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Cardioprotection and lifespan extension by the natural polyamine spermidine.
Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. Nat Med. 2016. PMID: 27841876 Free PMC article.
Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. ...Spermidine feeding failed to provide ca …
Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprote …
Mechanisms of spermidine-induced autophagy and geroprotection.
Hofer SJ, Simon AK, Bergmann M, Eisenberg T, Kroemer G, Madeo F. Hofer SJ, et al. Nat Aging. 2022 Dec;2(12):1112-1129. doi: 10.1038/s43587-022-00322-9. Epub 2022 Dec 22. Nat Aging. 2022. PMID: 37118547 Review.
Several recently discovered compounds that extend the healthspan and lifespan of model organisms decelerate pathways that govern the aging process. Among these geroprotectors, spermidine, a natural polyamine ubiquitously found in organisms from all kingdoms, prolong …
Several recently discovered compounds that extend the healthspan and lifespan of model organisms decelerate pathways that govern the …
Dietary spermidine improves cognitive function.
Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Müller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Üçal M, Schäfer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Tölle RC, Sótonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Rácz B, Kiechl S, Eisenberg T, Madeo F. Schroeder S, et al. Cell Rep. 2021 Apr 13;35(2):108985. doi: 10.1016/j.celrep.2021.108985. Cell Rep. 2021. PMID: 33852843 Free article.
Recent studies have revealed health-protective and lifespan-extending effects of dietary spermidine, a natural autophagy-promoting polyamine. ...Neuron-specific Pink1 knockdown abolishes spermidine-induced improvement of olfactory associative learning. This s …
Recent studies have revealed health-protective and lifespan-extending effects of dietary spermidine, a natural autophagy-promo …
Spermidine is essential for fasting-mediated autophagy and longevity.
Hofer SJ, Daskalaki I, Bergmann M, Friščić J, Zimmermann A, Mueller MI, Abdellatif M, Nicastro R, Masser S, Durand S, Nartey A, Waltenstorfer M, Enzenhofer S, Faimann I, Gschiel V, Bajaj T, Niemeyer C, Gkikas I, Pein L, Cerrato G, Pan H, Liang Y, Tadic J, Jerkovic A, Aprahamian F, Robbins CE, Nirmalathasan N, Habisch H, Annerer E, Dethloff F, Stumpe M, Grundler F, Wilhelmi de Toledo F, Heinz DE, Koppold DA, Rajput Khokhar A, Michalsen A, Tripolt NJ, Sourij H, Pieber TR, de Cabo R, McCormick MA, Magnes C, Kepp O, Dengjel J, Sigrist SJ, Gassen NC, Sedej S, Madl T, De Virgilio C, Stelzl U, Hoffmann MH, Eisenberg T, Tavernarakis N, Kroemer G, Madeo F. Hofer SJ, et al. Nat Cell Biol. 2024 Sep;26(9):1571-1584. doi: 10.1038/s41556-024-01468-x. Epub 2024 Aug 8. Nat Cell Biol. 2024. PMID: 39117797 Free PMC article.
Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health. The natural polyamine spermidine has been similarly linked to autophagy enhancement, geroprotection and reduced incidence of cardiovascular …
Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health. The nat …
Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging.
Hofer SJ, Liang Y, Zimmermann A, Schroeder S, Dengjel J, Kroemer G, Eisenberg T, Sigrist SJ, Madeo F. Hofer SJ, et al. Autophagy. 2021 Aug;17(8):2037-2039. doi: 10.1080/15548627.2021.1933299. Epub 2021 Jun 9. Autophagy. 2021. PMID: 34105442 Free PMC article.
Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. ...Importantly, externally supplied spermidine (via drinking water or food) prolongs lifespan, activates autophagy, improves mitochondrial f …
Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. ...Importantly …
Human trials exploring anti-aging medicines.
Guarente L, Sinclair DA, Kroemer G. Guarente L, et al. Cell Metab. 2024 Feb 6;36(2):354-376. doi: 10.1016/j.cmet.2023.12.007. Epub 2024 Jan 4. Cell Metab. 2024. PMID: 38181790 Free article. Review.
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD(+) precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatori …
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD( …
Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
Madeo F, Bauer MA, Carmona-Gutierrez D, Kroemer G. Madeo F, et al. Autophagy. 2019 Jan;15(1):165-168. doi: 10.1080/15548627.2018.1530929. Epub 2018 Oct 11. Autophagy. 2019. PMID: 30306826 Free PMC article.
External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine conc …
External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies a …
Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice.
Baek AR, Hong J, Song KS, Jang AS, Kim DJ, Chin SS, Park SW. Baek AR, et al. Exp Mol Med. 2020 Dec;52(12):2034-2045. doi: 10.1038/s12276-020-00545-z. Epub 2020 Dec 14. Exp Mol Med. 2020. PMID: 33318630 Free PMC article.
Spermidine is an endogenous biological polyamine that plays various longevity-extending roles and exerts antioxidative, antiaging, and cell growth-promoting effects. We previously reported that spermidine levels were significantly reduced in idiopathic pulmon …
Spermidine is an endogenous biological polyamine that plays various longevity-extending roles and exerts antioxidative, antiag …
Induction of autophagy by spermidine promotes longevity.
Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F. Eisenberg T, et al. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4. Nat Cell Biol. 2009. PMID: 19801973
Here, we report that administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells. In addition, spermidine administration pot …
Here, we report that administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing …
Glycine and aging: Evidence and mechanisms.
Johnson AA, Cuellar TL. Johnson AA, et al. Ageing Res Rev. 2023 Jun;87:101922. doi: 10.1016/j.arr.2023.101922. Epub 2023 Mar 31. Ageing Res Rev. 2023. PMID: 37004845 Free article. Review.
The restriction of calories, branched-chain amino acids, and methionine have all been shown to extend lifespan in model organisms. Recently, glycine was found to boost longevity in genetically heterogenous mice. ...In flies, Gnmt is required for reduced insulin/insu …
The restriction of calories, branched-chain amino acids, and methionine have all been shown to extend lifespan in model organisms. Re …
192 results