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Year Number of Results
2002 3
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2009 15
2010 16
2011 18
2012 13
2013 19
2014 12
2015 22
2016 19
2017 27
2018 30
2019 26
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472 results

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Page 1
Clinical criteria for the definition of refractory septic shock: a joint Delphi consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM).
Leone M, Myatra SN, Dugar S, Wieruszewski PM, Russell L, Evans L, Delamarre L, Sharif S, Chew MS, Gong MN, Hernández G, Schorr C, Lakbar I, Smith SE, Martin-Loeches I, Annane D, Balik M, Cecconi M, De Backer D, Donadello K, Dünser MW, Einav S, Ferrer R, Juffermans N, Hamzaoui O, Landoni G, Levy B, McKenzie C, Monnet X, Ostermann M, Spies C, Singer M, Theodorakopulou M, Topeli A, Barreto E, Bauer SR, Busse LW, Coopersmith CM, Deutschman C, Holder AL, Kamaleswaran R, Legrand M, Martin GS, Maves RC, Nazer L, Nunnally ME, Prescott HC, Rincon T, Sacha GL, Seymour CW, Arabi YM, Besen BAMP, Cavalcanti AB, Deane AM, Finfer S, Hammond N, Ibarra-Estrada M, Kattan E, Kotani Y, Machado FR, Ospina-Tascón GA, Mer M, Young PJ, Rochwerg B, Khanna AK. Leone M, et al. Among authors: singer m. Intensive Care Med. 2026 Mar 24. doi: 10.1007/s00134-026-08344-2. Online ahead of print. Intensive Care Med. 2026. PMID: 41874620
Clinical Criteria for the Definition of Refractory Septic Shock: A Joint Delphi Consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM).
Leone M, Myatra SN, Dugar S, Wieruszewski PM, Russell L, Evans L, Delamarre L, Sharif S, Chew MS, Gong MN, Hernández G, Schorr C, Lakbar I, Smith SE, Martin-Loeches I, Annane D, Balik M, Cecconi M, De Backer D, Donadello K, Dünser MW, Einav S, Ferrer R, Juffermans N, Hamzaoui O, Landoni G, Levy B, McKenzie C, Monnet X, Ostermann M, Spies C, Singer M, Theodorakopulou M, Topeli A, Barreto E, Bauer SR, Busse LW, Coopersmith CM, Deutschman C, Holder AL, Kamaleswaran R, Legrand M, Martin GS, Maves RC, Nazer L, Nunnally ME, Prescott HC, Rincon T, Sacha GL, Seymour CW, Arabi YM, Besen BA, Cavalcanti AB, Deane AM, Finfer S, Hammond N, Ibarra-Estrada M, Kattan E, Kotani Y, Machado FR, Ospina-Tascón GA, Mer M, Young PJ, Rochwerg B, Khanna AK. Leone M, et al. Among authors: singer m. Crit Care Med. 2026 May 1;54(5):1073-1091. doi: 10.1097/CCM.0000000000007124. Epub 2026 Mar 24. Crit Care Med. 2026. PMID: 41873857
Clarifying the SOFA-2 Score-Reply.
Ranzani OT, Singer M, Moreno RP. Ranzani OT, et al. Among authors: singer m. JAMA. 2026 Apr 21;335(15):1362-1363. doi: 10.1001/jama.2026.0313. JAMA. 2026. PMID: 41837958 No abstract available.
Sepsis.
Singer M, Angus DC, Annane D, Bauer M, Kalil AC, Klompas M, Machado FR, Martin GS, Randolph AG, Shankar-Hari M, Shapiro NI, Van den Berghe G. Singer M, et al. Lancet. 2026 Mar 28;407(10535):1276-1288. doi: 10.1016/S0140-6736(25)02422-5. Epub 2026 Feb 26. Lancet. 2026. PMID: 41765030 Review.
Making clinical guidelines work for people with multiple long term conditions: analysis and recommendations from review of single condition guidelines.
