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Year Number of Results
1999 4
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2026 0

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Page 1
Cardiovascular safety of sildenafil citrate (Viagra): an updated perspective.
Jackson G, Montorsi P, Cheitlin MD. Jackson G, et al. Urology. 2006 Sep;68(3 Suppl):47-60. doi: 10.1016/j.urology.2006.05.047. Urology. 2006. PMID: 17011375 Review.
Sildenafil citrate (Viagra; Pfizer Inc, New York, NY) relaxes vascular smooth muscle, resulting in modest reductions in blood pressure that are insufficient to stimulate a reflex increase in heart rate. ...Also, in the absence of information specific to mixed alpha/ …
Sildenafil citrate (Viagra; Pfizer Inc, New York, NY) relaxes vascular smooth muscle, resulting in modest reductions in blood …
Sildenafil: clinical toxicology profile.
Krenzelok EP. Krenzelok EP. J Toxicol Clin Toxicol. 2000;38(6):645-51. doi: 10.1081/clt-100102015. J Toxicol Clin Toxicol. 2000. PMID: 11185972
BACKGROUND: Sildenafil is indicated for the treatment of male erectile dysfunction. It has been used successfully in males to remediate problems associated with impaired neural and/or hemodynamic response to sexual stimulation. ...Drug interactions involving …
BACKGROUND: Sildenafil is indicated for the treatment of male erectile dysfunction. It has been used successfully in males to remedia …
[Interaction between sildenafil and antihypertensive drugs: what is evidence-based?].
Rosenkranz S, Erdmann E. Rosenkranz S, et al. Dtsch Med Wochenschr. 2001 Oct 12;126(41):1144-9. doi: 10.1055/s-2001-17743. Dtsch Med Wochenschr. 2001. PMID: 11595959 Review. German.
The most common adverse events of sildenafil (headache, flushing, hypotension) result from its moderate vasodilating properties. The concomitant use of sildenafil and organic nitrates is contraindicated because it may lead to a potentiation of the decr …
The most common adverse events of sildenafil (headache, flushing, hypotension) result from its moderate vasodilating properties. The …
Overall cardiovascular profile of sildenafil citrate.
Zusman RM, Morales A, Glasser DB, Osterloh IH. Zusman RM, et al. Am J Cardiol. 1999 Mar 4;83(5A):35C-44C. doi: 10.1016/s0002-9149(99)00046-6. Am J Cardiol. 1999. PMID: 10078541 Review.
Sildenafil, a selective inhibitor of phosphodiesterase type 5 (PDE5), is the first in a new class of orally effective treatments for erectile dysfunction. ...Sildenafil and nitrates both increase cGMP levels in the systemic circulation but at different points …
Sildenafil, a selective inhibitor of phosphodiesterase type 5 (PDE5), is the first in a new class of orally effective treatments for …
Cardiovascular effects of tadalafil.
Kloner RA, Mitchell M, Emmick JT. Kloner RA, et al. Am J Cardiol. 2003 Nov 6;92(9A):37M-46M. doi: 10.1016/s0002-9149(03)00074-2. Am J Cardiol. 2003. PMID: 14609622 Review.
In a study of older subjects (>or=55 years of age) with no overt evidence of CAD, the resulting mean maximal change in standing SBP after coadministration of sublingual nitroglycerin was -25 mm Hg for tadalafil 10 mg, -29 mm Hg for sildenafil 50 mg, and -25 mm Hg for pl …
In a study of older subjects (>or=55 years of age) with no overt evidence of CAD, the resulting mean maximal change in standing SBP after …
Potentiation of sildenafil-induced hypotension is minimal with nitrates generating a radical intermediate.
Schwemmer M, Bassenge E, Stoeter M, Hartmann B, Hess U, Fink B. Schwemmer M, et al. J Cardiovasc Pharmacol. 2001 Jul;38(1):149-55. doi: 10.1097/00005344-200107000-00016. J Cardiovasc Pharmacol. 2001. PMID: 11444498
Thus nitrovasodilators are contraindicated when sildenafil may be used and reports of a number of accidents have recently been published. ...Sildenafil (3 mg/kg) was given orally (after a 24-h fast) 30 min after start of nitrate infusion. ...
Thus nitrovasodilators are contraindicated when sildenafil may be used and reports of a number of accidents have recently been …
Cardiovascular effects of sildenafil citrate and recommendations for its use.
Kloner RA, Zusman RM. Kloner RA, et al. Am J Cardiol. 1999 Sep 9;84(5B):11N-17N. doi: 10.1016/s0002-9149(99)00114-9. Am J Cardiol. 1999. PMID: 10503571 Review.
Sildenafil citrate is the first orally active therapy proved to be effective and safe treatment for erectile dysfunction (ED). ...Sixteen men took or were administered nitroglycerin or an organic nitrate; 3 others had nitroglycerin in their possession. Physic …
Sildenafil citrate is the first orally active therapy proved to be effective and safe treatment for erectile dysfunction (ED). …
Time course of the interaction between tadalafil and nitrates.
Kloner RA, Hutter AM, Emmick JT, Mitchell MI, Denne J, Jackson G. Kloner RA, et al. J Am Coll Cardiol. 2003 Nov 19;42(10):1855-60. doi: 10.1016/j.jacc.2003.09.023. J Am Coll Cardiol. 2003. PMID: 14642699 Free article. Clinical Trial.
OBJECTIVES: This study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t(1/2)) of 17.5 h. BACKGROUND: The PDE5 inhibitors augment the blood pressure (BP)-lowering effects of …
OBJECTIVES: This study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 …
[Pharmacological profiles of sildenafil (VIAGRA) in the treatment of erectile dysfunction: efficacy and drug interaction with nitrate].
Omote M. Omote M. Nihon Yakurigaku Zasshi. 1999 Oct;114(4):213-8. doi: 10.1254/fpj.114.213. Nihon Yakurigaku Zasshi. 1999. PMID: 10584234 Review. Japanese.
The pharmacodynamic interaction with glyceryl trinitrate was also observed in human studies where sildenafil potentiated the hypotensive effect of the nitrate. ...Therefore, administration of sildenafil to patients who are using nitrates and NO …
The pharmacodynamic interaction with glyceryl trinitrate was also observed in human studies where sildenafil potentiated the h …
[Cardio-vascular effects of sildenafil: new data].
Danchin N. Danchin N. Ann Cardiol Angeiol (Paris). 2002 Dec;51(6):341-5. doi: 10.1016/s0003-3928(02)00137-3. Ann Cardiol Angeiol (Paris). 2002. PMID: 12608126 Review. French.
Sildenafil is an inhibitor of phosphodiesterase 5, which has important vasodilatory properties. ...Likewise, post-marketing surveys, in the US or United Kingdom, have recorded a number of cardio-vascular deaths following sildenafil administration which was lower tha …
Sildenafil is an inhibitor of phosphodiesterase 5, which has important vasodilatory properties. ...Likewise, post-marketing surveys, …
17 results