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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1981 2
1982 1
1983 1
1984 2
1985 1
1986 6
1987 3
1988 14
1989 15
1990 15
1991 24
1992 29
1993 29
1994 35
1995 29
1996 62
1997 42
1998 71
1999 78
2000 100
2001 118
2002 133
2003 126
2004 145
2005 180
2006 194
2007 210
2008 212
2009 221
2010 242
2011 205
2012 207
2013 205
2014 212
2015 180
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2017 209
2018 225
2019 210
2020 102
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3,897 results
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Page 1
KCNMA1-linked channelopathy.
Bailey CS, Moldenhauer HJ, Park SM, Keros S, Meredith AL. Bailey CS, et al. J Gen Physiol. 2019 Oct 7;151(10):1173-1189. doi: 10.1085/jgp.201912457. Epub 2019 Aug 19. J Gen Physiol. 2019. PMID: 31427379 Free PMC article. Review.
KCNMA1 encodes the pore-forming α subunit of the "Big K(+)" (BK) large conductance calcium and voltage-activated K(+) channel. BK channels are widely distributed across tissues, including both excitable and nonexcitable cells. Expression levels
KCNMA1 encodes the pore-forming α subunit of the "Big K(+)" (BK) large conductance calcium and voltage-activated K(+) chann
β1-Subunit of the calcium-sensitive potassium channel modulates the pulmonary vascular smooth muscle cell response to hypoxia.
Barnes EA, Lee L, Barnes SL, Brenner R, Alvira CM, Cornfield DN. Barnes EA, et al. Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L265-L275. doi: 10.1152/ajplung.00060.2018. Epub 2018 Apr 12. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 29644895 Free PMC article.
The β1 subunit increases Ca(2+) and voltagesensitivity of the BK(Ca) channel and is expressed exclusively in smooth muscle cells. ...To determine the role of the BK(Ca) channel β1 subunit in the regulation of pulmonary vascular tone and the response to …
The β1 subunit increases Ca(2+) and voltagesensitivity of the BK(Ca) channel and is expressed exclusively in smooth muscle cel …
Further studies of ion channels in the electroreceptor of the skate through deep sequencing, cloning and cross species comparisons.
Clusin WT, Wu TH, Shi LF, Kao PN. Clusin WT, et al. Gene. 2019 Nov 15;718:143989. doi: 10.1016/j.gene.2019.143989. Epub 2019 Jul 18. Gene. 2019. PMID: 31326551
The principal channels of the electroreceptor include a calcium activated K channel whose α subunit is Kcnma1, and a voltage-dependent calcium channel, Cacna1d. ...Large conductance calcium-activated K channels (BK) are comprised of four …
The principal channels of the electroreceptor include a calcium activated K channel whose α subunit is Kcnma1, and a vo …
Molecular Determinants of BK Channel Functional Diversity and Functioning.
Latorre R, Castillo K, Carrasquel-Ursulaez W, Sepulveda RV, Gonzalez-Nilo F, Gonzalez C, Alvarez O. Latorre R, et al. Physiol Rev. 2017 Jan;97(1):39-87. doi: 10.1152/physrev.00001.2016. Physiol Rev. 2017. PMID: 27807200 Free article. Review.
BK channels are tetramers in which the pore-forming α subunit is coded by a single gene (Slowpoke, KCNMA1). In this review, we first highlight the physiological importance of this ubiquitous channel, emphasizing the role that BK channe
BK channels are tetramers in which the pore-forming α subunit is coded by a single gene (Slowpoke, KCNMA1). In t
BK Channels in the Central Nervous System.
Contet C, Goulding SP, Kuljis DA, Barth AL. Contet C, et al. Int Rev Neurobiol. 2016;128:281-342. doi: 10.1016/bs.irn.2016.04.001. Epub 2016 May 13. Int Rev Neurobiol. 2016. PMID: 27238267 Free PMC article. Review.
Large conductance Ca(2+)- and voltage-activated K(+) (BK) channels are widely distributed in the postnatal central nervous system (CNS). ...In addition, BK channels located in astrocytes and arterial myocytes modulate cerebral blood flow. Not surprisin …
Large conductance Ca(2+)- and voltage-activated K(+) (BK) channels are widely distributed in the postnatal central nervous sys …
De novo loss-of-function KCNMA1 variants are associated with a new multiple malformation syndrome and a broad spectrum of developmental and neurological phenotypes.
