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9,054 results

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Page 1
Sildenafil in ophthalmology: An update.
Arora S, Surakiatchanukul T, Arora T, Cagini C, Lupidi M, Chhablani J. Arora S, et al. Surv Ophthalmol. 2022 Mar-Apr;67(2):463-487. doi: 10.1016/j.survophthal.2021.06.004. Epub 2021 Jun 25. Surv Ophthalmol. 2022. PMID: 34175342 Review.
Sildenafil citrate, a selective oral phosphodiesterase 5 inhibitor, is a widely used drug for erectile dysfunction that acts by elevating cGMP levels and causing smooth muscle relaxation. ...Another new observation is the effect of sildenafil on bipolar cells …
Sildenafil citrate, a selective oral phosphodiesterase 5 inhibitor, is a widely used drug for erectile dysfunction that acts b …
Sildenafil/Viagra in the treatment of premature ejaculation.
Krishnappa P, Fernandez-Pascual E, Carballido J, Martinez-Salamanca JI. Krishnappa P, et al. Int J Impot Res. 2019 Mar;31(2):65-70. doi: 10.1038/s41443-018-0099-2. Epub 2019 Mar 5. Int J Impot Res. 2019. PMID: 30837718 Review.
The arrival of Pfizer's blue pill Sildenafil in 1998 brought a great relief both to patient and physician signalling the start of a great era of medical therapy in sexual medicine. Since then the sexual medicine experts have been prescribing sildenafil in erectile d …
The arrival of Pfizer's blue pill Sildenafil in 1998 brought a great relief both to patient and physician signalling the start of a g …
Sildenafil in postprostatectomy erectile dysfunction (perspective).
Fode M, Jensen CFS, Østergren PB. Fode M, et al. Int J Impot Res. 2019 Mar;31(2):61-64. doi: 10.1038/s41443-018-0102-y. Epub 2019 Mar 5. Int J Impot Res. 2019. PMID: 30837719 Review.
Preclinical studies have confirmed the potential of sildenafil in this context and early human trials have suggested that a steady ingestion of sildenafil might protect the structural integrity of the penis. However, subsequent well-designed trials have not been abl …
Preclinical studies have confirmed the potential of sildenafil in this context and early human trials have suggested that a steady in …
Sildenafil as a Candidate Drug for Alzheimer's Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons.
Gohel D, Zhang P, Gupta AK, Li Y, Chiang CW, Li L, Hou Y, Pieper AA, Cummings J, Cheng F. Gohel D, et al. J Alzheimers Dis. 2024;98(2):643-657. doi: 10.3233/JAD-231391. J Alzheimers Dis. 2024. PMID: 38427489 Free PMC article.
We used both familial and sporadic AD patient induced pluripotent stem cells (iPSC) derived neurons to evaluate the sildenafil's mechanism-of-action. RESULTS: We showed that sildenafil usage is associated with reduced likelihood of AD across four new drug com …
We used both familial and sporadic AD patient induced pluripotent stem cells (iPSC) derived neurons to evaluate the sildenafil's …
Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis.
Gong B, Ma M, Xie W, Yang X, Huang Y, Sun T, Luo Y, Huang J. Gong B, et al. Int Urol Nephrol. 2017 Oct;49(10):1731-1740. doi: 10.1007/s11255-017-1644-5. Epub 2017 Jul 24. Int Urol Nephrol. 2017. PMID: 28741090 Free PMC article. Review.
RESULTS: A total of 16 trials that compared tadalafil with sildenafil for the treatment of ED were included in the meta-analysis. In the meta-analysis, tadalafil and sildenafil appeared to have similar efficacies and overall adverse event rates. However, compared wi …
RESULTS: A total of 16 trials that compared tadalafil with sildenafil for the treatment of ED were included in the meta-analysis. In …
Sildenafil for idiopathic pulmonary fibrosis: A systematic review and meta-analysis.
