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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1837 1
1840 1
1843 1
1844 3
1846 2
1847 1
1849 1
1850 3
1851 4
1855 4
1856 2
1857 1
1858 2
1859 1
1860 1
1861 1
1866 1
1871 1
1872 1
1873 1
1874 2
1875 5
1877 1
1879 1
1880 4
1881 5
1883 1
1884 2
1885 2
1886 1
1888 1
1889 4
1890 1
1893 5
1894 1
1895 1
1896 1
1897 3
1899 2
1900 1
1904 4
1905 1
1907 2
1909 3
1910 4
1911 9
1912 4
1913 5
1914 5
1915 4
1916 3
1917 1
1918 5
1919 5
1920 8
1921 4
1922 8
1923 9
1924 6
1925 2
1927 5
1928 3
1929 4
1930 4
1931 4
1932 4
1934 4
1935 3
1936 2
1937 5
1938 3
1939 6
1940 3
1941 5
1942 3
1943 2
1944 2
1945 21
1946 40
1947 50
1948 44
1949 55
1950 45
1951 74
1952 66
1953 71
1954 75
1955 71
1956 67
1957 93
1958 82
1959 71
1960 86
1961 95
1962 84
1963 111
1964 116
1965 126
1966 113
1967 94
1968 129
1969 120
1970 129
1971 129
1972 151
1973 151
1974 165
1975 575
1976 624
1977 605
1978 644
1979 785
1980 788
1981 799
1982 873
1983 1121
1984 1274
1985 1328
1986 1460
1987 1651
1988 1879
1989 2415
1990 2675
1991 2970
1992 3385
1993 3907
1994 4314
1995 4841
1996 5160
1997 5639
1998 6372
1999 7109
2000 7884
2001 8179
2002 8421
2003 8953
2004 9861
2005 10345
2006 11212
2007 11718
2008 12799
2009 14455
2010 15509
2011 16743
2012 17835
2013 18872
2014 19542
2015 20064
2016 22410
2017 23532
2018 24533
2019 25651
2020 28636
2021 31771
2022 29351
2023 27481
2024 29039
2025 34221
2026 21712
2027 2

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526,445 results

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Page 1
Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels.
Jiang Y, Yang X, Jiang J, Xiao B. Jiang Y, et al. Trends Biochem Sci. 2021 Jun;46(6):472-488. doi: 10.1016/j.tibs.2021.01.008. Epub 2021 Feb 17. Trends Biochem Sci. 2021. PMID: 33610426 Review.
The unusually curved TM region of the three blades shapes a signature nano-bowl configuration with potential to generate large in-plane membrane area expansion, which might confer exquisite mechanosensitivity to Piezo channels. ...
The unusually curved TM region of the three blades shapes a signature nano-bowl configuration with potential to generate large in-pla …
High-Throughput Discovery and Characterization of Human Transcriptional Effectors.
Tycko J, DelRosso N, Hess GT, Aradhana, Banerjee A, Mukund A, Van MV, Ego BK, Yao D, Spees K, Suzuki P, Marinov GK, Kundaje A, Bassik MC, Bintu L. Tycko J, et al. Cell. 2020 Dec 23;183(7):2020-2035.e16. doi: 10.1016/j.cell.2020.11.024. Epub 2020 Dec 15. Cell. 2020. PMID: 33326746 Free PMC article.
Using this approach, we measure gene silencing and activation for thousands of domains. We find a relationship between repressor function and evolutionary age for the KRAB domains, discover that Homeodomain repressor strength is collinear with Hox genetic organizati …
Using this approach, we measure gene silencing and activation for thousands of domains. We find a relationship between repressor func …
Site-saturation mutagenesis of 500 human protein domains.
Beltran A, Jiang X, Shen Y, Lehner B. Beltran A, et al. Nature. 2025 Jan;637(8047):885-894. doi: 10.1038/s41586-024-08370-4. Epub 2025 Jan 8. Nature. 2025. PMID: 39779847 Free PMC article.
Using DNA synthesis and cellular selection experiments we quantify the effect of more than 500,000 variants on the abundance of more than 500 human protein domains. This dataset reveals that 60% of pathogenic missense variants reduce protein stability. ...We …
Using DNA synthesis and cellular selection experiments we quantify the effect of more than 500,000 variants on the abundance of more than 50 …
Mega-scale experimental analysis of protein folding stability in biology and design.
