Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 2
2002 1
2009 1
2013 1
2014 3
2015 1
2016 1
2018 2
2019 1
2020 8
2021 9
2022 2
2023 1
2024 1
2025 4
2026 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

35 results

Results by year

Filters applied: . Clear all
Page 1
The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders.
Zou M, Li D, Yang Y. Zou M, et al. Ageing Res Rev. 2025 Jul;109:102787. doi: 10.1016/j.arr.2025.102787. Epub 2025 May 28. Ageing Res Rev. 2025. PMID: 40447058 Review.
Emerging lines of evidence indicates that supplementation of spermidine favors the improvement of memory performance and cognition function. In this article, recent findings regarding the metabolism of spermidine under pathophysiological conditions are …
Emerging lines of evidence indicates that supplementation of spermidine favors the improvement of memory performance and co …
Dietary spermidine improves cognitive function.
Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Müller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Üçal M, Schäfer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Tölle RC, Sótonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Rácz B, Kiechl S, Eisenberg T, Madeo F. Schroeder S, et al. Cell Rep. 2021 Apr 13;35(2):108985. doi: 10.1016/j.celrep.2021.108985. Cell Rep. 2021. PMID: 33852843 Free article.
Neuron-specific Pink1 knockdown abolishes spermidine-induced improvement of olfactory associative learning. This suggests that the maintenance of mitochondrial and autophagic function is essential for enhanced cognition by spermidine feeding. Finally, we show …
Neuron-specific Pink1 knockdown abolishes spermidine-induced improvement of olfactory associative learning. This suggests that the ma …
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.
Schwarz C, Benson GS, Horn N, Wurdack K, Grittner U, Schilling R, Märschenz S, Köbe T, Hofer SJ, Magnes C, Stekovic S, Eisenberg T, Sigrist SJ, Schmitz D, Wirth M, Madeo F, Flöel A. Schwarz C, et al. JAMA Netw Open. 2022 May 2;5(5):e2213875. doi: 10.1001/jamanetworkopen.2022.13875. JAMA Netw Open. 2022. PMID: 35616942 Free PMC article. Clinical Trial.
Spermidine supplementation has shown beneficial effects on brain and cognitive health in animal models, and there has been preliminary evidence of memory improvement in individuals with subjective cognitive decline. ...Exploratory analyses indicated po …
Spermidine supplementation has shown beneficial effects on brain and cognitive health in animal models, and there has been pre …
The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.
Wirth M, Benson G, Schwarz C, Köbe T, Grittner U, Schmitz D, Sigrist SJ, Bohlken J, Stekovic S, Madeo F, Flöel A. Wirth M, et al. Cortex. 2018 Dec;109:181-188. doi: 10.1016/j.cortex.2018.09.014. Epub 2018 Oct 4. Cortex. 2018. PMID: 30388439 Clinical Trial.
METHODS: Cognitively intact participants with subjective cognitive decline (n = 30, 60-80 years of age) were included in this three-months, randomized, placebo-controlled, double-blind Phase IIa pilot trial with a spermidine-rich plant extract supplement. ... …
METHODS: Cognitively intact participants with subjective cognitive decline (n = 30, 60-80 years of age) were included in this …
Spermidine improves memory consolidation in a contextual fear conditioning task in adult zebrafish.
Hoch C, Resmim CM, Borba JV, Canzian J, Fontana BD, Rubin MA, Rosemberg DB. Hoch C, et al. Physiol Behav. 2025 Oct 15;300:115015. doi: 10.1016/j.physbeh.2025.115015. Epub 2025 Jul 5. Physiol Behav. 2025. PMID: 40623579
Memory is essential for survival, depending on the activation of neurotransmitter signaling pathways, such as the glutamatergic system. ...Although polyamines are known to influence cognitive processes, the potential modulatory role of spermidine (SPD) in …
Memory is essential for survival, depending on the activation of neurotransmitter signaling pathways, such as the glutamatergic syste …
Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging.
Hofer SJ, Liang Y, Zimmermann A, Schroeder S, Dengjel J, Kroemer G, Eisenberg T, Sigrist SJ, Madeo F. Hofer SJ, et al. Autophagy. 2021 Aug;17(8):2037-2039. doi: 10.1080/15548627.2021.1933299. Epub 2021 Jun 9. Autophagy. 2021. PMID: 34105442 Free PMC article.
Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. ...In two adjacent studies, we explored how dietary spermidine supplementation enhances eEF5/EIF5A hypusination, cerebral mitochondrial function an …
Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. ...In two adja …
Spermidine supplementation and protein restriction protect from organismal and brain aging independently.
Liang Y, Krivograd A, Hofer SJ, Kollipara L, Züllig T, Sickmann A, Eisenberg T, Sigrist SJ. Liang Y, et al. Aging (Albany NY). 2025 Jun 7;17(6):1429-1451. doi: 10.18632/aging.206267. Epub 2025 Jun 7. Aging (Albany NY). 2025. PMID: 40489973 Free PMC article.
Recent studies suggest that intermittent fasting effects are mediated by the endogenous polyamine spermidine. Spermidine supplementation promotes mitochondrial integrity and functionality in aging brains by supporting hypusination of the translational initiation fac …
Recent studies suggest that intermittent fasting effects are mediated by the endogenous polyamine spermidine. Spermidine suppl …
Spermidine-triggered autophagy ameliorates memory during aging.
Sigrist SJ, Carmona-Gutierrez D, Gupta VK, Bhukel A, Mertel S, Eisenberg T, Madeo F. Sigrist SJ, et al. Autophagy. 2014 Jan;10(1):178-9. doi: 10.4161/auto.26918. Epub 2013 Nov 15. Autophagy. 2014. PMID: 24262970 Free PMC article.
Our understanding of this process eventually aims at the delay and/or prevention of age-related pathologies, among them the age-dependent decrease in cognitive performance (e.g., learning and memory). Using the fruit fly Drosophila melanogaster, which combines a gen …
Our understanding of this process eventually aims at the delay and/or prevention of age-related pathologies, among them the age-dependent de …
Spermidine attenuates microglial activation, neuroinflammation, and neuronal injury in rat model of vascular dementia.
Zhao X, Li D, Zhu Z, Li S, Qin Y, Yang Y. Zhao X, et al. Neuroscience. 2025 May 7;573:355-363. doi: 10.1016/j.neuroscience.2025.03.054. Epub 2025 Mar 30. Neuroscience. 2025. PMID: 40169099
Spermidine has been implicated to provide beneficial effects on cognitive function in several model organisms as well as older adults with mild and moderate dementia. Nevertheless, the potential impact of spermidine on learning and memory deficits in v …
Spermidine has been implicated to provide beneficial effects on cognitive function in several model organisms as well as older …
Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)-study protocol for a randomized controlled trial.
Wirth M, Schwarz C, Benson G, Horn N, Buchert R, Lange C, Köbe T, Hetzer S, Maglione M, Michael E, Märschenz S, Mai K, Kopp U, Schmitz D, Grittner U, Sigrist SJ, Stekovic S, Madeo F, Flöel A. Wirth M, et al. Alzheimers Res Ther. 2019 May 1;11(1):36. doi: 10.1186/s13195-019-0484-1. Alzheimers Res Ther. 2019. PMID: 31039826 Free PMC article. Clinical Trial.
Presence of SCD is known to increase the risk of objective cognitive decline and progression to dementia due to Alzheimer's disease. Therefore, it is our primary goal to determine whether spermidine supplementation has a positive impact on memory performance …
Presence of SCD is known to increase the risk of objective cognitive decline and progression to dementia due to Alzheimer's disease. …
35 results