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119 results
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Cardioprotection and lifespan extension by the natural polyamine spermidine.
Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. Nat Med. 2016. PMID: 27841876 Free PMC article.
Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. ...Spermidine feeding failed to provide ca …
Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprote …
Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy.
Yue F, Li W, Zou J, Jiang X, Xu G, Huang H, Liu L. Yue F, et al. Cancer Res. 2017 Jun 1;77(11):2938-2951. doi: 10.1158/0008-5472.CAN-16-3462. Epub 2017 Apr 6. Cancer Res. 2017. PMID: 28386016 Free PMC article.
Extending recent evidence that orally administered spermidine can extend lifespan in mice, we determined that life extension of up to 25% can be produced by lifelong administration, which also reduced liver fibrosis and HCC foci as induced by chemical insults. Genet …
Extending recent evidence that orally administered spermidine can extend lifespan in mice, we determined that life extension o …
Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
Madeo F, Bauer MA, Carmona-Gutierrez D, Kroemer G. Madeo F, et al. Autophagy. 2019 Jan;15(1):165-168. doi: 10.1080/15548627.2018.1530929. Epub 2018 Oct 11. Autophagy. 2019. PMID: 30306826 Free PMC article.
External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine conc …
External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies a …
Induction of autophagy by spermidine promotes longevity.
Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F. Eisenberg T, et al. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4. Nat Cell Biol. 2009. PMID: 19801973
Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of spermidine, a natural polyamine whose intracellular concentrati …
Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events tha …
Spermidine: a novel autophagy inducer and longevity elixir.
Madeo F, Eisenberg T, Büttner S, Ruckenstuhl C, Kroemer G. Madeo F, et al. Autophagy. 2010 Jan;6(1):160-2. doi: 10.4161/auto.6.1.10600. Autophagy. 2010. PMID: 20110777 Review.
Spermidine is a ubiquitous polycation that is synthesized from putrescine and serves as a precursor of spermine. ...Genetic inactivation of genes essential for autophagy abolishes the life span-prolonging effect of spermidine in yeast, nematodes and flies. These fin …
Spermidine is a ubiquitous polycation that is synthesized from putrescine and serves as a precursor of spermine. ...Genetic inactivat …
Autophagy and aging.
Rubinsztein DC, Mariño G, Kroemer G. Rubinsztein DC, et al. Cell. 2011 Sep 2;146(5):682-95. doi: 10.1016/j.cell.2011.07.030. Cell. 2011. PMID: 21884931 Free article. Review.
Pharmacological or genetic manipulations that increase life span in model organisms often stimulate autophagy, and its inhibition compromises the longevity-promoting effects of caloric restriction, Sirtuin 1 activation, inhibition of insulin/insulin growth factor signaling …
Pharmacological or genetic manipulations that increase life span in model organisms often stimulate autophagy, and its inhibition compromise …
Nutritional Aspects of Spermidine.
Madeo F, Hofer SJ, Pendl T, Bauer MA, Eisenberg T, Carmona-Gutierrez D, Kroemer G. Madeo F, et al. Annu Rev Nutr. 2020 Sep 23;40:135-159. doi: 10.1146/annurev-nutr-120419-015419. Epub 2020 Jul 7. Annu Rev Nutr. 2020. PMID: 32634331
Natural polyamines (spermidine and spermine) are small, positively charged molecules that are ubiquitously found within organisms and cells. ...Increased polyamine levels, including through enhanced dietary intake, have been consistently linked to improved health and reduc …
Natural polyamines (spermidine and spermine) are small, positively charged molecules that are ubiquitously found within organisms and …
Autophagy in Cardiovascular Aging.
Abdellatif M, Sedej S, Carmona-Gutierrez D, Madeo F, Kroemer G. Abdellatif M, et al. Circ Res. 2018 Sep 14;123(7):803-824. doi: 10.1161/CIRCRESAHA.118.312208. Circ Res. 2018. PMID: 30355077 Review.
Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to interfere with them. ...Calo …
Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this review, we revise …
Nutrition and longevity - From mechanisms to uncertainties.
Ekmekcioglu C. Ekmekcioglu C. Crit Rev Food Sci Nutr. 2020;60(18):3063-3082. doi: 10.1080/10408398.2019.1676698. Epub 2019 Oct 21. Crit Rev Food Sci Nutr. 2020. PMID: 31631676 Review.
Genetic, environmental, and lifestyle factors primarily determine the lifespan of humans. From these, nutrition is a key component affecting our health, and several studies particularly in model organisms and rodents have shown that nutrition has also the potential to incr …
Genetic, environmental, and lifestyle factors primarily determine the lifespan of humans. From these, nutrition is a key component af …
Higher spermidine intake is linked to lower mortality: a prospective population-based study.
Kiechl S, Pechlaner R, Willeit P, Notdurfter M, Paulweber B, Willeit K, Werner P, Ruckenstuhl C, Iglseder B, Weger S, Mairhofer B, Gartner M, Kedenko L, Chmelikova M, Stekovic S, Stuppner H, Oberhollenzer F, Kroemer G, Mayr M, Eisenberg T, Tilg H, Madeo F, Willeit J. Kiechl S, et al. Am J Clin Nutr. 2018 Aug 1;108(2):371-380. doi: 10.1093/ajcn/nqy102. Am J Clin Nutr. 2018. PMID: 29955838
BACKGROUND: Spermidine administration is linked to increased survival in several animal models. ...CONCLUSION: Our findings lend epidemiologic support to the concept that nutrition rich in spermidine is linked to increased survival in humans. This trial was register …
BACKGROUND: Spermidine administration is linked to increased survival in several animal models. ...CONCLUSION: Our findings lend epid …
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