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Year Number of Results
1997 1
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1999 5
2000 2
2001 3
2002 5
2003 4
2004 6
2005 3
2006 4
2007 1
2008 3
2009 5
2010 3
2011 5
2012 1
2013 4
2014 4
2015 4
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2017 5
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2020 6
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85 results

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Page 1
The effects of age and renal and hepatic impairment on the pharmacokinetics of sildenafil.
Muirhead GJ, Wilner K, Colburn W, Haug-Pihale G, Rouviex B. Muirhead GJ, et al. Br J Clin Pharmacol. 2002;53 Suppl 1(Suppl 1):21S-30S. doi: 10.1046/j.0306-5251.2001.00029.x. Br J Clin Pharmacol. 2002. PMID: 11879256 Free PMC article. Clinical Trial.
The second study included eight male volunteers with normal renal function and 16 male volunteers with varying degrees of renal impairment as assessed by measurement of creatinine clearance (CLcr). ...In the renal impairment study, significant c …
The second study included eight male volunteers with normal renal function and 16 male volunteers with varying degrees of renal …
Sildenafil and furosemide nanoparticles as a novel pharmacological treatment for acute renal failure in rats.
Sabra MS, Allam EAH, Hassanein KMA. Sabra MS, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct;397(10):7865-7879. doi: 10.1007/s00210-024-03128-1. Epub 2024 May 15. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38748227 Free PMC article.
Hospitalized patients often develop acute renal failure (ARF), which causes severe morbidity and death. This research investigates the potential renoprotective benefits of sildenafil and furosemide in glycerol-induced ARF, and measures kidney function metrics in res …
Hospitalized patients often develop acute renal failure (ARF), which causes severe morbidity and death. This research investigates th …
Gonadal dysfunction in chronic kidney disease.
Palmer BF, Clegg DJ. Palmer BF, et al. Rev Endocr Metab Disord. 2017 Mar;18(1):117-130. doi: 10.1007/s11154-016-9385-9. Rev Endocr Metab Disord. 2017. PMID: 27586847 Review.
Therapy is initially directed towards optimizing the delivery of dialysis, correcting anemia with recombinant erythropoietin, and controlling the degree of secondary hyperparathyroidism with vitamin D. For many practicing nephrologists sildenafil has become the first line …
Therapy is initially directed towards optimizing the delivery of dialysis, correcting anemia with recombinant erythropoietin, and controllin …
Sildenafil: a review of its use in erectile dysfunction.
Langtry HD, Markham A. Langtry HD, et al. Drugs. 1999 Jun;57(6):967-89. doi: 10.2165/00003495-199957060-00015. Drugs. 1999. PMID: 10400408 Review.
Blood pressure is reduced transiently by sildenafil, but more marked hypotension may occur during concurrent administration of sildenafil and organic nitrates; this combination is contraindicated. ...The maximum dose is 100mg when needed once daily and lower doses ( …
Blood pressure is reduced transiently by sildenafil, but more marked hypotension may occur during concurrent administration of sil …
Overall cardiovascular profile of sildenafil citrate.
Zusman RM, Morales A, Glasser DB, Osterloh IH. Zusman RM, et al. Am J Cardiol. 1999 Mar 4;83(5A):35C-44C. doi: 10.1016/s0002-9149(99)00046-6. Am J Cardiol. 1999. PMID: 10078541 Review.
Sildenafil and nitrates both increase cGMP levels in the systemic circulation but at different points along the NO-cGMP pathway. ...In clinical trials, the incidence of serious cardiovascular adverse events, including stroke and myocardial infarction, was the same for pati …
Sildenafil and nitrates both increase cGMP levels in the systemic circulation but at different points along the NO-cGMP pathway. ...I …
Chronic administration of sildenafil improves erectile function in a rat model of chronic renal failure.
Gurbuz N, Kol A, Ipekci T, Ates E, Baykal A, Usta MF. Gurbuz N, et al. Asian J Androl. 2015 Sep-Oct;17(5):797-801. doi: 10.4103/1008-682X.146973. Asian J Androl. 2015. PMID: 25652632 Free PMC article.
