Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1991 1
1992 1
1995 1
1998 1
1999 4
2000 1
2001 3
2002 3
2003 2
2004 5
2005 2
2006 8
2007 6
2008 6
2009 3
2010 8
2011 5
2012 7
2013 14
2014 18
2015 26
2016 31
2017 43
2018 30
2019 29
2020 42
2021 43
2022 54
2023 42
2024 62
2025 79
2026 38

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

552 results

Results by year

Filters applied: . Clear all
Page 1
Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis.
Li S, Duan F, Li S, Lu B. Li S, et al. Ann Hepatol. 2024 Mar-Apr;29(2):101174. doi: 10.1016/j.aohep.2023.101174. Epub 2023 Oct 29. Ann Hepatol. 2024. PMID: 38579127 Free article.
INTRODUCTION AND OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease with a high prevalence worldwide and poses serious harm to human health. ...CONCLUSIONS: Silymarin can regulate energy metabolism, attenuate liver d …
INTRODUCTION AND OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease with a high prevalence worldw …
Silymarin decreases liver stiffness associated with gut microbiota in patients with metabolic dysfunction-associated steatotic liver disease: a randomized, double-blind, placebo-controlled trial.
Jin Y, Wang X, Chen K, Chen Y, Zhou L, Zeng Y, Zhou Y, Pan Z, Wang D, Li Z, Liang Y, Ling W, Li D. Jin Y, et al. Lipids Health Dis. 2024 Aug 3;23(1):239. doi: 10.1186/s12944-024-02220-y. Lipids Health Dis. 2024. PMID: 39097726 Free PMC article. Clinical Trial.
BACKGROUND: Despite centuries of traditional use of silymarin for hepatoprotection, current randomized controlled trial (RCT) studies on the effectiveness of silymarin in managing metabolic dysfunction-associated steatotic liver disease (MASLD) are limited an …
BACKGROUND: Despite centuries of traditional use of silymarin for hepatoprotection, current randomized controlled trial (RCT) studies …
Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases.
Abenavoli L, Izzo AA, Milić N, Cicala C, Santini A, Capasso R. Abenavoli L, et al. Phytother Res. 2018 Nov;32(11):2202-2213. doi: 10.1002/ptr.6171. Epub 2018 Aug 6. Phytother Res. 2018. PMID: 30080294 Review.
MT fruits contain a mixture of flavonolignans collectively known as silymarin, being silybin (also named silibinin) the main component. This article reviews the chemistry of MT, the pharmacokinetics and bioavailability, the pharmacologically relevant actions for liver …
MT fruits contain a mixture of flavonolignans collectively known as silymarin, being silybin (also named silibinin) the main componen …
Current strategies for nonalcoholic fatty liver disease treatment (Review).
Sun J, Jin X, Li Y. Sun J, et al. Int J Mol Med. 2024 Oct;54(4):88. doi: 10.3892/ijmm.2024.5412. Epub 2024 Aug 12. Int J Mol Med. 2024. PMID: 39129305 Free PMC article. Review.
Nonalcoholic fatty liver disease (NAFLD), the most common chronic hepatic disease, has become a leading health problem worldwide. ...Biologically active substances, such as peptides, alkaloids, polyphenolic compounds, silymarin, antibiotics, fatty acids, vita …
Nonalcoholic fatty liver disease (NAFLD), the most common chronic hepatic disease, has become a leading health problem worldwi …
Antioxidants in liver health.
Casas-Grajales S, Muriel P. Casas-Grajales S, et al. World J Gastrointest Pharmacol Ther. 2015 Aug 6;6(3):59-72. doi: 10.4292/wjgpt.v6.i3.59. World J Gastrointest Pharmacol Ther. 2015. PMID: 26261734 Free PMC article. Review.
Liver diseases are a worldwide medical problem because the liver is the principal detoxifying organ and maintains metabolic homeostasis. ...Oxidative stress leads to deleterious processes in the liver and produces liver diseases. Therefore, restoring a …
