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1999 2
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Page 1
Visual Side Effects Linked to Sildenafil Consumption: An Update.
Ausó E, Gómez-Vicente V, Esquiva G. Ausó E, et al. Biomedicines. 2021 Mar 12;9(3):291. doi: 10.3390/biomedicines9030291. Biomedicines. 2021. PMID: 33809319 Free PMC article. Review.
A literature review was performed using PubMed, Cochrane Library and Clinical Trials databases from 1990 up to 2020, focusing on the pathophysiology of visual disorders induced by sildenafil. The aim of this review was not only to gather and summarize the informatio …
A literature review was performed using PubMed, Cochrane Library and Clinical Trials databases from 1990 up to 2020, focusing on the pathoph …
Sildenafil (Viagra) and ophthalmology.
Marmor MF, Kessler R. Marmor MF, et al. Surv Ophthalmol. 1999 Sep-Oct;44(2):153-62. doi: 10.1016/s0039-6257(99)00079-x. Surv Ophthalmol. 1999. PMID: 10541153 Free article. Review.
Sildenafil citrate (Viagra) is a new oral medication that inhibits phosphodiesterase-5 (PDE5) in the corpus cavernosum to facilitate penile erection for the treatment of male impotence. ...Ophthalmologists should alert patients to the ocular side effects …
Sildenafil citrate (Viagra) is a new oral medication that inhibits phosphodiesterase-5 (PDE5) in the corpus cavernosum to faci …
Viagra (sildenafil citrate) and ophthalmology.
Laties A, Zrenner E. Laties A, et al. Prog Retin Eye Res. 2002 Sep;21(5):485-506. doi: 10.1016/s1350-9462(02)00013-7. Prog Retin Eye Res. 2002. PMID: 12207947 Review.
Therefore, the effects of sildenafil on the visual system have been investigated in a wide variety of clinical and preclinical studies. ...The effects of sildenafil have been systematically investigated in visual function studies in volun …
Therefore, the effects of sildenafil on the visual system have been investigated in a wide variety of clinical and prec …
Visual short-term effects of Viagra: double-blind study in healthy young subjects.
Jägle H, Jägle C, Sérey L, Yu A, Rilk A, Sadowski B, Besch D, Zrenner E, Sharpe LT. Jägle H, et al. Am J Ophthalmol. 2004 May;137(5):842-9. doi: 10.1016/j.ajo.2003.11.081. Am J Ophthalmol. 2004. PMID: 15126148 Clinical Trial.
PURPOSE: To investigate short-term visual effects of a single 100-mg dose of Viagra (sildenafil citrate) in healthy men. DESIGN: Randomized, double-blind, placebo-controlled clinical trial of drug effects on normal volunteers conducted by a sing …
PURPOSE: To investigate short-term visual effects of a single 100-mg dose of Viagra (sildenafil citrate) in heal …
The molecular basis for the selectivity of tadalafil toward phosphodiesterase 5 and 6: a modeling study.
Huang YY, Li Z, Cai YH, Feng LJ, Wu Y, Li X, Luo HB. Huang YY, et al. J Chem Inf Model. 2013 Nov 25;53(11):3044-53. doi: 10.1021/ci400458z. Epub 2013 Nov 12. J Chem Inf Model. 2013. PMID: 24180640
Great attention has been paid to the clinical significance of phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, tadalafil, and vardenafil widely used for erectile dysfunction. However, sildenafil causes side effects on visual functions …
Great attention has been paid to the clinical significance of phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, tadalafil, a …
Electrophysiological determination of phosphodiesterase-6 inhibitor inhibition constants in intact mouse retina.
Turunen TT, Koskelainen A. Turunen TT, et al. Toxicol Appl Pharmacol. 2018 Apr 15;345:57-65. doi: 10.1016/j.taap.2018.03.002. Epub 2018 Mar 5. Toxicol Appl Pharmacol. 2018. PMID: 29518412 Free article.
We hypothesize that this is due to the ability of the PDE6 gamma-subunit to compete with sildenafil and zaprinast from the same binding sites near the catalytic domain of PDE6. The introduced methods are beneficial both for selecting potent molecules for P …
We hypothesize that this is due to the ability of the PDE6 gamma-subunit to compete with sildenafil and zaprinast from the sam …
Ocular safety in patients using sildenafil citrate therapy for erectile dysfunction.
Laties A, Sharlip I. Laties A, et al. J Sex Med. 2006 Jan;3(1):12-27. doi: 10.1111/j.1743-6109.2005.00194.x. J Sex Med. 2006. PMID: 16409214 Review.
Sildenafil citrate improves erectile function in men with erectile dysfunction (ED) by selectively inhibiting cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), which is present in all vascular tissue. ...Visual function studies i …
Sildenafil citrate improves erectile function in men with erectile dysfunction (ED) by selectively inhibiting cyclic guanosine …
Potency, selectivity, and consequences of nonselectivity of PDE inhibition.
Bischoff E. Bischoff E. Int J Impot Res. 2004 Jun;16 Suppl 1:S11-4. doi: 10.1038/sj.ijir.3901208. Int J Impot Res. 2004. PMID: 15224129 Review.
As PDEs are expressed in a variety of tissues, selectivity is a prerequisite for a therapeutically applicable PDE inhibitor. Sildenafil, vardenafil, and tadalafil are selective for PDE5, with vardenafil exhibiting the highest potency and minimal inhibition of other PDEs, w …
As PDEs are expressed in a variety of tissues, selectivity is a prerequisite for a therapeutically applicable PDE inhibitor. Sildenafil …
Ocular safety of Viagra, (sildenafil citrate).
Laties AM, Fraunfelder FT. Laties AM, et al. Trans Am Ophthalmol Soc. 1999;97:115-25; discussion 125-8. Trans Am Ophthalmol Soc. 1999. PMID: 10703120 Free PMC article.
To date, sildenafil citrate (Viagra) gives every evidence of being a safe drug for the eye despite a series of expressed concerns. ...A manifest need for improvement in evaluation of postmarketing side-effects. This need has led to the establishment of …
To date, sildenafil citrate (Viagra) gives every evidence of being a safe drug for the eye despite a series of expressed conce …
A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6.
Leinonen H, Cheng C, Pitkänen M, Sander CL, Zhang J, Saeid S, Turunen T, Shmara A, Weiss L, Ta L, Ton T, Koskelainen A, Vargas JD, Kimonis V, Palczewski K. Leinonen H, et al. J Pharmacol Exp Ther. 2021 Jul;378(1):31-41. doi: 10.1124/jpet.120.000486. Epub 2021 Apr 30. J Pharmacol Exp Ther. 2021. PMID: 33931547 Free PMC article.
In the biochemical assay, CB-5083 inhibited PDE6 activity with a potency higher than sildenafil but lower than that of vardenafil. Ex vivo ERG revealed a PDE6 inhibition constant of 80 nM for CB-5083, which is 7-fold smaller than that for sildenafil. . …
In the biochemical assay, CB-5083 inhibited PDE6 activity with a potency higher than sildenafil but lower than that of vardena …
17 results