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Regulation of SIRT1 and Its Roles in Inflammation.
Yang Y, Liu Y, Wang Y, Chao Y, Zhang J, Jia Y, Tie J, Hu D. Yang Y, et al. Front Immunol. 2022 Mar 11;13:831168. doi: 10.3389/fimmu.2022.831168. eCollection 2022. Front Immunol. 2022. PMID: 35359990 Free PMC article. Review.
The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD(+)-dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that plays a role in modulating inflammation. ...We also summarize factors that infl …
The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD(+)-dependent deacetylase belonging t …
SIRT1 and aging related signaling pathways.
Chen C, Zhou M, Ge Y, Wang X. Chen C, et al. Mech Ageing Dev. 2020 Apr;187:111215. doi: 10.1016/j.mad.2020.111215. Epub 2020 Feb 19. Mech Ageing Dev. 2020. PMID: 32084459 Review.
The expression of SIRT1 is diminished with aging in mice. By contrast, increased expression of SIRT1 is sufficient to extend lifespan in yeast, caenorhabditis elegans and mice. ...Meanwhile, the potential therapeutic strategies of targeting SIRT1 to anti-agin …
The expression of SIRT1 is diminished with aging in mice. By contrast, increased expression of SIRT1 is sufficient to extend l …
Sirt1 and the Mitochondria.
Tang BL. Tang BL. Mol Cells. 2016 Feb;39(2):87-95. doi: 10.14348/molcells.2016.2318. Epub 2016 Feb 2. Mol Cells. 2016. PMID: 26831453 Free PMC article. Review.
Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1alpha (PGC-1alpha) has been extensively implicated in metabolic control and mitochondrial biogenesis, which was proposed to partially underli …
Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1a …
SIRT1 and SIRT6: The role in aging-related diseases.
You Y, Liang W. You Y, et al. Biochim Biophys Acta Mol Basis Dis. 2023 Oct;1869(7):166815. doi: 10.1016/j.bbadis.2023.166815. Epub 2023 Jul 26. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 37499928 Free article. Review.
Sirtuins (SIRTs) are a family of NAD(+)-dependent enzymes that regulate fundamental biological functions from genomic stability and lifespan to energy metabolism and tumorigenesis. Of the seven mammalian SIRT isotypes (SIRT1-7), SIRT1 and SIRT6 are well-recognized f …
Sirtuins (SIRTs) are a family of NAD(+)-dependent enzymes that regulate fundamental biological functions from genomic stability and lifespan …
Nutraceutical activation of Sirt1: a review.
DiNicolantonio JJ, McCarty MF, O'Keefe JH. DiNicolantonio JJ, et al. Open Heart. 2022 Dec;9(2):e002171. doi: 10.1136/openhrt-2022-002171. Open Heart. 2022. PMID: 36522127 Free PMC article. Review.
The deacetylase sirtuin 1 (Sirt1), activated by calorie restriction and fasting, exerts several complementary effects on cellular function that are favourable to healthspan; it is often thought of as an 'anti-aging' enzyme. ...Since oxidative stress can reduc …
The deacetylase sirtuin 1 (Sirt1), activated by calorie restriction and fasting, exerts several complementary effects o …
SIRT1 is a regulator of autophagy: Implications for the progression and treatment of myocardial ischemia-reperfusion.
Ding X, Zhu C, Wang W, Li M, Ma C, Gao B. Ding X, et al. Pharmacol Res. 2024 Jan;199:106957. doi: 10.1016/j.phrs.2023.106957. Epub 2023 Oct 10. Pharmacol Res. 2024. PMID: 37820856 Free article. Review.
SIRT1 is a highly conserved nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylase. ...Increasing research on I/R injury has indicated that SIRT1 is involved in the process of autophagy and regulates myocardial I/R. SIRT1 regulates autophagy …
SIRT1 is a highly conserved nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylase. ...Increasing research on I/R i …
SIRT1 and Autophagy: Implications in Endocrine Disorders.
Kim JY, Mondaca-Ruff D, Singh S, Wang Y. Kim JY, et al. Front Endocrinol (Lausanne). 2022 Jul 14;13:930919. doi: 10.3389/fendo.2022.930919. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35909524 Free PMC article. Review.
Through its deacetylase activity, SIRT1 participates in the regulation of different steps of autophagy, from initiation to degradation. The levels and function of SIRT1 are also regulated by the autophagy process. Dysregulation in SIRT1-mediated autophagy hin …
Through its deacetylase activity, SIRT1 participates in the regulation of different steps of autophagy, from initiation to degradatio …
SIRT1: a novel regulator in colorectal cancer.
