Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 3
1974 1
1975 1
1976 1
1978 1
1979 2
1980 2
1981 3
1982 4
1983 3
1984 8
1985 9
1986 9
1987 11
1988 18
1989 15
1990 17
1991 27
1992 25
1993 41
1994 37
1995 35
1996 51
1997 44
1998 53
1999 51
2000 49
2001 52
2002 53
2003 58
2004 85
2005 98
2006 85
2007 97
2008 101
2009 114
2010 135
2011 122
2012 113
2013 145
2014 157
2015 124
2016 160
2017 142
2018 140
2019 152
2020 128
2021 131
2022 144
2023 124
2024 129
2025 130
2026 65

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

3,220 results

Results by year

Filters applied: . Clear all
Page 1
Reconstitution of SPO11-dependent double-strand break formation.
Zheng Z, Zheng L, Arter M, Liu K, Yamada S, Ontoso D, Kim S, Keeney S. Zheng Z, et al. Nature. 2025 Mar;639(8055):784-791. doi: 10.1038/s41586-025-08601-2. Epub 2025 Feb 19. Nature. 2025. PMID: 39972129 Free PMC article.
Meiotic recombination starts with SPO11 generation of DNA double-strand breaks (DSBs)(1). SPO11 is critical for meiosis in most species, but it generates dangerous DSBs with mutagenic(2) and gametocidal(3) potential. ...In vitro cleavage displays a sequence b …
Meiotic recombination starts with SPO11 generation of DNA double-strand breaks (DSBs)(1). SPO11 is critical for meiosis …
Mechanisms of insertions at a DNA double-strand break.
Min J, Zhao J, Zagelbaum J, Lee J, Takahashi S, Cummings P, Schooley A, Dekker J, Gottesman ME, Rabadan R, Gautier J. Min J, et al. Mol Cell. 2023 Jul 20;83(14):2434-2448.e7. doi: 10.1016/j.molcel.2023.06.016. Epub 2023 Jul 3. Mol Cell. 2023. PMID: 37402370 Free PMC article.
Indel-seq reveals that insertions are generated via multiple pathways. The broken acceptor site anneals with a resected DNA break or invades the displaced strand of a transcription bubble or R-loop, followed by DNA synthesis, displacement, and then ligation by non-h …
Indel-seq reveals that insertions are generated via multiple pathways. The broken acceptor site anneals with a resected DNA break …
Exploring factors influencing choice of DNA double-strand break repair pathways.
Otarbayev D, Myung K. Otarbayev D, et al. DNA Repair (Amst). 2024 Aug;140:103696. doi: 10.1016/j.dnarep.2024.103696. Epub 2024 May 25. DNA Repair (Amst). 2024. PMID: 38820807 Review.
DNA double-strand breaks (DSBs) represent one of the most severe threats to genomic integrity, demanding intricate repair mechanisms within eukaryotic cells. ...Furthermore, we elucidate the transformative role of Cas9, a site-specific endonuclease, in …
DNA double-strand breaks (DSBs) represent one of the most severe threats to genomic integrity, demanding intricate repa …
The Role of Noncoding RNAs in Double-Strand Break Repair.
Durut N, Mittelsten Scheid O. Durut N, et al. Front Plant Sci. 2019 Sep 27;10:1155. doi: 10.3389/fpls.2019.01155. eCollection 2019. Front Plant Sci. 2019. PMID: 31611891 Free PMC article. Review.
These ncRNAs are mainly connected with double-strand breaks (DSBs), the most dangerous type of DNA lesions. The possibility to intentionally generate site-specific DSBs in the genome with endonucleases constitutes a powerful tool to study, in vivo, how …
These ncRNAs are mainly connected with double-strand breaks (DSBs), the most dangerous type of DNA lesions. The possibi …
PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends.
Chappidi N, Quail T, Doll S, Vogel LT, Aleksandrov R, Felekyan S, Kühnemuth R, Stoynov S, Seidel CAM, Brugués J, Jahnel M, Franzmann TM, Alberti S. Chappidi N, et al. Cell. 2024 Feb 15;187(4):945-961.e18. doi: 10.1016/j.cell.2024.01.015. Epub 2024 Feb 5. Cell. 2024. PMID: 38320550 Free article.
