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399,432 results

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Page 1
Exercise induces hippocampal BDNF through a PGC-1alpha/FNDC5 pathway.
Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM. Wrann CD, et al. Cell Metab. 2013 Nov 5;18(5):649-59. doi: 10.1016/j.cmet.2013.09.008. Epub 2013 Oct 10. Cell Metab. 2013. PMID: 24120943 Free PMC article.
Exercise can improve cognitive function and has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). ...Here we show that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and secreted as irisin, …
Exercise can improve cognitive function and has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). …
Molecular insights of exercise therapy in disease prevention and treatment.
Walzik D, Wences Chirino TY, Zimmer P, Joisten N. Walzik D, et al. Signal Transduct Target Ther. 2024 May 29;9(1):138. doi: 10.1038/s41392-024-01841-0. Signal Transduct Target Ther. 2024. PMID: 38806473 Free PMC article. Review.
Several exercise benefits have been attributed to signaling molecules that are released in response to exercise by different tissues such as skeletal muscle, cardiac muscle, adipose, and liver tissue. ...Herein, we review the current in vivo evidence on exerk …
Several exercise benefits have been attributed to signaling molecules that are released in response to exercise by diff …
Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health.
Kusuyama J, Alves-Wagner AB, Conlin RH, Makarewicz NS, Albertson BG, Prince NB, Kobayashi S, Kozuka C, Møller M, Bjerre M, Fuglsang J, Miele E, Middelbeek RJW, Xiudong Y, Xia Y, Garneau L, Bhattacharjee J, Aguer C, Patti ME, Hirshman MF, Jessen N, Hatta T, Ovesen PG, Adamo KB, Nozik-Grayck E, Goodyear LJ. Kusuyama J, et al. Cell Metab. 2021 May 4;33(5):939-956.e8. doi: 10.1016/j.cmet.2021.03.004. Epub 2021 Mar 25. Cell Metab. 2021. PMID: 33770509 Free PMC article.
SOD3 activates an AMPK/TET signaling axis in fetal offspring liver, resulting in DNA demethylation at the promoters of glucose metabolic genes, enhancing liver function, and improving glucose tolerance. In humans, SOD3 is upregulated in serum and placenta from physi …
SOD3 activates an AMPK/TET signaling axis in fetal offspring liver, resulting in DNA demethylation at the promoters of glucose …
Impairment of an Endothelial NAD(+)-H(2)S Signaling Network Is a Reversible Cause of Vascular Aging.
Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. Das A, et al. Cell. 2018 Mar 22;173(1):74-89.e20. doi: 10.1016/j.cell.2018.02.008. Cell. 2018. PMID: 29570999 Free PMC article.
NAD precursors reverse aspects of aging, in part, by activating sirtuin deacylases (SIRT1-SIRT7) that mediate the benefits of exercise and dietary restriction (DR). We show that SIRT1 in endothelial cells is a key mediator of pro-angiogenic signals secreted f …
NAD precursors reverse aspects of aging, in part, by activating sirtuin deacylases (SIRT1-SIRT7) that mediate the benefits of exer …
Both enantiomers of beta-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes.
Sakamoto E, Kitase Y, Fitt AJ, Zhu Z, Awad K, Brotto M, White KE, Welc SS, Bergwitz C, Bonewald LF. Sakamoto E, et al. Cell Rep. 2024 Jul 23;43(7):114397. doi: 10.1016/j.celrep.2024.114397. Epub 2024 Jun 25. Cell Rep. 2024. PMID: 38935499 Free PMC article.
With exercise, muscle and bone produce factors with beneficial effects on brain, fat, and other organs. ...The two enantiomers both signal through the same receptor, Mas-related G-protein-coupled receptor type D, but activate distinct signali …
With exercise, muscle and bone produce factors with beneficial effects on brain, fat, and other organs. ...The two enantiomers both …
Aerobic exercise attenuates autophagy-lysosomal flux deficits by ADRB2/beta2-adrenergic receptor-mediated V-ATPase assembly factor VMA21 signaling in APP-PSEN1/PS1 mice.
Wu JJ, Yu H, Bi SG, Wang ZX, Gong J, Mao YM, Wang FZ, Zhang YQ, Nie YJ, Chai GS. Wu JJ, et al. Autophagy. 2024 May;20(5):1015-1031. doi: 10.1080/15548627.2023.2281134. Epub 2023 Nov 15. Autophagy. 2024. PMID: 37964627 Free PMC article.
Here, we revealed that AE could reverse autophagy-lysosomal deficits via activation of ADRB2/beta2-adrenergic receptor, leading to significant attenuation of amyloid-beta pathology in APP-PSEN1/PS1 mice. Molecular mechanism research found that AE could reverse autop …
Here, we revealed that AE could reverse autophagy-lysosomal deficits via activation of ADRB2/beta2-adrenergic receptor, leadin …
Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1/M2 polarization through adiponectin/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress.
Liu L, Tang J, Liang X, Li Y, Zhu P, Zhou M, Qin L, Deng Y, Li J, Wang Y, Jiang L, Huang D, Zhou Y, Wang S, Xiao Q, Luo Y, Tang Y. Liu L, et al. Mol Psychiatry. 2024 Jul;29(7):2031-2042. doi: 10.1038/s41380-024-02464-1. Epub 2024 Feb 15. Mol Psychiatry. 2024. PMID: 38361125
AdipoR1 is an adiponectin receptor that is involved in regulating microglial phenotypes and activation states. However, whether running exercise regulates hippocampal microglial phenotypes and neuroinflammation through adiponectin/AdipoR1 to exert its antidep …
AdipoR1 is an adiponectin receptor that is involved in regulating microglial phenotypes and activation states. However, whethe …
Exercise-induced leukocyte apoptosis.
Krüger K, Mooren FC. Krüger K, et al. Exerc Immunol Rev. 2014;20:117-34. Exerc Immunol Rev. 2014. PMID: 24974724 Free article. Review.
Two major signalling pathways of exercise induced apoptosis have been identified. First the external receptor mediated pathway using death receptors, and second the internal, oxidative-mediated pathway which encompasses the mitochondria. ...On the one …
Two major signalling pathways of exercise induced apoptosis have been identified. First the external receptor mediated …
Chronic voluntary exercise induces plasticity of noradrenaline-activated dopamine D(1)-like receptor signaling.
Kobayashi K. Kobayashi K. Mol Brain. 2025 Jun 16;18(1):51. doi: 10.1186/s13041-025-01219-5. Mol Brain. 2025. PMID: 40524260 Free PMC article.
Voluntary exercise by wheel running enhanced this noradrenaline-D(1)-like receptor signaling within 5 days. ...Notably, the effect of exercise was more robustly seen in D(1)-like receptor signaling activated by noradrenaline as com …
Voluntary exercise by wheel running enhanced this noradrenaline-D(1)-like receptor signaling within 5 days. ...Notably, …
Functions of estrogen and estrogen receptor signaling on skeletal muscle.
Ikeda K, Horie-Inoue K, Inoue S. Ikeda K, et al. J Steroid Biochem Mol Biol. 2019 Jul;191:105375. doi: 10.1016/j.jsbmb.2019.105375. Epub 2019 May 5. J Steroid Biochem Mol Biol. 2019. PMID: 31067490 Review.
Activity of estrogen, a sex steroid hormone, is not only limited to the reproductive organs but also involves other organs and tissues, including skeletal muscle. ...In addition, varying estrogen levels associated with the menstrual phases may modulate exercise perf …
Activity of estrogen, a sex steroid hormone, is not only limited to the reproductive organs but also involves other organs and tissue …
399,432 results
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