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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1981 2
1982 2
1983 2
1984 2
1985 2
1986 7
1987 6
1988 12
1989 17
1990 13
1991 24
1992 33
1993 36
1994 44
1995 35
1996 88
1997 76
1998 109
1999 111
2000 124
2001 140
2002 168
2003 181
2004 177
2005 209
2006 239
2007 224
2008 233
2009 244
2010 267
2011 236
2012 242
2013 244
2014 266
2015 231
2016 225
2017 226
2018 238
2019 212
2020 205
2021 200
2022 157
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4,990 results
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Page 1
Rare Variants in Genes Encoding Subunits of the Epithelial Na+ Channel Are Associated With Blood Pressure and Kidney Function.
Blobner BM, Kirabo A, Kashlan OB, Sheng S, Arnett DK, Becker LC, Boerwinkle E, Carlson JC, Gao Y, Gibbs RA, He J, Irvin MR, Kardia SLR, Kelly TN, Kooperberg C, McGarvey ST, Menon VK, Montasser ME, Naseri T, Redline S, Reiner AP, Reupena MS, Smith JA, Sun X, Vaidya D, Viaud-Martinez KA, Weeks DE, Yanek LR, Zhu X; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium*, Minster RL, Kleyman TR. Blobner BM, et al. Hypertension. 2022 Oct 4:101161HYPERTENSIONAHA12118513. doi: 10.1161/HYPERTENSIONAHA.121.18513. Online ahead of print. Hypertension. 2022. PMID: 36193739
BACKGROUND: The epithelial Na(+) channel (ENaC) is intrinsically linked to fluid volume homeostasis and blood pressure. ...
BACKGROUND: The epithelial Na(+) channel (ENaC) is intrinsically linked to fluid volume homeostasis and blood pressure. ...
The antidiabetic drug teneligliptin induces vasodilation via activation of PKG, Kv channels, and SERCA pumps in aortic smooth muscle.
Li H, An JR, Park M, Choi J, Heo R, Kang M, Mun SY, Zhuang W, Seo MS, Han ET, Han JH, Chun W, Park WS. Li H, et al. Eur J Pharmacol. 2022 Sep 29:175305. doi: 10.1016/j.ejphar.2022.175305. Online ahead of print. Eur J Pharmacol. 2022. PMID: 36183856
In addition, pretreatment with the nitric oxide synthase inhibitor L-NAME and small-conductance Ca(2+)-activated K(+) channel inhibitor apamin did not alter the teneligliptin-induced vasodilatory effect. ...However, pretreatment with the inward rectifier K(+) …
In addition, pretreatment with the nitric oxide synthase inhibitor L-NAME and small-conductance Ca(2+)-activated K(+) chann
Gene Expression Trajectories from Normal Nonsmokers to COPD Smokers and Disease Progression Discriminant Modeling in Response to Cigarette Smoking.
Zhang Z, Chen S, Li Q, Li D, Li Y, Xie X, Yuan L, Lin Z, Lin F, Wei X, Fang Y, Wang J, Lu W. Zhang Z, et al. Dis Markers. 2022 Sep 14;2022:9354286. doi: 10.1155/2022/9354286. eCollection 2022. Dis Markers. 2022. PMID: 36157207 Free PMC article.
RESULTS: The integrated bioinformatic analysis of 8 human GEO datasets (293 individuals) and 9 rat transcriptome databases revealed 13 overlapping genes between humans and rats in response to smoking exposure during COPD progression. Of these, 5 genes (AKR1C3/Akr1c3, ERP27/Erp27, …
RESULTS: The integrated bioinformatic analysis of 8 human GEO datasets (293 individuals) and 9 rat transcriptome databases revealed 13 overl …
α-Subunit Tyrosine Phosphorylation Is Required for Activation of the Large Conductance Ca2+-Activated Potassium Channel in the Rabbit Sphincter of Oddi.
