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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1988 4
1989 7
1990 9
1991 8
1992 15
1993 17
1994 21
1995 42
1996 22
1997 37
1998 34
1999 40
2000 44
2001 53
2002 52
2003 68
2004 76
2005 80
2006 69
2007 83
2008 78
2009 90
2010 90
2011 97
2012 90
2013 103
2014 83
2015 78
2016 77
2017 77
2018 47
2019 43
2020 35
2021 37
2022 39
2023 25
2024 27
2025 15

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Search Results

1,729 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* Trial).
Jones PH, Davidson MH, Stein EA, Bays HE, McKenney JM, Miller E, Cain VA, Blasetto JW; STELLAR Study Group. Jones PH, et al. Am J Cardiol. 2003 Jul 15;92(2):152-60. doi: 10.1016/s0002-9149(03)00530-7. Am J Cardiol. 2003. PMID: 12860216 Clinical Trial.
The primary objective of this 6-week, parallel-group, open-label, randomized, multicenter trial was to compare rosuvastatin with atorvastatin, pravastatin, and simvastatin across dose ranges for reduction of low-density lipoprotein (LDL) cholesterol. ...After a dietary lea …
The primary objective of this 6-week, parallel-group, open-label, randomized, multicenter trial was to compare rosuvastatin with atorvastati …
Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial.
Calfee CS, Delucchi KL, Sinha P, Matthay MA, Hackett J, Shankar-Hari M, McDowell C, Laffey JG, O'Kane CM, McAuley DF; Irish Critical Care Trials Group. Calfee CS, et al. Lancet Respir Med. 2018 Sep;6(9):691-698. doi: 10.1016/S2213-2600(18)30177-2. Epub 2018 Aug 2. Lancet Respir Med. 2018. PMID: 30078618 Free PMC article. Clinical Trial.
Although HARP-2 found no difference in 28-day survival between placebo and simvastatin, significantly different survival was identified across patients stratified by treatment and subphenotype (p<0.0001). Specifically, within the hyperinflammatory subphenotype, patients …
Although HARP-2 found no difference in 28-day survival between placebo and simvastatin, significantly different survival was identifi …
Simvastatin is Efficacious in Treating Cirrhosis: A Meta-analysis.
Zhang H, Zhang Q, Li S, Xie B. Zhang H, et al. J Clin Gastroenterol. 2022 Sep 1;56(8):e303-e312. doi: 10.1097/MCG.0000000000001732. Epub 2022 Jul 14. J Clin Gastroenterol. 2022. PMID: 35830548
Here, we performed a meta-analysis to evaluate the clinical efficacy of simvastatin in liver cirrhosis patients. METHODS: We searched PubMed, EMBASE, and Cochrane library databases for randomized controlled trials targeting simvastatin in patients with liver cirrhos …
Here, we performed a meta-analysis to evaluate the clinical efficacy of simvastatin in liver cirrhosis patients. METHODS: We searched …
Calcium Phosphate Carrying Simvastatin Enhances Bone Regeneration: A Systematic Review.
Cruz R, Pesce G, Calasans-Maia J, Moraschini V, Calasans-Maia MD, Granjeiro JM. Cruz R, et al. Braz Dent J. 2020 Mar-Apr;31(2):93-102. doi: 10.1590/0103-6440202002971. Braz Dent J. 2020. PMID: 32556021 Free article.
The eligibility criteria were animal studies, which evaluated bone repair treated with calcium phosphate as a simvastatin carrier. The selection process yielded 8 studies from the 657 retrieved. All manuscripts concluded that locally applied simvastatin carried by c …
The eligibility criteria were animal studies, which evaluated bone repair treated with calcium phosphate as a simvastatin carrier. Th …
Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis.
Pose E, Solà E, Lozano JJ, Juanola A, Sidorova J, Zaccherini G, de Wit K, Uschner F, Tonon M, Kazankov K, Jiménez C, Campion D, Napoleone L, Ma AT, Carol M, Morales-Ruiz M, Alessandria C, Beuers U, Caraceni P, Francoz C, Durand F, Mookerjee RP, Trebicka J, Vargas V, Piano S, Watson H, Abraldes JG, Kamath PS, Davis MM, Ginès P; investigators of the LIVERHOPE Consortium. Pose E, et al. Hepatol Commun. 2022 May;6(5):1100-1112. doi: 10.1002/hep4.1881. Epub 2021 Dec 28. Hepatol Commun. 2022. PMID: 34964311 Free PMC article. Clinical Trial.