Pretorius S, Bartle V, Bellass S, Blackburn ER, Bold H, Cooper R, Cordell H, Evison F, Holding R, Howe N, Lam E, Marshall T, Matthews F, Missier P, Pearson ER, Plummer C, Richards G, Robinson SM, Sapey E, Scharf T, Singer M, Suklan J, Walker P, Wason J, Sayer AA, Witham MD. Pretorius S, et al. Among authors: singer m. BMJ Med. 2026 Feb 23;5(1):e001495. doi: 10.1136/bmjmed-2025-001495. eCollection 2026. BMJ Med. 2026. PMID: 41756103 Free PMC article.
Is nitazene-related mortality underestimated? Findings from an in vivo and ex vivo rat study and pharmacoepidemiological analysis of coroner-reported deaths.
Chen S, Aldabergenov D, Alotaibi KS, Holland A, Moore R, Wood R, Hudson S, Milton H, Menzies E, Parks C, Lawson AJ, Harris M, Singer M, Dyson A, Copeland CS. Chen S, et al. Among authors: singer m. Clin Toxicol (Phila). 2026 Apr;64(4):311-323. doi: 10.1080/15563650.2025.2601141. Epub 2026 Feb 8. Clin Toxicol (Phila). 2026. PMID: 41655595
Challenges of monocyte HLA-DR targeted immunomodulation in sepsis-a prospective observational cohort study.
Snow TAC, Villa A, Cesar A, Ryckaert F, Saleem N, Smyth D, Pan H, Flint J, Brealey D, Singer M, Gilroy DW, Arulkumaran N; University College London Hospitals Critical Care Research Team. Snow TAC, et al. Among authors: singer m. Front Immunol. 2026 Jan 7;16:1709289. doi: 10.3389/fimmu.2025.1709289. eCollection 2025. Front Immunol. 2026. PMID: 41573541 Free PMC article.
Septic cardiomyopathy: a form of myocardial hibernation?
Hollenberg SM, Singer M. Hollenberg SM, et al. Among authors: singer m. Eur Heart J. 2025 Dec 23:ehaf1031. doi: 10.1093/eurheartj/ehaf1031. Online ahead of print. Eur Heart J. 2025. PMID: 41431884 No abstract available.
Systematic review and meta-analysis of humoral immunity proteins and mortality in sepsis.
Villa A, Dewar F, Pisciotta W, Rai A, Kerneis S, Batum G, McDonnell T, Scully M, McHugh TD, Hilpert K, Gilroy D, de Nooijer A, Netea MG, Hedetoft M, Bermejo-Martin JF, Akatsuka M, Heinz CC, Venet F, Monneret G, Meessen J, Cheng TH, Zhang M, Caironi P, Giamarellos-Bourboulis EJ, de la Torre Terrón MC, Ebelt H, Rademaker E, Bodelsson M, Tverring J, Mi Y, Knight JC, Lindsey ML, Langley RJ, Kingsmore SF, Brealey D, Singer M, Arulkumaran N. Villa A, et al. Among authors: singer m. Crit Care. 2025 Dec 22;30(1):41. doi: 10.1186/s13054-025-05758-0. Crit Care. 2025. PMID: 41430733 Free PMC article.
ESICM guidelines on circulatory shock and hemodynamic monitoring 2025.
Monnet X, Messina A, Greco M, Bakker J, Aissaoui N, Cecconi M, Coppalini G, De Backer D, Edul VK, Evans L, Hernández G, Hunsicker O, Ince C, Kaufmann T, Levy B, Malbrain MLNG, Mebazaa A, Myatra SN, Ostermann M, Pinsky MR, Saugel B, Savi M, Singer M, Teboul JL, Vieillard-Baron A, Vincent JL, Chew MS. Monnet X, et al. Among authors: singer m. Intensive Care Med. 2025 Nov;51(11):1971-2012. doi: 10.1007/s00134-025-08137-z. Epub 2025 Nov 14. Intensive Care Med. 2025. PMID: 41236566
Optimal Cutoffs for the Ratio of Arterial Oxygen Partial Pressure to Inspired Oxygen Fraction in Categorizing Respiratory Impairment Severity in Organ Failure Scores.
