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5,731 results

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Page 1
KCNMA1-linked channelopathy.
Bailey CS, Moldenhauer HJ, Park SM, Keros S, Meredith AL. Bailey CS, et al. J Gen Physiol. 2019 Oct 7;151(10):1173-1189. doi: 10.1085/jgp.201912457. Epub 2019 Aug 19. J Gen Physiol. 2019. PMID: 31427379 Free PMC article. Review.
KCNMA1 encodes the pore-forming alpha subunit of the "Big K(+)" (BK) large conductance calcium and voltage-activated K(+) channel. ...Establishing causality between KCNMA1-linked BK channel dysfunction and specific patient s …
KCNMA1 encodes the pore-forming alpha subunit of the "Big K(+)" (BK) large conductance calcium and voltage-activ …
BK Channelopathies and KCNMA1-Linked Disease Models.
Meredith AL. Meredith AL. Annu Rev Physiol. 2024 Feb 12;86:277-300. doi: 10.1146/annurev-physiol-030323-042845. Epub 2023 Oct 31. Annu Rev Physiol. 2024. PMID: 37906945 Free article. Review.
Novel KCNMA1 variants, encoding the BK K(+) channel, are associated with a debilitating dyskinesia and epilepsy syndrome. ...The mechanistic relationship of PNKD3 to epilepsy and the broader spectrum of KCNMA1-associated symptomology is unknown. This r …
Novel KCNMA1 variants, encoding the BK K(+) channel, are associated with a debilitating dyskinesia and epilepsy syndrom …
Biophysics of BK Channel Gating.
Pantazis A, Olcese R. Pantazis A, et al. Int Rev Neurobiol. 2016;128:1-49. doi: 10.1016/bs.irn.2016.03.013. Epub 2016 Apr 16. Int Rev Neurobiol. 2016. PMID: 27238260 Review.
BK channels are universal regulators of cell excitability, given their exceptional unitary conductance selective for K(+), joint activation mechanism by membrane depolarization and intracellular [Ca(2+)] elevation, and broad expression pattern. ...We also discuss ho …
BK channels are universal regulators of cell excitability, given their exceptional unitary conductance selective for K(+), joi …
Structural mapping of patient-associated KCNMA1 gene variants.
Moldenhauer HJ, Tammen K, Meredith AL. Moldenhauer HJ, et al. Biophys J. 2024 Jul 16;123(14):1984-2000. doi: 10.1016/j.bpj.2023.11.3404. Epub 2023 Dec 1. Biophys J. 2024. PMID: 38042986 Free PMC article.
In this study, 82 nonsynonymous patient-associated KCNMA1 variants were mapped within the BK channel protein. Fifty-three variants localized within cryoelectron microscopy-resolved structures, including 21 classified as either gain of function (GOF) or loss o …
In this study, 82 nonsynonymous patient-associated KCNMA1 variants were mapped within the BK channel protein. Fifty-thr …
The Role of KCNMB1 and BK Channels in Myofibroblast Differentiation and Pulmonary Fibrosis.
Scruggs AM, Grabauskas G, Huang SK. Scruggs AM, et al. Am J Respir Cell Mol Biol. 2020 Feb;62(2):191-203. doi: 10.1165/rcmb.2019-0163OC. Am J Respir Cell Mol Biol. 2020. PMID: 31486669 Free PMC article.
One of the top differentially methylated genes identified in our previous study was KCNMB1, which codes for the beta subunit of the large-conductance potassium (BK, also known as MaxiK or K(Ca)1.1) channel. ...Together, our findings demon …
One of the top differentially methylated genes identified in our previous study was KCNMB1, which codes for the beta subunit of the …
Evaluation of four KCNMA1 channelopathy variants on BK channel current under Ca(V)1.2 activation.
Dinsdale RL, Meredith AL. Dinsdale RL, et al. Channels (Austin). 2024 Dec;18(1):2396346. doi: 10.1080/19336950.2024.2396346. Epub 2024 Sep 1. Channels (Austin). 2024. PMID: 39217512 Free PMC article.
Variants in KCNMA1, encoding the voltage- and calcium-activated K(+) (BK) channel, are associated with human neurological disease. The effects of gain-of-function (GOF) and loss-of-function (LOF) variants have been predominantly studied on BK …
Variants in KCNMA1, encoding the voltage- and calcium-activated K(+) (BK) channel, are associated with hu …
Protein Network Interacting with BK Channels.
Kim H, Oh KH. Kim H, et al. Int Rev Neurobiol. 2016;128:127-61. doi: 10.1016/bs.irn.2016.03.003. Epub 2016 Mar 28. Int Rev Neurobiol. 2016. PMID: 27238263 Review.
The large conductance, voltage- and calcium-dependent potassium BK channel, also termed BKCa, Maxi-K, KCa1.1, or SLO1, regulates a wide array of key biological processes that are mediated by calcium ions. ...Proteins that interact with BK …
The large conductance, voltage- and calcium-dependent potassium BK channel, also termed BKCa, Maxi-K, KCa …
Downregulation of KCNMB4 expression and changes in BK channel subtype in hippocampal granule neurons following seizure activity.
Whitmire LE, Ling L, Bugay V, Carver CM, Timilsina S, Chuang HH, Jaffe DB, Shapiro MS, Cavazos JE, Brenner R. Whitmire LE, et al. PLoS One. 2017 Nov 16;12(11):e0188064. doi: 10.1371/journal.pone.0188064. eCollection 2017. PLoS One. 2017. PMID: 29145442 Free PMC article.
A major challenge is to understand maladaptive changes in ion channels that sets neurons on a course towards epilepsy development. Voltage- and calcium-activated K+ (BK) channels contribute to early spike timing in neurons, and studies indicate …
A major challenge is to understand maladaptive changes in ion channels that sets neurons on a course towards epilepsy development. Vo …
Cholesterol activates BK channels by increasing KCNMB1 protein levels in the plasmalemma.
Bukiya AN, Leo MD, Jaggar JH, Dopico AM. Bukiya AN, et al. J Biol Chem. 2021 Jan-Jun;296:100381. doi: 10.1016/j.jbc.2021.100381. Epub 2021 Feb 6. J Biol Chem. 2021. PMID: 33556372 Free PMC article.
Calcium-/voltage-gated, large-conductance potassium channels (BKs) control critical physiological processes, including smooth muscle contraction. ...Moreover, CLR enrichment of arteries with naturally high KCNMB1 levels, such as basilar and coro …
Calcium-/voltage-gated, large-conductance potassium channels (BKs) control critical physiological processes, inc …
The Yin and Yang of BK Channels in Epilepsy.
Zhu Y, Zhang S, Feng Y, Xiao Q, Cheng J, Tao J. Zhu Y, et al. CNS Neurol Disord Drug Targets. 2018;17(4):272-279. doi: 10.2174/1871527317666180213142403. CNS Neurol Disord Drug Targets. 2018. PMID: 29437015 Review.
BACKGROUND & OBJECTIVE: The large conductance calcium-activated potassium (BK) channel, extensively distributed in the central nervous system (CNS), is considered as a vital player in the pathogenesis of epilepsy, with evidence …
BACKGROUND & OBJECTIVE: The large conductance calcium-activated potassium (BK) channel, …
5,731 results