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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
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1968 1
1969 5
1970 3
1971 3
1972 19
1973 34
1974 51
1975 69
1976 80
1977 60
1978 68
1979 78
1980 82
1981 94
1982 93
1983 105
1984 127
1985 142
1986 128
1987 157
1988 191
1989 180
1990 215
1991 249
1992 325
1993 772
1994 1582
1995 1736
1996 1881
1997 1786
1998 1737
1999 1819
2000 1930
2001 2160
2002 2156
2003 2092
2004 2092
2005 1741
2006 1132
2007 1061
2008 933
2009 920
2010 789
2011 854
2012 930
2013 865
2014 798
2015 712
2016 730
2017 665
2018 595
2019 536
2020 499
2021 542
2022 475
2023 470
2024 483
2025 485
2026 305

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38,482 results

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Page 1
Single-Stranded DNA Binding Proteins and Their Identification Using Machine Learning-Based Approaches.
Guo JT, Malik F. Guo JT, et al. Biomolecules. 2022 Aug 26;12(9):1187. doi: 10.3390/biom12091187. Biomolecules. 2022. PMID: 36139026 Free PMC article. Review.
Single-stranded DNA (ssDNA) binding proteins (SSBs) are critical in maintaining genome stability by protecting the transient existence of ssDNA from damage during essential biological processes, such as DNA replication and gene transcription. Th …
Single-stranded DNA (ssDNA) binding proteins (SSBs) are critical in maintaining genome stability by protecting t …
Unravelling How Single-Stranded DNA Binding Protein Coordinates DNA Metabolism Using Single-Molecule Approaches.
Xu L, Halma MTJ, Wuite GJL. Xu L, et al. Int J Mol Sci. 2023 Feb 1;24(3):2806. doi: 10.3390/ijms24032806. Int J Mol Sci. 2023. PMID: 36769124 Free PMC article. Review.
Single-stranded DNA-binding proteins (SSBs) play vital roles in DNA metabolism. Proteins of the SSB family exclusively and transiently bind to ssDNA, preventing the DNA double helix from re-annealing and maintaining genome integrity. ...R …
Single-stranded DNA-binding proteins (SSBs) play vital roles in DNA metabolism. Proteins of the SSB famil …
RPA-like single-stranded DNA-binding protein complexes including CST serve as specialized processivity factors for polymerases.
Barbour AT, Wuttke DS. Barbour AT, et al. Curr Opin Struct Biol. 2023 Aug;81:102611. doi: 10.1016/j.sbi.2023.102611. Epub 2023 May 26. Curr Opin Struct Biol. 2023. PMID: 37245465 Free PMC article. Review.
Telomeres and other single-stranded regions of the genome require specialized management to maintain stability and for proper progression of DNA metabolism pathways. Human Replication Protein A and CTC1-STN1-TEN1 are structurally similar heterotrimeric protei …
Telomeres and other single-stranded regions of the genome require specialized management to maintain stability and for proper …
Eukaryotic single-stranded DNA binding proteins: central factors in genome stability.
Broderick S, Rehmet K, Concannon C, Nasheuer HP. Broderick S, et al. Subcell Biochem. 2010;50:143-63. doi: 10.1007/978-90-481-3471-7_8. Subcell Biochem. 2010. PMID: 20012581 Review.
The single-stranded DNA binding proteins (SSBs) are required to maintain the integrity of the genome in all organisms. ...Considering the DNA-binding properties of RPA a mechanism of "molecular counting" to initiate DNA damage-depe …
The single-stranded DNA binding proteins (SSBs) are required to maintain the integrity of the genome in all orga …
ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway.
Yang SF, Nelson CB, Wells JK, Fernando M, Lu R, Allen JAM, Malloy L, Lamm N, Murphy VJ, Mackay JP, Deans AJ, Cesare AJ, Sobinoff AP, Pickett HA. Yang SF, et al. Nat Commun. 2024 Mar 12;15(1):2210. doi: 10.1038/s41467-024-46578-0. Nat Commun. 2024. PMID: 38472229 Free PMC article.
