Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
2001 1
2002 1
2005 1
2006 2
2007 1
2008 2
2009 1
2011 2
2012 2
2013 1
2014 1
2015 2
2016 4
2017 1
2018 1
2019 3
2020 4
2021 4
2022 1
2023 2
2024 2
2025 7
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

43 results

Results by year

Citations

1 article found by citation matching

Search results

Filters applied: . Clear all
Page 1
3-O-Laurylglyceryl ascorbate reinforces skin barrier function through not only the reduction of oxidative stress but also the activation of ceramide synthesis.
Katsuyama Y, Taira N, Tsuboi T, Yoshioka M, Masaki H, Muraoka O. Katsuyama Y, et al. Int J Cosmet Sci. 2017 Feb;39(1):49-55. doi: 10.1111/ics.12347. Epub 2016 Jun 28. Int J Cosmet Sci. 2017. PMID: 27261166
Since these symptoms coexist with oxidative stress, we hypothesized that impairment of the skin barrier function is accelerated by oxidative stress. ...Furthermore, VC-3LG increased the quantity of ceramide in RHEEs. CONCLUSION: Taken tog …
Since these symptoms coexist with oxidative stress, we hypothesized that impairment of the skin barrier function …
Mechanisms and Repair of Skin Barrier Dysfunction: The TLC Strategy.
Liu Z, Qin X, Wang X, Zhang J, Yang B. Liu Z, et al. Int J Dermatol. 2025 Dec;64 Suppl 2:23-32. doi: 10.1111/ijd.70081. Int J Dermatol. 2025. PMID: 41404926 Review.
Skin barrier dysfunction is caused by various factors, including environmental stressors, genetic predisposition, psychological stress, and inadequate nutrition. ...Targeting skin disruption involves the implementation of interventions for skin …
Skin barrier dysfunction is caused by various factors, including environmental stressors, genetic predisposition, psychologica …
Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis.
Peters F, Tellkamp F, Brodesser S, Wachsmuth E, Tosetti B, Karow U, Bloch W, Utermöhlen O, Krönke M, Niessen CM. Peters F, et al. J Invest Dermatol. 2020 Oct;140(10):1927-1937.e5. doi: 10.1016/j.jid.2020.02.006. Epub 2020 Feb 22. J Invest Dermatol. 2020. PMID: 32092351 Free article.
We show that epidermal loss of ceramide synthase 4 first disturbs epidermal lipid metabolism and adult epidermal barrier function, ultimately resulting in chronic skin barrier disease characterized by acanthosis, hyperkeratosis, and immune cell …
We show that epidermal loss of ceramide synthase 4 first disturbs epidermal lipid metabolism and adult epidermal barrier fu …
Atopic Dermatitis: The Fate of the Fat.
Pavel P, Blunder S, Moosbrugger-Martinz V, Elias PM, Dubrac S. Pavel P, et al. Int J Mol Sci. 2022 Feb 14;23(4):2121. doi: 10.3390/ijms23042121. Int J Mol Sci. 2022. PMID: 35216234 Free PMC article. Review.
Genetic risk loci and epigenetic modifications reported in AD mainly locate to genes involved in the immune response and epidermal barrier function. However, AD pathogenesis cannot be fully explained by (epi)genetic factors since environmental triggers such as st …
Genetic risk loci and epigenetic modifications reported in AD mainly locate to genes involved in the immune response and epidermal barrie …
Effect of high population density environment on skin barrier function in mice.
Aioi A, Okuda M, Matsui M, Tonogaito H, Hamada K. Aioi A, et al. J Dermatol Sci. 2001 Apr;25(3):189-97. doi: 10.1016/s0923-1811(00)00133-x. J Dermatol Sci. 2001. PMID: 11240266
These results suggest that overcrowding stress induced impairment of barrier function and water retention property. To elucidate the mechanism of overcrowding stress-induce dry skin, contents of ceramide and pyrrolidone carboxylic acid, w …
These results suggest that overcrowding stress induced impairment of barrier function and water retention property. To …
Chronic liver injury in mice promotes impairment of skin barrier function via tumor necrosis factor-alpha.
Yokoyama S, Hiramoto K, Koyama M, Ooi K. Yokoyama S, et al. Cutan Ocul Toxicol. 2016 Sep;35(3):194-203. doi: 10.3109/15569527.2015.1076433. Epub 2015 Aug 28. Cutan Ocul Toxicol. 2016. PMID: 26362357
However, during chronic liver injury, it is unclear if/how these liver-derived factors affect distal tissues, such as the skin. OBJECTIVE: The purpose of this study was to evaluate skin barrier function during chronic liver injury. ...CONCLUSIONS: We p …
However, during chronic liver injury, it is unclear if/how these liver-derived factors affect distal tissues, such as the skin. OBJEC …
Bifidobacterium longum 68S mediated gut-skin axis homeostasis improved skin barrier damage in aging mice.
Gao T, Li Y, Wang X, Tao R, Ren F. Gao T, et al. Phytomedicine. 2023 Nov;120:155051. doi: 10.1016/j.phymed.2023.155051. Epub 2023 Aug 25. Phytomedicine. 2023. PMID: 37678055 Free article.
METHODS: B. longum 68S supplied natural aging mouse model and fecal microbiota transplantation (FMT) experiment proves the key role of intestinal microbiota in B. longum 68S up-regulating the production of ceramide synthesis key enzyme (SPT1) and ceramide level and …
METHODS: B. longum 68S supplied natural aging mouse model and fecal microbiota transplantation (FMT) experiment proves the key role of intes …
A Novel Skin Moisture Management Strategy.
Burns M, Siegel DM. Burns M, et al. J Drugs Dermatol. 2021 Jul 1;20(7):752-754. doi: 10.36849/JDD.5749. J Drugs Dermatol. 2021. PMID: 34231993
An important function of skin is prevention of water loss. When the normal skin barrier breaks down, strategies to treat dry skin include occlusives and humectants. ...The formulation enables penetration through stratum corneum and epidermis wit …
An important function of skin is prevention of water loss. When the normal skin barrier breaks down, strategies …
Protocatechuic acid modulates the circadian rhythm of keratinocytes and maintains skin barrier integrity.
Lee J, Kim JY, Lee JH, Lee KH. Lee J, et al. Mol Biol Rep. 2025 Jul 28;52(1):765. doi: 10.1007/s11033-025-10880-x. Mol Biol Rep. 2025. PMID: 40721875
BACKGROUND: Circadian rhythms are intrinsic 24-h biological cycles that regulate key physiological processes, including skin cell proliferation, DNA repair, and barrier homeostasis. Disruption of these rhythms accelerates skin aging, compromises barrier …
BACKGROUND: Circadian rhythms are intrinsic 24-h biological cycles that regulate key physiological processes, including skin cell pro …
Abnormal skin barrier in the etiopathogenesis of atopic dermatitis.
Elias PM, Schmuth M. Elias PM, et al. Curr Opin Allergy Clin Immunol. 2009 Oct;9(5):437-46. doi: 10.1097/ACI.0b013e32832e7d36. Curr Opin Allergy Clin Immunol. 2009. PMID: 19550302 Free PMC article. Review.
But additional acquired stressors to the barrier are required to initiate inflammation. Sustained hapten access through a defective barrier stimulates a Th1 --> Th2 shift in immunophenotype, which in turn further aggravates the barrier. Secondary Staphyloc …
But additional acquired stressors to the barrier are required to initiate inflammation. Sustained hapten access through a defective …
43 results