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The Role of SIRT3 in the Osteoporosis.
Hu S, Wang S. Hu S, et al. Front Endocrinol (Lausanne). 2022 May 25;13:893678. doi: 10.3389/fendo.2022.893678. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35692409 Free PMC article. Review.
However, the specific effects and mechanisms of SIRT3 in osteoporosis are not clear. In the current review, we elaborated on the physiological functions of SIRT3, the cell types involved in bone remodeling, and the role of SIRT3 in osteoporosis. Furthermore, …
However, the specific effects and mechanisms of SIRT3 in osteoporosis are not clear. In the current review, we elaborated on the phys …
The Role of SIRT3 in Exercise and Aging.
Zhou L, Pinho R, Gu Y, Radak Z. Zhou L, et al. Cells. 2022 Aug 20;11(16):2596. doi: 10.3390/cells11162596. Cells. 2022. PMID: 36010672 Free PMC article. Review.
One of the key cell-signaling candidates proposed to provide exercise-induced benefits is sirtuin 3 (SIRT3). SIRT3, an NAD+ dependent mitochondrial deacetylase, positively modulates many cellular processes, including energy metabolism, mitochondrial bi …
One of the key cell-signaling candidates proposed to provide exercise-induced benefits is sirtuin 3 (SIRT3). SIRT3
SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth.
Jin J, Bai L, Wang D, Ding W, Cao Z, Yan P, Li Y, Xi L, Wang Y, Zheng X, Wei H, Ding C, Wang Y. Jin J, et al. EMBO Rep. 2023 May 4;24(5):e56052. doi: 10.15252/embr.202256052. Epub 2023 Mar 10. EMBO Rep. 2023. PMID: 36896611 Free PMC article.
Here we report that SIRT3 can delactylate non-histone proteins and suppress HCC development. Using SILAC-based quantitative proteomics, we identify cyclin E2 (CCNE2) as one of the lactylated substrates of SIRT3 in HCC cells. Furthermore, our crystallographic study e …
Here we report that SIRT3 can delactylate non-histone proteins and suppress HCC development. Using SILAC-based quantitative proteomic …
SIRT3 consolidates heterochromatin and counteracts senescence.
Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, Hu J, Liu Z, Wang Q, Bi S, Huang D, Ji Z, Liu GH, Wang S, Song M, Qu J. Diao Z, et al. Nucleic Acids Res. 2021 May 7;49(8):4203-4219. doi: 10.1093/nar/gkab161. Nucleic Acids Res. 2021. PMID: 33706382 Free PMC article.
Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase linked to a broad range of physiological and pathological processes, including aging and aging-related diseases. However, the role of SIRT3 in regulating human stem cell homeostasis remains unclear. He
Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase linked to a broad range of physiological and pathological processes,
SENP1-Sirt3 signaling promotes alpha-ketoglutarate production during M2 macrophage polarization.
Zhou W, Hu G, He J, Wang T, Zuo Y, Cao Y, Zheng Q, Tu J, Ma J, Cai R, Chen Y, Fan Q, Dong B, Tan H, Wang Q, Xue W, Cheng J. Zhou W, et al. Cell Rep. 2022 Apr 12;39(2):110660. doi: 10.1016/j.celrep.2022.110660. Cell Rep. 2022. PMID: 35417703 Free article.
Activation of the SENP1-Sirt3 axis augments M2 macrophage polarization through the accumulation of alphaKG via glutaminolysis. ...Therefore, SENP1-Sirt3 signaling plays a critical role in alphaKG accumulation via glutaminolysis to promote M2 polarization....
Activation of the SENP1-Sirt3 axis augments M2 macrophage polarization through the accumulation of alphaKG via glutaminolysis. ...The …
SIRT3: A potential therapeutic target for liver fibrosis.
Ning Y, Dou X, Wang Z, Shi K, Wang Z, Ding C, Sang X, Zhong X, Shao M, Han X, Cao G. Ning Y, et al. Pharmacol Ther. 2024 May;257:108639. doi: 10.1016/j.pharmthera.2024.108639. Epub 2024 Mar 30. Pharmacol Ther. 2024. PMID: 38561088 Review.
Based on the functions and pharmacology of SIRT3, we will review its roles in liver fibrosis from three aspects: First, the main functions and pharmacological effects of SIRT3 were investigated based on its structure. ...Last, drugs that regulate SIRT3 to pre …
Based on the functions and pharmacology of SIRT3, we will review its roles in liver fibrosis from three aspects: First, the main func …
Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3-COX4I2 Axis Attenuates Osteoarthritis Progression.
Zhang Y, Liu Y, Hou M, Xia X, Liu J, Xu Y, Shi Q, Zhang Z, Wang L, Shen Y, Yang H, He F, Zhu X. Zhang Y, et al. Adv Sci (Weinh). 2023 Apr;10(10):e2206144. doi: 10.1002/advs.202206144. Epub 2023 Jan 22. Adv Sci (Weinh). 2023. PMID: 36683245 Free PMC article.
