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Did you mean shrna modification (4,271 results)?
Structures and mechanisms of U6 snRNA m(6)A modification by METTL16.
Ju J, Tomita K. Ju J, et al. Nat Commun. 2025 Aug 21;16(1):7708. doi: 10.1038/s41467-025-63021-0. Nat Commun. 2025. PMID: 40841561 Free PMC article.
The N(6)-methyladenosine (m(6)A) modification in U6 snRNA, catalyzed by METTL16 using S-adenosylmethionine (SAM) as the methyl donor, is required for efficient and accurate pre-mRNA splicing. However, the mechanism by which METTL16 modifies U6 snRNA with m(6) …
The N(6)-methyladenosine (m(6)A) modification in U6 snRNA, catalyzed by METTL16 using S-adenosylmethionine (SAM) as the methyl …
Mechanistic insights into m6A modification of U6 snRNA by human METTL16.
Aoyama T, Yamashita S, Tomita K. Aoyama T, et al. Nucleic Acids Res. 2020 May 21;48(9):5157-5168. doi: 10.1093/nar/gkaa227. Nucleic Acids Res. 2020. PMID: 32266935 Free PMC article.
The N6-methyladenosine modification at position 43 (m6A43) of U6 snRNA is catalyzed by METTL16, and is important for the 5'-splice site recognition by U6 snRNA during pre-mRNA splicing. ...Therefore, the MTD and VCR in METTL16 cooperatively facilitate the m6A …
The N6-methyladenosine modification at position 43 (m6A43) of U6 snRNA is catalyzed by METTL16, and is important for the 5'-sp …
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification.
Liu B, Wu T, Miao BA, Ji F, Liu S, Wang P, Zhao Y, Zhong Y, Sundaram A, Zeng TB, Majcherska-Agrawal M, Keenan RJ, Pan T, He C. Liu B, et al. Cell. 2025 Jan 23;188(2):465-483.e22. doi: 10.1016/j.cell.2024.10.046. Epub 2024 Nov 22. Cell. 2025. PMID: 39579764 Free PMC article.
Small nucleolar RNAs (snoRNAs) are non-coding RNAs known for guiding RNA modifications, including 2'-O-methylation (N(m)) and pseudouridine (psi). ...Many interactions occur outside of snoRNA-guided RNA modification sites, hinting at non-canonic …
Small nucleolar RNAs (snoRNAs) are non-coding RNAs known for guiding RNA modifications, including 2'-O-methylation (N(m …
NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion.
Wu R, Sun C, Chen X, Yang R, Luan Y, Zhao X, Yu P, Luo R, Hou Y, Tian R, Bian S, Li Y, Dong Y, Liu Q, Dai W, Fan Z, Yan R, Pan B, Feng S, Wu J, Chen F, Yang C, Wang H, Dai H, Shu M. Wu R, et al. Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2321611121. doi: 10.1073/pnas.2321611121. Epub 2024 Mar 28. Proc Natl Acad Sci U S A. 2024. PMID: 38547058 Free PMC article.
Malignant glioma exhibits immune evasion characterized by highly expressing the immune checkpoint CD47. RNA 5-methylcytosine(m5C) modification plays a pivotal role in tumor pathogenesis. However, the mechanism underlying m5C-modified RNA metabolism remains un …
Malignant glioma exhibits immune evasion characterized by highly expressing the immune checkpoint CD47. RNA 5-methylcytosine(m5C) …
Spliceosomal snRNA Epitranscriptomics.
Morais P, Adachi H, Yu YT. Morais P, et al. Front Genet. 2021 Mar 2;12:652129. doi: 10.3389/fgene.2021.652129. eCollection 2021. Front Genet. 2021. PMID: 33737950 Free PMC article. Review.
Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins ( …
Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNA …
m(6)A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5' splice site.