DNA double-strand breaks (DSBs) are repaired at DSB sites. How DSB sites assemble and how broken DNA is prevented from separating is not understood. ...
DNA double-strand breaks (DSBs) are repaired at DSB sites. How DSB sites assemble and how broken DNA is prevented from …
The democratization of gene editing: Insights from site-specific cleavage and double-strand break repair.
Jasin M, Haber JE. Jasin M, et al. DNA Repair (Amst). 2016 Aug;44:6-16. doi: 10.1016/j.dnarep.2016.05.001. Epub 2016 May 12. DNA Repair (Amst). 2016. PMID: 27261202 Free PMC article. Review.
DNA double-strand breaks (DSBs) are dangerous lesions that if not properly repaired can lead to genomic change or cell death. ...Here, we review DSB repair mechanisms and site-specific cleavage systems that have provided insight into these mechanisms a …
DNA double-strand breaks (DSBs) are dangerous lesions that if not properly repaired can lead to genomic change or cell …
Early steps of double-strand break repair in Bacillus subtilis.
Alonso JC, Cardenas PP, Sanchez H, Hejna J, Suzuki Y, Takeyasu K. Alonso JC, et al. DNA Repair (Amst). 2013 Mar 1;12(3):162-76. doi: 10.1016/j.dnarep.2012.12.005. Epub 2013 Feb 4. DNA Repair (Amst). 2013. PMID: 23380520 Review.
All organisms rely on integrated networks to repair DNA double-strand breaks (DSBs) in order to preserve the integrity of the genetic information, to re-establish replication, and to ensure proper chromosomal segregation. ...RecN, which is among the first res …
All organisms rely on integrated networks to repair DNA double-strand breaks (DSBs) in order to preserve the integrity …
Mechanism of DNA double-strand break repair by non-homologous end joining.
Hefferin ML, Tomkinson AE. Hefferin ML, et al. DNA Repair (Amst). 2005 Jun 8;4(6):639-48. doi: 10.1016/j.dnarep.2004.12.005. Epub 2005 Jan 23. DNA Repair (Amst). 2005. PMID: 15907771 Review.
The repair of DNA double-strand breaks (DSBs) is critical for maintaining genome stability. Although the non-homologous end joining (NHEJ) pathway frequently results in minor changes in DNA sequence at the break site and occasionally the joining …
The repair of DNA double-strand breaks (DSBs) is critical for maintaining genome stability. Although the non-homologous …
Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair.
Yasuhara T, Kato R, Hagiwara Y, Shiotani B, Yamauchi M, Nakada S, Shibata A, Miyagawa K. Yasuhara T, et al. Cell. 2018 Oct 4;175(2):558-570.e11. doi: 10.1016/j.cell.2018.08.056. Epub 2018 Sep 20. Cell. 2018. PMID: 30245011 Free article.
Given that genomic DNA exerts its function by being transcribed, it is critical for the maintenance of homeostasis that DNA damage, such as double-strand breaks (DSBs), within transcriptionally active regions undergoes accurate repair. ...We identify Rad52, w …
Given that genomic DNA exerts its function by being transcribed, it is critical for the maintenance of homeostasis that DNA damage, such as …
Resection of a DNA Double-Strand Break by Alkaline Gel Electrophoresis and Southern Blotting.
Casari E, Gobbini E, Clerici M, Longhese MP. Casari E, et al. Methods Mol Biol. 2021;2153:33-45. doi: 10.1007/978-1-0716-0644-5_3. Methods Mol Biol. 2021. PMID: 32840770
Generation of 3' single-stranded DNA (ssDNA) at the ends of a double-strand break (DSB) is essential to initiate repair by homology-directed mechanisms. Here we describe a Southern blot-based method to visualize the generation of ssDNA at the ends of site …
Generation of 3' single-stranded DNA (ssDNA) at the ends of a double-strand break (DSB) is essential to initiate repair …
3,220 results