Pölkki A, Reinikainen M, Rochwerg B, Jung C, Sendagire C, Chaudhuri D, Martin GS, Selander T, Rhodes A, Moreno R, Singer M, Laffey JG, Pekkarinen PT; SOFA‐2 study group. Pölkki A, et al. Among authors: singer m. Acta Anaesthesiol Scand. 2026 Jan;70(1):e70137. doi: 10.1111/aas.70137. Acta Anaesthesiol Scand. 2026. PMID: 41160043 Free PMC article.
Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score.
Ranzani OT, Singer M, Salluh JIF, Shankar-Hari M, Pilcher D, Berger-Estilita J, Coopersmith CM, Juffermans NP, Laffey J, Reinikainen M, Neto AS, Tavares M, Timsit JF, Arias Lopez MDP, Arulkumaran N, Aryal D, Azoulay E, Celi LA, Chaudhuri D, De Lange D, De Waele J, Dos Santos CC, Du B, Einav S, Engelbrecht T, Fazla F, Ferrer R, Finazzi S, Fujii T, Gershengorn HB, Greene JD, Haniffa R, Hao S, Hasan MS, Hollenberg S, Ippolito M, Jung C, Kirov M, Kobari S, Lakbar I, Lipman J, Liu V, Liu X, Lobo SM, Magatti D, Martin GS, Metnitz B, Metnitz P, Myatra SN, Oczkowski S, Paiva JA, Paruk F, Pekkarinen PT, Piquilloud L, Pölkki A, Prescott HC, Blaser AR, Rezende E, Robba C, Rochwerg B, Ruckly S, Samei R, Schenck EJ, Secombe P, Sendagire C, Siaw-Frimpong M, Simpkin AJ, Soares M, Summers C, Szczeklik W, Takala J, Tanaka S, Tricella G, Vincent JL, Wendon J, Zampieri FG, Rhodes A, Moreno R. Ranzani OT, et al. Among authors: singer m. JAMA. 2025 Dec 16;334(23):2090-2103. doi: 10.1001/jama.2025.20516. JAMA. 2025. PMID: 41159833 Free PMC article.
Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)-2 Score: A Consensus Statement.
Moreno R, Rhodes A, Ranzani O, Salluh JIF, Berger-Estilita J, Coopersmith CM, Juffermans NP, Laffey J, Reinikainen M, Neto AS, Tavares M, Timsit JF, Arias Lopez MDP, Arulkumaran N, Azoulay E, Chaudhuri D, De Lange D, De Waele J, Dos Santos CC, Du B, Einav S, Ferrer R, Fujii T, Gershengorn HB, Haniffa R, Hasan MS, Hollenberg S, Ippolito M, Jung C, Kirov M, Lakbar I, Lipman J, Liu V, Lobo SM, Martin GS, Metnitz P, Myatra SN, Oczkowski S, Paiva JA, Paruk F, Pekkarinen PT, Pilcher D, Piquilloud L, Pölkki A, Prescott HC, Blaser AR, Rezende E, Robba C, Rochwerg B, Schenck EJ, Sendagire C, Siaw-Frimpong M, Simpkin AJ, Soares M, Summers C, Szczeklik W, Takala J, Vincent JL, Wendon J, Zampieri FG, Shankar-Hari M, Singer M. Moreno R, et al. Among authors: singer m. JAMA Netw Open. 2025 Oct 1;8(10):e2545040. doi: 10.1001/jamanetworkopen.2025.45040. JAMA Netw Open. 2025. PMID: 41159829 Free article.
Peri-Operative Antimicrobial Prophylaxis Modulates CD4+ Lymphocyte Immunophenotype Ex Vivo in High-Risk Patients Undergoing Major Elective Surgery-A Preliminary Observational Study.
