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Silver nanoparticles crossing through and distribution in the blood-brain barrier in vitro.
Tang J, Xiong L, Zhou G, Wang S, Wang J, Liu L, Li J, Yuan F, Lu S, Wan Z, Chou L, Xi T. Tang J, et al. J Nanosci Nanotechnol. 2010 Oct;10(10):6313-7. doi: 10.1166/jnn.2010.2625. J Nanosci Nanotechnol. 2010. PMID: 21137724
Silver nanoparticles (SNPs) translocate to the brain through the blood stream after they are implanted in vivo. The aim of this study was to investigate the distribution of SNPs that crossed through the blood-brain barrier (BBB). A …
Silver nanoparticles (SNPs) translocate to the brain through the blood stream after they are implanted in vivo. …
Neurotoxicity of Silver Nanoparticles in Rat Brain After Intragastric Exposure.
Xu L, Shao A, Zhao Y, Wang Z, Zhang C, Sun Y, Deng J, Chou LL. Xu L, et al. J Nanosci Nanotechnol. 2015 Jun;15(6):4215-23. doi: 10.1166/jnn.2015.9612. J Nanosci Nanotechnol. 2015. PMID: 26369032
It is known that the biological half-life of silver in the central nervous system is longer than in other organs. However, the potential toxicity of silver nanoparticles (NPs) on brain tissue and the underlying mechanism(s) of action are not well understood. …
It is known that the biological half-life of silver in the central nervous system is longer than in other organs. However, the potential tox …
Influence of silver and titanium dioxide nanoparticles on in vitro blood-brain barrier permeability.
Chen IC, Hsiao IL, Lin HC, Wu CH, Chuang CY, Huang YJ. Chen IC, et al. Environ Toxicol Pharmacol. 2016 Oct;47:108-118. doi: 10.1016/j.etap.2016.09.009. Epub 2016 Sep 15. Environ Toxicol Pharmacol. 2016. PMID: 27664952
An in vitro blood-brain barrier (BBB) model being composed of co-culture with endothelial (bEnd.3) and astrocyte-like (ALT) cells was established to evaluate the toxicity and permeability of Ag nanoparticles (AgNPs; 8nm) and TiO(2) nanoparticles (TiO(2)NPs; 6 …
An in vitro blood-brain barrier (BBB) model being composed of co-culture with endothelial (bEnd.3) and astrocyte-like ( …
Mechanisms Underlying Neurotoxicity of Silver Nanoparticles.
Strużyńska L, Skalska J. Strużyńska L, et al. Adv Exp Med Biol. 2018;1048:227-250. doi: 10.1007/978-3-319-72041-8_14. Adv Exp Med Biol. 2018. PMID: 29453542 Review.
There is evidence that AgNPs can be translocated from the blood to the brain, regardless the route of exposure, and accumulate in the brain over time. ...AgNPs target endothelial cells forming the blood-brain barrier, neurons and glial ce …
There is evidence that AgNPs can be translocated from the blood to the brain, regardless the route of exposure, and accumulate …
Human brain endothelial barrier cells are distinctly less vulnerable to silver nanoparticles toxicity than human blood vessel cells: A cell-specific mechanism of the brain barrier?
Sokołowska P, Białkowska K, Siatkowska M, Rosowski M, Kucińska M, Komorowski P, Makowski K, Walkowiak B. Sokołowska P, et al. Nanomedicine. 2017 Oct;13(7):2127-2130. doi: 10.1016/j.nano.2017.05.015. Epub 2017 Jun 7. Nanomedicine. 2017. PMID: 28602937
The blood-brain barrier (BBB) constitutes a distinctive and tightly regulated interface between the brain and the peripheral circulation. The objective of studies was to compare responses of human endothelial cells representing the model of blood …
The blood-brain barrier (BBB) constitutes a distinctive and tightly regulated interface between the brain and th …
Potential role of alpha-lipoic acid and Ginkgo biloba against silver nanoparticles-induced neuronal apoptosis and blood-brain barrier impairments in rats.