Liang L, Li X, Moutton S, Schrier Vergano SA, Cogné B, Saint-Martin A, Hurst ACE, Hu Y, Bodamer O, Thevenon J, Hung CY, Isidor B, Gerard B, Rega A, Nambot S, Lehalle D, Duffourd Y, Thauvin-Robinet C, Faivre L, Bézieau S, Dure LS, Helbling DC, Bick D, Xu C, Chen Q, Mancini GMS, Vitobello A, Wang QK. Liang L, et al. Hum Mol Genet. 2019 Sep 1;28(17):2937-2951. doi: 10.1093/hmg/ddz117. Hum Mol Genet. 2019. PMID: 31152168
KCNMA1 encodes the large-conductance Ca2+- and voltage-activated K+ (BK) potassium channel α-subunit, and pathogenic gain-of-function variants in this gene have been associated with a dominant form of generalized epilepsy and paroxysmal dyskinesia. ...Patch c
KCNMA1 encodes the large-conductance Ca2+- and voltage-activated K+ (BK) potassium channel α-subunit, and pathogenic ga
The Large Conductance Calcium- and Voltage-activated Potassium Channel (BK) and Epilepsy.
Zang K, Zhang Y, Hu J, Wang Y. Zang K, et al. CNS Neurol Disord Drug Targets. 2018;17(4):248-254. doi: 10.2174/1871527317666180404104055. CNS Neurol Disord Drug Targets. 2018. PMID: 29623857 Review.
Moreover, after-hyperpolarization induced by BK channels closes Cav channels and thus precludes excessive Ca2+ influx. Considering this negative feedback effect, BK channel seemly acts to decrease membrane excitability in order to prevent hypere …
Moreover, after-hyperpolarization induced by BK channels closes Cav channels and thus precludes excessive Ca2+ influx. …
A large-conductance (BK) potassium channel subtype affects both growth and mineralization of human osteoblasts.
Henney NC, Li B, Elford C, Reviriego P, Campbell AK, Wann KT, Evans BA. Henney NC, et al. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1397-408. doi: 10.1152/ajpcell.00311.2009. Epub 2009 Sep 23. Am J Physiol Cell Physiol. 2009. PMID: 19776394 Free PMC article.
We used RT-PCR and patch-clamp methods to determine the expression of BK channel subunits and cell number assays in the absence and presence of BK channel modulators. RT-PCR showed the presence of KCNMA1, KCNMB1, KCNMB2, KCNMB3
We used RT-PCR and patch-clamp methods to determine the expression of BK channel subunits and cell number assays in the absenc …
Effects of Single Nucleotide Polymorphisms in Human KCNMA1 on BK Current Properties.
Plante AE, Lai MH, Lu J, Meredith AL. Plante AE, et al. Front Mol Neurosci. 2019 Dec 3;12:285. doi: 10.3389/fnmol.2019.00285. eCollection 2019. Front Mol Neurosci. 2019. PMID: 31849601 Free PMC article.
BK Ca(2+)-activated K(+) channels are important regulators of membrane excitability. Multiple regulatory mechanisms tailor BK current properties across tissues, such as alternative splicing, posttranslational modifications, and auxiliary subunits. ...The gene
BK Ca(2+)-activated K(+) channels are important regulators of membrane excitability. Multiple regulatory mechanisms tailor
[Downregulation of large conductance calcium-activated potassium channels in paraventricular nucleus contributes to sympathoexcitation in rats with chronic heart failure].
Wang RJ, Wen ML, Zhou Q, Wei XW, Li H, Zhao YB, Qi YF, Luan J, Zhou XF. Wang RJ, et al. Zhonghua Xin Xue Guan Bing Za Zhi. 2018 Mar 24;46(3):178-186. doi: 10.3760/cma.j.issn.0253-3758.2018.03.003. Zhonghua Xin Xue Guan Bing Za Zhi. 2018. PMID: 29562421 Chinese.
Objective: To elucidate the association between large conductance calcium-activated potassium channels (BK(Ca)) in the paraventricular hypothalamic nucleus (PVN) and sympathetic outflow in rats with chronic heart failure (CHF) . ...The protein and mRNA expression of …
Objective: To elucidate the association between large conductance calcium-activated potassium channels (BK(Ca)) in the paraven …
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