Paketci S, Williams J, Pisciotta W, Loye R, Waller AV, Haque R, Brealey D, Singer M, Whittle J, Moonesinghe R, Arulkumaran N, Snow TAC, The University College London Hospitals Critical Care Research Team. Paketci S, et al. Among authors: singer m. Antibiotics (Basel). 2025 Oct 14;14(10):1026. doi: 10.3390/antibiotics14101026. Antibiotics (Basel). 2025. PMID: 41148718 Free PMC article.
The immunology of sepsis: translating new insights into clinical practice.
Kox M, Bauer M, Bos LDJ, Bouma H, Calandra T, Calfee CS, Chousterman BG, Derde LPG, Giamarellos-Bourboulis EJ, Gómez H, Netea MG, Ostermann M, van der Poll T, Scicluna BP, Seymour C, Shankar-Hari M, Shapiro N, Singer M, Venet F, Vlaar APJ, van Vught LA, Weis S, Joost Wiersinga W, Pickkers P. Kox M, et al. Among authors: singer m. Nat Rev Nephrol. 2026 Jan;22(1):30-49. doi: 10.1038/s41581-025-01004-6. Epub 2025 Sep 24. Nat Rev Nephrol. 2026. PMID: 40993251 Review.
Exploring Similarities and Differences Between Methods That Exploit Patterns of Local Genetic Correlation to Identify Shared Causal Loci Through Application to Genome-Wide Association Studies of Multiple Long Term Conditions.
Darlay R, Shah RL, Dodds RM, Nair ATN, Pearson ER, Witham MD, Cordell HJ; ADMISSION Research Collaborative. Darlay R, et al. Genet Epidemiol. 2025 Jul;49(5):e70012. doi: 10.1002/gepi.70012. Genet Epidemiol. 2025. PMID: 40538118 Free PMC article.
Sepsis-induced cardiomyopathy.
Aissaoui N, Boissier F, Chew M, Singer M, Vignon P. Aissaoui N, et al. Among authors: singer m. Eur Heart J. 2025 Sep 8;46(34):3339-3353. doi: 10.1093/eurheartj/ehaf340. Eur Heart J. 2025. PMID: 40439150 Review.
Assessing perioperative risks in a mixed elderly surgical population using machine learning: A multi-objective symbolic regression approach to cardiorespiratory fitness derived from cardiopulmonary exercise testing.
Arina P, Ferrari D, Kaczorek MR, Tetlow N, Dewar A, Stephens R, Martin D, Moonesinghe R, Singer M, Whittle J, Mazomenos EB. Arina P, et al. Among authors: singer m. PLOS Digit Health. 2025 May 16;4(5):e0000851. doi: 10.1371/journal.pdig.0000851. eCollection 2025 May. PLOS Digit Health. 2025. PMID: 40378351 Free PMC article.
An international observational study validating gene-expression sepsis immune subgroups.
Antcliffe DB, Peronnet E, Pène F, Strålin K, Brealey D, Blein S, Cleaver R, Cronhjort M, Diehl JL, Voiriot G, Fleurie A, Lannsjö C, Lukaszewicz AC, Mårtensson J, Pham T, De Prost N, Ricard JD, Singer M, Terraz G, Timsit JF, Unge C, Vieillard-Baron A, Wahlin RR, Llitjos JF, Gordon AC. Antcliffe DB, et al. Among authors: singer m. Crit Care. 2025 Mar 3;29(1):98. doi: 10.1186/s13054-025-05319-5. Crit Care. 2025. PMID: 40033354 Free PMC article.
Building ADMISSION - A research collaborative to transform understanding of multiple long-term conditions for people admitted to hospital.
Witham MD, Bartle V, Bellass S, Bunn JG, Cartner D, Cordell HJ, Doal R, Evison F, Gallier S, Harris S, Hillman SJ, Holding R, Leroux P, Marshall T, Matthews FE, Missier P, Nair A, Osman M, Pearson ER, Plummer C, Pretorius S, Richardson SJ, Robinson SM, Sapey E, Scharf T, Shah R, Shahmandi M, Singer M, Suklan J, Wason JM, Cooper R, Sayer AA. Witham MD, et al. Among authors: singer m. J Multimorb Comorb. 2025 Feb 1;15:26335565251317940. doi: 10.1177/26335565251317940. eCollection 2025 Jan-Dec. J Multimorb Comorb. 2025. PMID: 39896928 Free PMC article.