Pitre T, Khalid MF, Cui S, Zhang MC, Husnudinov R, Mah J, Helmczi W, Su J, Guy B, Scallan C, Jones A, Zeraatkar D. Pitre T, et al. Pulm Pharmacol Ther. 2022 Jun;73-74:102128. doi: 10.1016/j.pupt.2022.102128. Epub 2022 Apr 20. Pulm Pharmacol Ther. 2022. PMID: 35452834
Pooled estimated showed sildenafil may not reduce the number of hospitalizations or acute exacerbations, [RR 1.10 (95% CI 0.61 to 1.98); low certainty]. There is probably no difference in drug discontinuation due to adverse effects when comparing sildenafil to the c …
Pooled estimated showed sildenafil may not reduce the number of hospitalizations or acute exacerbations, [RR 1.10 (95% CI 0.61 to 1.9 …
Sildenafil in Combination Therapy against Cancer: A Literature Review.
Iratni R, Ayoub MA. Iratni R, et al. Curr Med Chem. 2021;28(11):2248-2259. doi: 10.2174/0929867327666200730165338. Curr Med Chem. 2021. PMID: 32744956 Review.
The concepts of drug repurposing and Sildenafil or blue pill are tightly linked over the years. Indeed, in addition to its initial clinical application as an anti-hypertensive drug in the pulmonary system, Sildenafil is also known for its beneficial effects in erect …
The concepts of drug repurposing and Sildenafil or blue pill are tightly linked over the years. Indeed, in addition to its initial cl …
Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial.
Bermejo J, Yotti R, García-Orta R, Sánchez-Fernández PL, Castaño M, Segovia-Cubero J, Escribano-Subías P, San Román JA, Borrás X, Alonso-Gómez A, Botas J, Crespo-Leiro MG, Velasco S, Bayés-Genís A, López A, Muñoz-Aguilera R, de Teresa E, González-Juanatey JR, Evangelista A, Mombiela T, González-Mansilla A, Elízaga J, Martín-Moreiras J, González-Santos JM, Moreno-Escobar E, Fernández-Avilés F; Sildenafil for Improving Outcomes after VAlvular Correction (SIOVAC) investigators. Bermejo J, et al. Eur Heart J. 2018 Apr 14;39(15):1255-1264. doi: 10.1093/eurheartj/ehx700. Eur Heart J. 2018. PMID: 29281101 Free PMC article. Clinical Trial.
AIMS: We aimed to determine whether treatment with sildenafil improves outcomes of patients with persistent pulmonary hypertension (PH) after correction of valvular heart disease (VHD). ...Only 27 patients receiving sildenafil improved their composite clinical score …
AIMS: We aimed to determine whether treatment with sildenafil improves outcomes of patients with persistent pulmonary hypertension (P …
Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations.
De Bie FR, Basurto D, Kumar S, Deprest J, Russo FM. De Bie FR, et al. Int J Environ Res Public Health. 2022 Sep 6;19(18):11207. doi: 10.3390/ijerph191811207. Int J Environ Res Public Health. 2022. PMID: 36141480 Free PMC article. Review.
Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect, has been investigated concerning various conditions during pregnancy. ...For most indications, the rationale for administering prenatal sildenafil is based on limited, equivo …
Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect, has been investigated concerning various …
Sildenafil's impact on male infertility: what has changed in 20 years?
Scherzer ND, Le TV, Hellstrom WJG. Scherzer ND, et al. Int J Impot Res. 2019 Mar;31(2):71-73. doi: 10.1038/s41443-018-0067-x. Epub 2019 Mar 5. Int J Impot Res. 2019. PMID: 30837720 Review.
Sildenafil has had a dramatic influence on the field of sexual medicine over the past 20 years. ...A review of the literature between 1998 - 2018 was performed using PubMed with regards to sildenafil and male infertility. Numerous studies have demonstrated silden …
Sildenafil has had a dramatic influence on the field of sexual medicine over the past 20 years. ...A review of the literature between …
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