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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 1
2007 1
2010 1
2012 1
2014 2
2015 3
2017 1
2018 1
2019 5
2020 3
2021 2
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20 results
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Page 1
De novo design of potent and selective mimics of IL-2 and IL-15.
Silva DA, Yu S, Ulge UY, Spangler JB, Jude KM, Labão-Almeida C, Ali LR, Quijano-Rubio A, Ruterbusch M, Leung I, Biary T, Crowley SJ, Marcos E, Walkey CD, Weitzner BD, Pardo-Avila F, Castellanos J, Carter L, Stewart L, Riddell SR, Pepper M, Bernardes GJL, Dougan M, Garcia KC, Baker D. Silva DA, et al. Among authors: spangler jb. Nature. 2019 Jan;565(7738):186-191. doi: 10.1038/s41586-018-0830-7. Epub 2019 Jan 9. Nature. 2019. PMID: 30626941 Free PMC article.
IgM autoantibodies recognizing ACE2 are associated with severe COVID-19.
Casciola-Rosen L, Thiemann DR, Andrade F, Trejo Zambrano MI, Hooper JE, Leonard E, Spangler J, Cox AL, Machamer C, Sauer L, Laeyendecker O, Garibaldi BT, Ray SC, Mecoli C, Christopher-Stine L, Gutierrez-Alamillo L, Yang Q, Hines D, Clarke W, Rothman RE, Pekosz A, Fenstermacher K, Wang Z, Zeger SL, Rosen A. Casciola-Rosen L, et al. Among authors: spangler j. medRxiv. 2020 Oct 15:2020.10.13.20211664. doi: 10.1101/2020.10.13.20211664. Preprint. medRxiv. 2020. PMID: 33083808 Free PMC article.
Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.
Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, Waldmann TA, Garcia KC, Leonard WJ. Mitra S, et al. Among authors: spangler jb. Immunity. 2015 May 19;42(5):826-38. doi: 10.1016/j.immuni.2015.04.018. Immunity. 2015. PMID: 25992859 Free PMC article.
Weaponizing T-cell receptors through molecular engineering.
Leonard EK, Leff MI, Spangler JB. Leonard EK, et al. Among authors: spangler jb. J Biol Chem. 2019 Apr 12;294(15):5805-5806. doi: 10.1074/jbc.H119.008479. J Biol Chem. 2019. PMID: 30979848 Free PMC article.
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