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Page 1
Cardioprotection and lifespan extension by the natural polyamine spermidine.
Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. Nat Med. 2016. PMID: 27841876 Free PMC article.
Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. ...Spermidine feeding failed to provide ca …
Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprote …
Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol.
Morselli E, Galluzzi L, Kepp O, Criollo A, Maiuri MC, Tavernarakis N, Madeo F, Kroemer G. Morselli E, et al. Aging (Albany NY). 2009 Dec 23;1(12):961-70. doi: 10.18632/aging.100110. Aging (Albany NY). 2009. PMID: 20157579 Free PMC article. Review.
Recent evidence produced by our groups demonstrates that autophagy is also involved in pharmacological manipulations that increase longevity. Exogenous supply of the polyamine spermidine can prolong the lifespan of (while inducing autophagy in) yeast, nematod …
Recent evidence produced by our groups demonstrates that autophagy is also involved in pharmacological manipulations that increase longev …
Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
Madeo F, Bauer MA, Carmona-Gutierrez D, Kroemer G. Madeo F, et al. Autophagy. 2019 Jan;15(1):165-168. doi: 10.1080/15548627.2018.1530929. Epub 2018 Oct 11. Autophagy. 2019. PMID: 30306826 Free PMC article.
External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine conc …
External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies a …
A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity.
Hofer SJ, Daskalaki I, Abdellatif M, Stelzl U, Sedej S, Tavernarakis N, Kroemer G, Madeo F. Hofer SJ, et al. Autophagy. 2024 Dec;20(12):2824-2826. doi: 10.1080/15548627.2024.2396793. Epub 2024 Sep 12. Autophagy. 2024. PMID: 39212197 Free PMC article.
Acute nutrient deprivation (fasting) causes an immediate increase in spermidine biosynthesis in yeast, flies, mice and humans, as corroborated in four independent clinical studies. ...Moreover, knockout or knockdown of the enzymes required for EIF5A hypusination abolish fa …
Acute nutrient deprivation (fasting) causes an immediate increase in spermidine biosynthesis in yeast, flies, mice and humans, as cor …
Autophagy in the Heart.
Yamaguchi O. Yamaguchi O. Circ J. 2019 Mar 25;83(4):697-704. doi: 10.1253/circj.CJ-18-1065. Epub 2019 Feb 28. Circ J. 2019. PMID: 30814429 Free article. Review.
Complete digestion of mitochondrial DNA through mitophagy is important to avoid inflammatory responses that can induce heart failure. A polyamine, spermidine, is reported to bring about an extension of lifespan and to protect the heart from age-related cardia …
Complete digestion of mitochondrial DNA through mitophagy is important to avoid inflammatory responses that can induce heart failure. A poly …
Autophagy in Cardiovascular Aging.
Abdellatif M, Sedej S, Carmona-Gutierrez D, Madeo F, Kroemer G. Abdellatif M, et al. Circ Res. 2018 Sep 14;123(7):803-824. doi: 10.1161/CIRCRESAHA.118.312208. Circ Res. 2018. PMID: 30355077 Free article. Review.
In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to interfere with them. ...Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which tri …
In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to in …
Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy.
Yue F, Li W, Zou J, Jiang X, Xu G, Huang H, Liu L. Yue F, et al. Cancer Res. 2017 Jun 1;77(11):2938-2951. doi: 10.1158/0008-5472.CAN-16-3462. Epub 2017 Apr 6. Cancer Res. 2017. PMID: 28386016 Free PMC article.
Extending recent evidence that orally administered spermidine can extend lifespan in mice, we determined that life extension of up to 25% can be produced by lifelong administration, which also reduced liver fibrosis and HCC foci as induced by chemical insults …
Extending recent evidence that orally administered spermidine can extend lifespan in mice, we determined that life extensio …
Does autophagy take a front seat in lifespan extension?
Petrovski G, Das DK. Petrovski G, et al. J Cell Mol Med. 2010 Nov;14(11):2543-51. doi: 10.1111/j.1582-4934.2010.01196.x. J Cell Mol Med. 2010. PMID: 21114762 Free PMC article. Review.
Nutritional deprivation or calorie restriction as well as several nutriceuticals including resveratrol, spermidine, curcumin and piperine can enhance autophagy and increase lifespan. Such striking similarities indicate that lifespan is strongly dependent on a …
Nutritional deprivation or calorie restriction as well as several nutriceuticals including resveratrol, spermidine, curcumin and pipe …
Spermine and gene methylation: a mechanism of lifespan extension induced by polyamine-rich diet.
Soda K. Soda K. Amino Acids. 2020 Feb;52(2):213-224. doi: 10.1007/s00726-019-02733-2. Epub 2019 Apr 19. Amino Acids. 2020. PMID: 31004229 Review.
The polyamines spermidine and spermine are synthesized in almost all organisms and are also contained in food. ...This review discusses the relation between polyamine metabolism and DNA methylation, as well as the biological mechanism of lifespan extension in …
The polyamines spermidine and spermine are synthesized in almost all organisms and are also contained in food. ...This review discuss …
Role of autophagy in aging.
Yamaguchi O, Otsu K. Yamaguchi O, et al. J Cardiovasc Pharmacol. 2012 Sep;60(3):242-7. doi: 10.1097/FJC.0b013e31824cc31c. J Cardiovasc Pharmacol. 2012. PMID: 22343371 Review.
Autophagy-related genes are known to be essential for the lifespan extension of flies, nematodes, and mice. The inhibition of autophagy decreases the lifespan, and on the other hand, the induction of autophagy can prolong the lifespan. Pharmacological …
Autophagy-related genes are known to be essential for the lifespan extension of flies, nematodes, and mice. The inhibition of …
37 results