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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 3
1977 1
1978 3
1979 5
1980 13
1981 14
1982 31
1983 38
1984 72
1985 84
1986 108
1987 144
1988 157
1989 190
1990 206
1991 233
1992 240
1993 290
1994 281
1995 294
1996 288
1997 349
1998 322
1999 358
2000 387
2001 424
2002 359
2003 443
2004 529
2005 479
2006 494
2007 510
2008 546
2009 544
2010 542
2011 612
2012 694
2013 647
2014 566
2015 561
2016 525
2017 541
2018 548
2019 530
2020 547
2021 496
2022 409
2023 370
2024 461
2025 560
2026 350

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15,893 results

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Page 1
Proteolysis in protein import and export: signal peptide processing in eu- and prokaryotes.
Müller M. Müller M. Experientia. 1992 Feb 15;48(2):118-29. doi: 10.1007/BF01923506. Experientia. 1992. PMID: 1740185 Review.
Numerous proteins in pro- and eukaryotes must cross cellular membranes in order to reach their site of function. Many of these proteins carry signal sequences that are removed by specific signal peptidases during, or shortly after, membrane transport. ...No site-spe …
Numerous proteins in pro- and eukaryotes must cross cellular membranes in order to reach their site of function. Many of these proteins carr …
Signal Peptide Efficiency: From High-Throughput Data to Prediction and Explanation.
Grasso S, Dabene V, Hendriks MMWB, Zwartjens P, Pellaux R, Held M, Panke S, van Dijl JM, Meyer A, van Rij T. Grasso S, et al. ACS Synth Biol. 2023 Feb 17;12(2):390-404. doi: 10.1021/acssynbio.2c00328. Epub 2023 Jan 17. ACS Synth Biol. 2023. PMID: 36649479 Free PMC article.
Proteins are directed into the Sec pathway by a signal peptide at their N-terminus. Estimating the impact of physicochemical signal peptide features on protein secretion levels has not been achieved so far, partially due to the extreme sequence …
Proteins are directed into the Sec pathway by a signal peptide at their N-terminus. Estimating the impact of physicochemical …
Signal peptidases.
Paetzel M, Karla A, Strynadka NC, Dalbey RE. Paetzel M, et al. Chem Rev. 2002 Dec;102(12):4549-80. doi: 10.1021/cr010166y. Chem Rev. 2002. PMID: 12475201 Review. No abstract available.
Signal peptidases and signal peptide hydrolases.
Dev IK, Ray PH. Dev IK, et al. J Bioenerg Biomembr. 1990 Jun;22(3):271-90. doi: 10.1007/BF00763168. J Bioenerg Biomembr. 1990. PMID: 2202720 Review.
There are no data concerning the substrate binding site of these enzymes. In vivo, the signal peptide is rapidly degraded. Three different enzymes in Escherichia coli that can degrade a signal peptide in vitro have been identified. The intact signal …
There are no data concerning the substrate binding site of these enzymes. In vivo, the signal peptide is rapidly degraded. Thr …
Role of the signal peptide in the synthesis and processing of the glucagon-like peptide-1 receptor.
Huang Y, Wilkinson GF, Willars GB. Huang Y, et al. Br J Pharmacol. 2010 Jan;159(1):237-51. doi: 10.1111/j.1476-5381.2009.00517.x. Epub 2009 Nov 27. Br J Pharmacol. 2010. PMID: 20002095 Free PMC article.
Family B G protein-coupled receptors contain a putative N-terminal signal peptide, but its role in receptor synthesis and trafficking are unclear. ...The signal peptide is cleaved during synthesis and processing of the receptor. An enhanc …
Family B G protein-coupled receptors contain a putative N-terminal signal peptide, but its role in receptor synthesis a …
Signal peptide peptidase- and ClpP-like proteins of Bacillus subtilis required for efficient translocation and processing of secretory proteins.
Bolhuis A, Matzen A, Hyyryläinen HL, Kontinen VP, Meima R, Chapuis J, Venema G, Bron S, Freudl R, van Dijl JM. Bolhuis A, et al. J Biol Chem. 1999 Aug 27;274(35):24585-92. doi: 10.1074/jbc.274.35.24585. J Biol Chem. 1999. PMID: 10455123 Free article.
Signal peptides direct the export of secretory proteins from the cytoplasm. After processing by signal peptidase, they are degraded in the membrane and cytoplasm. ...These observations suggest important roles for signal peptide peptidases. The p …
Signal peptides direct the export of secretory proteins from the cytoplasm. After processing by signal peptidase, they …
An alternate pathway for the processing of the prolipoprotein signal peptide in Escherichia coli.
Ghrayeb J, Lunn CA, Inouye S, Inouye M. Ghrayeb J, et al. J Biol Chem. 1985 Sep 15;260(20):10961-5. J Biol Chem. 1985. PMID: 2993296 Free article.
The mutant prolipo-beta-lactamase proteins were cleaved at a site 5 amino acid residues downstream of the prolipoprotein signal peptide cleavage site. This new cleavage between alanine and lysine residues was resistant to globomycin, a specific inhibitor for sign …
The mutant prolipo-beta-lactamase proteins were cleaved at a site 5 amino acid residues downstream of the prolipoprotein signal pe …
The use of signal peptide domains as vaccine candidates.
Kovjazin R, Carmon L. Kovjazin R, et al. Hum Vaccin Immunother. 2014;10(9):2733-40. doi: 10.4161/21645515.2014.970916. Epub 2014 Oct 30. Hum Vaccin Immunother. 2014. PMID: 25483491 Free PMC article. Review.
Signal peptide (SP) domains have a common motif but also sequence specific features. This knowledge was mainly ignored by immunologists who considered SP as generic, short-lived, targeting sequences. ...Recently we demonstrated the rational of selecting entire SP do …
Signal peptide (SP) domains have a common motif but also sequence specific features. This knowledge was mainly ignored by immu …
SPdb--a signal peptide database.
Choo KH, Tan TW, Ranganathan S. Choo KH, et al. BMC Bioinformatics. 2005 Oct 13;6:249. doi: 10.1186/1471-2105-6-249. BMC Bioinformatics. 2005. PMID: 16221310 Free PMC article.
BACKGROUND: The signal peptide plays an important role in protein targeting and protein translocation in both prokaryotic and eukaryotic cells. ...Understanding how signal peptides function is crucial in predicting where proteins are translocate …
BACKGROUND: The signal peptide plays an important role in protein targeting and protein translocation in both pr …
The signal peptide as a new target for drug design.
Lumangtad LA, Bell TW. Lumangtad LA, et al. Bioorg Med Chem Lett. 2020 May 15;30(10):127115. doi: 10.1016/j.bmcl.2020.127115. Epub 2020 Mar 17. Bioorg Med Chem Lett. 2020. PMID: 32209293 Free PMC article. Review.
They are targeted to translocon channels across the membrane of the endoplasmic reticulum (ER) by signal peptides (SPs), which are temporary structures on the N-termini of their nascent chains. During translation, such proteins enter the lumen and membrane of the ER by a …
They are targeted to translocon channels across the membrane of the endoplasmic reticulum (ER) by signal peptides (SPs), which are te …
15,893 results
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