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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1977 1
1978 1
1979 1
1980 2
1981 2
1982 4
1983 4
1984 11
1985 6
1986 5
1987 6
1988 9
1989 8
1990 6
1991 5
1992 2
1993 6
1994 6
1995 8
1996 13
1997 14
1998 12
1999 9
2000 11
2001 8
2002 12
2003 16
2004 12
2005 16
2006 18
2007 16
2008 19
2009 20
2010 17
2011 26
2012 19
2013 20
2014 19
2015 19
2016 23
2017 29
2018 34
2019 28
2020 30
2021 27
2022 13
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524 results
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Page 1
Clinical pharmacokinetics of metformin.
Graham GG, Punt J, Arora M, Day RO, Doogue MP, Duong JK, Furlong TJ, Greenfield JR, Greenup LC, Kirkpatrick CM, Ray JE, Timmins P, Williams KM. Graham GG, et al. Clin Pharmacokinet. 2011 Feb;50(2):81-98. doi: 10.2165/11534750-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21241070 Review.
Chemically, it is a hydrophilic base which exists at physiological pH as the cationic species (>99.9%). Consequently, its passive diffusion through cell membranes should be very limited. The mean SD fractional oral bioavailability (F) of metformin is 55 16 …
Chemically, it is a hydrophilic base which exists at physiological pH as the cationic species (>99.9%). Consequently, its passive …
Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol.
Chimento A, De Amicis F, Sirianni R, Sinicropi MS, Puoci F, Casaburi I, Saturnino C, Pezzi V. Chimento A, et al. Int J Mol Sci. 2019 Mar 19;20(6):1381. doi: 10.3390/ijms20061381. Int J Mol Sci. 2019. PMID: 30893846 Free PMC article. Review.
In mammalian models, RSV is extensively metabolized and rapidly eliminated and therefore it shows a poor bioavailability, in spite it of its lipophilic nature. During the past decade, in order to improve RSV low aqueous solubility, absorption, membrane transport, and its p …
In mammalian models, RSV is extensively metabolized and rapidly eliminated and therefore it shows a poor bioavailability, in spite it …
Role of P-glycoprotein in pharmacokinetics: clinical implications.
Lin JH, Yamazaki M. Lin JH, et al. Clin Pharmacokinet. 2003;42(1):59-98. doi: 10.2165/00003088-200342010-00003. Clin Pharmacokinet. 2003. PMID: 12489979 Review.
P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter, functions as a biological barrier by extruding toxins and xenobiotics out of cells. ...Current information from our laboratory suggests that in vivo P-glycoprotein activity for a given dru …
P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter, functions as a biological barrier by extruding t …
Reconciling Human-Canine Differences in Oral Bioavailability: Looking beyond the Biopharmaceutics Classification System.
Martinez MN, El-Kattan A, Awji E, Papich M. Martinez MN, et al. AAPS J. 2019 Aug 8;21(5):99. doi: 10.1208/s12248-019-0364-4. AAPS J. 2019. PMID: 31396733
The extrapolation of oral bioavailability (F) information between dogs and humans has had an important role in the drug development process, whether it be to support an assessment of potential human pharmaceutical formulations or to identify the bioavailability
The extrapolation of oral bioavailability (F) information between dogs and humans has had an important role in the drug develo …
Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides.
He YL, Murby S, Warhurst G, Gifford L, Walker D, Ayrton J, Eastmond R, Rowland M. He YL, et al. J Pharm Sci. 1998 May;87(5):626-33. doi: 10.1021/js970120d. J Pharm Sci. 1998. PMID: 9572915
However, there is little comparative quantitative information on species differences in paracellular permeation, which is an important route for oral absorption of small to medium-sized hydrophilic drug molecules. ...A clear molecular mass dependency in or
However, there is little comparative quantitative information on species differences in paracellular permeation, which is an i …
Species comparison of oral bioavailability, first-pass metabolism and pharmacokinetics of acetaminophen.
Neirinckx E, Vervaet C, De Boever S, Remon JP, Gommeren K, Daminet S, De Backer P, Croubels S. Neirinckx E, et al. Res Vet Sci. 2010 Aug;89(1):113-9. doi: 10.1016/j.rvsc.2010.02.002. Epub 2010 Mar 7. Res Vet Sci. 2010. PMID: 20211479
Species differences in oral bioavailability, first-pass metabolism and pharmacokinetics of biopharmaceutics classification system (BCS) class I compound acetaminophen were studied. ...Evidence of species differences in acetaminophen metab
Species differences in oral bioavailability, first-pass metabolism and pharmacokinetics of biopharmaceutics clas
Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development.
McReynolds CB, Yang J, Guedes A, Morisseau C, Garcia R, Knych H, Tearney C, Hamamoto B, Hwang SH, Wagner K, Hammock BD. McReynolds CB, et al. Molecules. 2021 Aug 19;26(16):5034. doi: 10.3390/molecules26165034. Molecules. 2021. PMID: 34443621 Free PMC article.
The purpose of this paper was to assess the pharmacokinetics after oral and intravenous dosing in domesticated animal species (dogs, cats, and horses) of a novel soluble epoxide hydrolase inhibitor, EC1728, being developed for the treatment of pain in animals. Resul …
The purpose of this paper was to assess the pharmacokinetics after oral and intravenous dosing in domesticated animal species
Species differences in oral bioavailability of methotrexate between rats and monkeys.
Kuroda T, Namba K, Torimaru T, Kawashima K, Hayashi M. Kuroda T, et al. Biol Pharm Bull. 2000 Mar;23(3):334-8. doi: 10.1248/bpb.23.334. Biol Pharm Bull. 2000. PMID: 10726889
Plasma concentration profiles of MTX in rats showed linear and nonlinear pharmacokinetics respectively after intravenous (i.v.) and oral dosing of 0.1, 0.5 or 2.5 mg/kg MTX. In rats, most of the dose was excreted as the parent compound into bile and urine after i.v. dosing …
Plasma concentration profiles of MTX in rats showed linear and nonlinear pharmacokinetics respectively after intravenous (i.v.) and oral
Species comparison of enantioselective oral bioavailability and pharmacokinetics of ketoprofen.
Neirinckx E, Croubels S, De Boever S, Remon JP, Bosmans T, Daminet S, De Backer P, Vervaet C. Neirinckx E, et al. Res Vet Sci. 2011 Dec;91(3):415-21. doi: 10.1016/j.rvsc.2010.08.017. Epub 2010 Oct 18. Res Vet Sci. 2011. PMID: 20961590
As a part of ongoing research to further elucidate frequent and species-specific causes of differences in oral bioavailability, a 3mg/kg dose of racemic ketoprofen, a high permeability/low solubility compound in the human biopharmaceutics classificatio …
As a part of ongoing research to further elucidate frequent and species-specific causes of differences in oral bioav
In vivo oral bioavailability of fish mercury and comparison with in vitro bioaccessibility.
Li W, Wang WX. Li W, et al. Sci Total Environ. 2019 Sep 15;683:648-658. doi: 10.1016/j.scitotenv.2019.05.290. Epub 2019 May 22. Sci Total Environ. 2019. PMID: 31150885
The long-term absolute bioavailability of mice was comparable between the liver and kidney, but much lower in the blood. The calculated absolute total Hg bioavailability ranged between 38% and 99% and decreased as the Hg dosage increased. ...
The long-term absolute bioavailability of mice was comparable between the liver and kidney, but much lower in the blood. The calculat …
524 results