among authors: li sd. Biomaterials. 2015 Aug;59:66-76. doi: 10.1016/j.biomaterials.2015.04.032. Epub 2015 May 15. Biomaterials. 2015. PMID: 25956852 Free PMC article.
In the SPARC-positive cells, a >2-fold increase in cellular internalization of Cellax was observed in the presence of albumin. In the SPARC-negative cells, no difference in Cellax internalization was observed in the presence or absence of albumin. ...Thus, this a …
In the SPARC-positive cells, a >2-fold increase in cellular internalization of Cellax was observed in the presence of albumin. In …
Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticle.
Ernsting MJ, Hoang B, Lohse I, Undzys E, Cao P, Do T, Gill B, Pintilie M, Hedley D, Li SD. Ernsting MJ, et al. Among authors: li sd. J Control Release. 2015 May 28;206:122-30. doi: 10.1016/j.jconrel.2015.03.023. Epub 2015 Mar 21. J Control Release. 2015. PMID: 25804872 Free PMC article.
Greater than 90% of Cellax-DTX particles accumulate in smooth muscle actin (SMA) positive cancer-associated fibroblasts which results in long-term depletion of this stromal cell population, an effect not observed with Nab-paclitaxel (Nab-PTX). ...Cellax-DTX nanopart …
Greater than 90% of Cellax-DTX particles accumulate in smooth muscle actin (SMA) positive cancer-associated fibroblasts which results …
Docetaxel-carboxymethylcellulose nanoparticles display enhanced anti-tumor activity in murine models of castration-resistant prostate cancer.
Hoang B, Ernsting MJ, Murakami M, Undzys E, Li SD. Hoang B, et al. Among authors: li sd. Int J Pharm. 2014 Aug 25;471(1-2):224-33. doi: 10.1016/j.ijpharm.2014.05.021. Epub 2014 May 20. Int J Pharm. 2014. PMID: 24853460 Free PMC article.
PC3 tumor xenografts in mice. In addition, Cellax elicited fewer side effects compared to native DTX. Importantly, Cellax did not increase the expression of drug resistance molecules in androgen-independent PC3 prostate cancer cells in comparison with DTX. ...These …
PC3 tumor xenografts in mice. In addition, Cellax elicited fewer side effects compared to native DTX. Importantly, Cellax did …
Carboxymethylcellulose-based and docetaxel-loaded nanoparticles circumvent P-glycoprotein-mediated multidrug resistance.
Roy A, Murakami M, Ernsting MJ, Hoang B, Undzys E, Li SD. Roy A, et al. Among authors: li sd. Mol Pharm. 2014 Aug 4;11(8):2592-9. doi: 10.1021/mp400643p. Epub 2014 Mar 6. Mol Pharm. 2014. PMID: 24564177 Free PMC article.
Treatment with DTX led to 4-7-fold higher Pgp mRNA expression and 2-fold higher Pgp protein expression compared with Cellax treatment in the in vitro and in vivo system, respectively. Cellax also exhibited significantly increased efficacy compared with that of DTX i …
Treatment with DTX led to 4-7-fold higher Pgp mRNA expression and 2-fold higher Pgp protein expression compared with Cellax treatment …
Docetaxel conjugate nanoparticles that target α-smooth muscle actin-expressing stromal cells suppress breast cancer metastasis.
Murakami M, Ernsting MJ, Undzys E, Holwell N, Foltz WD, Li SD. Murakami M, et al. Among authors: li sd. Cancer Res. 2013 Aug 1;73(15):4862-71. doi: 10.1158/0008-5472.CAN-13-0062. Cancer Res. 2013. PMID: 23907638
The antistromal effect of Cellax treatment corresponded to a significantly enhanced antimetastatic effect: lung nodules were reduced by 7- to 24-fold by Cellax treatment, whereas native docetaxel and nab-paclitaxel treatments were ineffective. ...The 4T1 tumor epith …
The antistromal effect of Cellax treatment corresponded to a significantly enhanced antimetastatic effect: lung nodules were reduced …
A docetaxel-carboxymethylcellulose nanoparticle outperforms the approved taxane nanoformulation, Abraxane, in mouse tumor models with significant control of metastases.
Ernsting MJ, Murakami M, Undzys E, Aman A, Press B, Li SD. Ernsting MJ, et al. Among authors: li sd. J Control Release. 2012 Sep 28;162(3):575-81. doi: 10.1016/j.jconrel.2012.07.043. Epub 2012 Aug 10. J Control Release. 2012. PMID: 22967490
Cellax increased the systemic exposure of taxanes by 37 compared to Abraxane, and improved the delivery specificity: Cellax uptake was selective to the tumor, liver and spleen, with a 203 increase in tumor accumulation compared to Abraxane. ...PC3 (prostate) and B16 …
Cellax increased the systemic exposure of taxanes by 37 compared to Abraxane, and improved the delivery specificity: Cellax up …
Tumor-targeted drug delivery using MR-contrasted docetaxel - carboxymethylcellulose nanoparticles.
Ernsting MJ, Foltz WD, Undzys E, Tagami T, Li SD. Ernsting MJ, et al. Among authors: li sd. Biomaterials. 2012 May;33(15):3931-41. doi: 10.1016/j.biomaterials.2012.02.019. Epub 2012 Feb 25. Biomaterials. 2012. PMID: 22369962
We examined Cellax and Taxotere efficacy in four tumor models (EMT-6, B16F10, PC3, and MDA-MB-231), and observed variances in efficacy. To explore whether differences in tumor uptake of Cellax were responsible for these effects, we incorporated superparamagnetic iro …
We examined Cellax and Taxotere efficacy in four tumor models (EMT-6, B16F10, PC3, and MDA-MB-231), and observed variances in efficac …
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