Feng D, Guo YY, Wang W, Yan LF, Sun T, Liu QQ, Cui GB, Nan HY. Feng D, et al. Am J Pathol. 2022 Sep 21:S0002-9440(22)00281-4. doi: 10.1016/j.ajpath.2022.08.005. Online ahead of print. Am J Pathol. 2022. PMID: 36150507
Large conductance Ca(2+)-activated potassium (BK(Ca)) channels are regulated by intracellular free Ca(2+) concentrations ([Ca(2+)]i) and channel protein phosphorylation. ...The present study suggests that alpha-subunit tyrosine pho
Large conductance Ca(2+)-activated potassium (BK(Ca)) channels are regulated by intracellular free
Cerebral arteriolar and neurovascular dysfunction after chemically-induced menopause in mice.
Blackwell JA, Silva JF, Louis EM, Savu A, Largent-Milnes TM, Brooks HL, Pires PW. Blackwell JA, et al. Am J Physiol Heart Circ Physiol. 2022 Sep 23. doi: 10.1152/ajpheart.00276.2022. Online ahead of print. Am J Physiol Heart Circ Physiol. 2022. PMID: 36149767
These vessels are bottlenecks of the cerebral microcirculation, and dysfunction can limit functional hyperemia in the brain. Large conductance Ca(2+)-activated K(+) channels (BK(Ca)) are the final effectors of several pathways responsible for fu …
These vessels are bottlenecks of the cerebral microcirculation, and dysfunction can limit functional hyperemia in the brain. Large
Role of Cholesterol in the Regulation of Hydrogen Sulfide Signaling within the Vascular Endothelium.
Mendiola PJ, Morin EE, Gonzalez Bosc LV, Naik JS, Kanagy NL. Mendiola PJ, et al. Antioxidants (Basel). 2022 Aug 28;11(9):1680. doi: 10.3390/antiox11091680. Antioxidants (Basel). 2022. PMID: 36139754 Free PMC article.
We previously reported that H(2)S-induced vasodilation is mediated through transient receptor potential cation channel subfamily V member 4 (TRPV4) and large conductance (BK(Ca)) potassium channels; however, regulators of this pathway hav …
We previously reported that H(2)S-induced vasodilation is mediated through transient receptor potential cation channel subfamily V me …
Neurodegenerative Lysosomal Storage Disorders: TPC2 Comes to the Rescue!
Prat Castro S, Kudrina V, Jaślan D, Böck J, Scotto Rosato A, Grimm C. Prat Castro S, et al. Cells. 2022 Sep 8;11(18):2807. doi: 10.3390/cells11182807. Cells. 2022. PMID: 36139381 Free PMC article. Review.
One of the main basic mechanisms through which the endolysosomal ion channels regulate the function of the endolysosomal system is Ca(2+) release, which is thought to be essential for intracellular compartment fusion, fission, trafficking and lysosomal exocytosis. The intr …
One of the main basic mechanisms through which the endolysosomal ion channels regulate the function of the endolysosomal system is Ca …
Vascular Response of Tetrabromobisphenol a in Rat Aorta: Calcium Channels Inhibition and Potassium Channels Activation.
Feiteiro J, Rocha SM, Mariana M, Maia CJ, Cairrao E. Feiteiro J, et al. Toxics. 2022 Sep 9;10(9):529. doi: 10.3390/toxics10090529. Toxics. 2022. PMID: 36136495 Free PMC article.
Through an ex vivo approach, Wistar rat aortas were used in an organ bath to evaluate the vascular effect of TBBPA (0.01-100 muM). Additionally, TBBPA's mode of action was studied through calcium and potassium channel inhibitors. Resorting to in vitro studies …
Through an ex vivo approach, Wistar rat aortas were used in an organ bath to evaluate the vascular effect of TBBPA (0.01-100 muM). Additiona …
Rosa damascena Miller essential oil relaxes rat trachea via KV channels, KATP channels, and BKCa channels.
Demirel S. Demirel S. Prostaglandins Other Lipid Mediat. 2022 Sep 14;163:106673. doi: 10.1016/j.prostaglandins.2022.106673. Online ahead of print. Prostaglandins Other Lipid Mediat. 2022. PMID: 36115499
AIM/OBJECTIVE: This study aimed to investigate the effects of Rosa damascena Miller essential oil on rat tracheal smooth muscle contractility and the hypothesis that voltage-gated potassium (K(V)) channels, ATP-sensitive potassium (K(ATP)) channels, an …
AIM/OBJECTIVE: This study aimed to investigate the effects of Rosa damascena Miller essential oil on rat tracheal smooth muscle contractilit …
4,990 results