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. ...We find that ZN …
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ss …
A Novel Family of Winged-Helix Single-Stranded DNA-Binding Proteins from Archaea.
Huang C, Liu X, Chen Y, Zhou J, Li W, Ding N, Huang L, Chen J, Zhang Z. Huang C, et al. Int J Mol Sci. 2022 Mar 22;23(7):3455. doi: 10.3390/ijms23073455. Int J Mol Sci. 2022. PMID: 35408816 Free PMC article.
Here, we report the identification and characterization of Sul7s, a novel winged-helix single-stranded DNA binding protein family highly conserved in Sulfolobaceae. Sul7s from Sulfolobus islandicus binds ssDNA with an affinity approximately 15-f …
Here, we report the identification and characterization of Sul7s, a novel winged-helix single-stranded DNA binding …
Bloom Syndrome Helicase Compresses Single-Stranded DNA into Phase-Separated Condensates.
Wang T, Hu J, Li Y, Bi L, Guo L, Jia X, Zhang X, Li D, Hou XM, Modesti M, Xi XG, Liu C, Sun B. Wang T, et al. Angew Chem Int Ed Engl. 2022 Sep 26;61(39):e202209463. doi: 10.1002/anie.202209463. Epub 2022 Aug 23. Angew Chem Int Ed Engl. 2022. PMID: 35922882
BLM has been widely recognized as a genome "caretaker" that processes structured DNA. In contrast, our knowledge of how BLM behaves on single-stranded (ss) DNA is still limited. ...Moreover, BLM is also capable of condensing replication protein A (RPA) …
BLM has been widely recognized as a genome "caretaker" that processes structured DNA. In contrast, our knowledge of how BLM behaves o …
Alignment of helicases on single-stranded DNA increases activity.
Ozaslan D, Byrd AK, Belachew B, Raney KD. Ozaslan D, et al. Methods Enzymol. 2022;672:29-54. doi: 10.1016/bs.mie.2022.03.066. Epub 2022 Apr 26. Methods Enzymol. 2022. PMID: 35934480 Free PMC article.
Dda helicase from bacteriophage T4 and NS3 helicase domain from the hepatitis C virus are examples of monomeric helicases. These helicases can bind to single-stranded DNA in a manner that appears like train engines on a track. When monomeric helicases align o …
Dda helicase from bacteriophage T4 and NS3 helicase domain from the hepatitis C virus are examples of monomeric helicases. These helicases c …
iMab antibody binds single-stranded cytosine-rich sequences and unfolds DNA i-motifs.
Boissieras J, Bonnet H, Susanto MF, Gomez D, Defrancq E, Granzhan A, Dejeu J. Boissieras J, et al. Nucleic Acids Res. 2024 Aug 12;52(14):8052-8062. doi: 10.1093/nar/gkae531. Nucleic Acids Res. 2024. PMID: 38908025 Free PMC article.

i-Motifs (iMs) are non-canonical, four-stranded secondary structures formed by stacking of hemi-protonated CH+.C base pairs in cytosine-rich DNA sequences, predominantly at pH < 7. ...Moreover, the results of the bulk-FRET assay indicate that interaction with iMa

…
i-Motifs (iMs) are non-canonical, four-stranded secondary structures formed by stacking of hemi-protonated CH+.C base pairs in cytosi …
Single-Stranded DNA Aptamers Against TNF and Their Potential Applications.
Tao S, Song P, Zhang X, Zhang L, Chu CQ. Tao S, et al. Methods Mol Biol. 2020;2108:181-196. doi: 10.1007/978-1-0716-0247-8_16. Methods Mol Biol. 2020. PMID: 31939181
Aptamers are short, single-stranded RNA or DNA sequences, which can bind to protein ligands with high affinity and specificity. ...However, manufacturing these biological TNF inhibitors is expensive and a significant proportion of patients do not respond to T …
Aptamers are short, single-stranded RNA or DNA sequences, which can bind to protein ligands with high affinity and spec …
38,482 results
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