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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1977 1
1978 1
1979 1
1980 2
1981 2
1982 4
1983 4
1984 11
1985 6
1986 5
1987 6
1988 9
1989 8
1990 6
1991 5
1992 2
1993 6
1994 6
1995 8
1996 13
1997 14
1998 12
1999 9
2000 11
2001 8
2002 12
2003 16
2004 12
2005 16
2006 18
2007 16
2008 19
2009 20
2010 17
2011 26
2012 19
2013 20
2014 19
2015 19
2016 23
2017 29
2018 33
2019 28
2020 23
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486 results
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Page 1
Clinical pharmacokinetics of metformin.
Graham GG, Punt J, Arora M, Day RO, Doogue MP, Duong JK, Furlong TJ, Greenfield JR, Greenup LC, Kirkpatrick CM, Ray JE, Timmins P, Williams KM. Graham GG, et al. Clin Pharmacokinet. 2011 Feb;50(2):81-98. doi: 10.2165/11534750-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21241070 Review.
Chemically, it is a hydrophilic base which exists at physiological pH as the cationic species (>99.9%). Consequently, its passive diffusion through cell membranes should be very limited. The mean SD fractional oral bioavailability (F) of metformin is 55 16 …
Chemically, it is a hydrophilic base which exists at physiological pH as the cationic species (>99.9%). Consequently, its passive …
Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol.
Chimento A, De Amicis F, Sirianni R, Sinicropi MS, Puoci F, Casaburi I, Saturnino C, Pezzi V. Chimento A, et al. Int J Mol Sci. 2019 Mar 19;20(6):1381. doi: 10.3390/ijms20061381. Int J Mol Sci. 2019. PMID: 30893846 Free PMC article. Review.
In mammalian models, RSV is extensively metabolized and rapidly eliminated and therefore it shows a poor bioavailability, in spite it of its lipophilic nature. During the past decade, in order to improve RSV low aqueous solubility, absorption, membrane transport, and its p …
In mammalian models, RSV is extensively metabolized and rapidly eliminated and therefore it shows a poor bioavailability, in spite it …
Species comparison of oral bioavailability, first-pass metabolism and pharmacokinetics of acetaminophen.
Neirinckx E, Vervaet C, De Boever S, Remon JP, Gommeren K, Daminet S, De Backer P, Croubels S. Neirinckx E, et al. Res Vet Sci. 2010 Aug;89(1):113-9. doi: 10.1016/j.rvsc.2010.02.002. Epub 2010 Mar 7. Res Vet Sci. 2010. PMID: 20211479
Species differences in oral bioavailability, first-pass metabolism and pharmacokinetics of biopharmaceutics classification system (BCS) class I compound acetaminophen were studied. ...Evidence of species differences in acetaminophen metab
Species differences in oral bioavailability, first-pass metabolism and pharmacokinetics of biopharmaceutics clas
Role of P-glycoprotein in pharmacokinetics: clinical implications.
Lin JH, Yamazaki M. Lin JH, et al. Clin Pharmacokinet. 2003;42(1):59-98. doi: 10.2165/00003088-200342010-00003. Clin Pharmacokinet. 2003. PMID: 12489979 Review.
P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter, functions as a biological barrier by extruding toxins and xenobiotics out of cells. ...Current information from our laboratory suggests that in vivo P-glycoprotein activity for a given dru …
P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter, functions as a biological barrier by extruding t …
Reconciling Human-Canine Differences in Oral Bioavailability: Looking beyond the Biopharmaceutics Classification System.
Martinez MN, El-Kattan A, Awji E, Papich M. Martinez MN, et al. AAPS J. 2019 Aug 8;21(5):99. doi: 10.1208/s12248-019-0364-4. AAPS J. 2019. PMID: 31396733
The extrapolation of oral bioavailability (F) information between dogs and humans has had an important role in the drug development process, whether it be to support an assessment of potential human pharmaceutical formulations or to identify the bioavailability
The extrapolation of oral bioavailability (F) information between dogs and humans has had an important role in the drug develo …
Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species.
