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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 2
1997 1
1998 5
1999 18
2000 16
2001 30
2002 43
2003 28
2004 48
2005 40
2006 45
2007 52
2008 57
2009 32
2010 49
2011 44
2012 42
2013 41
2014 45
2015 41
2016 34
2017 45
2018 41
2019 26
2020 30
2021 29
2022 19
2023 18
2024 36
2025 27
2026 8

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864 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis.
Gong B, Ma M, Xie W, Yang X, Huang Y, Sun T, Luo Y, Huang J. Gong B, et al. Int Urol Nephrol. 2017 Oct;49(10):1731-1740. doi: 10.1007/s11255-017-1644-5. Epub 2017 Jul 24. Int Urol Nephrol. 2017. PMID: 28741090 Free PMC article.
RESULTS: A total of 16 trials that compared tadalafil with sildenafil for the treatment of ED were included in the meta-analysis. In the meta-analysis, tadalafil and sildenafil appeared to have similar efficacies and overall adverse event rates. However, compared wi …
RESULTS: A total of 16 trials that compared tadalafil with sildenafil for the treatment of ED were included in the meta-analysis. In …
Intrapartum Sildenafil to Improve Perinatal Outcomes: A Randomized Clinical Trial.
Kumar S, Tarnow-Mordi W, Mol BW, Flenady V, Liley HG, Badawi N, Walker S, Hyett J, Seidler AL, Callander E, Simes J, O'Connell RL; iSEARCH Investigators. Kumar S, et al. JAMA. 2025 Jul 8;334(2):149-159. doi: 10.1001/jama.2025.7710. JAMA. 2025. PMID: 40489090 Free PMC article. Clinical Trial.
IMPORTANCE: Sildenafil citrate may increase uteroplacental blood flow. Its ability to reduce perinatal complications related to fetal hypoxia during labor is uncertain. ...Induction of labor occurred in 1353 of 1621 women (83.5%) in the sildenafil citrate …
IMPORTANCE: Sildenafil citrate may increase uteroplacental blood flow. Its ability to reduce perinatal complications related t …
Sildenafil and risk of Alzheimer disease: a systematic review and meta-analysis.
Chua WY, Lim LKE, Wang JJD, Mai AS, Chan LL, Tan EK. Chua WY, et al. Aging (Albany NY). 2025 Mar 17;17(3):726-739. doi: 10.18632/aging.206222. Epub 2025 Mar 17. Aging (Albany NY). 2025. PMID: 40096550 Free PMC article.
BACKGROUND: Alzheimer Disease (AD) affects more than 50 million people worldwide, with 10 million new diagnosis each year. The link between Sildenafil, a Phosphodiesterase-5 (PDE5) inhibitor, and risk of AD has been debated. We conducted the first meta-analysis on the asso …
BACKGROUND: Alzheimer Disease (AD) affects more than 50 million people worldwide, with 10 million new diagnosis each year. The link between …
Sildenafil for idiopathic pulmonary fibrosis: A systematic review and meta-analysis.
Pitre T, Khalid MF, Cui S, Zhang MC, Husnudinov R, Mah J, Helmczi W, Su J, Guy B, Scallan C, Jones A, Zeraatkar D. Pitre T, et al. Pulm Pharmacol Ther. 2022 Jun;73-74:102128. doi: 10.1016/j.pupt.2022.102128. Epub 2022 Apr 20. Pulm Pharmacol Ther. 2022. PMID: 35452834
Pooled estimated showed sildenafil may not reduce the number of hospitalizations or acute exacerbations, [RR 1.10 (95% CI 0.61 to 1.98); low certainty]. There is probably no difference in drug discontinuation due to adverse effects when comparing sildenafil to the c …
Pooled estimated showed sildenafil may not reduce the number of hospitalizations or acute exacerbations, [RR 1.10 (95% CI 0.61 to 1.9 …
Sildenafil improves clinical signs and radiographic features in dogs with congenital idiopathic megaoesophagus: a randomised controlled trial.
Quintavalla F, Menozzi A, Pozzoli C, Poli E, Donati P, Wyler DK, Serventi P, Bertini S. Quintavalla F, et al. Vet Rec. 2017 Apr 22;180(16):404. doi: 10.1136/vr.103832. Epub 2017 Feb 10. Vet Rec. 2017. PMID: 28188161 Clinical Trial.