An ACLF-specific signature was identified. Treatment with simvastatin and rifaximin was associated with changes in 161 of 985 metabolites in comparison to treatment with placebo. ...Notably, 18 of the 32 metabolites of the ACLF signature were affected by the treatment. Con …
An ACLF-specific signature was identified. Treatment with simvastatin and rifaximin was associated with changes in 161 of 985 metabol …
Simvastatin reduces plasma membrane caveolae and caveolin-1 in uterine leiomyomas.
Afrin S, El Sabeh M, Miyashita-Ishiwata M, Charewycz N, Singh B, Borahay MA. Afrin S, et al. Life Sci. 2022 Sep 1;304:120708. doi: 10.1016/j.lfs.2022.120708. Epub 2022 Jun 12. Life Sci. 2022. PMID: 35705139 Clinical Trial.
AIMS: Uterine leiomyomas, or fibroids, are estrogen dependent benign tumor in women, however, they have limited treatment options. Simvastatin, a drug commonly used to treat high cholesterol. Recently we demonstrated that simvastatin alters estrogen signaling by red …
AIMS: Uterine leiomyomas, or fibroids, are estrogen dependent benign tumor in women, however, they have limited treatment options. Simvas …
Can simvastatin reduce COPD exacerbations? A randomised double-blind controlled study.
Schenk P, Spiel AO, Hüttinger F, Gmeiner M, Fugger J, Pichler M, Pichler G, Schmeikal S, Janistyn W, Schügerl S, Sajdik C, Herkner H. Schenk P, et al. Eur Respir J. 2021 Jul 29;58(1):2001798. doi: 10.1183/13993003.01798-2020. Print 2021 Jul. Eur Respir J. 2021. PMID: 33574076 Free article. Clinical Trial.
Hazard ratio for risk of first exacerbation for the simvastatin group was 0.51 (95% CI 0.34-0.75; p=0.001). Rate of exacerbations was significantly lower with simvastatin: 103 (41%) versus 147 (59%) (p=0.003). ...We found no effect on quality of life, lung function, …
Hazard ratio for risk of first exacerbation for the simvastatin group was 0.51 (95% CI 0.34-0.75; p=0.001). Rate of exacerbations was …
Safety and efficacy of Simvastatin in the treatment of vitiligo: a systematic review and meta-analysis of randomized controlled trials.
Zhang S, Serag I, Olama SM, Saleh MGA, Shaban EA, Moawad MHED. Zhang S, et al. Arch Dermatol Res. 2025 Apr 19;317(1):726. doi: 10.1007/s00403-025-04234-7. Arch Dermatol Res. 2025. PMID: 40252138 Review.
Only RCTs comparing Simvastatin with a control or pre-post Simvastatin assessments in vitiligo patients were included. ...Simvastatin demonstrates significant efficacy in vitiligo treatment, improving VASI scores and repigmentation while also lowering lipid l …
Only RCTs comparing Simvastatin with a control or pre-post Simvastatin assessments in vitiligo patients were included. ...S …
Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation.
Afrin S, El Sabeh M, Islam MS, Miyashita-Ishiwata M, Malik M, Catherino WH, Akimzhanov AM, Boehning D, Yang Q, Al-Hendy A, Segars JH, Borahay MA. Afrin S, et al. Pharmacol Res. 2021 Oct;172:105856. doi: 10.1016/j.phrs.2021.105856. Epub 2021 Aug 28. Pharmacol Res. 2021. PMID: 34461224 Free PMC article. Clinical Trial.
To explain simvastatin effects on ER-alpha level and trafficking, we examined its effects on ER-alpha post-translational processing. ...Thus, our data suggest that simvastatin modulates several E(2)/ER signaling targets with potential implications in leiomyoma thera …
To explain simvastatin effects on ER-alpha level and trafficking, we examined its effects on ER-alpha post-translational processing. …
Topical application of simvastatin acid sodium salt and atorvastatin calcium salt in vitiligo patients. Results of the randomized, double-blind EVRAAS pilot study.
Niezgoda A, Winnicki A, Krysiński J, Niezgoda P, Nowowiejska L, Czajkowski R. Niezgoda A, et al. Sci Rep. 2024 Jun 25;14(1):14612. doi: 10.1038/s41598-024-65722-w. Sci Rep. 2024. PMID: 38918590 Free PMC article. Clinical Trial.
Use of active forms of simvastatin and atorvastatin did not result in a significant repigmentation of the skin lesions throughout the study period. ...Further studies of topical simvastatin in vitiligo patients should be considered....
Use of active forms of simvastatin and atorvastatin did not result in a significant repigmentation of the skin lesions throughout the …
1,729 results