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Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges.
Liu Q, Li J, Sun X, Lin J, Yu Z, Xiao Y, Li D, Sun B, Bao H, Liu Y. Liu Q, et al. J Hematol Oncol. 2025 Aug 22;18(1):81. doi: 10.1186/s13045-025-01735-w. J Hematol Oncol. 2025. PMID: 40846970 Free PMC article. Review.
Immunosenescence, the age-related decline in immune function, profoundly impacts cancer progression and therapeutic outcomes by fostering a tumor-promoting microenvironment and impairing immune surveillance. ...Emerging strategies-including senolytics, epigenetic modulator …
Immunosenescence, the age-related decline in immune function, profoundly impacts cancer progression and therapeutic outcomes by foste …
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
Zhang H, Alsaleh G, Feltham J, Sun Y, Napolitano G, Riffelmacher T, Charles P, Frau L, Hublitz P, Yu Z, Mohammed S, Ballabio A, Balabanov S, Mellor J, Simon AK. Zhang H, et al. Mol Cell. 2019 Oct 3;76(1):110-125.e9. doi: 10.1016/j.molcel.2019.08.005. Epub 2019 Aug 29. Mol Cell. 2019. PMID: 31474573 Free PMC article.
Spermidine is depleted in the elderly, leading to reduced TFEB expression and autophagy. Spermidine supplementation restored this pathway and improved the responses of old human B cells. ...
Spermidine is depleted in the elderly, leading to reduced TFEB expression and autophagy. Spermidine supplementation restored t …
Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study.
Alsaleh G, Ali M, Kayvanjoo AH, Liu F, Moreau T, Bibi S, Luo L, Govender M, Carroll M, Hofer SJ, Tobias E, Magnes C, Kell L, Chung C, Deng Y, Bhandari A, Garner L, Conrad T, Chen L, Kronsteiner-Dobramysl B, Dunachie S, Spiller OB, Lambe T, Klenerman P, Jones LC, Simon AK. Alsaleh G, et al. Aging Cell. 2026 Jun;25(6):e70545. doi: 10.1111/acel.70545. Aging Cell. 2026. PMID: 42169618 Free PMC article. Clinical Trial.
Older adults are highly vulnerable to infectious diseases, and vaccines are often less effective in this population because of diminished B and T cell memory responses driven by impaired autophagy, immunosenescence, and chronic low-grade inflammation. Spermidine has …
Older adults are highly vulnerable to infectious diseases, and vaccines are often less effective in this population because of diminished B …
Specific features of immune ageing are detected in the earliest stages in rheumatoid arthritis development.
Raza K, Sharma-Oates A, Padyukov L, van der Helm-van Mil AHM, Pratt AG, Jones SW, Filer A, Lord JM, Duggal NA. Raza K, et al. EBioMedicine. 2025 Sep;119:105900. doi: 10.1016/j.ebiom.2025.105900. Epub 2025 Sep 3. EBioMedicine. 2025. PMID: 40908179 Free PMC article.
Future research should determine whether geroprotective drugs such as spermidine (autophagy booster), senolytics (clearance of senescent cells) and metformin (attenuates inflammation and boosts autophagy) reduce progression of the disease in patients at risk of RA. ...
Future research should determine whether geroprotective drugs such as spermidine (autophagy booster), senolytics (clearance of senesc …
Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism.
Soda K. Soda K. Int J Mol Sci. 2018 Oct 10;19(10):3106. doi: 10.3390/ijms19103106. Int J Mol Sci. 2018. PMID: 30309036 Free PMC article. Review.
SAH, which is converted from SAM by adding a methyl group to cytosine residues in DNA, is an intermediate precursor of homocysteine. dcSAM, converted from SAM by the enzymatic activity of adenosylmethionine decarboxylase, provides an aminopropyl group to synthesize the polyamines …
SAH, which is converted from SAM by adding a methyl group to cytosine residues in DNA, is an intermediate precursor of homocysteine. dcSAM, …
New roles for autophagy and spermidine in T cells.
Puleston DJ, Simon AK. Puleston DJ, et al. Microb Cell. 2015 Mar 2;2(3):91-93. doi: 10.15698/mic2015.03.195. Microb Cell. 2015. PMID: 28357282 Free PMC article.
We observed diminished autophagy levels in T cells from aged mice, linking autophagy to immunosenescence. Importantly, T cell responses to influenza vaccination could be significantly improved using the autophagy-inducing compound spermidine. ...
We observed diminished autophagy levels in T cells from aged mice, linking autophagy to immunosenescence. Importantly, T cell respons …
REPROGRAM: REsilience PROmotion with GeRoprotectors: AssessMent of biological effect: Rationale and protocol for a trial of biological effect.
Wilson D, Acharjee A, Duggal NA, Hombrebueno JR, Jones SW, Lewis JW, de Magalhães JP, Martinez-Serrato Y, Mazaheri A, McGettrick HM, Mondal S, Naylor AJ, Nixon A, Nicholson T, Partridge J, Pinkney T, Rattray NJW, Steves C, Tomkova K, Welch C, Jackson T. Wilson D, et al. PLoS One. 2026 Jun 17;21(6):e0346347. doi: 10.1371/journal.pone.0346347. eCollection 2026. PLoS One. 2026. PMID: 42308222
Participants will be randomised to one of three arms (Metformin MR 1500 mg, Fisetin 100 mg or Spermidine 15 mg). Participants will be extensively clinically characterised at baseline. ...The primary research question will answer whether a three-week course of Metformin, …
Participants will be randomised to one of three arms (Metformin MR 1500 mg, Fisetin 100 mg or Spermidine 15 mg). Participants will be …