Dong W, Lu J, Li Y, Zeng J, Du X, Yu A, Zhao X, Chi F, Xi Z, Cao S. Dong W, et al. Biomed Pharmacother. 2024 Sep;178:117176. doi: 10.1016/j.biopha.2024.117176. Epub 2024 Jul 25. Biomed Pharmacother. 2024. PMID: 39059350 Free article. Review.
Accumulating evidence indicates that SIRT1 is a therapeutic target for CRC; however, the function and underlying mechanism of SIRT1 in CRC still need to be elucidated. ...From epigenetic regulation to its potential therapeutic effect, we hope to offer novel insights …
Accumulating evidence indicates that SIRT1 is a therapeutic target for CRC; however, the function and underlying mechanism of SIRT …
SIRT1: A Novel Protective Molecule in Pre-eclampsia.
Liu Z, Wang C, Pei J, Li M, Gu W. Liu Z, et al. Int J Med Sci. 2022 May 29;19(6):993-1002. doi: 10.7150/ijms.73012. eCollection 2022. Int J Med Sci. 2022. PMID: 35813294 Free PMC article. Review.
Several studies showed that SIRT1 might play a vital role in the pathogenesis of pre-eclampsia. In this review, we aim to integrate the latest research on SIRT1 and pre-eclampsia to explore the comprehensive mechanisms of SIRT1 in pre-eclampsia. ...Furthermor …
Several studies showed that SIRT1 might play a vital role in the pathogenesis of pre-eclampsia. In this review, we aim to integrate t …
SIRT1 promotes glucolipid metabolic conversion to facilitate tumor development in colorectal carcinoma.
Wei Z, Xia J, Li J, Cai J, Shan J, Zhang C, Zhang L, Wang T, Qian C, Liu L. Wei Z, et al. Int J Biol Sci. 2023 Mar 27;19(6):1925-1940. doi: 10.7150/ijbs.76704. eCollection 2023. Int J Biol Sci. 2023. PMID: 37063423 Free PMC article.
We used Seahorse metabolic analysis, immunoblotting, immunofluorescence, and immunohistochemical (IHC) technology to verify the prediction and mechanism of this regulator in cancer cell lines, a nude mouse xenograft model, and clinical CRC samples. Results: We demonstrated that …
We used Seahorse metabolic analysis, immunoblotting, immunofluorescence, and immunohistochemical (IHC) technology to verify the prediction a …
SIRT1: A Potential Therapeutic Target in Autoimmune Diseases.
Shen P, Deng X, Chen Z, Ba X, Qin K, Huang Y, Huang Y, Li T, Yan J, Tu S. Shen P, et al. Front Immunol. 2021 Nov 23;12:779177. doi: 10.3389/fimmu.2021.779177. eCollection 2021. Front Immunol. 2021. PMID: 34887866 Free PMC article. Review.
The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide, and the identification of novel therapeutic strategies for prevention and treatment is urgently needed. Sirtuin 1 (SIRT1), a member of the class III family of nicotinamid …
The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide, and the identification of novel therapeutic strateg …
Role of SIRT1 in Chemoresistant Leukemia.
Fajardo-Orduña GR, Ledesma-Martínez E, Aguiñiga-Sanchez I, Weiss-Steider B, Santiago-Osorio E. Fajardo-Orduña GR, et al. Int J Mol Sci. 2023 Sep 23;24(19):14470. doi: 10.3390/ijms241914470. Int J Mol Sci. 2023. PMID: 37833921 Free PMC article. Review.
The regulatory functions of SIRT1 in different biological processes and molecular pathways are dependent on the type and stage of the neoplasia; thus, it may act as both an oncogenic and tumor suppressor factor and may also participate in drug resistance. In this review, w …
The regulatory functions of SIRT1 in different biological processes and molecular pathways are dependent on the type and stage of the …
p300 arrests intervertebral disc degeneration by regulating the FOXO3/Sirt1/Wnt/beta-catenin axis.
Hao Y, Ren Z, Yu L, Zhu G, Zhang P, Zhu J, Cao S. Hao Y, et al. Aging Cell. 2022 Aug;21(8):e13677. doi: 10.1111/acel.13677. Epub 2022 Jul 30. Aging Cell. 2022. PMID: 35907249 Free PMC article.
Clinical tissue samples were collected from patients with lumbar disc herniation (LDH), in which the expression of p300, forkhead box O3 (FOXO3), and sirtuin 1 (Sirt1) was determined. Nucleus pulposus cells (NPCs) isolated from clinical degenerative intervert …
Clinical tissue samples were collected from patients with lumbar disc herniation (LDH), in which the expression of p300, forkhead box O3 (FO …
Flavonoids-mediated SIRT1 signaling activation in hepatic disorders.