Collectively, the loss of mitochondrial SIRT3 is essential for the development of OA, whereas SIRT3-mediated proteins deacetylation of COX4I2 rescues OA-impaired mitochondrial respiratory chain functions to improve the OA phenotype. Herein, the induction of SIRT3
Collectively, the loss of mitochondrial SIRT3 is essential for the development of OA, whereas SIRT3-mediated proteins deacetyl …
Sirt3 deficiency accelerates ovarian senescence without affecting spermatogenesis in aging mice.
Zhu J, Yang Q, Li H, Wang Y, Jiang Y, Wang H, Cong L, Xu J, Shen Z, Chen W, Zeng X, Wang M, Lei M, Sun Y. Zhu J, et al. Free Radic Biol Med. 2022 Nov 20;193(Pt 2):511-525. doi: 10.1016/j.freeradbiomed.2022.10.324. Epub 2022 Nov 3. Free Radic Biol Med. 2022. PMID: 36336229
Sirtuin-3 (SIRT3), the main deacetylase in the mitochondria, maintains cellular energy metabolism and redox balance by deacetylating mitochondrial proteins in a NAD(+)-dependent manner. Growing evidence indicates that decreased Sirt3 expression is invo
Sirtuin-3 (SIRT3), the main deacetylase in the mitochondria, maintains cellular energy metabolism and redox balance by
SIRT3 regulates mitophagy in liver fibrosis through deacetylation of PINK1/NIPSNAP1.
Li R, Wang Z, Wang Y, Sun R, Zou B, Tian X, Liu D, Zhao X, Zhou J, Zhao Y, Yao J. Li R, et al. J Cell Physiol. 2023 Sep;238(9):2090-2102. doi: 10.1002/jcp.31069. Epub 2023 Jul 7. J Cell Physiol. 2023. PMID: 37417912
PINK1 (PTEN-induced kinase 1) and NIPSNAP1 (nonneuronal SNAP25-like protein 1), which cooperatively regulate mitophagy, have been predicted to include the sites of lysine acetylation related to SIRT3 (mitochondrial deacetylase sirtuin 3). Our study aimed to d …
PINK1 (PTEN-induced kinase 1) and NIPSNAP1 (nonneuronal SNAP25-like protein 1), which cooperatively regulate mitophagy, have been predicted …
Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway.
Wang X, Shen T, Lian J, Deng K, Qu C, Li E, Li G, Ren Y, Wang Z, Jiang Z, Sun X, Li X. Wang X, et al. Mol Med. 2023 Oct 19;29(1):137. doi: 10.1186/s10020-023-00730-6. Mol Med. 2023. PMID: 37858064 Free PMC article.
We hypothesized that resveratrol, an agonist of SIRT3, could ameliorate intestinal ischemia-reperfusion injury by compensating the GSH/GPX4 pathway. ...Resveratrol could reduce ferroptosis and ameliorate I/R injury by activating SIRT3. In Sirt3(-/-) mice, mor …
We hypothesized that resveratrol, an agonist of SIRT3, could ameliorate intestinal ischemia-reperfusion injury by compensating the GS …
SIRT3 Deficiency Enhances Ferroptosis and Promotes Cardiac Fibrosis via p53 Acetylation.
Su H, Cantrell AC, Chen JX, Gu W, Zeng H. Su H, et al. Cells. 2023 May 19;12(10):1428. doi: 10.3390/cells12101428. Cells. 2023. PMID: 37408261 Free PMC article.
Cardiac fibrosis plays an essential role in the development of diastolic dysfunction and contributes to heart failure with preserved ejection fraction (HFpEF). Our previous studies suggested Sirtuin 3 (SIRT3) as a potential target for cardiac fibrosis and hea …
Cardiac fibrosis plays an essential role in the development of diastolic dysfunction and contributes to heart failure with preserved ejectio …
SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity.
Zhang T, Liu J, Shen S, Tong Q, Ma X, Lin L. Zhang T, et al. Cell Death Differ. 2020 Jan;27(1):329-344. doi: 10.1038/s41418-019-0356-z. Epub 2019 Jun 3. Cell Death Differ. 2020. PMID: 31160717 Free PMC article.
Moreover, SIRT3 reduced the expression of stearoyl-CoA desaturase 1, to suppress lipogenesis. In addition, SIRT3 overexpression promoted LDs dispersion on detyrosinated microtubules, and directly deacetylated long-chain acyl-CoA dehydrogenase to enhance mitochondria …
Moreover, SIRT3 reduced the expression of stearoyl-CoA desaturase 1, to suppress lipogenesis. In addition, SIRT3 overexpressio …
SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress.
Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S, Xu J, Chen L, Cao K, Long J, Li Z, Shen W, Liu J. Gao J, et al. Cell Death Differ. 2018 Feb;25(2):229-240. doi: 10.1038/cdd.2017.144. Epub 2017 Sep 15. Cell Death Differ. 2018. PMID: 28914882 Free PMC article.
Both SOD2 and SIRT3 knockdown resulted in suppression of differentiation. Meanwhile, mice deficient in SIRT3 exhibited obvious osteopenia accompanied by osteoblast dysfunction, whereas overexpression of SOD2 or SIRT3 improved the differentiation capability of …
Both SOD2 and SIRT3 knockdown resulted in suppression of differentiation. Meanwhile, mice deficient in SIRT3 exhibited obvious …
Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice.
Li M, Li CM, Ye ZC, Huang J, Li Y, Lai W, Peng H, Lou TQ. Li M, et al. J Cell Mol Med. 2020 May;24(9):5109-5121. doi: 10.1111/jcmm.15148. Epub 2020 Apr 12. J Cell Mol Med. 2020. PMID: 32281286 Free PMC article.
Fatty acid oxidation (FAO) dysfunction is one of the important mechanisms of renal fibrosis. Sirtuin 3 (Sirt3) has been confirmed to alleviate acute kidney injury (AKI) by improving mitochondrial function and participate in the regulation of FAO in other dise …
Fatty acid oxidation (FAO) dysfunction is one of the important mechanisms of renal fibrosis. Sirtuin 3 (Sirt3) has been …
Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1alpha/Sirt3.
Wang D, Cao L, Zhou X, Wang G, Ma Y, Hao X, Fan H. Wang D, et al. J Hazard Mater. 2022 Sep 5;437:129381. doi: 10.1016/j.jhazmat.2022.129381. Epub 2022 Jun 16. J Hazard Mater. 2022. PMID: 35752048
Further studies revealed that honokiol activated AMPK and upregulated the PGC-1alpha and Sirt3 protein expression in vivo and in vitro. Intriguingly, the protective actions of honokiol on oxidative stress and mitochondrial dysfunction were abolished by AMPK shRNA or Sir
Further studies revealed that honokiol activated AMPK and upregulated the PGC-1alpha and Sirt3 protein expression in vivo and in vitr …
Mitochondrial SIRT3 and neurodegenerative brain disorders.
Anamika, Khanna A, Acharjee P, Acharjee A, Trigun SK. Anamika, et al. J Chem Neuroanat. 2019 Jan;95:43-53. doi: 10.1016/j.jchemneu.2017.11.009. Epub 2017 Nov 9. J Chem Neuroanat. 2019. PMID: 29129747 Review.
Out of seven homologues of Sirtuins identified in mammals, SIRT3, 4 & 5 have been found to be localized and active in mitochondria. During recent past, clusters of protein substrates for SIRT3 have been identified in mitochondria and thereby advocating SIRT3
Out of seven homologues of Sirtuins identified in mammals, SIRT3, 4 & 5 have been found to be localized and active in mitochondri …
PM2.5 contributed to pulmonary epithelial senescence and ferroptosis by regulating USP3-SIRT3-P53 axis.
Li N, Xiong R, Li G, Wang B, Geng Q. Li N, et al. Free Radic Biol Med. 2023 Aug 20;205:291-304. doi: 10.1016/j.freeradbiomed.2023.06.017. Epub 2023 Jun 20. Free Radic Biol Med. 2023. PMID: 37348684
Previous studies have reported that particulate matter 2.5 (PM2.5) could trigger pulmonary inflammation and fibrosis by inducing pulmonary epithelial senescence and ferroptosis. Sirtuin 3 (SIRT3) is one of critical the mitochondrial NAD(+)-dependent deacetyla …
Previous studies have reported that particulate matter 2.5 (PM2.5) could trigger pulmonary inflammation and fibrosis by inducing pulmonary e …
S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis.
Liu F, Yuan L, Li L, Yang J, Liu J, Chen Y, Zhang J, Lu Y, Yuan Y, Cheng J. Liu F, et al. Pharmacol Res. 2023 Jun;192:106788. doi: 10.1016/j.phrs.2023.106788. Epub 2023 May 3. Pharmacol Res. 2023. PMID: 37146925 Free article.
S-sulfhydration of cysteine residues favorably enhances SIRT3 activity by forming persulfides. Nevertheless, the underlying molecular mechanism of SIRT3 S-sulfhydration on mitochondrial/heterochromatic homeostasis involved in BMSC senescence remains unknown. ...The …
S-sulfhydration of cysteine residues favorably enhances SIRT3 activity by forming persulfides. Nevertheless, the underlying molecular …
SIRT3: as simple as it seems?
Lombard DB, Zwaans BM. Lombard DB, et al. Gerontology. 2014;60(1):56-64. doi: 10.1159/000354382. Epub 2013 Oct 25. Gerontology. 2014. PMID: 24192814 Free PMC article. Review.