Zhong CC, Chen F, Yang JL, Jia WW, Li L, Cheng C, Du FF, Zhang SP, Xie CY, Zhang NT, Olaleye OE, Wang FQ, Xu F, Lou LG, Chen DY, Niu W, Li C. Zhong CC, et al. Acta Pharmacol Sin. 2018 Jun;39(6):1048-1063. doi: 10.1038/aps.2017.199. Epub 2018 Apr 5. Acta Pharmacol Sin. 2018. PMID: 29620050 Free PMC article.
Anlotinib, having good membrane permeability, was rapidly absorbed with oral bioavailability of 28%-58% in rats and 41%-77% in dogs. Terminal half-life of anlotinib in dogs (22.811.0 h) was longer than that in rats (5.11.6 h). This difference appeared to be m …
Anlotinib, having good membrane permeability, was rapidly absorbed with oral bioavailability of 28%-58% in rats and 41%-77% in …
Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides.
He YL, Murby S, Warhurst G, Gifford L, Walker D, Ayrton J, Eastmond R, Rowland M. He YL, et al. J Pharm Sci. 1998 May;87(5):626-33. doi: 10.1021/js970120d. J Pharm Sci. 1998. PMID: 9572915
However, there is little comparative quantitative information on species differences in paracellular permeation, which is an important route for oral absorption of small to medium-sized hydrophilic drug molecules. ...A clear molecular mass dependency in or
However, there is little comparative quantitative information on species differences in paracellular permeation, which is an i …
Species comparison of enantioselective oral bioavailability and pharmacokinetics of ketoprofen.
Neirinckx E, Croubels S, De Boever S, Remon JP, Bosmans T, Daminet S, De Backer P, Vervaet C. Neirinckx E, et al. Res Vet Sci. 2011 Dec;91(3):415-21. doi: 10.1016/j.rvsc.2010.08.017. Epub 2010 Oct 18. Res Vet Sci. 2011. PMID: 20961590
As a part of ongoing research to further elucidate frequent and species-specific causes of differences in oral bioavailability, a 3mg/kg dose of racemic ketoprofen, a high permeability/low solubility compound in the human biopharmaceutics classificatio …
As a part of ongoing research to further elucidate frequent and species-specific causes of differences in oral bioav
Species differences in oral bioavailability of methotrexate between rats and monkeys.
Kuroda T, Namba K, Torimaru T, Kawashima K, Hayashi M. Kuroda T, et al. Biol Pharm Bull. 2000 Mar;23(3):334-8. doi: 10.1248/bpb.23.334. Biol Pharm Bull. 2000. PMID: 10726889
Plasma concentration profiles of MTX in rats showed linear and nonlinear pharmacokinetics respectively after intravenous (i.v.) and oral dosing of 0.1, 0.5 or 2.5 mg/kg MTX. In rats, most of the dose was excreted as the parent compound into bile and urine after i.v. dosing …
Plasma concentration profiles of MTX in rats showed linear and nonlinear pharmacokinetics respectively after intravenous (i.v.) and oral
A pilot study of oral bioavailability of dioxins and furans from contaminated soils: Impact of differential hepatic enzyme activity and species differences.
Budinsky RA, Rowlands JC, Casteel S, Fent G, Cushing CA, Newsted J, Giesy JP, Ruby MV, Aylward LL. Budinsky RA, et al. Chemosphere. 2008 Feb;70(10):1774-86. doi: 10.1016/j.chemosphere.2007.08.035. Epub 2007 Oct 22. Chemosphere. 2008. PMID: 17945330
When hepatic enzyme induction was matched between the soil and spiked control groups, the apparent relative bioavailability for TCDF was reduced significantly. Overall, after controlling for hepatic enzyme induction, estimates of relative bioavailability in rats and …
When hepatic enzyme induction was matched between the soil and spiked control groups, the apparent relative bioavailability for TCDF …
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