Sayed AM, Hassanein EHM, Salem SH, Hussein OE, Mahmoud AM. Sayed AM, et al. Life Sci. 2020 Oct 15;259:118173. doi: 10.1016/j.lfs.2020.118173. Epub 2020 Aug 1. Life Sci. 2020. PMID: 32750437 Review.
Therefore, targeting the SIRT1 signaling pathways may be a reasonable therapeutic approach to treat different diseases, including hepatic disorders. ...The complied information and molecular docking simulations suggested that SIRT1 signaling is involved in the benef …
Therefore, targeting the SIRT1 signaling pathways may be a reasonable therapeutic approach to treat different diseases, including hep …
Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis.
Zhang Y, Huang W, Zheng Z, Wang W, Yuan Y, Hong Q, Lin J, Li X, Meng Y. Zhang Y, et al. Free Radic Biol Med. 2021 Apr;166:116-127. doi: 10.1016/j.freeradbiomed.2021.02.013. Epub 2021 Feb 17. Free Radic Biol Med. 2021. PMID: 33609723
The reduction in autophagy, in turn, decreased SIRT1 activity by promoting mitochondrial oxidative stress-related DNA damage, thereby establishing a positive feedback loop between SIRT1 and autophagy in CS-induced AT2 cells senescence. Consequently, CS-inactivated …
The reduction in autophagy, in turn, decreased SIRT1 activity by promoting mitochondrial oxidative stress-related DNA damage, thereby …
The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis.
Liang J, Huang G, Liu X, Taghavifar F, Liu N, Wang Y, Deng N, Yao C, Xie T, Kulur V, Dai K, Burman A, Rowan SC, Weigt SS, Belperio J, Stripp B, Parks WC, Jiang D, Noble PW. Liang J, et al. J Clin Invest. 2022 Jun 1;132(11):e157338. doi: 10.1172/JCI157338. J Clin Invest. 2022. PMID: 35389887 Free PMC article.
ZIP8 regulation of AEC2 progenitor function was dependent on SIRT1. Replenishment with exogenous zinc and SIRT1 activation promoted self-renewal and differentiation of AEC2s from lung tissues of IPF patients and old mice. ...Therapeutic strategies to restore zinc me …
ZIP8 regulation of AEC2 progenitor function was dependent on SIRT1. Replenishment with exogenous zinc and SIRT1 activation pro …
Trending topics of SIRT1 in tumorigenicity.
Garcia-Peterson LM, Li X. Garcia-Peterson LM, et al. Biochim Biophys Acta Gen Subj. 2021 Sep;1865(9):129952. doi: 10.1016/j.bbagen.2021.129952. Epub 2021 Jun 18. Biochim Biophys Acta Gen Subj. 2021. PMID: 34147543 Free PMC article. Review.
BACKGROUND: Carcinogenesis is governed by a series of genetic alterations and epigenetic changes that lead to aberrant patterns in neoplastic cells. Sirtuin-1(SIRT1), an NAD(+)-dependent protein deacetylase, is capable of deacetylating histones and non-histon …
BACKGROUND: Carcinogenesis is governed by a series of genetic alterations and epigenetic changes that lead to aberrant patterns in neoplasti …
SIRT1 as a Potential Therapeutic Target for Chronic Obstructive Pulmonary Disease.
Li S, Huang Q, He B. Li S, et al. Lung. 2023 Apr;201(2):201-215. doi: 10.1007/s00408-023-00607-9. Epub 2023 Feb 15. Lung. 2023. PMID: 36790647 Review.
Although the pathogenesis of COPD is complex and remains to be robustly elucidated, numerous studies have shown that oxidative stress, inflammatory responses, cell apoptosis, autophagy, and aging are involved in the pathogenesis of COPD. Sirtuin 1 (SIRT1) is …
Although the pathogenesis of COPD is complex and remains to be robustly elucidated, numerous studies have shown that oxidative stress, infla …
SIRT1: potential target in glucocorticoid-resistant diseases.
Xie J, Che S, Liu J, Long X. Xie J, et al. Front Immunol. 2025 May 9;16:1514745. doi: 10.3389/fimmu.2025.1514745. eCollection 2025. Front Immunol. 2025. PMID: 40416964 Free PMC article. Review.
In some glucocorticoid-resistant diseases, SIRT1 expression is reduced. Here, we review recent advances in the role of SIRT1 in regulating glucocorticoid signaling. First, we describe the structure, tissue expression, and subcellular localization of SIRT1. We …
In some glucocorticoid-resistant diseases, SIRT1 expression is reduced. Here, we review recent advances in the role of SIRT1 i …
Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis.
