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In silico prediction of the cosmetic whitening effects of naturally occurring lead compounds.
Fong P, Tong HH. Fong P, et al. Nat Prod Commun. 2012 Oct;7(10):1287-94. Nat Prod Commun. 2012. PMID: 23156992
The identification of tyrosinase inhibitors is important, not only for the treatment of skin hyperpigmentation disorders, such as melasma, but also for the production of cosmetic whitening effects. The aim of this study was the in silico prediction of …
The identification of tyrosinase inhibitors is important, not only for the treatment of skin hyperpigmentation disorders, such …
The melanogenesis and mechanisms of skin-lightening agents--existing and new approaches.
Gillbro JM, Olsson MJ. Gillbro JM, et al. Int J Cosmet Sci. 2011 Jun;33(3):210-21. doi: 10.1111/j.1468-2494.2010.00616.x. Epub 2011 Jan 25. Int J Cosmet Sci. 2011. PMID: 21265866 Free article. Review.
Skin-lightening products are commercially available for cosmetic purposes to obtain lighter skin complexion. ...In this review, we present an overview of commonly used skin-whitening ingredients that are commercialized, but we also hypothesize o …
Skin-lightening products are commercially available for cosmetic purposes to obtain lighter skin complexion. ...In this review …
The High Content of Ent-11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays.
Hamamoto A, Isogai R, Maeda M, Hayazaki M, Horiyama E, Takashima S, Koketsu M, Takemori H. Hamamoto A, et al. Foods. 2020 Jan 9;9(1):73. doi: 10.3390/foods9010073. Foods. 2020. PMID: 31936516 Free PMC article.
Although a number of therapeutic applications of 11alphaOH-KA have been proposed (e.g., anti-cancer, anti-inflammation, and skin whitening), the content of 11alphaOH-KA in these ferns is not high. Adenostemma lavenia (L.) ...The results may also be helpful in the fu …
Although a number of therapeutic applications of 11alphaOH-KA have been proposed (e.g., anti-cancer, anti-inflammation, and skin w …
Anti-melanogenic activity of salacinol by inhibition of tyrosinase oligosaccharide processing.
Homma T, Kageyama S, Nishikawa A, Nagata K. Homma T, et al. J Biochem. 2020 May 1;167(5):503-511. doi: 10.1093/jb/mvz115. J Biochem. 2020. PMID: 31883005
Hyperpigmentation that manifests through melasma and solar lentigo (age spots), although mostly harmless for health, bothers many people. ...Owing to high activity, low cytotoxicity and high hydrophilicity, salacinol is a promising candidate compound in whitening …
Hyperpigmentation that manifests through melasma and solar lentigo (age spots), although mostly harmless for health, bothers m …
4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation.
Kolbe L, Mann T, Gerwat W, Batzer J, Ahlheit S, Scherner C, Wenck H, Stäb F. Kolbe L, et al. J Eur Acad Dermatol Venereol. 2013 Jan;27 Suppl 1:19-23. doi: 10.1111/jdv.12051. J Eur Acad Dermatol Venereol. 2013. PMID: 23205541 Clinical Trial.
BACKGROUND: Hyperpigmentary disorders like melasma, actinic and senile lentigines are a major cosmetic concern. Therefore, many topical products are available, containing various active ingredients aiming to reduce melanin production and distribution. ...METHODS: We …
BACKGROUND: Hyperpigmentary disorders like melasma, actinic and senile lentigines are a major cosmetic concern. Therefore, many topic …
Uncovering the bioactive constituents and their mechanisms of the Forsythiae Fructus against hyperpigmentation using a combined strategy integrating cell-specific extraction, plasma pharmaceutical chemistry and network pharmacology.
Yin J, Hu Y, Yan K, Xu Y, Li D. Yin J, et al. J Pharm Biomed Anal. 2025 Sep 1;262:116865. doi: 10.1016/j.jpba.2025.116865. Epub 2025 Apr 2. J Pharm Biomed Anal. 2025. PMID: 40194472
Skin hyperpigmentation is a type of difficult-to-treat disease that frequently results from the improper metabolism of facial pigment. The herb Forsythiae Fructus (FF) possesses whitening and freckle-removal properties. Its probable active components and anti …
Skin hyperpigmentation is a type of difficult-to-treat disease that frequently results from the improper metabolism of facial …