Specifically, it has been found that SIRT3 promotes activities of the upstream mitochondrial regulators adenosine monophosphate-activated protein kinase and PGC1alpha. In addition, studies of tissue-specific SIRT3 knockouts suggest non-tissue-autonomous roles for …
Specifically, it has been found that SIRT3 promotes activities of the upstream mitochondrial regulators adenosine monophosphate-activ …
SIRT3 regulates mitochondrial function: A promising star target for cardiovascular disease therapy.
Zhang Q, Siyuan Z, Xing C, Ruxiu L. Zhang Q, et al. Biomed Pharmacother. 2024 Jan;170:116004. doi: 10.1016/j.biopha.2023.116004. Epub 2023 Dec 11. Biomed Pharmacother. 2024. PMID: 38086147 Free article. Review.
As an important mediator and node in the network of mechanisms, SIRT3 is essential to many activities. This review explains how SIRT3 regulates mitochondrial homeostasis and the tricarboxylic acid cycle to treat common cardiovascular diseases. A novel description of …
As an important mediator and node in the network of mechanisms, SIRT3 is essential to many activities. This review explains how SI
Retuning Mitochondrial Apoptosis/Mitophagy Balance via SIRT3-Energized and Microenvironment-Modulated Hydrogel Microspheres to Impede Osteoarthritis.
Xia X, Liu Y, Lu Y, Liu J, Deng Y, Wu Y, Hou M, He F, Yang H, Xu Y, Zhang Y, Zhu X. Xia X, et al. Adv Healthc Mater. 2023 Dec;12(32):e2302475. doi: 10.1002/adhm.202302475. Epub 2023 Sep 22. Adv Healthc Mater. 2023. PMID: 37696643
However, the dynamic regulation of mitochondrial rise and demise in impaired chondrocytes and the exact role of mitochondrial metronome sirtuins 3 (SIRT3) is not clarified. Herein, chondrocytes are treated with SIRT3 natural agonist dihydromyricetin (DMY) or chemica …
However, the dynamic regulation of mitochondrial rise and demise in impaired chondrocytes and the exact role of mitochondrial metronome sirt …
Role of SIRT3 in neurological diseases and rehabilitation training.
Li Y, Li J, Wu G, Yang H, Yang X, Wang D, He Y. Li Y, et al. Metab Brain Dis. 2023 Jan;38(1):69-89. doi: 10.1007/s11011-022-01111-4. Epub 2022 Nov 14. Metab Brain Dis. 2023. PMID: 36374406 Free PMC article. Review.
Considerable evidence has shown that the content and activity of SIRT3 are altered in neurological diseases. Furthermore, SIRT3 affects the occurrence and development of neurological diseases. ...However, SIRT3 may sometimes have the opposite effect. SIRT3
Considerable evidence has shown that the content and activity of SIRT3 are altered in neurological diseases. Furthermore, SIRT3
Context-dependent role of SIRT3 in cancer.
Zhang J, Ye J, Zhu S, Han B, Liu B. Zhang J, et al. Trends Pharmacol Sci. 2024 Feb;45(2):173-190. doi: 10.1016/j.tips.2023.12.005. Epub 2024 Jan 19. Trends Pharmacol Sci. 2024. PMID: 38242748 Review.
Sirtuin 3 (SIRT3), an NAD(+)-dependent deacetylase, plays a key role in the modulation of metabolic reprogramming and regulation of cell death, as well as in shaping tumor phenotypes. Owing to its critical role in determining tumor-type specificity or the dir
Sirtuin 3 (SIRT3), an NAD(+)-dependent deacetylase, plays a key role in the modulation of metabolic reprogramming and r
SIRT3-mediated cardiac remodeling/repair following myocardial infarction.
Mihanfar A, Nejabati HR, Fattahi A, Latifi Z, Faridvand Y, Pezeshkian M, Jodati AR, Safaie N, Afrasiabi A, Nouri M. Mihanfar A, et al. Biomed Pharmacother. 2018 Dec;108:367-373. doi: 10.1016/j.biopha.2018.09.079. Epub 2018 Sep 15. Biomed Pharmacother. 2018. PMID: 30227330 Free article. Review.
The recent investigations have extensively focused on the importance of sirtuins, as a highly conserved family of gene products, particularly SIRT3 in various biological and pathological processes. SIRT3, the mitochondrial NAD+-dependent deacetylase has been demonst …
The recent investigations have extensively focused on the importance of sirtuins, as a highly conserved family of gene products, particularl …
Mitochondrial deacetylase Sirt3 in vascular dysfunction and hypertension.
Dikalov S, Dikalova A. Dikalov S, et al. Curr Opin Nephrol Hypertens. 2022 Mar 1;31(2):151-156. doi: 10.1097/MNH.0000000000000771. Curr Opin Nephrol Hypertens. 2022. PMID: 35086984 Free PMC article. Review.
