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Cardioprotection and lifespan extension by the natural polyamine spermidine.
Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. Nat Med. 2016. PMID: 27841876 Free PMC article.
Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. ...Spermidine feeding failed to provide ca …
Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprote …
Mechanisms of spermidine-induced autophagy and geroprotection.
Hofer SJ, Simon AK, Bergmann M, Eisenberg T, Kroemer G, Madeo F. Hofer SJ, et al. Nat Aging. 2022 Dec;2(12):1112-1129. doi: 10.1038/s43587-022-00322-9. Epub 2022 Dec 22. Nat Aging. 2022. PMID: 37118547 Review.
Several recently discovered compounds that extend the healthspan and lifespan of model organisms decelerate pathways that govern the aging process. Among these geroprotectors, spermidine, a natural polyamine ubiquitously found in organisms from all kingdoms, prolong …
Several recently discovered compounds that extend the healthspan and lifespan of model organisms decelerate pathways that govern the …
Dietary spermidine improves cognitive function.
Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Müller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Üçal M, Schäfer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Tölle RC, Sótonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Rácz B, Kiechl S, Eisenberg T, Madeo F. Schroeder S, et al. Cell Rep. 2021 Apr 13;35(2):108985. doi: 10.1016/j.celrep.2021.108985. Cell Rep. 2021. PMID: 33852843 Free article.
Decreased cognitive performance is a hallmark of brain aging, but the underlying mechanisms and potential therapeutic avenues remain poorly understood. Recent studies have revealed health-protective and lifespan-extending effects of dietary spermidine, a natural aut …
Decreased cognitive performance is a hallmark of brain aging, but the underlying mechanisms and potential therapeutic avenues remain poorly …
Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging.
Hofer SJ, Liang Y, Zimmermann A, Schroeder S, Dengjel J, Kroemer G, Eisenberg T, Sigrist SJ, Madeo F. Hofer SJ, et al. Autophagy. 2021 Aug;17(8):2037-2039. doi: 10.1080/15548627.2021.1933299. Epub 2021 Jun 9. Autophagy. 2021. PMID: 34105442 Free PMC article. Review.
Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. ...Importantly, externally supplied spermidine (via drinking water or food) prolongs lifespan, activates autophagy, improves mitochondrial f
Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. ...Importantly
Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
Madeo F, Bauer MA, Carmona-Gutierrez D, Kroemer G. Madeo F, et al. Autophagy. 2019 Jan;15(1):165-168. doi: 10.1080/15548627.2018.1530929. Epub 2018 Oct 11. Autophagy. 2019. PMID: 30306826 Free PMC article.
External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine conc …
External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies a …
Glycine and aging: Evidence and mechanisms.
Johnson AA, Cuellar TL. Johnson AA, et al. Ageing Res Rev. 2023 Jun;87:101922. doi: 10.1016/j.arr.2023.101922. Epub 2023 Mar 31. Ageing Res Rev. 2023. PMID: 37004845 Free article. Review.
The restriction of calories, branched-chain amino acids, and methionine have all been shown to extend lifespan in model organisms. Recently, glycine was found to boost longevity in genetically heterogenous mice. ...In flies, Gnmt is required for reduced insulin/insu …
The restriction of calories, branched-chain amino acids, and methionine have all been shown to extend lifespan in model organisms. Re …
Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice.
Baek AR, Hong J, Song KS, Jang AS, Kim DJ, Chin SS, Park SW. Baek AR, et al. Exp Mol Med. 2020 Dec;52(12):2034-2045. doi: 10.1038/s12276-020-00545-z. Epub 2020 Dec 14. Exp Mol Med. 2020. PMID: 33318630 Free PMC article.
Spermidine is an endogenous biological polyamine that plays various longevity-extending roles and exerts antioxidative, antiaging, and cell growth-promoting effects. We previously reported that spermidine levels were significantly reduced in idiopathic pulmon
Spermidine is an endogenous biological polyamine that plays various longevity-extending roles and exerts antioxidative, antiag
Human trials exploring anti-aging medicines.
Guarente L, Sinclair DA, Kroemer G. Guarente L, et al. Cell Metab. 2024 Feb 6;36(2):354-376. doi: 10.1016/j.cmet.2023.12.007. Epub 2024 Jan 4. Cell Metab. 2024. PMID: 38181790 Review.
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD(+) precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatori …
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD( …
Induction of autophagy by spermidine promotes longevity.
Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F. Eisenberg T, et al. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4. Nat Cell Biol. 2009. PMID: 19801973
Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of spermidine, a natural polyamine whose intracellular concentrati …
Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events tha …
Molecular targets of spermidine: implications for cancer suppression.
Zimmermann A, Hofer SJ, Madeo F. Zimmermann A, et al. Cell Stress. 2023 Jul 10;7(7):50-58. doi: 10.15698/cst2023.07.281. eCollection 2023 Jul. Cell Stress. 2023. PMID: 37431488 Free PMC article.
Spermidine is a ubiquitous, natural polyamine with geroprotective features. Supplementation of spermidine extends the lifespan of yeast, worms, flies, and mice, and dietary spermidine intake correlates with reduced human mortality. ...
Spermidine is a ubiquitous, natural polyamine with geroprotective features. Supplementation of spermidine extends the lifes
172 results