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24,382 results

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Page 1
Did you mean small intestinal mucosa cell (24,319 results)?
Oral administration of Robinia pseudoacacia L. flower exosome-like nanoparticles attenuates gastric and small intestinal mucosal ferroptosis caused by hypoxia through inhibiting HIF-1alpha- and HIF-2alpha-mediated lipid peroxidation.
Wang D, Zhang H, Liao X, Li J, Zeng J, Wang Y, Zhang M, Ma X, Wang X, Ren F, Wang Y, Li M, Xu J, Jin P, Sheng J. Wang D, et al. J Nanobiotechnology. 2024 Aug 12;22(1):479. doi: 10.1186/s12951-024-02663-6. J Nanobiotechnology. 2024. PMID: 39134988 Free PMC article.
In vitro experiments using gastric and small intestinal epithelial cell lines showed that cell death caused by elevated HIF-1alpha and HIF-2alpha under 1% O(2) mainly occurred via ferroptosis. ...In conclusion, our findings underscore the potential of …
In vitro experiments using gastric and small intestinal epithelial cell lines showed that cell death caused by e …
A two-front nutrient supply environment fuels small intestinal physiology through differential regulation of nutrient absorption and host defense.
Zhang J, Tian R, Liu J, Yuan J, Zhang S, Chi Z, Yu W, Yu Q, Wang Z, Chen S, Li M, Yang D, Hu T, Deng Q, Lu X, Yang Y, Zhou R, Zhang X, Liu W, Wang D. Zhang J, et al. Cell. 2024 Oct 31;187(22):6251-6271.e20. doi: 10.1016/j.cell.2024.08.012. Epub 2024 Oct 19. Cell. 2024. PMID: 39427662 Free article.
Yet, it is unknown how each side contributes differentially to the small intestinal physiology. Here, we generated a comprehensive, high-resolution map of the small intestinal two-front nutrient supply environment. ...This study improves our understand …
Yet, it is unknown how each side contributes differentially to the small intestinal physiology. Here, we generated a comprehen …
Glutamine for Amelioration of Radiation and Chemotherapy Associated Mucositis during Cancer Therapy.
Anderson PM, Lalla RV. Anderson PM, et al. Nutrients. 2020 Jun 4;12(6):1675. doi: 10.3390/nu12061675. Nutrients. 2020. PMID: 32512833 Free PMC article. Review.
Benefits include not only better nutrition, but also decreased mucosal damage (mucositis, stomatitis, pharyngitis, esophagitis, and enteritis). Glutamine supplementation in a high protein diet (10 grams/day) + disaccharides, such as sucrose and/or trehalose, is a co …
Benefits include not only better nutrition, but also decreased mucosal damage (mucositis, stomatitis, pharyngitis, esophagitis …
RANK drives structured intestinal epithelial expansion during pregnancy.
Onji M, Sigl V, Lendl T, Novatchkova M, Ullate-Agote A, Andersson-Rolf A, Kozieradzki I, Koglgruber R, Pai TP, Lichtscheidl D, Nayak K, Zilbauer M, Carranza García NA, Sievers LK, Falk-Paulsen M, Cronin SJF, Hagelkruys A, Sawa S, Osborne LC, Rosenstiel P, Pasparakis M, Ruland J, Takayanagi H, Clevers H, Koo BK, Penninger JM. Onji M, et al. Nature. 2025 Jan;637(8044):156-166. doi: 10.1038/s41586-024-08284-1. Epub 2024 Dec 4. Nature. 2025. PMID: 39633049 Free PMC article.
Receptor activator of nuclear factor-kappabeta (RANK, encoded by TNFRSF11A) and its ligand RANKL were identified as a molecular pathway involved in this villous expansion of the small intestine in vivo in mice and in intestinal mouse and human organoids. Mech …
Receptor activator of nuclear factor-kappabeta (RANK, encoded by TNFRSF11A) and its ligand RANKL were identified as a molecular pathway invo …
Akkermansia muciniphila Selectively Reshapes Small Intestinal Cell Populations.