Indeed, genetic deletion of Sirt3 in mice promotes vascular dysfunction and hypertension. Sirt3 depletion promotes endothelial dysfunction, increases smooth muscle cell hypertrophy, instigates vascular inflammation, and induces age-dependent hypertension. SUMMARY: …
Indeed, genetic deletion of Sirt3 in mice promotes vascular dysfunction and hypertension. Sirt3 depletion promotes endothelial …
SIRT3: A New Regulator of Cardiovascular Diseases.
Sun W, Liu C, Chen Q, Liu N, Yan Y, Liu B. Sun W, et al. Oxid Med Cell Longev. 2018 Feb 13;2018:7293861. doi: 10.1155/2018/7293861. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 29643974 Free PMC article. Review.
Cardiovascular diseases (CVDs) are the leading causes of death worldwide, and defects in mitochondrial function contribute largely to the occurrence of CVDs. Recent studies suggest that sirtuin 3 (SIRT3), the mitochondrial NAD(+)-dependent deacetylase, may re …
Cardiovascular diseases (CVDs) are the leading causes of death worldwide, and defects in mitochondrial function contribute largely to the oc …
SIRT3: A Potential Target of Different Types of Osteoporosis.
Pan B, Chen C, Zhao Y, Cai J, Fu S, Liu J. Pan B, et al. Cell Biochem Biophys. 2024 Jun;82(2):489-500. doi: 10.1007/s12013-024-01254-4. Epub 2024 Mar 21. Cell Biochem Biophys. 2024. PMID: 38512537 Review.
SIRT3 plays an important role in different types of osteoporosis by affecting osteoblasts, osteoclasts, and bone marrow mesenchymal cells. In this review, we discuss the classification and physiological functions of SIRTs, the effects of SIRT3 on OCs osteoblasts, an
SIRT3 plays an important role in different types of osteoporosis by affecting osteoblasts, osteoclasts, and bone marrow mesenchymal c
SIRT3 alleviates painful diabetic neuropathy by mediating the FoxO3a-PINK1-Parkin signaling pathway to activate mitophagy.
Yang J, Yu Z, Jiang Y, Zhang Z, Tian Y, Cai J, Wei M, Lyu Y, Yang D, Shen S, Xing GG, Li M. Yang J, et al. CNS Neurosci Ther. 2024 Apr;30(4):e14703. doi: 10.1111/cns.14703. CNS Neurosci Ther. 2024. PMID: 38572816 Free PMC article.
RESULTS: We found that damaged mitochondria were accumulated and mitophagy was inhibited in PDN rats. The expression of sirtuin 3 (SIRT3), which is an NAD(+)-dependent deacetylase in mitochondria, was inhibited. Overexpression of SIRT3 in DRG neurons b …
RESULTS: We found that damaged mitochondria were accumulated and mitophagy was inhibited in PDN rats. The expression of sirtuin 3
Role of SIRT3 in mitochondrial biology and its therapeutic implications in neurodegenerative disorders.
Mishra Y, Kaundal RK. Mishra Y, et al. Drug Discov Today. 2023 Jun;28(6):103583. doi: 10.1016/j.drudis.2023.103583. Epub 2023 Apr 5. Drug Discov Today. 2023. PMID: 37028501 Review.
Sirtuin 3 (SIRT3), a mitochondrial deacetylase expressed preferentially in high-metabolic-demand tissues including the brain, requires NAD(+) as a cofactor for catalytic activity. ...A body of evidence has suggested, SIRT3 activation as a potential the
Sirtuin 3 (SIRT3), a mitochondrial deacetylase expressed preferentially in high-metabolic-demand tissues including the
SIRT3 and mitochondrial metabolism in neurodegenerative diseases.
Salvatori I, Valle C, Ferri A, Carrì MT. Salvatori I, et al. Neurochem Int. 2017 Oct;109:184-192. doi: 10.1016/j.neuint.2017.04.012. Epub 2017 Apr 25. Neurochem Int. 2017. PMID: 28449871 Review.
The NAD(+)-dependent deacetylase protein Sirtuin 3 (SIRT3) is emerging among the factors playing a key role in the regulation of mitochondrial function and in the prevention of oxidative stress. ...These data reinforce the concept that SIRT3 may be a r …
The NAD(+)-dependent deacetylase protein Sirtuin 3 (SIRT3) is emerging among the factors playing a key role in the regu …
SirT3 and p53 Deacetylation in Aging and Cancer.
Chen J, Wang A, Chen Q. Chen J, et al. J Cell Physiol. 2017 Sep;232(9):2308-2311. doi: 10.1002/jcp.25669. Epub 2017 Apr 10. J Cell Physiol. 2017. PMID: 27791271 Review.
The mammalian Sirtuins family has identified seven different types of sirtuin. Sirtuins 3(SirT3) is localized to mitochondria, and is a multiple functional protein deacylase through deacetylating a variety of substrates. Cellular senescence represents a permanent withdraw …
The mammalian Sirtuins family has identified seven different types of sirtuin. Sirtuins 3(SirT3) is localized to mitochondria, and is …
SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension.
