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Cardioprotection and lifespan extension by the natural polyamine spermidine.
Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. Nat Med. 2016. PMID: 27841876 Free PMC article.
Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. ...Spermidine feeding failed to provide …
Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotectiv …
Spermidine in health and disease.
Madeo F, Eisenberg T, Pietrocola F, Kroemer G. Madeo F, et al. Science. 2018 Jan 26;359(6374):eaan2788. doi: 10.1126/science.aan2788. Science. 2018. PMID: 29371440 Review.
One such agent, the natural polyamine spermidine, has prominent cardioprotective and neuroprotective effects and stimulates anticancer immunosurveillance in rodent models. Moreover, dietary polyamine uptake correlates with reduced cardiovascular and cancer-related m …
One such agent, the natural polyamine spermidine, has prominent cardioprotective and neuroprotective effects and stimulates an …
Spermidine is essential for fasting-mediated autophagy and longevity.
Hofer SJ, Daskalaki I, Bergmann M, Friščić J, Zimmermann A, Mueller MI, Abdellatif M, Nicastro R, Masser S, Durand S, Nartey A, Waltenstorfer M, Enzenhofer S, Faimann I, Gschiel V, Bajaj T, Niemeyer C, Gkikas I, Pein L, Cerrato G, Pan H, Liang Y, Tadic J, Jerkovic A, Aprahamian F, Robbins CE, Nirmalathasan N, Habisch H, Annerer E, Dethloff F, Stumpe M, Grundler F, Wilhelmi de Toledo F, Heinz DE, Koppold DA, Rajput Khokhar A, Michalsen A, Tripolt NJ, Sourij H, Pieber TR, de Cabo R, McCormick MA, Magnes C, Kepp O, Dengjel J, Sigrist SJ, Gassen NC, Sedej S, Madl T, De Virgilio C, Stelzl U, Hoffmann MH, Eisenberg T, Tavernarakis N, Kroemer G, Madeo F. Hofer SJ, et al. Nat Cell Biol. 2024 Sep;26(9):1571-1584. doi: 10.1038/s41556-024-01468-x. Epub 2024 Aug 8. Nat Cell Biol. 2024. PMID: 39117797 Free PMC article.
Genetic or pharmacological blockade of endogenous spermidine synthesis reduced fasting-induced autophagy in yeast, nematodes and human cells. Furthermore, perturbing the polyamine pathway in vivo abrogated the lifespan- and healthspan-extending effects, as well as the c …
Genetic or pharmacological blockade of endogenous spermidine synthesis reduced fasting-induced autophagy in yeast, nematodes and huma …
Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice.
Wierich MC, Schipke J, Brandenberger C, Abdellatif M, Eisenberg T, Madeo F, Sedej S, Mühlfeld C. Wierich MC, et al. Exp Gerontol. 2019 May;119:82-88. doi: 10.1016/j.exger.2019.01.026. Epub 2019 Jan 28. Exp Gerontol. 2019. PMID: 30703435
Recently, it was shown that the natural polyamine spermidine preserves cardiac function and cardiomyocyte composition in old mice. As cardiac function critically relies on blood supply, we tested whether spermidine has also beneficial effects on ageing-associated ch …
Recently, it was shown that the natural polyamine spermidine preserves cardiac function and cardiomyocyte composition in old mice. As …
Spermidine Promotes Cardioprotective Autophagy.
Tong D, Hill JA. Tong D, et al. Circ Res. 2017 Apr 14;120(8):1229-1231. doi: 10.1161/CIRCRESAHA.117.310603. Circ Res. 2017. PMID: 28408448 Free PMC article.
A recent study published in Nature Medicine reports that dietary supplementation with spermidine, a natural polyamine, extends life span and reverses aging-associated cardiac dysfunction in mice through induction of autophagy. Similar protective effects of spermidine …
A recent study published in Nature Medicine reports that dietary supplementation with spermidine, a natural polyamine, extends life s …
Absorption, anti-inflammatory, antioxidant, and cardioprotective impacts of a novel fasting mimetic containing spermidine, nicotinamide, palmitoylethanolamide, and oleoylethanolamide: A pilot dose-escalation study in healthy young adult men.
Rhodes CH, Hong BV, Tang X, Weng CY, Kang JW, Agus JK, Lebrilla CB, Zivkovic AM. Rhodes CH, et al. Nutr Res. 2024 Dec;132:125-135. doi: 10.1016/j.nutres.2024.10.006. Epub 2024 Oct 23. Nutr Res. 2024. PMID: 39549554 Free article. Clinical Trial.

Plasma concentrations of spermidine, 1-methylnicotinamide, PEA and OEA were quantified by liquid chromatography-mass spectrometry. ...Plasma 1-methylnicotinamide, PEA, and OEA concentrations increased after supplement intake (P < .05). Spermidine concentrations d

…
Plasma concentrations of spermidine, 1-methylnicotinamide, PEA and OEA were quantified by liquid chromatography-mass spectrometry. .. …
Autophagy in Cardiovascular Aging.
Abdellatif M, Sedej S, Carmona-Gutierrez D, Madeo F, Kroemer G. Abdellatif M, et al. Circ Res. 2018 Sep 14;123(7):803-824. doi: 10.1161/CIRCRESAHA.118.312208. Circ Res. 2018. PMID: 30355077 Free article. Review.
Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which trigger autophagy) are among the most promising cardioprotective interventions during aging. ...
Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which trigger autophagy) are am …
Cardioprotective effect of polyamine spermidine.
Gostner JM, Fuchs D. Gostner JM, et al. Am J Clin Nutr. 2019 Jan 1;109(1):218. doi: 10.1093/ajcn/nqy221. Am J Clin Nutr. 2019. PMID: 30576404 Free article. No abstract available.
Spermidine exerts cardiometabolic protection in estrogen-deprived rats via mitigating cardiac mitochondrial dysfunction and apoptosis.
Kaorop W, Maneechote C, Pratchayasakul W, Kumfu S, Arunsak B, Kongkaew A, Chattipakorn SC, Chattipakorn N. Kaorop W, et al. Toxicol Appl Pharmacol. 2025 Aug;501:117399. doi: 10.1016/j.taap.2025.117399. Epub 2025 May 21. Toxicol Appl Pharmacol. 2025. PMID: 40409731
However, the cardioprotective effects of spermidine against estrogen deprivation-related cardiac dysfunctions remain unclear. ...The OVX rats were randomly assigned to receive either vehicle treatment, spermidine (OS, 20 mg/kg/day, p.o., n = 10), or estradiol …
However, the cardioprotective effects of spermidine against estrogen deprivation-related cardiac dysfunctions remain unclear. …
40 results