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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 2
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2008 6
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326 results

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Page 1
Nrf2-Keap1 signaling in oxidative and reductive stress.
Bellezza I, Giambanco I, Minelli A, Donato R. Bellezza I, et al. Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):721-733. doi: 10.1016/j.bbamcr.2018.02.010. Epub 2018 Feb 27. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 29499228 Free article. Review.
Sequestered by cytoplasmic Keap1 and targeted to proteasomal degradation in basal conditions, in case of oxidative stress Nrf2 detaches from Keap1 and translocates to the nucleus, where it heterodimerizes with one of the small Maf proteins. The heterodimers recogniz …
Sequestered by cytoplasmic Keap1 and targeted to proteasomal degradation in basal conditions, in case of oxidative stress Nrf2 detaches from …
Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells.
Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R, Tang D. Sun X, et al. Hepatology. 2016 Jan;63(1):173-84. doi: 10.1002/hep.28251. Epub 2015 Nov 26. Hepatology. 2016. PMID: 26403645 Free PMC article.
However, the molecular mechanisms regulating ferroptosis remain obscure. Here, we report that nuclear factor erythroid 2-related factor 2 (NRF2) plays a central role in protecting hepatocellular carcinoma (HCC) cells against ferroptosis. ...Additionally, nuclear NRF …
However, the molecular mechanisms regulating ferroptosis remain obscure. Here, we report that nuclear factor erythroid 2-related f …
The small MAF transcription factor MAFG co-opts MITF to promote melanoma progression.
Vera O, Martinez M, Soto-Vargas Z, Wang K, Xu X, Ruiz-Buceta S, Mecozzi N, Chadourne M, Posorske B, Angarita A, Bok I, Liu Q, Murikipudi H, Kim Y, Messina JL, Tsai KY, Major MB, Lau EK, Yu X, Ibanez-de-Caceres I, Karreth FA. Vera O, et al. bioRxiv [Preprint]. 2024 Sep 6:2024.09.03.611024. doi: 10.1101/2024.09.03.611024. bioRxiv. 2024. PMID: 39282450 Free PMC article. Preprint.
Transcription factor deregulation potently drives melanoma progression by dynamically and reversibly controlling gene expression programs. We previously identified the small MAF family transcription factor MAFG as a putative driver of mel …
Transcription factor deregulation potently drives melanoma progression by dynamically and reversibly controlling gene expressi …
Targeting the oncogenic transcription factor c-Maf for the treatment of multiple myeloma.
Jiang Q, Mao H, He G, Mao X. Jiang Q, et al. Cancer Lett. 2022 Sep 1;543:215791. doi: 10.1016/j.canlet.2022.215791. Epub 2022 Jun 11. Cancer Lett. 2022. PMID: 35700821
By triggering the transcription of critical genes including CCND2, ITGB7, CCR1, ARK5, c-Maf promotes MM progress, proliferation, survival and chemoresistance. Notably, c-Maf is usually expressed at the embryonic stage to promote cell differentiation but less …
By triggering the transcription of critical genes including CCND2, ITGB7, CCR1, ARK5, c-Maf promotes MM progress, proliferatio …
Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer.
Liu M, Tong Z, Ding C, Luo F, Wu S, Wu C, Albeituni S, He L, Hu X, Tieri D, Rouchka EC, Hamada M, Takahashi S, Gibb AA, Kloecker G, Zhang HG, Bousamra M 2nd, Hill BG, Zhang X, Yan J. Liu M, et al. J Clin Invest. 2020 Apr 1;130(4):2081-2096. doi: 10.1172/JCI131335. J Clin Invest. 2020. PMID: 31945018 Free PMC article.
However, the transcriptional regulation of macrophages driving the protumor function remains elusive. Here, we demonstrate that the transcription factor c-Maf is a critical controller for immunosuppressive macrophage polarization and function in cancer. c- …
However, the transcriptional regulation of macrophages driving the protumor function remains elusive. Here, we demonstrate that the trans …
Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10.
Brockmann L, Tran A, Huang Y, Edwards M, Ronda C, Wang HH, Ivanov II. Brockmann L, et al. Immunity. 2023 Dec 12;56(12):2719-2735.e7. doi: 10.1016/j.immuni.2023.11.003. Epub 2023 Nov 30. Immunity. 2023. PMID: 38039966 Free PMC article.
The anti-inflammatory phenotype of gut-resident commensal-specific Th17 cells was driven by the transcription factor c-MAF. IL-10-producing commensal-specific Th17 cells were heterogeneous and derived from a TCF1(+) gut-resident progenitor Th17 cell populatio …
The anti-inflammatory phenotype of gut-resident commensal-specific Th17 cells was driven by the transcription factor c-MAF …
Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1.
Johnsen O, Skammelsrud N, Luna L, Nishizawa M, Prydz H, Kolstø AB. Johnsen O, et al. Nucleic Acids Res. 1996 Nov 1;24(21):4289-97. doi: 10.1093/nar/24.21.4289. Nucleic Acids Res. 1996. PMID: 8932385 Free PMC article.
The human TCF11 gene encodes a ubiquitously expressed bZIP transcription factor of the cap n' collar (CNC) domain family. It has a high sequence similarity to the erythroid-specific bZIP factor p45 NF-E2 in the CNC domain, which is involved in DNA binding. .. …
The human TCF11 gene encodes a ubiquitously expressed bZIP transcription factor of the cap n' collar (CNC) domain family. It h …
Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins.
Freitas-Cortez MA, Masrorpour F, Jiang H, Mahmud I, Lu Y, Huang A, Duong LK, Wang Q, Voss TA, Kettlun Leyton CS, Wei B, Chan WK, Lin K, Zhang J, Tsouko E, Ganjoo S, Barsoumian HB, Riad TS, Hu Y, Leuschner C, Puebla-Osorio N, Wang J, Hu J, Davies MA, Puduvalli VK, Billon C, Burris TP, Lorenzi PL, Gan B, Welsh JW. Freitas-Cortez MA, et al. Mol Cancer. 2025 Feb 3;24(1):40. doi: 10.1186/s12943-024-02198-2. Mol Cancer. 2025. PMID: 39901247 Free PMC article.
Methods included mass spectrometry-based lipidomics, targeted lipidomics, Oil Red O staining, Seahorse analysis, quantitative PCR, immunohistochemistry, PPARgamma transcription factor assays, ChIP-seq, untargeted lipidomic analysis, ROS assay, ex vivo co-culture of …
Methods included mass spectrometry-based lipidomics, targeted lipidomics, Oil Red O staining, Seahorse analysis, quantitative PCR, immunohis …
The small MAF transcription factors MAFF, MAFG and MAFK: current knowledge and perspectives.
Kannan MB, Solovieva V, Blank V. Kannan MB, et al. Biochim Biophys Acta. 2012 Oct;1823(10):1841-6. doi: 10.1016/j.bbamcr.2012.06.012. Epub 2012 Jun 18. Biochim Biophys Acta. 2012. PMID: 22721719 Free article. Review.
Previous studies have linked small MAF function, by virtue of their heterodimerization with the Cap 'n' Collar (CNC) family of transcription factors, to the stress response and detoxification pathways. Recent analyses have revealed a complex regulatory …
Previous studies have linked small MAF function, by virtue of their heterodimerization with the Cap 'n' Collar (CNC) family of …
326 results