Li M, Plecitá-Hlavatá L, Dobrinskikh E, McKeon BA, Gandjeva A, Riddle S, Laux A, Prasad RR, Kumar S, Tuder RM, Zhang H, Hu CJ, Stenmark KR. Li M, et al. Am J Respir Cell Mol Biol. 2023 Nov;69(5):570-583. doi: 10.1165/rcmb.2022-0360OC. Am J Respir Cell Mol Biol. 2023. PMID: 37343939 Free PMC article.
Pulmonary hypertension (PH) is a heterogeneous and life-threatening cardiopulmonary disorder in which mitochondrial dysfunction is believed to drive pathogenesis, although the underlying mechanisms remain unclear. To determine if abnormal SIRT3 (sirtuin 3) ac …
Pulmonary hypertension (PH) is a heterogeneous and life-threatening cardiopulmonary disorder in which mitochondrial dysfunction is believed …
Exogenous NADPH exerts a positive inotropic effect and enhances energy metabolism via SIRT3 in pathological cardiac hypertrophy and heart failure.
Qian K, Tang J, Ling YJ, Zhou M, Yan XX, Xie Y, Zhu LJ, Nirmala K, Sun KY, Qin ZH, Sheng R. Qian K, et al. EBioMedicine. 2023 Dec;98:104863. doi: 10.1016/j.ebiom.2023.104863. Epub 2023 Nov 9. EBioMedicine. 2023. PMID: 37950995 Free PMC article.
The underlying mechanisms of NADPH were studied using SIRT3 knockout mice, echocardiography, Western blotting, transmission electron microscopy, and immunoprecipitation. ...Importantly, inhibition of SIRT3 abolished the positive inotropic effect of NADPH, and the an …
The underlying mechanisms of NADPH were studied using SIRT3 knockout mice, echocardiography, Western blotting, transmission electron …
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases.
Wu J, Zeng Z, Zhang W, Deng Z, Wan Y, Zhang Y, An S, Huang Q, Chen Z. Wu J, et al. Free Radic Res. 2019 Feb;53(2):139-149. doi: 10.1080/10715762.2018.1549732. Epub 2018 Dec 26. Free Radic Res. 2019. PMID: 30458637 Review.
As a nicotinamide adenine dinucleotide (NAD)(+)-dependent protein deacetylase, SIRT3 is highly expressed in tissues with high metabolic turnover and mitochondrial content. ...In the suppression of SIRT3, functional deficiencies of mitochondria contribute to the deve …
As a nicotinamide adenine dinucleotide (NAD)(+)-dependent protein deacetylase, SIRT3 is highly expressed in tissues with high metabol …
Boosting the Exhausted Vasculature-SIRT3 (to the) Rescue.
Ljubojevic-Holzer S, Crnkovic S. Ljubojevic-Holzer S, et al. Am J Respir Cell Mol Biol. 2023 Nov;69(5):497-499. doi: 10.1165/rcmb.2023-0199ED. Am J Respir Cell Mol Biol. 2023. PMID: 37586074 Free PMC article. No abstract available.
Sirt3 improves monosodium urate crystal-induced inflammation by suppressing Acod1 expression.
Lv L, Jiang H, Song D, Zhou X, Chen F, Ren L, Xie Y, Zeng M. Lv L, et al. Arthritis Res Ther. 2023 Jul 19;25(1):121. doi: 10.1186/s13075-023-03107-6. Arthritis Res Ther. 2023. PMID: 37468929 Free PMC article.
Function and molecular mechanism of Sirt3 in MSU crystal-induced inflammation were investigated in bone marrow-derived macrophages (BMDMs), C57BL/6 mouse, and Sirt3(-/-) mouse. RESULTS: Sirt3 expression was decreased in the PBMCs of patients with gout. Sir
Function and molecular mechanism of Sirt3 in MSU crystal-induced inflammation were investigated in bone marrow-derived macrophages (B …
SIRT3 Activator Honokiol Inhibits Th17 Cell Differentiation and Alleviates Colitis.
Chen X, Zhang M, Zhou F, Gu Z, Li Y, Yu T, Peng C, Zhou L, Li X, Zhu D, Zhang X, Yu C. Chen X, et al. Inflamm Bowel Dis. 2023 Dec 5;29(12):1929-1940. doi: 10.1093/ibd/izad099. Inflamm Bowel Dis. 2023. PMID: 37335900 Free PMC article.
BACKGROUND: Honokiol (HKL), a natural extract of the bark of the magnolia tree and an activator of the mitochondrial protein sirtuin-3 (SIRT3), has been proposed to possess anti-inflammatory effects. This study investigated the inhibitory effects of HKL on T …
BACKGROUND: Honokiol (HKL), a natural extract of the bark of the magnolia tree and an activator of the mitochondrial protein sirtuin- …
SIRT3 regulates progression and development of diseases of aging.