Chen Y, Xiao H, Liu Z, Teng F, Yang A, Geng B, Sheng X, Xia Y. Chen Y, et al. Biomolecules. 2024 Aug 8;14(8):970. doi: 10.3390/biom14080970. Biomolecules. 2024. PMID: 39199358 Free PMC article. Review.
However, our understanding of the mechanisms of bone remodeling and factors affecting bone mass remains incomplete. Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase that regulates a variety of cellular metabolisms, including inflammation, tumor …
However, our understanding of the mechanisms of bone remodeling and factors affecting bone mass remains incomplete. Sirtuin1 (SIRT1) …
SIRT1 in cardiovascular aging.
Luo XY, Qu SL, Tang ZH, Zhang Y, Liu MH, Peng J, Tang H, Yu KL, Zhang C, Ren Z, Jiang ZS. Luo XY, et al. Clin Chim Acta. 2014 Nov 1;437:106-14. doi: 10.1016/j.cca.2014.07.019. Epub 2014 Jul 22. Clin Chim Acta. 2014. PMID: 25063737 Review.
Effective interventions are necessary to delay aging. Sirtuin1 (SIRT1), a NAD(+)-dependent histone deacetylase, is closely related to lifespan extension. SIRT1 exerts beneficial effects on aging and age-related diseases, such as atherosclerosis. ...
Effective interventions are necessary to delay aging. Sirtuin1 (SIRT1), a NAD(+)-dependent histone deacetylase, is closely related to …
SIRT1: a promising therapeutic target in type 2 diabetes mellitus.
Mihanfar A, Akbarzadeh M, Ghazizadeh Darband S, Sadighparvar S, Majidinia M. Mihanfar A, et al. Arch Physiol Biochem. 2024 Feb;130(1):13-28. doi: 10.1080/13813455.2021.1956976. Epub 2021 Aug 11. Arch Physiol Biochem. 2024. PMID: 34379994 Review.
A significant increase in the worldwide incidence and prevalence of type 2 diabetic mellitus (T2DM) has elevated the need for studies on novel and effective therapeutic strategies. Sirtuin 1 (SIRT1) is an NAD + dependent protein deacetylase with a critical fu …
A significant increase in the worldwide incidence and prevalence of type 2 diabetic mellitus (T2DM) has elevated the need for studies on nov …
Involvement of SIRT1-mediated cellular immune response in cancer.
Liu N, Li J, Dai H, Liang X, Fan H. Liu N, et al. Biomed Pharmacother. 2024 Nov;180:117482. doi: 10.1016/j.biopha.2024.117482. Epub 2024 Sep 24. Biomed Pharmacother. 2024. PMID: 39321514 Free article. Review.
The morbidity and mortality of cancer are rising rapidly worldwide and immunotherapy has become an effective means to curb the progress of cancer. Sirtuin-1(SIRT1) is a NAD+ -dependent deacetylase that plays a key role in cancer development and immune regulat …
The morbidity and mortality of cancer are rising rapidly worldwide and immunotherapy has become an effective means to curb the progress of c …
The Role of SIRT1 in Neuropathic Pain from the Viewpoint of Neuroimmunity.
Fan Y, Dong R, Zhang H, Yu B, Lu H. Fan Y, et al. Curr Pharm Des. 2022;28(4):280-286. doi: 10.2174/1381612827666210705162610. Curr Pharm Des. 2022. PMID: 34225609 Review.
However, in the case of neuropathic pain, mitochondrial regulatory dysfunction occurs, which may result from the decreased expression of SIRT1. In this study, we review the role of SIRT1 in neuropathic pain from the viewpoint of neuroimmunity....
However, in the case of neuropathic pain, mitochondrial regulatory dysfunction occurs, which may result from the decreased expression of …
SIRT1 Promotes Neuronal Fortification in Neurodegenerative Diseases through Attenuation of Pathological Hallmarks and Enhancement of Cellular Lifespan.
Mishra P, Mittal AK, Kalonia H, Madan S, Ghosh S, Sinha JK, Rajput SK. Mishra P, et al. Curr Neuropharmacol. 2021;19(7):1019-1037. doi: 10.2174/1570159X18666200729111744. Curr Neuropharmacol. 2021. PMID: 32727328 Free PMC article. Review.
Sirtuins have been widely investigated for their neuroprotective role, with SIRT1 being the most contemplated member of the family. SIRT1 exhibits significant capabilities to enhance neurogenesis and cellular lifespan by regulating various pathways, which makes it a …
Sirtuins have been widely investigated for their neuroprotective role, with SIRT1 being the most contemplated member of the family. …
SIRT1, metabolism and cancer.