Tsuboyama K, Dauparas J, Chen J, Laine E, Mohseni Behbahani Y, Weinstein JJ, Mangan NM, Ovchinnikov S, Rocklin GJ. Tsuboyama K, et al. Nature. 2023 Aug;620(7973):434-444. doi: 10.1038/s41586-023-06328-6. Epub 2023 Jul 19. Nature. 2023. PMID: 37468638 Free PMC article.
The hidden thermodynamics of folding can drive disease(3,4), shape protein evolution(5-7) and guide protein engineering(8-10), and new approaches are needed to reveal these thermodynamics for every sequence and structure. Here we present cDNA display proteolysis, a …
The hidden thermodynamics of folding can drive disease(3,4), shape protein evolution(5-7) and guide protein engineering(8-10), …
Protein-coding tRNA sequences?
Jimenez J. Jimenez J. Gene. 2022 Mar 10;814:146154. doi: 10.1016/j.gene.2021.146154. Epub 2022 Jan 4. Gene. 2022. PMID: 34995735
These extremely conserved RNA molecules transfer amino acids to the ribosome for the synthesis of proteins encoded by mRNAs, but canonical tRNAs are not protein-coding RNAs. Surprisely, when virtually translated, I observed that peptides derived from tRNA sequences match t …
These extremely conserved RNA molecules transfer amino acids to the ribosome for the synthesis of proteins encoded by mRNAs, but canonical t …
Networking counters stress.
Ullrich F. Ullrich F. Nat Struct Mol Biol. 2021 Nov;28(11):873. doi: 10.1038/s41594-021-00686-3. Nat Struct Mol Biol. 2021. PMID: 34728836 No abstract available.
The GYF domain.
Kofler MM, Freund C. Kofler MM, et al. FEBS J. 2006 Jan;273(2):245-56. doi: 10.1111/j.1742-4658.2005.05078.x. FEBS J. 2006. PMID: 16403013 Free article. Review.
GYF domains are small, versatile adaptor domains that recognize proline-rich sequences (PRS). They are present in most eukaryotic species sequenced so far, but in contrast to other PRS-recognition domains (PRD), GYF domains have not experienced the sam …
GYF domains are small, versatile adaptor domains that recognize proline-rich sequences (PRS). They are present in most eukaryo …
Targeting non-bromodomain chromatin readers.
Arrowsmith CH, Schapira M. Arrowsmith CH, et al. Nat Struct Mol Biol. 2019 Oct;26(10):863-869. doi: 10.1038/s41594-019-0290-2. Epub 2019 Oct 3. Nat Struct Mol Biol. 2019. PMID: 31582844 Review.
Many of these proteins harbor one or more so called 'reader domains' that recognize covalent modifications of lysine and arginine residues, typically on histones, which mediate specific interactions within chromatin. Here we review recent progress in the discovery of drug- …
Many of these proteins harbor one or more so called 'reader domains' that recognize covalent modifications of lysine and arginine res …
Structural Evolution of TIR-Domain Signalosomes.
Nimma S, Gu W, Maruta N, Li Y, Pan M, Saikot FK, Lim BYJ, McGuinness HY, Zaoti ZF, Li S, Desa S, Manik MK, Nanson JD, Kobe B. Nimma S, et al. Front Immunol. 2021 Nov 17;12:784484. doi: 10.3389/fimmu.2021.784484. eCollection 2021. Front Immunol. 2021. PMID: 34868065 Free PMC article. Review.
TIR (Toll/interleukin-1 receptor/resistance protein) domains are cytoplasmic domains widely found in animals and plants, where they are essential components of the innate immune system. A key feature of TIR-domain function in signaling is weak and transient s …
TIR (Toll/interleukin-1 receptor/resistance protein) domains are cytoplasmic domains widely found in animals and plants …
The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from phytocytokines and microbes.
Hou S, Liu D, Huang S, Luo D, Liu Z, Xiang Q, Wang P, Mu R, Han Z, Chen S, Chai J, Shan L, He P. Hou S, et al. Nat Commun. 2021 Sep 17;12(1):5494. doi: 10.1038/s41467-021-25580-w. Nat Commun. 2021. PMID: 34535661 Free PMC article.
Here, we report that the Arabidopsis receptor kinase MALE DISCOVERER 1-INTERACTING RECEPTOR-LIKE KINASE 2 (MIK2) recognizes the conserved signature motif of SERINE-RICH ENDOGENOUS PEPTIDEs (SCOOPs) from Brassicaceae plants as well as proteins present in fungal Fusarium spp …
Here, we report that the Arabidopsis receptor kinase MALE DISCOVERER 1-INTERACTING RECEPTOR-LIKE KINASE 2 (MIK2) recognizes the conserved …
526,445 results
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