The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study.
Thomas JL, McGee KC, Hossain A, Perkins GD, Gordon AC, Young D, McAuley D, Singer M, Lall R, Kramaric T, Lord JM, Whitehouse T, Mur LAJ; STRESS-L. collaborators. Thomas JL, et al. Among authors: singer m. Intensive Care Med Exp. 2025 Jan 22;13(1):9. doi: 10.1186/s40635-024-00708-6. Intensive Care Med Exp. 2025. PMID: 39841388 Free PMC article.
Beta Blockers and Septic Shock: More Work to Do.
Whitehouse T, Singer M. Whitehouse T, et al. Among authors: singer m. Chest. 2025 Jan;167(1):9-10. doi: 10.1016/j.chest.2024.09.007. Chest. 2025. PMID: 39794080 No abstract available.
Effects of two different dexamethasone dosing regimens on ventilator-free days and long-term mortality in COVID-19 patients with moderate-to-severe ARDS: the REMED randomized clinical trial.
Maláska J, Stašek J, Máca J, Kutěj M, Duška F, Kafka P, Klementová O, Doubravská L, Hruda J, Fencl M, Gabrhelík T, Číž L, Zatloukal J, Pouska J, Novotný P, Balík M, Demlová R, Kubátová J, Vinklerová J, Grodová K, Štěpánová R, Svobodník A, Kratochvíl M, Klučka J, Štourač P, Singer M; REMED Study Group. Maláska J, et al. Among authors: singer m. Eur J Med Res. 2024 Dec 23;29(1):616. doi: 10.1186/s40001-024-02215-6. Eur J Med Res. 2024. PMID: 39710693 Free PMC article. Clinical Trial.
Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.
Dark P, Hossain A, McAuley DF, Brealey D, Carlson G, Clayton JC, Felton TW, Ghuman BK, Gordon AC, Hellyer TP, Lone NI, Manazar U, Richards G, McCullagh IJ, McMullan R, McNamee JJ, McNeil HC, Mouncey PR, Naisbitt MJ, Parker RJ, Poole RL, Rostron AJ, Singer M, Stevenson MD, Walsh TS, Welters ID, Whitehouse T, Whiteley S, Wilson P, Young KK, Perkins GD, Lall R; ADAPT-Sepsis Collaborators. Dark P, et al. Among authors: singer m. JAMA. 2025 Feb 25;333(8):682-693. doi: 10.1001/jama.2024.26458. JAMA. 2025. PMID: 39652885 Free PMC article. Clinical Trial.
Causal inference can lead us to modifiable mechanisms and informative archetypes in sepsis.
Baillie JK, Angus D, Burnham K, Calandra T, Calfee C, Gutteridge A, Hacohen N, Khatri P, Langley R, Ma'ayan A, Marshall J, Maslove D, Prescott HC, Rowan K, Scicluna BP, Seymour C, Shankar-Hari M, Shapiro N, Joost Wiersinga W, Singer M, Randolph AG. Baillie JK, et al. Among authors: singer m. Intensive Care Med. 2024 Dec;50(12):2031-2042. doi: 10.1007/s00134-024-07665-4. Epub 2024 Oct 21. Intensive Care Med. 2024. PMID: 39432104 Free PMC article. Review.
Taming hemoglobin chemistry-a new hemoglobin-based oxygen carrier engineered with both decreased rates of nitric oxide scavenging and lipid oxidation.
Cooper CE, Simons M, Dyson A, Leiva Eriksson N, Silkstone GGA, Syrett N, Allen-Baume V, Bülow L, Ronda L, Mozzarelli A, Singer M, Reeder BJ. Cooper CE, et al. Among authors: singer m. Exp Mol Med. 2024 Oct;56(10):2260-2270. doi: 10.1038/s12276-024-01323-x. Epub 2024 Oct 1. Exp Mol Med. 2024. PMID: 39349830 Free PMC article.
472 results