Parker MT, Soanes BK, Kusakina J, Larrieu A, Knop K, Joy N, Breidenbach F, Sherwood AV, Barton GJ, Fica SM, Davies BH, Simpson GG. Parker MT, et al. Elife. 2022 Nov 21;11:e78808. doi: 10.7554/eLife.78808. Elife. 2022. PMID: 36409063 Free PMC article.
Here, we show that m(6)A modified U6 snRNA determines the accuracy and efficiency of splicing. We reveal that the conserved methyltransferase, FIONA1, is required for Arabidopsis U6 snRNA m(6)A modification. ...In non-mutant plants, this enzyme chemically mod …
Here, we show that m(6)A modified U6 snRNA determines the accuracy and efficiency of splicing. We reveal that the conserved methyltra …
scaRNA20 promotes pseudouridylatory modification of small nuclear snRNA U12 and improves cardiomyogenesis.
Perales S, Sigamani V, Rajasingh S, Gurusamy N, Bittel D, Czirok A, Radic M, Rajasingh J. Perales S, et al. Exp Cell Res. 2024 Mar 1;436(1):113961. doi: 10.1016/j.yexcr.2024.113961. Epub 2024 Feb 9. Exp Cell Res. 2024. PMID: 38341080 Free PMC article.
Non-coding RNAs, particularly small Cajal-body associated RNAs (scaRNAs), play a significant role in spliceosomal RNA modifications. ...STAT3 inhibition in scaRNA20-OE-iPSCs hindered cardiac differentiation. RNA immunoprecipitation revealed increased p …
Non-coding RNAs, particularly small Cajal-body associated RNAs (scaRNAs), play a significant role in spliceosomal RNA modif …
LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice.
Wang X, Li ZT, Yan Y, Lin P, Tang W, Hasler D, Meduri R, Li Y, Hua MM, Qi HT, Lin DH, Shi HJ, Hui J, Li J, Li D, Yang JH, Lin J, Meister G, Fischer U, Liu MF. Wang X, et al. Mol Cell. 2020 Mar 5;77(5):999-1013.e6. doi: 10.1016/j.molcel.2020.01.002. Epub 2020 Feb 3. Mol Cell. 2020. PMID: 32017896 Free article.
U6 snRNA, as an essential component of the catalytic core of the pre-mRNA processing spliceosome, is heavily modified post-transcriptionally, with 2'-O-methylation being most common. The role of these modifications in pre-mRNA splicing as well as their physiological …
U6 snRNA, as an essential component of the catalytic core of the pre-mRNA processing spliceosome, is heavily modified post-transcript …
GlycoRNA: A new player in cellular communication.
Kim HS. Kim HS. Oncol Res. 2025 Apr 18;33(5):995-1000. doi: 10.32604/or.2025.060616. eCollection 2025. Oncol Res. 2025. PMID: 40296915 Free PMC article.
The discovery of glycosylated RNA molecules, known as glycoRNAs, introduces a novel dimension to cellular biology. ...
The discovery of glycosylated RNA molecules, known as glycoRNAs, introduces a novel dimension to cellular biology. ...
U6 snRNA m6A modification is required for accurate and efficient splicing of C. elegans and human pre-mRNAs.
Shen A, Hencel K, Parker MT, Scott R, Skukan R, Adesina AS, Metheringham CL, Miska EA, Nam Y, Haerty W, Simpson GG, Akay A. Shen A, et al. Nucleic Acids Res. 2024 Aug 27;52(15):9139-9160. doi: 10.1093/nar/gkae447. Nucleic Acids Res. 2024. PMID: 38808663 Free PMC article.
Both cis- and trans-splicing rely on accurately recognising splice site sequences by spliceosomal U snRNAs and associated proteins. Spliceosomal snRNAs carry multiple RNA modifications with the potential to affect different stages of pre-mRNA splicing. …
Both cis- and trans-splicing rely on accurately recognising splice site sequences by spliceosomal U snRNAs and associated proteins. S …
1,943 results