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Year Number of Results
1973 1
1977 1
1979 3
1980 3
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1982 8
1983 11
1984 18
1985 39
1986 70
1987 113
1988 192
1989 276
1990 362
1991 381
1992 430
1993 568
1994 723
1995 899
1996 1003
1997 1093
1998 1263
1999 1391
2000 1702
2001 1802
2002 1976
2003 2099
2004 2065
2005 2353
2006 2375
2007 2347
2008 2619
2009 2667
2010 2822
2011 3057
2012 3463
2013 3574
2014 3459
2015 3365
2016 3424
2017 3172
2018 2918
2019 2972
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2022 2202
2023 2027
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2025 2526
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71,823 results

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Page 1
Small GTPase peripheral binding to membranes: molecular determinants and supramolecular organization.
Peurois F, Peyroche G, Cherfils J. Peurois F, et al. Biochem Soc Trans. 2019 Feb 28;47(1):13-22. doi: 10.1042/BST20170525. Epub 2018 Dec 17. Biochem Soc Trans. 2019. PMID: 30559268 Review.
Thereby, membrane association potentiates small GTPase interactions with GEFs, GAPs and effectors through colocalization and positional matching. Furthermore, it leads to small GTPase nanoclustering and to lipid demixing, which drives the assembly of m …
Thereby, membrane association potentiates small GTPase interactions with GEFs, GAPs and effectors through colocalization and p …
In vitro reconstitution of small GTPase regulation.
Loose M, Auer A, Brognara G, Budiman HR, Kowalski L, Matijević I. Loose M, et al. FEBS Lett. 2023 Mar;597(6):762-777. doi: 10.1002/1873-3468.14540. Epub 2022 Nov 29. FEBS Lett. 2023. PMID: 36448231 Review.
Small GTPases play essential roles in the organization of eukaryotic cells. In recent years, it has become clear that their intracellular functions result from intricate biochemical networks of the GTPase and their regulators that dynamically bind to a membrane surf …
Small GTPases play essential roles in the organization of eukaryotic cells. In recent years, it has become clear that their intracell …
The small GTPase Sar1, control centre of COPII trafficking.
Van der Verren SE, Zanetti G. Van der Verren SE, et al. FEBS Lett. 2023 Mar;597(6):865-882. doi: 10.1002/1873-3468.14595. Epub 2023 Feb 20. FEBS Lett. 2023. PMID: 36737236 Review.
Sar1 is a small GTPase of the ARF family. Upon exchange of GDP for GTP, Sar1 associates with the endoplasmic reticulum (ER) membrane and recruits COPII components, orchestrating cargo concentration and membrane deformation. ...
Sar1 is a small GTPase of the ARF family. Upon exchange of GDP for GTP, Sar1 associates with the endoplasmic reticulum (ER) me …
Regulation of small GTPase activity by G1 cyclins.
Pedraza N, Cemeli T, Monserrat MV, Garí E, Ferrezuelo F. Pedraza N, et al. Small GTPases. 2019 Jan;10(1):47-53. doi: 10.1080/21541248.2016.1268665. Epub 2017 Jan 27. Small GTPases. 2019. PMID: 28129038 Free PMC article. Review.
These processes are mainly controlled by the small GTPase Cdc42, and G1 cyclins regulate the activity of this and other small GTPases through the modulation of their regulators and effectors. ...Here we briefly review the evidence supporting a role of G1 cycl …
These processes are mainly controlled by the small GTPase Cdc42, and G1 cyclins regulate the activity of this and other sma …
Targeting the Small GTPase Superfamily through Their Regulatory Proteins.
Gray JL, von Delft F, Brennan PE. Gray JL, et al. Angew Chem Int Ed Engl. 2020 Apr 16;59(16):6342-6366. doi: 10.1002/anie.201900585. Epub 2020 Jan 30. Angew Chem Int Ed Engl. 2020. PMID: 30869179 Free PMC article. Review.
The GTP-dependent signaling of these proteins is controlled by their regulators; guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs), and in the Rho and Rab subfamilies, guanine nucleotide dissociation inhibitors (GDIs). ...It highli …
The GTP-dependent signaling of these proteins is controlled by their regulators; guanine nucleotide exchange factors (GEFs), GTPas …
Small GTPase-A Key Role in Host Cell for Coronavirus Infection and a Potential Target for Coronavirus Vaccine Adjuvant Discovery.
Hou W, Wang S, Wu H, Xue L, Wang B, Wang S, Wang H. Hou W, et al. Viruses. 2022 Sep 14;14(9):2044. doi: 10.3390/v14092044. Viruses. 2022. PMID: 36146850 Free PMC article. Review.
In this review, we discuss the role of small GTPases in the coronavirus life cycle, especially pre-entry, endocytosis, intracellular traffic, replication, and egress from the host cell. Furthermore, we also suggest the molecules that have potent adjuvant activity by target …
In this review, we discuss the role of small GTPases in the coronavirus life cycle, especially pre-entry, endocytosis, intracellular …
Small GTPase-dependent regulation of leukocyte-endothelial interactions in inflammation.
Chu JY, McCormick B, Vermeren S. Chu JY, et al. Biochem Soc Trans. 2018 Jun 19;46(3):649-658. doi: 10.1042/BST20170530. Epub 2018 May 9. Biochem Soc Trans. 2018. PMID: 29743277 Review.
This results in increased vascular permeability and increased expression of adhesion proteins, and promotes adhesion of leukocytes, especially neutrophils to the endothelium. ...As key regulators of cell-cell and cell-substratum adhesion, small GTPases (guanosine tr …
This results in increased vascular permeability and increased expression of adhesion proteins, and promotes adhesion of leukocytes, e …
Regulation of small GTPases by GEFs, GAPs, and GDIs.
Cherfils J, Zeghouf M. Cherfils J, et al. Physiol Rev. 2013 Jan;93(1):269-309. doi: 10.1152/physrev.00003.2012. Physiol Rev. 2013. PMID: 23303910 Free article. Review.
Recent studies reveal that small GTPase regulators have themselves unexpectedly sophisticated regulatory mechanisms, by which they process cellular signals and build up specific cell responses. ...This review presents an overview of the current knowledge of these ma …
Recent studies reveal that small GTPase regulators have themselves unexpectedly sophisticated regulatory mechanisms, by which …
Methods for Controlling Small GTPase Activity.
Faulkner B, He Y, Sitrin D, Stains CI. Faulkner B, et al. Chembiochem. 2025 Jul 11;26(13):e202500156. doi: 10.1002/cbic.202500156. Epub 2025 Jun 13. Chembiochem. 2025. PMID: 40396811 Free PMC article. Review.
Small GTPases comprise a diverse class of signaling proteins in mammalian cells and regulate a variety of cellular processes such as cell growth, cell movement, vesicle formation, and nuclear transport. ...Current approaches within each area are discussed within the …
Small GTPases comprise a diverse class of signaling proteins in mammalian cells and regulate a variety of cellular processes s …
Drugging the Small GTPase Pathways in Cancer Treatment: Promises and Challenges.
Prieto-Dominguez N, Parnell C, Teng Y. Prieto-Dominguez N, et al. Cells. 2019 Mar 16;8(3):255. doi: 10.3390/cells8030255. Cells. 2019. PMID: 30884855 Free PMC article. Review.
Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle between an inactive state when bound to GDP and an active state when associated to GTP. ...Therefore, the development of inhibitors that target dysfunctional small GTPases could re …
Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle between an inactive state when bound to GDP and …
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