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Cardioprotection and lifespan extension by the natural polyamine spermidine.
Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. Nat Med. 2016. PMID: 27841876 Free PMC article.
In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diast …
In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, sper …
The role of polyamine metabolism in cellular function and physiology.
Schibalski RS, Shulha AS, Tsao BP, Palygin O, Ilatovskaya DV. Schibalski RS, et al. Am J Physiol Cell Physiol. 2024 Aug 1;327(2):C341-C356. doi: 10.1152/ajpcell.00074.2024. Epub 2024 Jun 17. Am J Physiol Cell Physiol. 2024. PMID: 38881422 Free PMC article. Review.
The major polyamines are putrescine, spermidine, spermine, and cadaverine. Polyamines are important for posttranscriptional regulation, autophagy, programmed cell death, proliferation, redox homeostasis, and ion channel function. ...Currently, manipulating polyamine levels …
The major polyamines are putrescine, spermidine, spermine, and cadaverine. Polyamines are important for posttranscriptional regulatio …
Mechano-energetic uncoupling in heart failure.
Aksentijevic D, Sedej S, Fauconnier J, Paillard M, Abdellatif M, Streckfuss-Bömeke K, Ventura-Clapier R, van der Velden J, de Boer RA, Bertero E, Dudek J, Sequeira V, Maack C. Aksentijevic D, et al. Nat Rev Cardiol. 2025 Oct;22(10):773-797. doi: 10.1038/s41569-025-01167-6. Epub 2025 Jun 22. Nat Rev Cardiol. 2025. PMID: 40544170 Review.
Heart failure (HF) is a major global and life-threatening disease. Despite advances in therapies, the prevalence of HF is increasing owing to an ageing population and the pervasive pandemic of obesity and metabolic disorders, which have transformed the pathophysiolo …
Heart failure (HF) is a major global and life-threatening disease. Despite advances in therapies, the prevalence of HF is incr …
Autophagy in the Heart.
Yamaguchi O. Yamaguchi O. Circ J. 2019 Mar 25;83(4):697-704. doi: 10.1253/circj.CJ-18-1065. Epub 2019 Feb 28. Circ J. 2019. PMID: 30814429 Free article. Review.
A polyamine, spermidine, is reported to bring about an extension of lifespan and to protect the heart from age-related cardiac dysfunction, both of which are mediated through induction of autophagy. Therefore, appropriate induction of autophagy could be a novel ther …
A polyamine, spermidine, is reported to bring about an extension of lifespan and to protect the heart from age-related cardiac …
Dietary spermidine for lowering high blood pressure.
Eisenberg T, Abdellatif M, Zimmermann A, Schroeder S, Pendl T, Harger A, Stekovic S, Schipke J, Magnes C, Schmidt A, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Carmona-Gutierrez D, Pietrocola F, Pieber TR, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Autophagy. 2017 Apr 3;13(4):767-769. doi: 10.1080/15548627.2017.1280225. Epub 2017 Jan 24. Autophagy. 2017. PMID: 28118075 Free PMC article.
We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the development of cardiovascular disease. ...In salt-sensitive rats, spermidine …
We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension …
Hypusine Signaling Promotes Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
Lemay SE, Grobs Y, Romanet C, Martineau S, Salem M, Shimauchi T, Breuils-Bonnet S, Bourgeois A, Théberge C, Pelletier A, Potus F, Provencher S, Bonnet S, Boucherat O. Lemay SE, et al. Am J Respir Crit Care Med. 2024 Jun 1;209(11):1376-1391. doi: 10.1164/rccm.202305-0909OC. Am J Respir Crit Care Med. 2024. PMID: 38261723
Rationale: The ubiquitous polyamine spermidine is essential for cell survival and proliferation. One important function of spermidine is to serve as a substrate for hypusination, a posttranslational modification process that occurs exclusively on eukaryotic translat …
Rationale: The ubiquitous polyamine spermidine is essential for cell survival and proliferation. One important function of spermid …
Anti-ageing interventions for the treatment of cardiovascular disease.
Abdellatif M, Schmid ST, Fuerlinger A, Kroemer G. Abdellatif M, et al. Cardiovasc Res. 2025 Aug 28;121(10):1524-1536. doi: 10.1093/cvr/cvae177. Cardiovasc Res. 2025. PMID: 39172536 Free PMC article. Review.
As the global demographic landscape continues to shift towards an aged population, so does the medical and socioeconomic burden of cardiovascular diseases. Indeed, ageing is one of, if not, the key risk factor for the development of cardiovascular diseases. ...In do …
As the global demographic landscape continues to shift towards an aged population, so does the medical and socioeconomic burden of cardiovas …
Beclin-1-dependent autophagy protects perivascular adipose tissue function from hyperaldosteronism effects.
Costa RM, Bruder-Nascimento A, Alves JV, Awata WMC, Singh S, Rodrigues D, Bruder-Nascimento T, Tostes RC. Costa RM, et al. Am J Physiol Heart Circ Physiol. 2025 Jun 1;328(6):H1253-H1266. doi: 10.1152/ajpheart.00829.2024. Epub 2025 May 6. Am J Physiol Heart Circ Physiol. 2025. PMID: 40327449 Free article.
Finally, BCN1-knock-in mice exhibited partial protection against HA-induced hypertension, highlighting the systemic vascular benefits of enhanced autophagic flux. In summary, our findings demonstrate that the activation of autophagy provides protection against HA-induced P …
Finally, BCN1-knock-in mice exhibited partial protection against HA-induced hypertension, highlighting the systemic vascular benefits …
Spermine Regulates Immune and Signal Transduction Dysfunction in Diabetic Cardiomyopathy.
Wei C, Sun M, Liang X, Che B, Wang N, Shi L, Fan Y. Wei C, et al. Front Endocrinol (Lausanne). 2022 Jan 31;12:740493. doi: 10.3389/fendo.2021.740493. eCollection 2021. Front Endocrinol (Lausanne). 2022. PMID: 35173678 Free PMC article.
BACKGROUND: Diabetic cardiomyopathy (DCM) is a specific form of cardiomyopathy that is independent of coronary artery disease and hypertension. Exploring the transcriptomics of DCM is of great significance for understanding the biology of the disease and for …
BACKGROUND: Diabetic cardiomyopathy (DCM) is a specific form of cardiomyopathy that is independent of coronary artery disease and …
Protective effects of spermidine levels against cardiovascular risk factors: An exploration of causality based on a bi-directional Mendelian randomization analysis.
Wang T, Li N, Zeng Y. Wang T, et al. Nutrition. 2024 Nov;127:112549. doi: 10.1016/j.nut.2024.112549. Epub 2024 Aug 5. Nutrition. 2024. PMID: 39243489 Free article.
The findings suggest a protective role of elevated spermidine levels against hypertension, elevated blood glucose, and lipid profiles (LDL-C and HDL-C). ...These results underline the potential of spermidine as a modifiable dietary target for the prevention a …
The findings suggest a protective role of elevated spermidine levels against hypertension, elevated blood glucose, and lipid p …
21 results