Bacterial ADP-heptose triggers stem cell regeneration in the intestinal epithelium following injury.
Goyal S, Guo CX, Singh O, Ranger A, Harrigan CF, Meade J, Luchak A, Tsang DK, Gaisano HY, Gao N, Yuzwa SA, Wrana JL, Philpott DJ, Gray-Owen SD, Girardin SE.
Goyal S, et al.
Cell Stem Cell. 2025 Aug 7;32(8):1235-1250.e6. doi: 10.1016/j.stem.2025.06.009. Epub 2025 Jul 11.
Cell Stem Cell. 2025.
PMID: 40651470
Single-cell transcriptomics and lineage-tracing experiments identified Paneth cells as a cell of origin for revSC induction in response to ADP-Hep. In vivo, revSC emergence following irradiation or dextran-sodium-sulfate-induced injury was blunted in Tifa(-/- …
Single-cell transcriptomics and lineage-tracing experiments identified Paneth cells as a cell of origin for revSC induction in respon …