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Page 1
Combinatorial use of sodium laurate with taurine or L-glutamine enhances colonic absorption of rebamipide, poorly absorbable antiulcer drug, without any serious histopathological mucosal damages.
Miyake M, Oka Y, Minami T, Toguchi H, Odomi M, Ogawara K, Higaki K, Kimura T. Miyake M, et al. J Pharm Sci. 2003 Apr;92(4):911-21. doi: 10.1002/jps.10362. J Pharm Sci. 2003. PMID: 12661076
We previously reported that the combinatorial use of sodium laurate (C12) with several amino acids such as taurine (Tau) and L-glutamine (L-Gln) enhanced the colonic absorption of phenol red with attenuating the local toxicity caused by C12. However, even the …
We previously reported that the combinatorial use of sodium laurate (C12) with several amino acids such as taurine (Tau …
Optimization of suppository preparation containing sodium laurate and taurine that can safely improve rectal absorption of rebamipide.
Miyake M, Minami T, Oka Y, Kamada N, Yamazaki H, Kato Y, Mukai T, Toguchi H, Odomi M, Ogawara K, Higaki K, Kimura T. Miyake M, et al. Biol Pharm Bull. 2006 Feb;29(2):330-5. doi: 10.1248/bpb.29.330. Biol Pharm Bull. 2006. PMID: 16462041 Free article.
We previously reported that the fatty base suppository containing sodium laurate (C12) and taurine (Tau) (C12-Tau suppository) could enhance the colonic absorption of rebamipide, a poorly water-soluble and poorly absorbable drug, without any serious mucosal d …
We previously reported that the fatty base suppository containing sodium laurate (C12) and taurine (Tau) (C12-Tau suppo …
Development of suppository formulation safely improving rectal absorption of rebamipide, a poorly absorbable drug, by utilizing sodium laurate and taurine.
Miyake M, Kamada N, Oka Y, Mukai T, Minami T, Toguchi H, Odomi M, Ogawara K, Higaki K, Kimura T. Miyake M, et al. J Control Release. 2004 Sep 14;99(1):63-71. doi: 10.1016/j.jconrel.2004.06.007. J Control Release. 2004. PMID: 15342181
To develop the safe formulation that can safely improve bioavailability of poorly absorbable drugs and that is practically available, we prepared the suppositories of rebamipide, a poorly soluble and poorly absorbable antiulcer drug, by employing the combinatorial use of sodiu …
To develop the safe formulation that can safely improve bioavailability of poorly absorbable drugs and that is practically available, we pre …
[Improvement and prediction of intestinal drug absorption].
Miyake M. Miyake M. Yakugaku Zasshi. 2013;133(9):995-1006. doi: 10.1248/yakushi.13-00172. Yakugaku Zasshi. 2013. PMID: 23995808 Free article. Review. Japanese.
The suppository preparation, which can improve the absorption of poorly absorbable drugs safer than commercially available suppositories, was developed by utilizing sodium laurate and taurine. Additionally, the novel oral absorption-improving system was also …
The suppository preparation, which can improve the absorption of poorly absorbable drugs safer than commercially available suppositories, wa …
Amino acids suppress apoptosis induced by sodium laurate, an absorption enhancer.
Takayama C, Mukaizawa F, Fujita T, Ogawara K, Higaki K, Kimura T. Takayama C, et al. J Pharm Sci. 2009 Dec;98(12):4629-38. doi: 10.1002/jps.21757. J Pharm Sci. 2009. PMID: 19630065
The formulation containing sodium laurate (C12), an absorption enhancer, and several amino acids such as taurine (Tau) and L-glutamine (L-Gln) is a promising preparation that can safely improve the intestinal absorption of poorly absorbable drugs. ...
The formulation containing sodium laurate (C12), an absorption enhancer, and several amino acids such as taurine (Tau) …
[Safe improvement of drug absorption by combinatorial use of sodium laurate with amino acids: cytoprotection by amino acids and its mechanisms].
Higaki K. Higaki K. Yakugaku Zasshi. 2007 Apr;127(4):589-99. doi: 10.1248/yakushi.127.589. Yakugaku Zasshi. 2007. PMID: 17409688 Free article. Review. Japanese.
Our biochemical and histopathologic studies showed that several amino acids such as taurine and L-glutamine had cytoprotective activity, and it has been found that the combinatorial use of sodium laurate (C12) with these amino acids could maintain the absorpt …
Our biochemical and histopathologic studies showed that several amino acids such as taurine and L-glutamine had cytoprotective activi …
Enhancement of colonic drug absorption by the paracellular permeation route.
Tomita M, Shiga M, Hayashi M, Awazu S. Tomita M, et al. Pharm Res. 1988 Jun;5(6):341-6. doi: 10.1023/a:1015999309353. Pharm Res. 1988. PMID: 3244645
Colonic absorption of poorly absorbable cefmetazole was shown to increase considerably by the addition of 1% sodium caprate, sodium laurate, and mixed micelles composed of sodium oleate and sodium taurocholate. ...These results suggest that ther …
Colonic absorption of poorly absorbable cefmetazole was shown to increase considerably by the addition of 1% sodium caprate, sodiu …
Involvement of intracellular Ca2+ dynamics in cytoprotective action by amino acids and cytotoxicity by sodium laurate, an absorption enhancer.
Okuda T, Kadotsuji K, Takayama C, Hanada K, Mukaizawa F, Ogawara K, Higaki K, Kimura T. Okuda T, et al. J Pharm Sci. 2006 Oct;95(10):2256-65. doi: 10.1002/jps.20712. J Pharm Sci. 2006. PMID: 16886194
In our previous studies, taurine (Tau) and L-glutamine protected intestinal epithelial cells from local toxicity caused by sodium laurate (C12), an absorption enhancer, while maintaining sufficient absorption-enhancing effect of C12, and it was suggested that …
In our previous studies, taurine (Tau) and L-glutamine protected intestinal epithelial cells from local toxicity caused by sodium …
Mechanisms of cytoprotective effect of amino acids on local toxicity caused by sodium laurate, a drug absorption enhancer, in intestinal epithelium.
Endo Y, Hanada K, Miyake M, Ogawara K, Higaki K, Kimura T. Endo Y, et al. J Pharm Sci. 2002 Mar;91(3):730-43. doi: 10.1002/jps.10049. J Pharm Sci. 2002. PMID: 11920758
Several amino acids, including L-glutamine (L-Gln), were found to protect the intestinal epithelial cells from the local toxicity caused by a drug absorption enhancer, sodium laurate (C12), in our previous study. To develop more efficient and safer formulations for …
Several amino acids, including L-glutamine (L-Gln), were found to protect the intestinal epithelial cells from the local toxicity caused by …
Effect of various detergents on protein migration in the second dimension of two-dimensional gels.
Lopez MF, Patton WF, Utterback BL, Chung-Welch N, Barry P, Skea WM, Cambria RP. Lopez MF, et al. Anal Biochem. 1991 Nov 15;199(1):35-44. doi: 10.1016/0003-2697(91)90266-v. Anal Biochem. 1991. PMID: 1807160
The effect of substituting various detergents for sodium dodecyl sulfate (SDS) in the second dimension (PAGE) was investigated. Individual C-10 through C-14 alkyl sulfates, C-11 through C-14 alkyl sulfonates, sodium N-lauroyl-N-methyl-taurine, N-lauroylsarcos …
The effect of substituting various detergents for sodium dodecyl sulfate (SDS) in the second dimension (PAGE) was investigated. Indiv …
11 results