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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 3
1969 2
1970 3
1971 8
1972 5
1973 14
1974 11
1975 17
1976 11
1977 22
1978 15
1979 16
1980 15
1981 13
1982 14
1983 12
1984 8
1985 17
1986 15
1987 16
1988 21
1989 19
1990 26
1991 18
1992 27
1993 22
1994 17
1995 13
1996 18
1997 29
1998 29
1999 33
2000 40
2001 44
2002 58
2003 67
2004 63
2005 103
2006 110
2007 141
2008 128
2009 154
2010 201
2011 214
2012 231
2013 261
2014 246
2015 255
2016 266
2017 304
2018 286
2019 260
2020 289
2021 163
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3,898 results
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Page 1
Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years.
Federico A, Dallio M, Loguercio C. Federico A, et al. Molecules. 2017 Jan 24;22(2):191. doi: 10.3390/molecules22020191. Molecules. 2017. PMID: 28125040 Free PMC article. Review.
Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound is silybin, which has a remarkable biological effect. ...Furthermore, silymarin/silybin use has important biological effects in non-alcoholic fatty liver disease. ...
Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound is silybin, which has a remarkable biolo
Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review.
Gillessen A, Schmidt HH. Gillessen A, et al. Adv Ther. 2020 Apr;37(4):1279-1301. doi: 10.1007/s12325-020-01251-y. Epub 2020 Feb 17. Adv Ther. 2020. PMID: 32065376 Free PMC article.
Eurosil 85() is a proprietary formulation developed to maximize the oral bioavailability of silymarin. Most of the clinical research on silymarin has used this formulation. ...Moreover, in patients with diabetes and alcoholic cirrhosis, silymarin was also abl …
Eurosil 85() is a proprietary formulation developed to maximize the oral bioavailability of silymarin. Most of the clinical research …
Silymarin and Its Role in Chronic Diseases.
Neha, Jaggi AS, Singh N. Neha, et al. Adv Exp Med Biol. 2016;929:25-44. doi: 10.1007/978-3-319-41342-6_2. Adv Exp Med Biol. 2016. PMID: 27771919 Review.
Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25 containing flavonolignan. ...In this present chapter, a comprehensive attempt has been made to discuss the potential of silymarin in chronic disorders. An insight into modulation
Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25 containing flavonolignan. ...In this present c
Antiviral Activities of Silymarin and Derivatives.
Liu CH, Jassey A, Hsu HY, Lin LT. Liu CH, et al. Molecules. 2019 Apr 19;24(8):1552. doi: 10.3390/molecules24081552. Molecules. 2019. PMID: 31010179 Free PMC article. Review.
Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. ...This review will describe some of the latest preclinical and clinical studies detailing the antiviral profiles of silymarin and
Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective function
Effect of silymarin on biochemical indicators in patients with liver disease: Systematic review with meta-analysis.
de Avelar CR, Pereira EM, de Farias Costa PR, de Jesus RP, de Oliveira LPM. de Avelar CR, et al. World J Gastroenterol. 2017 Jul 21;23(27):5004-5017. doi: 10.3748/wjg.v23.i27.5004. World J Gastroenterol. 2017. PMID: 28785154 Free PMC article. Review.
AIM: To evaluate the effect of silymarin on the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma glutamyl transpeptidase (gammaGT) in patients with liver diseases. ...The trials with adult and elderly patients of both sexes, with L …
AIM: To evaluate the effect of silymarin on the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and …
Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the Art.
Di Costanzo A, Angelico R. Di Costanzo A, et al. Molecules. 2019 Jun 7;24(11):2155. doi: 10.3390/molecules24112155. Molecules. 2019. PMID: 31181687 Free PMC article. Review.
Equally promising are the effects of silymarin in protecting the brain from the inflammatory and oxidative stress effects by which metabolic syndrome contributes to neurodegenerative diseases. ...The purpose of this study is to review the different nanostructured systems a …
Equally promising are the effects of silymarin in protecting the brain from the inflammatory and oxidative stress effects by which me …
Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial.
Navarro VJ, Belle SH, D'Amato M, Adfhal N, Brunt EM, Fried MW, Reddy KR, Wahed AS, Harrison S; Silymarin in NASH and C Hepatitis (SyNCH) Study Group. Navarro VJ, et al. PLoS One. 2019 Sep 19;14(9):e0221683. doi: 10.1371/journal.pone.0221683. eCollection 2019. PLoS One. 2019. PMID: 31536511 Free PMC article. Clinical Trial.
We aimed to assess the safety and efficacy of higher than customary doses of silymarin in non-cirrhotic patients with NASH. This exploratory randomized double-blind placebo controlled multicenter Phase II trial tested a proprietary standardized silymarin preparation …
We aimed to assess the safety and efficacy of higher than customary doses of silymarin in non-cirrhotic patients with NASH. This expl …
Silymarin's Inhibition and Treatment Effects for Alzheimer's Disease.
Guo H, Cao H, Cui X, Zheng W, Wang S, Yu J, Chen Z. Guo H, et al. Molecules. 2019 May 6;24(9):1748. doi: 10.3390/molecules24091748. Molecules. 2019. PMID: 31064071 Free PMC article. Review.
Recent studies have shown that silymarin also has good pharmacological activity in the nervous system, especially for the treatment of AD. ...Silymarin can also increase the acetylcholine content in the nervous system by inhibiting cholinesterase activity. ...
Recent studies have shown that silymarin also has good pharmacological activity in the nervous system, especially for the treatment o …
The silymarin composition and why does it matter???
Chambers CS, Holečková V, Petrásková L, Biedermann D, Valentová K, Buchta M, Křen V. Chambers CS, et al. Food Res Int. 2017 Oct;100(Pt 3):339-353. doi: 10.1016/j.foodres.2017.07.017. Epub 2017 Jul 12. Food Res Int. 2017. PMID: 28964357 Review.
As silybin is the main component of silymarin, the literature mainly focuses on this compound, ignoring all other components. ...There are studies dealing with the analytical separation and quantification of silymarin components as well as studies focused on sily
As silybin is the main component of silymarin, the literature mainly focuses on this compound, ignoring all other components. ...Ther …
Silymarin: An interesting modality in dermatological therapeutics.
Dorjay K, Arif T, Adil M. Dorjay K, et al. Indian J Dermatol Venereol Leprol. 2018;84(2):238-243. doi: 10.4103/ijdvl.IJDVL_746_16. Indian J Dermatol Venereol Leprol. 2018. PMID: 29350205 Free article. Review. No abstract available.
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