Knight JR, Milner J. Knight JR, et al. Curr Opin Oncol. 2012 Jan;24(1):68-75. doi: 10.1097/CCO.0b013e32834d813b. Curr Opin Oncol. 2012. PMID: 22080944 Review.
This review covers the recent discoveries linking SIRT1 with the regulation of mammalian metabolism and considers ways in which abnormal metabolism in disease may, in turn, impact upon SIRT1 because of SIRT1's functional dependency upon NAD. ...SUMMARY …
This review covers the recent discoveries linking SIRT1 with the regulation of mammalian metabolism and considers ways in which abnor …
The role of deacetylase SIRT1 in allergic diseases.
Lu Y, Tang X, Wang W, Yang J, Wang S. Lu Y, et al. Front Immunol. 2024 Jul 16;15:1422541. doi: 10.3389/fimmu.2024.1422541. eCollection 2024. Front Immunol. 2024. PMID: 39081309 Free PMC article. Review.
The silent information regulator sirtuin 1 (SIRT1) protein is an NAD(+)-dependent class-III lysine deacetylase that serves as an important post-transcriptional modifier targeting lysine acetylation sites to mediate deacetylation modifications of histones and …
The silent information regulator sirtuin 1 (SIRT1) protein is an NAD(+)-dependent class-III lysine deacetylase that ser …
SIRT1 and energy metabolism.
Li X. Li X. Acta Biochim Biophys Sin (Shanghai). 2013 Jan;45(1):51-60. doi: 10.1093/abbs/gms108. Acta Biochim Biophys Sin (Shanghai). 2013. PMID: 23257294 Free PMC article. Review.
Sirtuin 1 (SIRT1) is the most conserved mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. ...This review focuses on the role of SIRT1 in regulating energy metabolism at different met …
Sirtuin 1 (SIRT1) is the most conserved mammalian NAD(+)-dependent protein deacetylase that has emerged as a key metabo …
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
Ren R, Wang Z, Wu M, Wang H. Ren R, et al. Int J Biol Sci. 2020 Oct 17;16(16):3174-3183. doi: 10.7150/ijbs.49535. eCollection 2020. Int J Biol Sci. 2020. PMID: 33162823 Free PMC article. Review.
It has been demonstrated that ALD is mediated in whole or in part by a central signaling molecule sirtuin 1 (SIRT1), a conserved class III histone deacetylase.SIRT1 plays beneficial roles in regulating hepatic lipid metabolism, inhibiting hepatic infla …
It has been demonstrated that ALD is mediated in whole or in part by a central signaling molecule sirtuin 1 (SIRT1), a …
The Role of Sirtuin-1 (SIRT1) in the Physiology and Pathophysiology of the Human Placenta.
Wątroba M, Szewczyk G, Szukiewicz D. Wątroba M, et al. Int J Mol Sci. 2023 Nov 11;24(22):16210. doi: 10.3390/ijms242216210. Int J Mol Sci. 2023. PMID: 38003402 Free PMC article. Review.
Sirtuins, especially SIRT1, play a significant role in regulating inflammatory response, autophagy, and cell response to oxidative stress. ...Furthermore, more and more research studies indicate that SIRT1 may prevent pre-eclampsia development or at least alleviate …
Sirtuins, especially SIRT1, play a significant role in regulating inflammatory response, autophagy, and cell response to oxidative st …
SIRT1 in neurodevelopment and brain senescence.
Herskovits AZ, Guarente L. Herskovits AZ, et al. Neuron. 2014 Feb 5;81(3):471-83. doi: 10.1016/j.neuron.2014.01.028. Neuron. 2014. PMID: 24507186 Free PMC article. Review.
During neuronal development, the SIR2 ortholog SIRT1 is structurally important, promoting axonal elongation, neurite outgrowth, and dendritic branching. ...Drugs that activate SIRT1 may offer a promising approach to treat these disorders....
During neuronal development, the SIR2 ortholog SIRT1 is structurally important, promoting axonal elongation, neurite outgrowth, and d …
SIRT1 is a key regulatory target for the treatment of the endoplasmic reticulum stress-related organ damage.
Wang F, Yao S, Xia H. Wang F, et al. Biomed Pharmacother. 2020 Oct;130:110601. doi: 10.1016/j.biopha.2020.110601. Epub 2020 Aug 9. Biomed Pharmacother. 2020. PMID: 32784049 Free article. Review.
