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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1986 2
1989 1
1990 2
1991 2
1993 1
1994 3
1995 2
1996 5
1997 3
1998 3
1999 8
2000 6
2001 8
2002 16
2003 15
2004 17
2005 28
2006 28
2007 42
2008 36
2009 35
2010 44
2011 45
2012 38
2013 49
2014 45
2015 66
2016 56
2017 59
2018 49
2019 44
2020 46
2021 20
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730 results
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Page 1
Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity.
Delmas D, Xiao J, Vejux A, Aires V. Delmas D, et al. Molecules. 2020 Apr 25;25(9):2009. doi: 10.3390/molecules25092009. Molecules. 2020. PMID: 32344919 Free PMC article. Review.
Silymarin extracted from milk thistle consisting of flavonolignan silybin has shown chemopreventive and chemosensitizing activity against various cancers. The present review summarizes the current knowledge on the potential targets of silymarin against variou
Silymarin extracted from milk thistle consisting of flavonolignan silybin has shown chemopreventive and chemosensitizing activity aga
Silymarin: not just another antioxidant.
Camini FC, Costa DC. Camini FC, et al. J Basic Clin Physiol Pharmacol. 2020 Mar 5;31(4):/j/jbcpp.2020.31.issue-4/jbcpp-2019-0206/jbcpp-2019-0206.xml. doi: 10.1515/jbcpp-2019-0206. J Basic Clin Physiol Pharmacol. 2020. PMID: 32134732 Review.
Silymarin (Silybum marianum; SM), popularly known as milk thistle, is an extract that has been used for many centuries to treat liver diseases. ...This review aims at demonstrating the main protective activities of SM in diseases, such as cancer, diabetes, hepatitis
Silymarin (Silybum marianum; SM), popularly known as milk thistle, is an extract that has been used for many centuries to treat liver
Metabolism, Transport and Drug-Drug Interactions of Silymarin.
Xie Y, Zhang D, Zhang J, Yuan J. Xie Y, et al. Molecules. 2019 Oct 14;24(20):3693. doi: 10.3390/molecules24203693. Molecules. 2019. PMID: 31615114 Free PMC article. Review.
Here, we aimed to summarize and highlight the current knowledge of the metabolism and transport of silymarin. It was concluded that the major efflux transporters of silybin are multidrug resistance-associated protein (MRP2) and breast cancer resistance protein (BCRP …
Here, we aimed to summarize and highlight the current knowledge of the metabolism and transport of silymarin. It was concluded that t …
Silymarin and Its Role in Chronic Diseases.
Neha, Jaggi AS, Singh N. Neha, et al. Adv Exp Med Biol. 2016;929:25-44. doi: 10.1007/978-3-319-41342-6_2. Adv Exp Med Biol. 2016. PMID: 27771919 Review.
Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25 containing flavonolignan. ...In this present chapter, a comprehensive attempt has been made to discuss the potential of silymarin in chronic disorders. An insight into modulation
Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25 containing flavonolignan. ...In this present c
Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the Art.
Di Costanzo A, Angelico R. Di Costanzo A, et al. Molecules. 2019 Jun 7;24(11):2155. doi: 10.3390/molecules24112155. Molecules. 2019. PMID: 31181687 Free PMC article. Review.
Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable from milk thistle (Silybum marianum) seeds, has anti-oxidant, anti-inflammatory, anti-cancer and anti-viral activities potentially useful in the treatment of several liver disorde
Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable from milk thistle (Silybum marianum) seeds, ha
Silymarin antiproliferative and apoptotic effects: Insights into its clinical impact in various types of cancer.
Hosseinabadi T, Lorigooini Z, Tabarzad M, Salehi B, Rodrigues CF, Martins N, Sharifi-Rad J. Hosseinabadi T, et al. Phytother Res. 2019 Nov;33(11):2849-2861. doi: 10.1002/ptr.6470. Epub 2019 Aug 12. Phytother Res. 2019. PMID: 31407422 Review.
Following that, apoptotic pathways, such as p53, Akt, STAT-3, Ras, and caspases pathways, have been extensively studied, although other mechanisms involved in inflammation and angiogenesis have also been highlighted as silymarin-likely targets in cancer therapy. The …
Following that, apoptotic pathways, such as p53, Akt, STAT-3, Ras, and caspases pathways, have been extensively studied, although other mech …
Silymarin and epithelial cancer chemoprevention: how close we are to bedside?
Kaur M, Agarwal R. Kaur M, et al. Toxicol Appl Pharmacol. 2007 Nov 1;224(3):350-9. doi: 10.1016/j.taap.2006.11.011. Epub 2006 Nov 15. Toxicol Appl Pharmacol. 2007. PMID: 17184801 Free PMC article. Review.
In recent years, increasing body of evidence has underscored the cancer preventive efficacy of silymarin in both in vitro and in vivo animal models of various epithelial cancers. ...Widespread use of silymarin for liver health in humans and commercial …
In recent years, increasing body of evidence has underscored the cancer preventive efficacy of silymarin in both in vitro and …
Multitargeted therapy of cancer by silymarin.
Ramasamy K, Agarwal R. Ramasamy K, et al. Cancer Lett. 2008 Oct 8;269(2):352-62. doi: 10.1016/j.canlet.2008.03.053. Epub 2008 May 9. Cancer Lett. 2008. PMID: 18472213 Free PMC article. Review.
In this review, we summarize the recent investigations and mechanistic studies regarding possible molecular targets of silymarin for cancer prevention. Number of studies has established the cancer chemopreventive role of silymarin in both in vivo and i …
In this review, we summarize the recent investigations and mechanistic studies regarding possible molecular targets of silymarin for …
Chemopreventive efficacy of silymarin in skin and prostate cancer.
Deep G, Agarwal R. Deep G, et al. Integr Cancer Ther. 2007 Jun;6(2):130-45. doi: 10.1177/1534735407301441. Integr Cancer Ther. 2007. PMID: 17548792 Free article. Review.
Prevention and therapeutic intervention by phytochemicals are newer dimensions in the arena of cancer management. In this regard, the cancer chemopreventive role of silymarin (Silybum marianum) has been extensively studied and has shown anticancer efficacy ag …
Prevention and therapeutic intervention by phytochemicals are newer dimensions in the arena of cancer management. In this regard, the …
In vitro and in vivo anti-cancer activity of silymarin on oral cancer.
Won DH, Kim LH, Jang B, Yang IH, Kwon HJ, Jin B, Oh SH, Kang JH, Hong SD, Shin JA, Cho SD. Won DH, et al. Tumour Biol. 2018 May;40(5):1010428318776170. doi: 10.1177/1010428318776170. Tumour Biol. 2018. PMID: 29764340 Free article.
Silymarin, a standardized extract from milk thistle fruits has been found to exhibit anti-cancer effects against various cancers. Here, we explored the anti-cancer activity of silymarin and its molecular target in human oral cancer in vit
Silymarin, a standardized extract from milk thistle fruits has been found to exhibit anti-cancer effects against various ca
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