The relationship between erectile dysfunction (ED) and chronic renal failure (CRF) has been reported in several studies. This study aimed to investigate whether the chronic use of sildenafil could enhance the erectile capacity in CRF-induced rats. ...The results of …
The relationship between erectile dysfunction (ED) and chronic renal failure (CRF) has been reported in several studies. This study a …
Anticoagulation Timing in Acute Stroke With Atrial Fibrillation According to Chronic Kidney Disease: The OPTIMAS Trial.
Nash PS, Dehbi HM, Ahmed N, Arram L, Best JG, Balogun M, Bennett K, Bordea E, Caverly E, Chau M, Cohen H, Cullen M, Doré CJ, Engelter ST, Fenner R, Ford GA, Gill A, Hunter R, James M, Jayanthi A, Lip GYH, Massingham S, Murray ML, Mazurczak I, Ndoutoumou A, Norrving B, Philip J, Sims H, Sprigg N, Vanniyasingam T, Freemantle N, Wheeler DC, Werring DJ; OPTIMAS Investigators. Nash PS, et al. Stroke. 2025 Aug;56(8):1970-1979. doi: 10.1161/STROKEAHA.125.051457. Epub 2025 May 22. Stroke. 2025. PMID: 40402086 Free article. Clinical Trial.
The clinical efficacy of cGMP-specific sildenafil on mitochondrial biogenesis induction and renal damage in cats with acute on chronic kidney disease.
Maden M, Ider M, Or ME, Dokuzeylül B, Gülersoy E, Kılıçkaya MC, Bilgiç B, Durgut MK, İzmirli S, Iyigün SS, Telci DZ, Naseri A. Maden M, et al. BMC Vet Res. 2024 Oct 31;20(1):499. doi: 10.1186/s12917-024-04345-9. BMC Vet Res. 2024. PMID: 39478527 Free PMC article.
This study aimed to investigate the effects of MB induction with sildenafil citrate on the cGMP/NO pathway, glomerular filtration, and reduction of kidney damage and fibrosis (TGF-beta/SMAD pathway) in cats with acute on chronic kidney disease (ACKD). Thirty-three c …
This study aimed to investigate the effects of MB induction with sildenafil citrate on the cGMP/NO pathway, glomerular filtrat …
Treatment of erectile dysfunction with sildenafil citrate in renal allograft recipients: a randomized, double-blind, placebo-controlled, crossover trial.
Sharma RK, Prasad N, Gupta A, Kapoor R. Sharma RK, et al. Am J Kidney Dis. 2006 Jul;48(1):128-33. doi: 10.1053/j.ajkd.2006.04.061. Am J Kidney Dis. 2006. PMID: 16797395 Clinical Trial.
BACKGROUND: Erectile dysfunction (ED) is observed frequently in patients with end-stage renal disease, hemodialysis patients, and renal allograft recipients. There are few studies of sildenafil use in renal allograft recipients. ...CONCLUSION: Treatmen …
BACKGROUND: Erectile dysfunction (ED) is observed frequently in patients with end-stage renal disease, hemodialysis patients, and …
Simulation-Based Analysis of the Impact of Renal Impairment on the Pharmacokinetics of Highly Metabolized Compounds.
Follman KE, Morris ME. Follman KE, et al. Pharmaceutics. 2019 Mar 2;11(3):105. doi: 10.3390/pharmaceutics11030105. Pharmaceutics. 2019. PMID: 30832339 Free PMC article.
Renal impairment (RI) is a highly prevalent disease which can alter the pharmacokinetics (PK) of xenobiotics, including those that are predominately metabolized. ...In vitro and preclinical data were utilized to inform simulations for nifedipine, sildenafil a …
Renal impairment (RI) is a highly prevalent disease which can alter the pharmacokinetics (PK) of xenobiotics, including those …
85 results