Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1977 1
1978 1
1979 1
1980 2
1981 2
1982 4
1983 4
1984 11
1985 6
1986 5
1987 6
1988 9
1989 8
1990 6
1991 5
1992 2
1993 6
1994 6
1995 8
1996 13
1997 14
1998 12
1999 9
2000 11
2001 8
2002 12
2003 16
2004 12
2005 16
2006 18
2007 16
2008 19
2009 20
2010 17
2011 26
2012 19
2013 20
2014 19
2015 19
2016 23
2017 29
2018 34
2019 28
2020 30
2021 29
2022 27
2023 32

Text availability

Article attribute

Article type

Publication date

Search Results

569 results

Results by year

Filters applied: . Clear all
Page 1
Clinical pharmacokinetics of metformin.
Graham GG, Punt J, Arora M, Day RO, Doogue MP, Duong JK, Furlong TJ, Greenfield JR, Greenup LC, Kirkpatrick CM, Ray JE, Timmins P, Williams KM. Graham GG, et al. Clin Pharmacokinet. 2011 Feb;50(2):81-98. doi: 10.2165/11534750-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21241070 Review.
Chemically, it is a hydrophilic base which exists at physiological pH as the cationic species (>99.9%). Consequently, its passive diffusion through cell membranes should be very limited. The mean SD fractional oral bioavailability (F) of metformin is 55 16 …
Chemically, it is a hydrophilic base which exists at physiological pH as the cationic species (>99.9%). Consequently, its passive …
Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery.
Zhou J, Li M, Chen Q, Li X, Chen L, Dong Z, Zhu W, Yang Y, Liu Z, Chen Q. Zhou J, et al. Nat Commun. 2022 Jun 14;13(1):3432. doi: 10.1038/s41467-022-31171-0. Nat Commun. 2022. PMID: 35701435 Free PMC article.
Here, Escherichia coli Nissle 1917 (ECN), a kind of oral probiotic, was genetically engineered to overexpress catalase and superoxide dismutase (ECN-pE) for the treatment of intestinal inflammation. ...In a mouse IBD model induced by different chemical drugs, chitos …
Here, Escherichia coli Nissle 1917 (ECN), a kind of oral probiotic, was genetically engineered to overexpress catalase and superoxide …
Role of P-glycoprotein in pharmacokinetics: clinical implications.
Lin JH, Yamazaki M. Lin JH, et al. Clin Pharmacokinet. 2003;42(1):59-98. doi: 10.2165/00003088-200342010-00003. Clin Pharmacokinet. 2003. PMID: 12489979 Review.
P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter, functions as a biological barrier by extruding toxins and xenobiotics out of cells. ...Current information from our laboratory suggests that in vivo P-glycoprotein activity for a given dru …
P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter, functions as a biological barrier by extruding t …
Defining the Optimal Duration of Therapy for Hospitalized Patients With Complicated Urinary Tract Infections and Associated Bacteremia.
McAteer J, Lee JH, Cosgrove SE, Dzintars K, Fiawoo S, Heil EL, Kendall RE, Louie T, Malani AN, Nori P, Percival KM, Tamma PD. McAteer J, et al. Clin Infect Dis. 2023 May 3;76(9):1604-1612. doi: 10.1093/cid/ciad009. Clin Infect Dis. 2023. PMID: 36633559
When limiting the 7-day versus 14-day analysis to the 627 patients who remained on intravenous beta-lactam therapy or were transitioned to highly bioavailable oral agents, differences in outcomes no longer persisted (aOR: .76; 95% CI: .38-1.52). ...CONCLUSION …
When limiting the 7-day versus 14-day analysis to the 627 patients who remained on intravenous beta-lactam therapy or were transitioned to h …
Reconciling Human-Canine Differences in Oral Bioavailability: Looking beyond the Biopharmaceutics Classification System.
Martinez MN, El-Kattan A, Awji E, Papich M. Martinez MN, et al. AAPS J. 2019 Aug 8;21(5):99. doi: 10.1208/s12248-019-0364-4. AAPS J. 2019. PMID: 31396733
The extrapolation of oral bioavailability (F) information between dogs and humans has had an important role in the drug development process, whether it be to support an assessment of potential human pharmaceutical formulations or to identify the bioavailability …