McDonnell E, Peterson BS, Bomze HM, Hirschey MD. McDonnell E, et al. Trends Endocrinol Metab. 2015 Sep;26(9):486-492. doi: 10.1016/j.tem.2015.06.001. Epub 2015 Jun 29. Trends Endocrinol Metab. 2015. PMID: 26138757 Free PMC article. Review.
In this review, we discuss functions of SIRT3 in pathways involved in diseases of aging and how the lack of SIRT3 might accelerate the aging process. We also suggest that further studies on SIRT3 will help uncover important new pathways driving the aging proc …
In this review, we discuss functions of SIRT3 in pathways involved in diseases of aging and how the lack of SIRT3 might accele …
Advances in characterization of SIRT3 deacetylation targets in mitochondrial function.
Wang S, Zhang J, Deng X, Zhao Y, Xu K. Wang S, et al. Biochimie. 2020 Dec;179:1-13. doi: 10.1016/j.biochi.2020.08.021. Epub 2020 Sep 6. Biochimie. 2020. PMID: 32898647 Review.
The homeostasis of mitochondrial functional state is intimately in relation with SIRT3 (sirtuin3). SIRT3, the deacetylase mainly anchored in mitochondria, acts as a modulator of metabolic regulation via manipulating the activity and function of downstream targets at …
The homeostasis of mitochondrial functional state is intimately in relation with SIRT3 (sirtuin3). SIRT3, the deacetylase main …
SIRT3 ameliorates polycystic ovary syndrome through FOXO1/PGC-1alpha signaling pathway.
Pang X, Cheng J, Wu T, Sun L. Pang X, et al. Endocrine. 2023 Apr;80(1):201-211. doi: 10.1007/s12020-022-03262-x. Epub 2023 Jan 4. Endocrine. 2023. PMID: 36598711
The specific regulatory role and mechanism of SIRT3 in PCOS have not been reported. METHODS: SIRT3 was overexpressed in dihydrotestosterone (DHT)-induced PCOS model in mice. ...CONCLUSION: SIRT3 regulated FOXO1/PGC-1alpha signaling pathway to reduce mitochond …
The specific regulatory role and mechanism of SIRT3 in PCOS have not been reported. METHODS: SIRT3 was overexpressed in dihydr …
Role of histone deacetylase Sirt3 in the development and regression of atherosclerosis.
Liu Y, Shen X, Pang M, Sun Z, Qian Y, Xue W, Wang Z, Li L. Liu Y, et al. Life Sci. 2021 May 1;272:119178. doi: 10.1016/j.lfs.2021.119178. Epub 2021 Feb 19. Life Sci. 2021. PMID: 33610576 Review.
Sirt3 is an important factor in the normal physiology of blood vessels through deacetylation of mitochondrial proteins and participates in various metabolic activities. Besides, medical research targeting Sirt3 is in full swing as well. This review combining histone
Sirt3 is an important factor in the normal physiology of blood vessels through deacetylation of mitochondrial proteins and participat
Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target.
Zhang J, Xiang H, Liu J, Chen Y, He RR, Liu B. Zhang J, et al. Theranostics. 2020 Jul 9;10(18):8315-8342. doi: 10.7150/thno.45922. eCollection 2020. Theranostics. 2020. PMID: 32724473 Free PMC article. Review.
Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism of multiple organs. ...Accumulating evidence has recently docum
Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which
Skeletal Muscle SIRT3 Deficiency Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction.
Jheng JR, Bai Y, Noda K, Huot JR, Cook T, Fisher A, Chen YY, Goncharov DA, Goncharova EA, Simon MA, Zhang Y, Forman DE, Rojas M, Machado RF, Auwerx J, Gladwin MT, Lai YC. Jheng JR, et al. Circulation. 2024 Sep 10;150(11):867-883. doi: 10.1161/CIRCULATIONAHA.124.068624. Epub 2024 May 28. Circulation. 2024. PMID: 38804138
We have recently reported on the role of skeletal muscle SIRT3 (sirtuin-3) in modulation of PH-HFpEF, suggesting a novel endocrine signaling pathway for skeletal muscle modulation of pulmonary vascular remodeling. METHODS: Using skeletal muscle-specific Si
We have recently reported on the role of skeletal muscle SIRT3 (sirtuin-3) in modulation of PH-HFpEF, suggesting a nove …
SIRT3 as a regulator of hepatic autophagy.
Cho CS, Lombard DB, Lee JH. Cho CS, et al. Hepatology. 2017 Sep;66(3):700-702. doi: 10.1002/hep.29271. Epub 2017 Jul 20. Hepatology. 2017. PMID: 28520180 Free PMC article. No abstract available.
SIRT3 improved peroxisomes-mitochondria interplay and prevented cardiac hypertrophy via preserving PEX5 expression.