Lebda MA, Sadek KM, Tohamy HG, Abouzed TK, Shukry M, Umezawa M, El-Sayed YS. Lebda MA, et al. Life Sci. 2018 Nov 1;212:251-260. doi: 10.1016/j.lfs.2018.10.011. Epub 2018 Oct 7. Life Sci. 2018. PMID: 30304694
AIMS: This study explored whether silver nanoparticles (AgNPs) can disrupt tight-junctions integrity resulted in blood-brain barrier dysfunction along with oxidative stress, pro-inflammation, and apoptosis induction. ...SIGNIFICANCE: LA and rela …
AIMS: This study explored whether silver nanoparticles (AgNPs) can disrupt tight-junctions integrity resulted in blood- …
Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood-brain barrier primary triple coculture model.
Xu L, Dan M, Shao A, Cheng X, Zhang C, Yokel RA, Takemura T, Hanagata N, Niwa M, Watanabe D. Xu L, et al. Int J Nanomedicine. 2015 Sep 29;10:6105-18. doi: 10.2147/IJN.S85265. eCollection 2015. Int J Nanomedicine. 2015. PMID: 26491287 Free PMC article.
BACKGROUND: Silver nanoparticles (Ag-NPs) can enter the brain and induce neurotoxicity. However, the toxicity of Ag-NPs on the blood-brain barrier (BBB) and the underlying mechanism(s) of action on the BBB and the brain are not wel …
BACKGROUND: Silver nanoparticles (Ag-NPs) can enter the brain and induce neurotoxicity. However, the toxicity of Ag-NPs …
Assessing cytotoxicity and endoplasmic reticulum stress in human blood-brain barrier cells due to silver and copper oxide nanoparticles.
Chojnacka-Puchta L, Sawicka D, Zapor L, Miranowicz-Dzierzawska K. Chojnacka-Puchta L, et al. J Appl Genet. 2025 Feb;66(1):87-103. doi: 10.1007/s13353-024-00833-8. Epub 2024 Feb 9. J Appl Genet. 2025. PMID: 38332387 Free PMC article.
We investigated the expression of tight junction (TJ) proteins (barrier junctions) and showed that both types of NP reduced of OCLN gene expression. Morphological changes were observed after Ag-NP or CuO-NP exposure using holotomographic microscopy. ...
We investigated the expression of tight junction (TJ) proteins (barrier junctions) and showed that both types of NP reduced of OCLN g …
From the Cover: Comparative Proteomics Reveals Silver Nanoparticles Alter Fatty Acid Metabolism and Amyloid Beta Clearance for Neuronal Apoptosis in a Triple Cell Coculture Model of the Blood-Brain Barrier.
Lin HC, Ho MY, Tsen CM, Huang CC, Wu CC, Huang YJ, Hsiao IL, Chuang CY. Lin HC, et al. Toxicol Sci. 2017 Jul 1;158(1):151-163. doi: 10.1093/toxsci/kfx079. Toxicol Sci. 2017. PMID: 28460142
Silver nanoparticles (AgNPs) enter the central nervous system through the blood-brain barrier (BBB). ...This study investigated whether AgNPs disrupt the tight junction proteins of brain endothelial cells, and alter the proteomic metaboli …
Silver nanoparticles (AgNPs) enter the central nervous system through the blood-brain barrier (BBB). ...T …
Bactericidal and Cytotoxic Properties of Silver Nanoparticles.
Liao C, Li Y, Tjong SC. Liao C, et al. Int J Mol Sci. 2019 Jan 21;20(2):449. doi: 10.3390/ijms20020449. Int J Mol Sci. 2019. PMID: 30669621 Free PMC article. Review.
Silver nanoparticles (AgNPs) can be synthesized from a variety of techniques including physical, chemical and biological routes. ...AgNPs induce a dose-, size- and time-dependent cytotoxicity, particularly for those with sizes 10 nm. Furthermore, AgNPs can cross th …
Silver nanoparticles (AgNPs) can be synthesized from a variety of techniques including physical, chemical and biological route …
67 results