Edens-Valentine R, Engevik KA, Engevik MA, Engevik AC. Edens-Valentine R, et al. J Histochem Cytochem. 2026 Mar-Apr;74(2):215-233. doi: 10.1369/00221554261417734. Epub 2026 Feb 16. J Histochem Cytochem. 2026. PMID: 41693610 Free PMC article.
While well studied in the colon, its influence on the small intestine remains underexplored. To examine direct effects of A. muciniphila, we used gnotobiotic mice. ...Analysis of conditioned media and the A. muciniphila genome identified succinate production, a meta …
While well studied in the colon, its influence on the small intestine remains underexplored. To examine direct effects of A. m …
Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.
Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J. Nadjsombati MS, et al. Immunity. 2018 Jul 17;49(1):33-41.e7. doi: 10.1016/j.immuni.2018.06.016. Immunity. 2018. PMID: 30021144 Free PMC article.
In the small intestine, type 2 responses are regulated by a signaling circuit that involves tuft cells and group 2 innate lymphoid cells (ILC2s). Here, we identified the microbial metabolite succinate as an activating ligand for small intesti …
In the small intestine, type 2 responses are regulated by a signaling circuit that involves tuft cells and group 2 inna …
Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages.
Gabanyi I, Muller PA, Feighery L, Oliveira TY, Costa-Pinto FA, Mucida D. Gabanyi I, et al. Cell. 2016 Jan 28;164(3):378-91. doi: 10.1016/j.cell.2015.12.023. Epub 2016 Jan 14. Cell. 2016. PMID: 26777404 Free PMC article.
Proper adaptation to environmental perturbations is essential for tissue homeostasis. In the intestine, diverse environmental cues can be sensed by immune cells, which must balance resistance to microorganisms with tolerance, avoiding excess tissue damage. ...
Proper adaptation to environmental perturbations is essential for tissue homeostasis. In the intestine, diverse environmental cues ca …
HIV/SIV enteropathy.
Zeitz M, Ullrich R, Schneider T, Kewenig S, Hohloch K, Riecken EO. Zeitz M, et al. Ann N Y Acad Sci. 1998 Nov 17;859:139-48. doi: 10.1111/j.1749-6632.1998.tb11118.x. Ann N Y Acad Sci. 1998. PMID: 9928377 Review.
It has been shown in both humans infected with HIV and in nonhuman primates infected with SIV that a rapid, very early, and more pronounced loss of CD4+ T-cells occurs in the mucosa in comparison to the peripheral blood. The loss of this important regulatory T-cell …
It has been shown in both humans infected with HIV and in nonhuman primates infected with SIV that a rapid, very early, and more pronounced …
A single cell survey of the microbial impacts on the mouse small intestinal epithelium.
Tsang DKL, Wang RJ, De Sa O, Ayyaz A, Foerster EG, Bayer G, Goyal S, Trcka D, Ghoshal B, Wrana JL, Girardin SE, Philpott DJ. Tsang DKL, et al. Gut Microbes. 2022 Jan-Dec;14(1):2108281. doi: 10.1080/19490976.2022.2108281. Gut Microbes. 2022. PMID: 35939622 Free PMC article.
The small intestinal epithelial barrier inputs signals from the gut microbiota in order to balance physiological inflammation and tolerance, and to promote homeostasis. ...Here, we used single-cell RNA sequencing of small intestinal epithelial …
The small intestinal epithelial barrier inputs signals from the gut microbiota in order to balance physiological inflammation …
Towards Full Thickness Small Intestinal Models: Incorporation of Stromal Cells.
Asal M, Rep M, Bontkes HJ, van Vliet SJ, Mebius RE, Gibbs S. Asal M, et al. Tissue Eng Regen Med. 2024 Apr;21(3):369-377. doi: 10.1007/s13770-023-00600-6. Epub 2023 Dec 19. Tissue Eng Regen Med. 2024. PMID: 38113015 Free PMC article. Review.
INTRODUCTION: Since small intestine is one of the major barriers of the human body, there is a need to develop reliable in vitro human small intestinal models. ...In addition, stromal cells influence the intestinal epithelial barrier, sup …
INTRODUCTION: Since small intestine is one of the major barriers of the human body, there is a need to develop reliable in vit …
24,382 results
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