The extrapolation of oral bioavailability (F) information between dogs and humans has had an important role in the drug develo …
Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides.
He YL, Murby S, Warhurst G, Gifford L, Walker D, Ayrton J, Eastmond R, Rowland M. He YL, et al. J Pharm Sci. 1998 May;87(5):626-33. doi: 10.1021/js970120d. J Pharm Sci. 1998. PMID: 9572915
However, there is little comparative quantitative information on species differences in paracellular permeation, which is an important route for oral absorption of small to medium-sized hydrophilic drug molecules. ...A clear molecular mass dependency in or …
However, there is little comparative quantitative information on species differences in paracellular permeation, which is an i …
Species comparison of oral bioavailability, first-pass metabolism and pharmacokinetics of acetaminophen.
Neirinckx E, Vervaet C, De Boever S, Remon JP, Gommeren K, Daminet S, De Backer P, Croubels S. Neirinckx E, et al. Res Vet Sci. 2010 Aug;89(1):113-9. doi: 10.1016/j.rvsc.2010.02.002. Epub 2010 Mar 7. Res Vet Sci. 2010. PMID: 20211479 Free article.
Species differences in oral bioavailability, first-pass metabolism and pharmacokinetics of biopharmaceutics classification system (BCS) class I compound acetaminophen were studied. ...Evidence of species differences in acetaminophen metab …
Species differences in oral bioavailability, first-pass metabolism and pharmacokinetics of biopharmaceutics clas …
Impact of gastrointestinal differences in veterinary species on the oral drug solubility, in vivo dissolution, and formulation of veterinary therapeutics.
Martinez MN, Papich MG, Fahmy R. Martinez MN, et al. ADMET DMPK. 2022 Feb 14;10(1):1-25. doi: 10.5599/admet.1140. eCollection 2022. ADMET DMPK. 2022. PMID: 35360673 Free PMC article.
This information gap can lead to uncertainties with regard to how best to formulate pharmaceuticals for veterinary use or the in vitro test conditions that will be most predictive of species-specific in vivo oral product performance. To address these challenges, thi …
This information gap can lead to uncertainties with regard to how best to formulate pharmaceuticals for veterinary use or the in vitro test …
Species differences in oral bioavailability of methotrexate between rats and monkeys.
Kuroda T, Namba K, Torimaru T, Kawashima K, Hayashi M. Kuroda T, et al. Biol Pharm Bull. 2000 Mar;23(3):334-8. doi: 10.1248/bpb.23.334. Biol Pharm Bull. 2000. PMID: 10726889
Plasma concentration profiles of MTX in rats showed linear and nonlinear pharmacokinetics respectively after intravenous (i.v.) and oral dosing of 0.1, 0.5 or 2.5 mg/kg MTX. In rats, most of the dose was excreted as the parent compound into bile and urine after i.v. dosing …
Plasma concentration profiles of MTX in rats showed linear and nonlinear pharmacokinetics respectively after intravenous (i.v.) and oral …
Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol.
Chimento A, De Amicis F, Sirianni R, Sinicropi MS, Puoci F, Casaburi I, Saturnino C, Pezzi V. Chimento A, et al. Int J Mol Sci. 2019 Mar 19;20(6):1381. doi: 10.3390/ijms20061381. Int J Mol Sci. 2019. PMID: 30893846 Free PMC article. Review.
In mammalian models, RSV is extensively metabolized and rapidly eliminated and therefore it shows a poor bioavailability, in spite it of its lipophilic nature. During the past decade, in order to improve RSV low aqueous solubility, absorption, membrane transport, and its p …
In mammalian models, RSV is extensively metabolized and rapidly eliminated and therefore it shows a poor bioavailability, in spite it …
569 results