We evaluated the efficacy of oral sildenafil citrate in dogs with congenital idiopathic megaoesophagus (CIM). Twenty-one puppies were randomly assigned to two groups (treatment and control). ...These results suggest that sildenafil citrate helps amelio …
We evaluated the efficacy of oral sildenafil citrate in dogs with congenital idiopathic megaoesophagus (CIM). Twenty-one puppi …
Sildenafil for congenital heart diseases induced pulmonary hypertension, a meta-analysis of randomized controlled trials.
Awad AK, Gad ER, Abdelgalil MS, Elsaeidy AS, Ahmed O, Elbadawy MA. Awad AK, et al. BMC Pediatr. 2023 Jul 20;23(1):372. doi: 10.1186/s12887-023-04180-1. BMC Pediatr. 2023. PMID: 37474896 Free PMC article.
BACKGROUND: Sildenafil was first prescribed for angina pectoris and then for erectile dysfunction from its effects on vascular smooth muscle relaxation and vasodilatation. ...Randomized controlled trials that assess the efficacy of using sildenafil in comparison to …
BACKGROUND: Sildenafil was first prescribed for angina pectoris and then for erectile dysfunction from its effects on vascular smooth …
Oral sildenafil versus bosentan for treatment of persistent pulmonary hypertension of the newborn: a randomized controlled trial.
Kallimath A, Deshpande S, Singh P, Garegrat R, Lakshminrusimha S, Maheshwari R, Suryawanshi P. Kallimath A, et al. BMC Pediatr. 2024 Nov 1;24(1):698. doi: 10.1186/s12887-024-05107-0. BMC Pediatr. 2024. PMID: 39487423 Free PMC article. Clinical Trial.
The median (IQR) time for the primary outcome (PASP to reduce by 25% within 48 h) was 36 (24-48) h and 96 (48-120) h in sildenafil and bosentan groups respectively (p = 0.008). There was also a higher need to add other pulmonary vasodilators in bosentan group as compared t …
The median (IQR) time for the primary outcome (PASP to reduce by 25% within 48 h) was 36 (24-48) h and 96 (48-120) h in sildenafil an …
Cerebrovascular Effects of Sildenafil in Small Vessel Disease: The OxHARP Trial.
Webb AJS, Birks JS, Feakins KA, Lawson A, Dawson J, Rothman AMK, Werring DJ, Llwyd O, Stewart CR, Thomas J. Webb AJS, et al. Circ Res. 2024 Jul 5;135(2):320-331. doi: 10.1161/CIRCRESAHA.124.324327. Epub 2024 Jun 4. Circ Res. 2024. PMID: 38832504 Free PMC article. Clinical Trial.
Both drugs increased headaches (P=1.1 10(-4)), while cilostazol increased moderate-severe diarrhea (P=0.013). CONCLUSIONS: Sildenafil did not reduce pulsatility but increased cerebrovascular reactivity and perfusion. Sildenafil merits further study to determine whet …
Both drugs increased headaches (P=1.1 10(-4)), while cilostazol increased moderate-severe diarrhea (P=0.013). CONCLUSIONS: Sildenafil …
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease.
Fang J, Zhang P, Zhou Y, Chiang CW, Tan J, Hou Y, Stauffer S, Li L, Pieper AA, Cummings J, Cheng F. Fang J, et al. Nat Aging. 2021 Dec;1(12):1175-1188. doi: 10.1038/s43587-021-00138-z. Epub 2021 Dec 6. Nat Aging. 2021. PMID: 35572351 Free PMC article. Clinical Trial.
We developed an endophenotype disease module-based methodology for Alzheimer's disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier. Based on retrospective case-control pharmacoepidemiologic analyses of insurance claims data for 7.23 …
We developed an endophenotype disease module-based methodology for Alzheimer's disease (AD) drug repurposing and identified sildenafil …
Sildenafil for adult Asian patients with pulmonary arterial hypertension: a systematic review and meta-analysis.
Shi Q, Wang Z, Yang N, Ma Y, Chen Y, Wei H, Yao H. Shi Q, et al. Ann Palliat Med. 2022 Jan;11(1):339-351. doi: 10.21037/apm-21-3979. Ann Palliat Med. 2022. PMID: 35144425 Free article.
Previous studies have recommended that sildenafil was beneficial, but the dose varies greatly. In this study, we aimed to evaluate the safety and effectiveness of sildenafil [dose: 20 mg/three times a day (TID)] for adult Asian PAH patients. ...We recruited all rand …
Previous studies have recommended that sildenafil was beneficial, but the dose varies greatly. In this study, we aimed to evaluate th …
864 results