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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
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1979 1
1980 2
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1983 4
1984 11
1985 6
1986 5
1987 6
1988 9
1989 8
1990 6
1991 5
1992 2
1993 6
1994 6
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1996 13
1997 14
1998 12
1999 9
2000 11
2001 8
2002 12
2003 16
2004 12
2005 16
2006 18
2007 16
2008 19
2009 20
2010 17
2011 26
2012 19
2013 20
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2015 19
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2019 28
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628 results

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Page 1
Clinical pharmacokinetics of metformin.
Graham GG, Punt J, Arora M, Day RO, Doogue MP, Duong JK, Furlong TJ, Greenfield JR, Greenup LC, Kirkpatrick CM, Ray JE, Timmins P, Williams KM. Graham GG, et al. Clin Pharmacokinet. 2011 Feb;50(2):81-98. doi: 10.2165/11534750-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21241070 Review.
Chemically, it is a hydrophilic base which exists at physiological pH as the cationic species (>99.9%). Consequently, its passive diffusion through cell membranes should be very limited. The mean SD fractional oral bioavailability (F) of metformin is 55 16 …
Chemically, it is a hydrophilic base which exists at physiological pH as the cationic species (>99.9%). Consequently, its passive …
Role of P-glycoprotein in pharmacokinetics: clinical implications.
Lin JH, Yamazaki M. Lin JH, et al. Clin Pharmacokinet. 2003;42(1):59-98. doi: 10.2165/00003088-200342010-00003. Clin Pharmacokinet. 2003. PMID: 12489979 Review.
However, the relative contribution of intestinal P-glycoprotein to overall drug absorption is unlikely to be quantitatively important unless a very small oral dose is given, or the dissolution and diffusion rates of the drug are very slow. ...On the other hand, there are s …
However, the relative contribution of intestinal P-glycoprotein to overall drug absorption is unlikely to be quantitatively important unless …
Defining the Optimal Duration of Therapy for Hospitalized Patients With Complicated Urinary Tract Infections and Associated Bacteremia.
McAteer J, Lee JH, Cosgrove SE, Dzintars K, Fiawoo S, Heil EL, Kendall RE, Louie T, Malani AN, Nori P, Percival KM, Tamma PD. McAteer J, et al. Clin Infect Dis. 2023 May 3;76(9):1604-1612. doi: 10.1093/cid/ciad009. Clin Infect Dis. 2023. PMID: 36633559 Free PMC article.
When limiting the 7-day versus 14-day analysis to the 627 patients who remained on intravenous beta-lactam therapy or were transitioned to highly bioavailable oral agents, differences in outcomes no longer persisted (aOR: .76; 95% CI: .38-1.52). ...CONCLUSION …
When limiting the 7-day versus 14-day analysis to the 627 patients who remained on intravenous beta-lactam therapy or were transitioned to h …
Reconciling Human-Canine Differences in Oral Bioavailability: Looking beyond the Biopharmaceutics Classification System.
Martinez MN, El-Kattan A, Awji E, Papich M. Martinez MN, et al. AAPS J. 2019 Aug 8;21(5):99. doi: 10.1208/s12248-019-0364-4. AAPS J. 2019. PMID: 31396733
The extrapolation of oral bioavailability (F) information between dogs and humans has had an important role in the drug development process, whether it be to support an assessment of potential human pharmaceutical formulations or to identify the bioavailability …
The extrapolation of oral bioavailability (F) information between dogs and humans has had an important role in the drug develo …
Species differences in oral bioavailability of methotrexate between rats and monkeys.
Kuroda T, Namba K, Torimaru T, Kawashima K, Hayashi M. Kuroda T, et al. Biol Pharm Bull. 2000 Mar;23(3):334-8. doi: 10.1248/bpb.23.334. Biol Pharm Bull. 2000. PMID: 10726889 Free article.