Furthermore, a lot of factors have shown effective regulation of SIRT1, which indicates the feasibility of treating SIRT1 as a target for the treatment of ER stress-related diseases. We summarize and reveal the molecular mechanisms underlying the protective effect o …
Furthermore, a lot of factors have shown effective regulation of SIRT1, which indicates the feasibility of treating SIRT1 as a …
SIRT1 and microRNAs: The role in breast, lung and prostate cancers.
Karbasforooshan H, Roohbakhsh A, Karimi G. Karbasforooshan H, et al. Exp Cell Res. 2018 Jun 1;367(1):1-6. doi: 10.1016/j.yexcr.2018.03.023. Epub 2018 Mar 21. Exp Cell Res. 2018. PMID: 29574020 Review.
MicroRNAs and SIRT1 serve as tumor suppressors or tumor promotors depending on the oncogenic pathway specific to particular tumors. MicroRNAs modulate cancer development by targeting SIRT1. In this review, we underlie the specific mechanisms involved in these threat …
MicroRNAs and SIRT1 serve as tumor suppressors or tumor promotors depending on the oncogenic pathway specific to particular tumors. M …
The protective effects of activating Sirt1/NF-kappaB pathway for neurological disorders.
Song Y, Wu Z, Zhao P. Song Y, et al. Rev Neurosci. 2021 Nov 8;33(4):427-438. doi: 10.1515/revneuro-2021-0118. Print 2022 Jun 27. Rev Neurosci. 2021. PMID: 34757706 Review.
Sirt1, a member of the sirtuins family, is a nicotinamide adenosine dinucleotide (NAD(+))-dependent deacetylase. ...In this review, we focus on new advances in the neuroprotective effects of the Sirt1/NF-kappaB pathway. First, we briefly review Sirt1 and NF-k …
Sirt1, a member of the sirtuins family, is a nicotinamide adenosine dinucleotide (NAD(+))-dependent deacetylase. ...In this review, w …
SIRT1 Prevents R-Loops during Chronological Aging by Modulating DNA Replication at rDNA Loci.
Thakur BL, Kusi NA, Mosavarpour S, Zhu R, Redon CE, Fu H, Dhall A, Pongor LS, Sebastian R, Indig FE, Aladjem MI. Thakur BL, et al. Cells. 2023 Nov 15;12(22):2630. doi: 10.3390/cells12222630. Cells. 2023. PMID: 37998365 Free PMC article.
In primary, untransformed cells, SIRT1 activity declined and the prevalence of R-loops rose with chronological aging. Both the reduction in SIRT1 activity and the increased abundance of R-loops were also observed during the passage of primary cells in culture. ...Ho …
In primary, untransformed cells, SIRT1 activity declined and the prevalence of R-loops rose with chronological aging. Both the reduct …
SIRT1: a potential therapeutic target for coronary heart disease combined with anxiety or depression.
Yu H, Li X, Ning B, Feng L, Ren Y, Li S, Kang Y, Ma J, Zhao M. Yu H, et al. J Drug Target. 2025 Mar;33(3):328-340. doi: 10.1080/1061186X.2024.2422882. Epub 2024 Dec 23. J Drug Target. 2025. PMID: 39470049 Review.
The latest progress in the mechanism of SIRT1's role in CHD combined with anxiety or depression was emphasised, including its specific mechanisms in regulating inflammatory response, alleviating oxidative stress, and mediating various signalling pathways. In additio …
The latest progress in the mechanism of SIRT1's role in CHD combined with anxiety or depression was emphasised, including its …
Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer.
García-Martínez JM, Chocarro-Calvo A, Martínez-Useros J, Fernández-Aceñero MJ, Fiuza MC, Cáceres-Rentero J, De la Vieja A, Barbáchano A, Muñoz A, Larriba MJ, García-Jiménez C. García-Martínez JM, et al. Elife. 2023 Aug 2;12:RP86913. doi: 10.7554/eLife.86913. Elife. 2023. PMID: 37530744 Free PMC article.
Here, we reveal that 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3,) calcitriol), the active metabolite of vitamin D (VD), promotes SIRT1 activation through auto-deacetylation in human colon carcinoma cells, and identify lysine 610 as an essential driver of SIRT1 …
Here, we reveal that 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3,) calcitriol), the active metabolite of vitamin D (VD), promotes SIR …
Deciphering therapeutic options for neurodegenerative diseases: insights from SIRT1.
Wang R, Wu Y, Liu R, Liu M, Li Q, Ba Y, Huang H. Wang R, et al. J Mol Med (Berl). 2022 Apr;100(4):537-553. doi: 10.1007/s00109-022-02187-2. Epub 2022 Mar 11. J Mol Med (Berl). 2022. PMID: 35275221 Review.
Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD +)-dependent protein deacetylase that exerts biological effects through nucleoplasmic transfer. ...Meanwhile, the potential of targeting SIRT1 to block the occurrence and progression …
Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD +)-dependent protein deacetylase that exerts biolo …
[SIRT1].
Hattori Y, Ihara M. Hattori Y, et al. Nihon Rinsho. 2016 Apr;74(4):589-94. Nihon Rinsho. 2016. PMID: 27333745 Review. Japanese.
In addition, SIRT1 can counter cerebral hypoperfusion and ischemia through deacetylating anti-inflammatory and anti-apoptotic molecules and also through deacetylating endothelial nitric oxide synthase and inducing arterial dilation. Since cerebral hypoperfusion/ischemia, i …
In addition, SIRT1 can counter cerebral hypoperfusion and ischemia through deacetylating anti-inflammatory and anti-apoptotic molecul …
SIRT1 regulates cardiomyocyte alignment during maturation.
Fang Y, Fan W, Xu X, Janoshazi AK, Fargo DC, Li X. Fang Y, et al. J Cell Sci. 2022 Apr 1;135(7):jcs259076. doi: 10.1242/jcs.259076. Epub 2022 Apr 1. J Cell Sci. 2022. PMID: 35260907 Free PMC article.
We observed that SIRT1 deficiency impairs the alignment of cardiomyocytes/myofibrils and disrupts normal beating patterns at late developmental stages in an in vitro differentiation system from human embryonic stem cells. Consistently, deletion of SIRT1 at a late de …
We observed that SIRT1 deficiency impairs the alignment of cardiomyocytes/myofibrils and disrupts normal beating patterns at late dev …
Sirt1: def-eating senescence?
Fusco S, Maulucci G, Pani G. Fusco S, et al. Cell Cycle. 2012 Nov 15;11(22):4135-46. doi: 10.4161/cc.22074. Epub 2012 Sep 14. Cell Cycle. 2012. PMID: 22983125 Free PMC article. Review.
Sirt1, the closest mammalian homolog of the Sir2 yeast longevity protein, has been extensively investigated in the last few years as an avenue to understand the connection linking nutrients and energy metabolism with aging and related diseases. From this research effort th …
Sirt1, the closest mammalian homolog of the Sir2 yeast longevity protein, has been extensively investigated in the last few years as …
The systemic role of SIRT1 in exercise mediated adaptation.
Radak Z, Suzuki K, Posa A, Petrovszky Z, Koltai E, Boldogh I. Radak Z, et al. Redox Biol. 2020 Aug;35:101467. doi: 10.1016/j.redox.2020.101467. Epub 2020 Feb 14. Redox Biol. 2020. PMID: 32086007 Free PMC article. Review.
Cellular energy demands are readily changed during physical exercise resulting in adaptive responses by signaling proteins of metabolic processes, including the NAD(+) dependent lysine deacetylase SIRT1. Regular exercise results in systemic adaptation that restores the lev …
Cellular energy demands are readily changed during physical exercise resulting in adaptive responses by signaling proteins of metabolic proc …
A systematic review and meta-analysis of the SIRT1 response to exercise.
Juan CG, Matchett KB, Davison GW. Juan CG, et al. Sci Rep. 2023 Sep 7;13(1):14752. doi: 10.1038/s41598-023-38843-x. Sci Rep. 2023. PMID: 37679377 Free PMC article.
Sirtuin 1 (SIRT1) is a key physiological regulator of metabolism and a target of therapeutic interventions for cardiometabolic and ageing-related disorders. ...A limited number of studies also show a propensity for an increase in muscle SIRT1 activity …
Sirtuin 1 (SIRT1) is a key physiological regulator of metabolism and a target of therapeutic interventions for cardiome …
The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An Update.
Campagna R, Mazzanti L, Pompei V, Alia S, Vignini A, Emanuelli M. Campagna R, et al. Cells. 2024 Sep 1;13(17):1469. doi: 10.3390/cells13171469. Cells. 2024. PMID: 39273039 Free PMC article. Review.
NAD(+)-dependent deacetylase sirtuin-1 (Sirt1) belongs to the sirtuins family, known to be longevity regulators, and exerts a key role in the prevention of vascular aging. ...In this context, the impact of Sirt1 activity in preventing endothelial senes …
NAD(+)-dependent deacetylase sirtuin-1 (Sirt1) belongs to the sirtuins family, known to be longevity regulators, and ex …
SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway.