Wang M, Ding Y, Hu Y, Li Z, Luo W, Liu P, Li Z. Wang M, et al. Redox Biol. 2023 Jun;62:102652. doi: 10.1016/j.redox.2023.102652. Epub 2023 Mar 4. Redox Biol. 2023. PMID: 36906951 Free PMC article.
The present study identified a novel mechanism underlying the protective effect of Sirtuin 3 (SIRT3) against pathological cardiac hypertrophy, beyond its well-accepted role as a deacetylase in mitochondria. ...Downregulation of PEX5 was observed in the hearts …
The present study identified a novel mechanism underlying the protective effect of Sirtuin 3 (SIRT3) against pathologic …
Mitochondrial dysfunction caused by SIRT3 inhibition drives proinflammatory macrophage polarization in obesity.
Zhou Q, Wang Y, Lu Z, Wang B, Li L, You M, Wang L, Cao T, Zhao Y, Li Q, Mou A, Shu W, He H, Zhao Z, Liu D, Zhu Z, Gao P, Yan Z. Zhou Q, et al. Obesity (Silver Spring). 2023 Apr;31(4):1050-1063. doi: 10.1002/oby.23707. Epub 2023 Mar 9. Obesity (Silver Spring). 2023. PMID: 36894333
Therefore, the study aim was to explore whether sirtuin 3 (SIRT3), a mitochondrial deacetylase, participates in this pathophysiological process. METHODS: Macrophage-specific Sirt3 knockout (Sirt3-MKO) mice and wild-type littermates were treated …
Therefore, the study aim was to explore whether sirtuin 3 (SIRT3), a mitochondrial deacetylase, participates in this pa …
A Promising Strategy to Treat Neurodegenerative Diseases by SIRT3 Activation.
Tyagi A, Pugazhenthi S. Tyagi A, et al. Int J Mol Sci. 2023 Jan 13;24(2):1615. doi: 10.3390/ijms24021615. Int J Mol Sci. 2023. PMID: 36675125 Free PMC article. Review.
SIRT3 plays a key role in brain energy metabolism and provides substrate flexibility to neurons. ...Recent studies have also suggested that SIRT3 may act through multiple pathways to reduce plaque formation in the AD brain. In this review, we give an overview of
SIRT3 plays a key role in brain energy metabolism and provides substrate flexibility to neurons. ...Recent studies have also suggeste
SIRT3 promotes metabolic maturation of human iPSC-derived cardiomyocytes via OPA1-controlled mitochondrial dynamics.
Wang R, Xu H, Tan B, Yi Q, Sun Y, Xiang H, Chen T, Liu H, Xie Q, Wang L, Tian J, Zhu J. Wang R, et al. Free Radic Biol Med. 2023 Feb 1;195:270-282. doi: 10.1016/j.freeradbiomed.2022.12.101. Epub 2022 Dec 31. Free Radic Biol Med. 2023. PMID: 36596388 Free article.
In this research, We investigated the role and regulatory mechanism of SIRT3 in energy metabolism in HiPSC-CMs. We found that the expression of SIRT3 was increased during the differentiation and maturation of HiPSC-CMs. ...In summary, SIRT3 regulated energeti …
In this research, We investigated the role and regulatory mechanism of SIRT3 in energy metabolism in HiPSC-CMs. We found that the exp …
Mitochondrial sirtuins, metabolism, and aging.
Ji Z, Liu GH, Qu J. Ji Z, et al. J Genet Genomics. 2022 Apr;49(4):287-298. doi: 10.1016/j.jgg.2021.11.005. Epub 2021 Nov 29. J Genet Genomics. 2022. PMID: 34856390 Free article. Review.
Therefore, by understanding how sirtuins regulate metabolic processes, we can start to understand how they slow down or accelerate biological aging from the perspectives of metabolic regulation. Here, we review the biology of SIRT3, SIRT4, and SIRT5, known as the mitochond …
Therefore, by understanding how sirtuins regulate metabolic processes, we can start to understand how they slow down or accelerate biologica …
Sirt3 deficiency induced down regulation of insulin degrading enzyme in comorbid Alzheimer's disease with metabolic syndrome.
Tyagi A, Musa M, Labeikovsky W, Pugazhenthi S. Tyagi A, et al. Sci Rep. 2022 Nov 17;12(1):19808. doi: 10.1038/s41598-022-23652-5. Sci Rep. 2022. PMID: 36396721 Free PMC article.
SIRT3 deacetylates mitochondrial proteins, thereby enhancing their function. We have previously demonstrated that Sirt3 gene deletion leads to brain mitochondrial dysfunction and neuroinflammation. ...Western diet feeding of Sirt3(-/-) and APP/PS1 mice result
SIRT3 deacetylates mitochondrial proteins, thereby enhancing their function. We have previously demonstrated that Sirt3 gene d
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