Liver diseases are a worldwide medical problem because the liver is the principal detoxifying organ and maintains metabolic ho …
Impact of Silymarin Supplements on Liver Enzyme Levels: A Systematic Review.
Calderon Martinez E, Herrera D, Mogan S, Hameed Z, Jangda AA, Khan TJ, Mroke P, Sajid S, Shah YR, Baig I. Calderon Martinez E, et al. Cureus. 2023 Oct 24;15(10):e47608. doi: 10.7759/cureus.47608. eCollection 2023 Oct. Cureus. 2023. PMID: 38021897 Free PMC article. Review.
Notably, silymarin's impact on liver enzymes could be context-dependent, with varying responses among different conditions, with the decrease of liver enzyme levels in patients with non-alcoholic fatty liver disease. Silymarin supplements exhibi …
Notably, silymarin's impact on liver enzymes could be context-dependent, with varying responses among different conditions, wi …
Chronic Liver Disease and Silymarin: A Biochemical and Clinical Review.
Tighe SP, Akhtar D, Iqbal U, Ahmed A. Tighe SP, et al. J Clin Transl Hepatol. 2020 Dec 28;8(4):454-458. doi: 10.14218/JCTH.2020.00012. Epub 2020 Oct 16. J Clin Transl Hepatol. 2020. PMID: 33447529 Free PMC article. Review.
Chronic liver disease (CLD) is an under-recognized epidemic that continues to increase in prevalence and is a major health concern. ...Despite the use of silymarin being extensively studied in alcoholic liver disease, metabolic-associated fatty live …
Chronic liver disease (CLD) is an under-recognized epidemic that continues to increase in prevalence and is a major health con …
Silymarin for Treating Toxic Liver Disease: International Consensus Recommendations.
Gillessen A, Angelico F, Chen J, Lu L, Lucena MI, Fu Q, Xie Q, Andrade RJ, Xie W, Xu X, Yu Y, Mao YM, Nan Y. Gillessen A, et al. Gastro Hep Adv. 2022 May 14;1(5):882-893. doi: 10.1016/j.gastha.2022.05.006. eCollection 2022. Gastro Hep Adv. 2022. PMID: 39131840 Free PMC article. Review.
Chronic liver disease (CLD) is a leading health problem impacting the quality of life globally. China shares a major global burden of CLD-including alcoholic liver disease, nonalcoholic fatty liver disease/metabolic dysfunction-associated fatty live …
Chronic liver disease (CLD) is a leading health problem impacting the quality of life globally. China shares a major global bu …
Oral Plant-Derived Nanomedicines Mitigate Acetaminophen-Induced Liver Injury by Modulating the Gut-Liver Axis and Intestinal Microbiota Metabolism.
Chen L, Zu M, Cao Y, Wang Y, Jiang A, Bao S, Yang Q, Liu G, Ge L, Xiao B, Li L. Chen L, et al. Small. 2025 Aug;21(31):e2502001. doi: 10.1002/smll.202502001. Epub 2025 Jun 13. Small. 2025. PMID: 40511710
Excessive use of acetaminophen (APAP) can lead to drug-induced liver injury, with its severity influenced by gut microbiota and their metabolites. The gut-liver axis, a complex bidirectional communication system between the gut and liver, plays a crucial role …
Excessive use of acetaminophen (APAP) can lead to drug-induced liver injury, with its severity influenced by gut microbiota and their …
Silymarin for adults with metabolic dysfunction-associated steatotic liver disease.
Wang C, Shang Y, Kanaan G, Chai L, Li H, Qi X. Wang C, et al. Cochrane Database Syst Rev. 2025 Jun 24;6(6):CD015524. doi: 10.1002/14651858.CD015524.pub2. Cochrane Database Syst Rev. 2025. PMID: 40552569 Free PMC article.
RATIONALE: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major public health challenge, with approximately 32.4% of adults globally diagnosed with the condition and a steadily increasing prevalence. ...When compared with no intervention or pl …
RATIONALE: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major public health challenge, with approxima …
552 results