Plasma concentration profiles of MTX in rats showed linear and nonlinear pharmacokinetics respectively after intravenous (i.v.) and oral dosing of 0.1, 0.5 or 2.5 mg/kg MTX. In rats, most of the dose was excreted as the parent compound into bile and urine after i.v. dosing …
Plasma concentration profiles of MTX in rats showed linear and nonlinear pharmacokinetics respectively after intravenous (i.v.) and oral …
Species comparison of oral bioavailability, first-pass metabolism and pharmacokinetics of acetaminophen.
Neirinckx E, Vervaet C, De Boever S, Remon JP, Gommeren K, Daminet S, De Backer P, Croubels S. Neirinckx E, et al. Res Vet Sci. 2010 Aug;89(1):113-9. doi: 10.1016/j.rvsc.2010.02.002. Epub 2010 Mar 7. Res Vet Sci. 2010. PMID: 20211479 Free article.
Species differences in oral bioavailability, first-pass metabolism and pharmacokinetics of biopharmaceutics classification system (BCS) class I compound acetaminophen were studied. ...Evidence of species differences in acetaminophen metab …
Species differences in oral bioavailability, first-pass metabolism and pharmacokinetics of biopharmaceutics clas …
Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides.
He YL, Murby S, Warhurst G, Gifford L, Walker D, Ayrton J, Eastmond R, Rowland M. He YL, et al. J Pharm Sci. 1998 May;87(5):626-33. doi: 10.1021/js970120d. J Pharm Sci. 1998. PMID: 9572915
However, there is little comparative quantitative information on species differences in paracellular permeation, which is an important route for oral absorption of small to medium-sized hydrophilic drug molecules. ...A clear molecular mass dependency in or …
However, there is little comparative quantitative information on species differences in paracellular permeation, which is an i …
Impact of gastrointestinal differences in veterinary species on the oral drug solubility, in vivo dissolution, and formulation of veterinary therapeutics.
Martinez MN, Papich MG, Fahmy R. Martinez MN, et al. ADMET DMPK. 2022 Feb 14;10(1):1-25. doi: 10.5599/admet.1140. eCollection 2022. ADMET DMPK. 2022. PMID: 35360673 Free PMC article.
This information gap can lead to uncertainties with regard to how best to formulate pharmaceuticals for veterinary use or the in vitro test conditions that will be most predictive of species-specific in vivo oral product performance. To address these challenges, thi …
This information gap can lead to uncertainties with regard to how best to formulate pharmaceuticals for veterinary use or the in vitro test …
Species comparison of enantioselective oral bioavailability and pharmacokinetics of ketoprofen.
Neirinckx E, Croubels S, De Boever S, Remon JP, Bosmans T, Daminet S, De Backer P, Vervaet C. Neirinckx E, et al. Res Vet Sci. 2011 Dec;91(3):415-21. doi: 10.1016/j.rvsc.2010.08.017. Epub 2010 Oct 18. Res Vet Sci. 2011. PMID: 20961590
As a part of ongoing research to further elucidate frequent and species-specific causes of differences in oral bioavailability, a 3mg/kg dose of racemic ketoprofen, a high permeability/low solubility compound in the human biopharmaceutics classificatio …
As a part of ongoing research to further elucidate frequent and species-specific causes of differences in oral bioav …
Therapeutic Potential of Ginger Exosome-Like Nanoparticles for Alleviating Periodontitis-Induced Tissue Damage.
Xie Q, Gu J, Sun Y, Hong J, Wang J, Li N, Zhang Y, Liu M, Zhang X, Zhao X, Chen X, Wang X. Xie Q, et al. Int J Nanomedicine. 2024 Nov 15;19:11941-11956. doi: 10.2147/IJN.S483091. eCollection 2024. Int J Nanomedicine. 2024. PMID: 39569064 Free PMC article.
PURPOSE: Periodontitis is a chronic inflammatory oral disease that causes defects in periodontal tissue. Conventional therapies are limited, and often lead to high recurrence rates. ...However, fresh ginger exhibits poor stability and bioavailability. Ginger exosome …
PURPOSE: Periodontitis is a chronic inflammatory oral disease that causes defects in periodontal tissue. Conventional therapies are l …
628 results