Patra S, Singh A, Praharaj PP, Mohanta NK, Jena M, Patro BS, Abusharha A, Patil S, Bhutia SK. Patra S, et al. Cell Death Dis. 2023 Nov 10;14(11):732. doi: 10.1038/s41419-023-06232-x. Cell Death Dis. 2023. PMID: 37949849 Free PMC article.
SIRT1 (NAD-dependent protein deacetylase sirtuin-1), a class III histone deacetylase acting as a tumor suppressor gene, is downregulated in oral cancer cells. ...In this setting, SIRT1 knockdown hinders apoptosis activation in GA-primed oral cancer cel …
SIRT1 (NAD-dependent protein deacetylase sirtuin-1), a class III histone deacetylase acting as a tumor suppressor gene, …
SIRT1 in acute lung injury: unraveling its pleiotropic functions and therapeutic development prospects.
Chen Y, Peng S, Liang J, Wei K. Chen Y, et al. Mol Cell Biochem. 2025 Mar;480(3):1449-1464. doi: 10.1007/s11010-024-05111-z. Epub 2024 Sep 13. Mol Cell Biochem. 2025. PMID: 39269678 Review.
Research in recent years has focused on the use of SIRT1 for the treatment of ALI. In this paper, we reviewed the role of SIRT1 in ALI in terms of its cellular and molecular mechanism, targeting of SIRT1 by non-coding RNAs and drug components, as well as poin …
Research in recent years has focused on the use of SIRT1 for the treatment of ALI. In this paper, we reviewed the role of SIRT1 …
Role of the AMPK/SIRT1 pathway in non-alcoholic fatty liver disease (Review).
Anggreini P, Kuncoro H, Sumiwi SA, Levita J. Anggreini P, et al. Mol Med Rep. 2023 Feb;27(2):35. doi: 10.3892/mmr.2022.12922. Epub 2022 Dec 23. Mol Med Rep. 2023. PMID: 36562343 Free PMC article. Review.
There is evidence to indicate that AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) may play a crucial role in DNL and are the regulatory proteins in type 2 diabetes mellitus, obesity and cardiovascular disease. Therefore, AMPK and SIRT1 may b …
There is evidence to indicate that AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) may play a crucial role in …
SIRT1 in metabolic syndrome: where to target matters.
Wang Y, Xu C, Liang Y, Vanhoutte PM. Wang Y, et al. Pharmacol Ther. 2012 Dec;136(3):305-18. doi: 10.1016/j.pharmthera.2012.08.009. Epub 2012 Aug 24. Pharmacol Ther. 2012. PMID: 22939883 Review.
Sirtuin 1 (SIRT1), the mammalian ortholog of yeast Sir2p, is a highly conserved NAD(+)-dependent protein deacetylase that has emerged as a key cardiometabolic regulator. ...Although the extrapolation of data obtained from yeast Sir2p to mammalian SIRT1 …
Sirtuin 1 (SIRT1), the mammalian ortholog of yeast Sir2p, is a highly conserved NAD(+)-dependent protein deacetylase th …
The role and regulation of SIRT1 in pulmonary fibrosis.
Ma X, Jiang M, Ji W, Yu M, Tang C, Tian K, Gao Z, Su L, Tang J, Zhao X. Ma X, et al. Mol Biol Rep. 2024 Feb 23;51(1):338. doi: 10.1007/s11033-024-09296-w. Mol Biol Rep. 2024. PMID: 38393490 Review.
PF has caused a huge socio-economic burden, and its pathogenesis has become a research hotspot. SIRT1 is a nicotinamide adenosine dinucleotide (NAD)-dependent sirtuin essential in tumours, Epithelial mesenchymal transition (EMT), and anti-aging. ...This article reviews the …
PF has caused a huge socio-economic burden, and its pathogenesis has become a research hotspot. SIRT1 is a nicotinamide adenosine din …
Harnessing the FOXO-SIRT1 axis: insights into cellular stress, metabolism, and aging.
Gupta S, Afzal M, Agrawal N, Almalki WH, Rana M, Gangola S, Chinni SV, Kumar K B, Ali H, Singh SK, Jha SK, Gupta G. Gupta S, et al. Biogerontology. 2025 Feb 26;26(2):65. doi: 10.1007/s10522-025-10207-0. Biogerontology. 2025. PMID: 40011269 Review.
Aging and metabolic disorders share intricate molecular pathways, with the Forkhead box O (FOXO)- Sirtuin 1 (SIRT1) axis emerging as a pivotal regulator of cellular stress adaptation, metabolic homeostasis, and longevity. ...FOXO transcription factors, regula …
Aging and metabolic disorders share intricate molecular pathways, with the Forkhead box O (FOXO)- Sirtuin 1 (SIRT1) axi …
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