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Page 1
Spermidine in health and disease.
Madeo F, Eisenberg T, Pietrocola F, Kroemer G. Madeo F, et al. Science. 2018 Jan 26;359(6374):eaan2788. doi: 10.1126/science.aan2788. Science. 2018. PMID: 29371440 Review.
One such agent, the natural polyamine spermidine, has prominent cardioprotective and neuroprotective effects and stimulates anticancer immunosurveillance in rodent models. Moreover, dietary polyamine uptake correlates with reduced cardiovascular and cancer-related mortalit …
One such agent, the natural polyamine spermidine, has prominent cardioprotective and neuroprotective effects and stimulates anticance …
A comprehensive review of spermidine: Safety, health effects, absorption and metabolism, food materials evaluation, physical and chemical processing, and bioprocessing.
Zou D, Zhao Z, Li L, Min Y, Zhang D, Ji A, Jiang C, Wei X, Wu X. Zou D, et al. Compr Rev Food Sci Food Saf. 2022 May;21(3):2820-2842. doi: 10.1111/1541-4337.12963. Epub 2022 Apr 27. Compr Rev Food Sci Food Saf. 2022. PMID: 35478379 Review.
In particular, the core metabolic pathways, key gene targets, and efficient metabolic engineering strategies involved in the biosynthesis of spermidine and its precursors were discussed. Moreover, limitations and future perspectives of spermidine research were propo …
In particular, the core metabolic pathways, key gene targets, and efficient metabolic engineering strategies involved in the biosynthesis of …
Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice.
Xu TT, Li H, Dai Z, Lau GK, Li BY, Zhu WL, Liu XQ, Liu HF, Cai WW, Huang SQ, Wang Q, Zhang SJ. Xu TT, et al. Aging (Albany NY). 2020 Apr 8;12(7):6401-6414. doi: 10.18632/aging.103035. Epub 2020 Apr 8. Aging (Albany NY). 2020. PMID: 32268299 Free PMC article.
The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia. ...Spermidine and spermine phosphorylate AMPK and regulate autophagy proteins (LC3, Beclin 1 and p62). ...
The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia. ...Spermidine …
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway.
Liu X, Chen A, Liang Q, Yang X, Dong Q, Fu M, Wang S, Li Y, Ye Y, Lan Z, Chen Y, Ou JS, Yang P, Lu L, Yan J. Liu X, et al. Aging Cell. 2021 Jun;20(6):e13377. doi: 10.1111/acel.13377. Epub 2021 May 9. Aging Cell. 2021. PMID: 33969611 Free PMC article.
Additionally, western blot analysis revealed that spermidine treatment inhibited osteogenic differentiation of rat and human VSMCs. Moreover, spermidine treatment remarkably attenuated calcification of rat and human arterial rings ex vivo and aortic calcification in …
Additionally, western blot analysis revealed that spermidine treatment inhibited osteogenic differentiation of rat and human VSMCs. M …
Spermidine as a target for cancer therapy.
Fan J, Feng Z, Chen N. Fan J, et al. Pharmacol Res. 2020 Sep;159:104943. doi: 10.1016/j.phrs.2020.104943. Epub 2020 May 24. Pharmacol Res. 2020. PMID: 32461185 Review.
Spermidine, as a natural component from polyamine members, is originally isolated from semen and also existed in many natural plants, and can be responsible for cell growth and development in eukaryotes. The supplementation of spermidine can extend health and lifesp …
Spermidine, as a natural component from polyamine members, is originally isolated from semen and also existed in many natural plants, …
Spermidine - an old molecule with a new age-defying immune function.
Chamoto K, Zhang B, Tajima M, Honjo T, Fagarasan S. Chamoto K, et al. Trends Cell Biol. 2024 May;34(5):363-370. doi: 10.1016/j.tcb.2023.08.002. Epub 2023 Sep 16. Trends Cell Biol. 2024. PMID: 37723019 Review.
Therefore, spermidine insufficiency is associated with various physio-pathological processes, such as aging and cancers. ...We highlight the effectiveness of spermidine in enhancing antitumor responses in aged animals otherwise nonresponsive to immune checkpoint the …
Therefore, spermidine insufficiency is associated with various physio-pathological processes, such as aging and cancers. ...We highli …
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.
Schwarz C, Benson GS, Horn N, Wurdack K, Grittner U, Schilling R, Märschenz S, Köbe T, Hofer SJ, Magnes C, Stekovic S, Eisenberg T, Sigrist SJ, Schmitz D, Wirth M, Madeo F, Flöel A. Schwarz C, et al. JAMA Netw Open. 2022 May 2;5(5):e2213875. doi: 10.1001/jamanetworkopen.2022.13875. JAMA Netw Open. 2022. PMID: 35616942 Free PMC article. Clinical Trial.
INTERVENTIONS: One hundred participants were randomly assigned (1:1 ratio) to 12 months of dietary supplementation with either a spermidine-rich dietary supplement extracted from wheat germ (0.9 mg spermidine/d) or placebo (microcrystalline cellulose). ...RESULTS: A …
INTERVENTIONS: One hundred participants were randomly assigned (1:1 ratio) to 12 months of dietary supplementation with either a spermidi …
Spermidine, an autophagy inducer, as a therapeutic strategy in neurological disorders.
Ghosh I, Sankhe R, Mudgal J, Arora D, Nampoothiri M. Ghosh I, et al. Neuropeptides. 2020 Oct;83:102083. doi: 10.1016/j.npep.2020.102083. Epub 2020 Aug 24. Neuropeptides. 2020. PMID: 32873420 Review.
Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. ...Exogenously administered spermidine helps in the treatment of brain diseases. Further, current studies highlight the ability of spermidine to promote longevity by …
Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. ...Exogenously administered spermidi …
The untapped potential of spermidine alkaloids: Sources, structures, bioactivities and syntheses.
Shi YJ, Zhang J, Wang YW, Ding K, Yan Y, Xia CY, Li XX, He J, Zhang WK, Xu JK. Shi YJ, et al. Eur J Med Chem. 2022 Oct 5;240:114600. doi: 10.1016/j.ejmech.2022.114600. Epub 2022 Jul 9. Eur J Med Chem. 2022. PMID: 35863273 Review.
In order to better understand the research status of spermidine alkaloids and promote their applications in human health, this paper systematically reviewed the biological sources, structures, pharmacological actions, and synthetic processes of spermidine alkaloids …
In order to better understand the research status of spermidine alkaloids and promote their applications in human health, this paper …
Spermidine ameliorates osteoarthritis via altering macrophage polarization.
Ou Q, Tang S, Zhu J, Xue S, Huang H, Zhao Y, Cai Y, Wu C, Chen J, Ruan G, Ding C. Ou Q, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Apr;1870(4):167083. doi: 10.1016/j.bbadis.2024.167083. Epub 2024 Feb 15. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38367900
OBJECTIVE: Spermidine (SPD) is an anti-aging natural substance, and it exerts effects through anti-apoptosis and anti-inflammation. ...
OBJECTIVE: Spermidine (SPD) is an anti-aging natural substance, and it exerts effects through anti-apoptosis and anti-inflammation. . …
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